KR850002983A - 플루오르 알킬레이티드 카르바 펜엠유도체의 제조방법 - Google Patents

플루오르 알킬레이티드 카르바 펜엠유도체의 제조방법 Download PDF

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KR850002983A
KR850002983A KR1019840006145A KR840006145A KR850002983A KR 850002983 A KR850002983 A KR 850002983A KR 1019840006145 A KR1019840006145 A KR 1019840006145A KR 840006145 A KR840006145 A KR 840006145A KR 850002983 A KR850002983 A KR 850002983A
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formula
group
compound
mono
hydrogen
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KR1019840006145A
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KR910009290B1 (ko
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칭퐁막, (외 1)
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예안 크라메르 한스 루돌프 하우스
산도즈 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

플루오르 알킬레이티드 카르바 펜엠유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. -S-R2-기를 하기식(Ⅲ) 화합물에 삽입 시키거나 하기식(Ⅳ) 화합물을 또는 그 전구체의 OH 기를 푸로로로 교환하고 필요하다면 얻어진 화합물을 탈보호화하거나 다른 생리적으로 가수분해될 수 있고 허용될 수 있는 에스테르 형태 또는 그것의 보호된 형태로 전환시키고 얻어진 화합물을 유리산 또는 염의 형태 또는 쥬피터이온 형태로 회수하는 단계로 이루어지는 하기식(Ⅰ) 화합물의 제조 공정.
    여기서 R1은 수소 또는 메틸, R2는 수소 또는 저급알킬, 저급알케닐 저급알키닐 또는 사이크로 알킬이며, 각각은 아미노, 모노 또는 디-(저급)-알킬아미노, 저급아실아미노, 카르복시, 저급알콕시카르보닐 또는 카르바모일에 의해 치환되지 않거나 모노 또는 다중 치환되었으며,
    하기식 (Ⅱc)의 기
    (CH2)P-R5(Ⅱc)
    여기서 R5는 페닐 또는 O. S 및 N으로 부터 선택된 하나 또는 그 이상의 헤테로 원자를 포함하는 5- 또는 6-원소의 포화 또는 불포화된 헤테로 사이클이며 이는 푸로로, 크로로, 브로모, 아미노모노 또는 디-(저급)-알킬아미노, 하이드록시, 저급알콕시, 멀캅토, 알킬티오, 페닐티오, 설파모일, 구아니디노, 니트로, 시아노, 아실아미노, 카르복시, 알콕시카르보닐 또는 카르바모일에 의해 치환되지 않거나 모노 또는 다중 치환되었으며 p는 0, 1, 2 또는 3 : 이거나,
    하기식(Ⅱ)(Ⅱa)(Ⅱb)기
    여기서 R6, R7과 R8는 같거나 각각은 수소 또는 저급알킬이거나 R6와 R8및 R7과 CH2기의 하나는 상기식(Ⅱ)의 R7과 R8에서와 같이 결합되어 고리를 형성하고 상기식(Ⅱa)와 (Ⅱb)의 R6와 R7의 고리는 알킬, 하이드록 시, 카르복시 또는 디-(저급)-알킬아미노에 의해 치환되지 않거나 모노 또는 다중치환되며 m은 2 또는 3이고, n은 1,2 또는 3, R3는 수소 또는 저급알킬, R4는 저급알킬 또는 이것의 보호된 형태 또는 생리적으로 가수분해 될 수 있고 허용될 수 있는 에스테르 형태 : 유리산 또는 염형태 또는 쥬피터 이온형태이고, R10은 유리기를 나타내고, R9는 보호기 또는 생리적으로 가수분해되고 허용될 수 있는 에스테르기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840006145A 1983-10-03 1984-10-02 플루오르 알킬레이티드 카르바 펜엠 유도체의 제조방법 KR910009290B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH5363 1983-10-03
CH5363/83 1983-10-03
CH5363/83A CH660736A5 (de) 1983-10-03 1983-10-03 Carbapenemderivate.

Publications (2)

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KR850002983A true KR850002983A (ko) 1985-05-28
KR910009290B1 KR910009290B1 (ko) 1991-11-09

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US (1) US4720491A (ko)
JP (2) JPS60105676A (ko)
KR (1) KR910009290B1 (ko)
AT (1) AT386204B (ko)
AU (1) AU3376084A (ko)
BE (1) BE900718A (ko)
CA (1) CA1241656A (ko)
CH (2) CH662117A5 (ko)
DE (1) DE3434504A1 (ko)
DK (1) DK470684A (ko)
ES (1) ES8706680A1 (ko)
FI (1) FI843847L (ko)
FR (1) FR2552763B1 (ko)
GB (1) GB2147298B (ko)
GR (1) GR80515B (ko)
HU (1) HUT36478A (ko)
IL (1) IL73127A0 (ko)
IT (1) IT1199203B (ko)
LU (1) LU85570A1 (ko)
NL (1) NL8402936A (ko)
PL (1) PL249834A1 (ko)
PT (1) PT79293B (ko)
SE (1) SE462493B (ko)
ZA (1) ZA847781B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
EP0234484B1 (en) * 1986-02-19 1993-10-20 Sanraku Incorporated Novel azetidinone derivatives
EP0464900A3 (en) 1990-06-26 1992-07-22 Merck & Co. Inc. 2-biphenyl-carbapenems
CA2052730A1 (en) 1990-10-11 1992-04-12 Frank P. Dininno 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
ES8404184A1 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
FI832619A (fi) * 1982-07-26 1984-01-27 Sandoz Ag Fluoralkylerade karbapenemderivat

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JPH0670059B2 (ja) 1994-09-07
IT8448934A1 (it) 1986-04-02
IL73127A0 (en) 1984-12-31
JPH04364183A (ja) 1992-12-16
GR80515B (en) 1985-01-28
SE8404906L (sv) 1985-04-04
ES8706680A1 (es) 1987-07-01
DK470684A (da) 1985-04-04
FR2552763B1 (fr) 1987-01-09
ZA847781B (en) 1986-05-28
AT386204B (de) 1988-07-25
CH662117A5 (de) 1987-09-15
BE900718A (fr) 1985-04-01
CA1241656A (en) 1988-09-06
ES536443A0 (es) 1987-07-01
JPH0564153B2 (ko) 1993-09-14
PT79293B (en) 1986-09-10
HUT36478A (en) 1985-09-30
IT1199203B (it) 1988-12-30
DK470684D0 (da) 1984-10-01
IT8448934A0 (it) 1984-10-02
CH660736A5 (de) 1987-06-15
PL249834A1 (en) 1985-12-03
DE3434504A1 (de) 1985-04-18
LU85570A1 (fr) 1985-06-19
FI843847A0 (fi) 1984-10-01
GB8424708D0 (en) 1984-11-07
NL8402936A (nl) 1985-05-01
SE462493B (sv) 1990-07-02
FR2552763A1 (fr) 1985-04-05
KR910009290B1 (ko) 1991-11-09
AU3376084A (en) 1985-04-18
FI843847L (fi) 1985-04-04
GB2147298A (en) 1985-05-09
ATA311584A (de) 1987-12-15
PT79293A (en) 1984-11-01
GB2147298B (en) 1988-01-13
SE8404906D0 (sv) 1984-10-01
JPS60105676A (ja) 1985-06-11
US4720491A (en) 1988-01-19

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