ES479804A1 - Un procedimiento para la preparacion de derivados del acido amino-desoxi-clavulanico. - Google Patents

Un procedimiento para la preparacion de derivados del acido amino-desoxi-clavulanico.

Info

Publication number
ES479804A1
ES479804A1 ES479804A ES479804A ES479804A1 ES 479804 A1 ES479804 A1 ES 479804A1 ES 479804 A ES479804 A ES 479804A ES 479804 A ES479804 A ES 479804A ES 479804 A1 ES479804 A1 ES 479804A1
Authority
ES
Spain
Prior art keywords
group
preparation
alkyl
compositions
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479804A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES479804A1 publication Critical patent/ES479804A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un procedimiento para la preparación de derivados del ácido aminodesoxi-clavulanico de fórmula-01 (II): **(Fórmula-01)** o un ester de los mismos o una sal de adición de ácido del ester en donde R1 es un grupo heterocíclico, monocíclico o bicíclico aromático opcionalmente sustituido unido a través de un átomo de carbono y R2 es un grupo CH2R1, un átomo de hidrógeno, un grupo alquilo o hidroxialquilo de C1-6, un grupo bencilo opcionalmente sustituido, o un grupo de la sub- fórmula-02 (a): **(Fórmula-02)** en la que Ra es un grupo alquilo C1-3 y R6 y Rc son, independientemente, hidrógeno, alquilo C1-3 o fenilo, cuyo procedimiento comprende (A) hacer reaccionar de un éster de un compuesto de fórmula-03 (X): **(Fórmula-03)** con un compuesto de fórmula-04 (XI): **(Fórmula-04)** donde R1 y R2 son tales como se han definido en relación con la fórmula-01 (II) excepto en que R2 no es átomo de hidrógeno; (B) si se desea, y cuando R2 es un grupo de sub-fórmula- 02 (a) o un grupo CH2R1 o bencilo, someter el producto de la etapa anterior a reacción de hidrogenólisis; y (C) si se desea convertir el éster del compuesto (II) en una sal de adición de ácido, ácido libre o un ester alternativo o sal de adición de ácido del mismo.
ES479804A 1978-04-22 1979-04-20 Un procedimiento para la preparacion de derivados del acido amino-desoxi-clavulanico. Expired ES479804A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1598578 1978-04-22
GB7836267 1978-09-09
GB7840148 1978-10-11
GB7842338 1978-10-27

Publications (1)

Publication Number Publication Date
ES479804A1 true ES479804A1 (es) 1980-08-16

Family

ID=27448332

Family Applications (2)

Application Number Title Priority Date Filing Date
ES479804A Expired ES479804A1 (es) 1978-04-22 1979-04-20 Un procedimiento para la preparacion de derivados del acido amino-desoxi-clavulanico.
ES488256A Expired ES8103092A1 (es) 1978-04-22 1980-02-04 Un procedimiento para la preparacion de derivados del acido aminodesoxi-clavulanico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES488256A Expired ES8103092A1 (es) 1978-04-22 1980-02-04 Un procedimiento para la preparacion de derivados del acido aminodesoxi-clavulanico

Country Status (6)

Country Link
EP (1) EP0005014A1 (es)
JP (1) JPS54141796A (es)
AU (1) AU525534B2 (es)
CA (1) CA1137479A (es)
DK (1) DK164879A (es)
ES (2) ES479804A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2966347D1 (en) * 1978-09-09 1983-12-01 Beecham Group Plc Clavulanic acid derivatives and process for their preparation
EP0046349A1 (en) * 1980-08-16 1982-02-24 Beecham Group Plc Clavulanic acid derivatives, their preparation and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU503489B2 (en) * 1975-10-13 1979-09-06 Beecham Group Limited Substituted aminodeoxy clavulanic acid
GB1604822A (en) * 1977-04-22 1981-12-16 Beecham Group Ltd N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative
NZ187013A (en) * 1977-04-27 1985-04-30 Beecham Group Ltd 9-amino-9-deoxy-clavulanic acid derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0005014A1 (en) 1979-10-31
AU4590679A (en) 1979-11-01
JPS54141796A (en) 1979-11-05
DK164879A (da) 1979-10-23
AU525534B2 (en) 1982-11-11
ES488256A0 (es) 1981-02-16
CA1137479A (en) 1982-12-14
ES8103092A1 (es) 1981-02-16

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