KR840004438A - 세팔로스포린 유도체의 제조방법 - Google Patents

세팔로스포린 유도체의 제조방법 Download PDF

Info

Publication number
KR840004438A
KR840004438A KR1019830001397A KR830001397A KR840004438A KR 840004438 A KR840004438 A KR 840004438A KR 1019830001397 A KR1019830001397 A KR 1019830001397A KR 830001397 A KR830001397 A KR 830001397A KR 840004438 A KR840004438 A KR 840004438A
Authority
KR
South Korea
Prior art keywords
carbon atoms
group
represent
atom
alkyl group
Prior art date
Application number
KR1019830001397A
Other languages
English (en)
Inventor
마사히로 아리모또 (외 2)
Original Assignee
미야다께 가즈오
다이이찌 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57057010A external-priority patent/JPS58174386A/ja
Priority claimed from JP57132501A external-priority patent/JPS5921695A/ja
Priority claimed from JP57193607A external-priority patent/JPS5982390A/ja
Application filed by 미야다께 가즈오, 다이이찌 세이야꾸 가부시끼 가이샤 filed Critical 미야다께 가즈오
Publication of KR840004438A publication Critical patent/KR840004438A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

세팔로스포린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 일반식(Ⅱ의 화합물 또는 그의 보호된 화합물을 일반식또는 HS-R6(R4, R5및 R6는 하기에서 정의한 바와 같다)의 화합물과 반응시키고, 생성되는 화합물의 술폭시드 부위를 술피드로 전환시킨 다음, 필요에 따라서 보호기(들)을 제거함을 특징으로 하는 하기 일반식(Ⅰ)의 세팔로스포린 유도체 및 생리적으로 허용되는 그의 염의 제조방법.
    상기식들에 있어서,
    R1은 COOH, COC- 또는 COOM(M은 알카리금속 또는 알카리토금속임)을 나타내고:
    θ1,θ2및 θ3는 각각 질소원자 또는 탄소원자를 나타내고, θ1,θ|2및 θ3중 적어도 2개는 질소원자를 나타내며;
    R2는 수소원자 또는 1내지 6개의 탄소원자를 갖는 알킬기를 나타내며;
    R3는 탄소원자수 2 내지 7의 아실옥시기,또는 -S-R6(여기에서, R4와 R5는 각각 수소원자, 카밤오일기 또는 탄소원자수 1 내지 6의 알킬기를 나타내고; R6는 1 내지 4개의 복소원자를 가지며, 탄소원자수 1 내지 6개를 갖는 알킬기로 치환될 수 있는 5 또는 6원환을 나타낸다)을 나타내며;
    n은 1 또는 2를 나타내며;
    x는 할로겐원자 또는 탄소원자수 2 내지 7의 아실옥시기를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001397A 1982-04-06 1983-04-04 세팔로스포린 유도체의 제조방법 KR840004438A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP57010/82 1982-04-06
JP57057010A JPS58174386A (ja) 1982-04-06 1982-04-06 セフアロスポリン誘導体
JP132501/82 1982-07-29
JP57132501A JPS5921695A (ja) 1982-07-29 1982-07-29 セフアロスポリン誘導体
JP57193607A JPS5982390A (ja) 1982-11-04 1982-11-04 セフアロスポリン誘導体
JP193607/82 1982-11-04

Publications (1)

Publication Number Publication Date
KR840004438A true KR840004438A (ko) 1984-10-15

Family

ID=27296108

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001397A KR840004438A (ko) 1982-04-06 1983-04-04 세팔로스포린 유도체의 제조방법

Country Status (10)

Country Link
US (1) US4603198A (ko)
EP (1) EP0091130B1 (ko)
KR (1) KR840004438A (ko)
AU (1) AU550462B2 (ko)
CA (1) CA1215970A (ko)
DE (1) DE3370801D1 (ko)
ES (1) ES8501407A1 (ko)
GR (1) GR78176B (ko)
PH (1) PH19163A (ko)
YU (1) YU79383A (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0157073B1 (ko) * 1992-10-01 1998-11-16 김태훈 세팔로스포린 유도체 및 그의 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
GB2029823A (en) * 1978-05-26 1980-03-26 Glaxo Group Ltd Cephalosporin Antibiotics
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
GB2028305A (en) * 1978-08-03 1980-03-05 Hoechst Ag Cephem derivatives and processes for their manufacture
JPS5677287A (en) * 1979-10-25 1981-06-25 Squibb & Sons Inc Imidazole and tetrazole derivative of aminothiazolylloxyiminocephalosporin
US4271157A (en) * 1980-02-28 1981-06-02 E. R. Squibb & Sons, Inc. Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
GB2061276B (en) * 1979-10-25 1983-05-25 Squibb & Sons Inc Imidazole and tetrazole derivatives of 7-((2-amino-4-thiazolyl)-oximino)cephalosporins

Also Published As

Publication number Publication date
GR78176B (ko) 1984-09-26
US4603198A (en) 1986-07-29
DE3370801D1 (en) 1987-05-14
ES521246A0 (es) 1984-12-01
ES8501407A1 (es) 1984-12-01
AU1318483A (en) 1983-10-13
EP0091130A3 (en) 1984-07-25
AU550462B2 (en) 1986-03-20
EP0091130B1 (en) 1987-04-08
PH19163A (en) 1986-01-16
CA1215970A (en) 1986-12-30
EP0091130A2 (en) 1983-10-12
YU79383A (en) 1986-04-30

Similar Documents

Publication Publication Date Title
KR860001104A (ko) 테트라히드로프탈이미드의 제조방법
KR850000406A (ko) 4-클로로-2-페닐이미다졸-5-아세트산유도체의 제조방법
KR850000033A (ko) 8-클로로-1,5-벤조티아제핀 유도체의 제조방법
KR850006391A (ko) 벤조치아졸 및 벤조치오펜 유도체의 제조방법
SE7707341L (sv) 4-hydroxifenylalkanolamin-derivat och forfarande for framstellning derav
KR920008018A (ko) 피페라진 유도체의 제조방법
KR830007626A (ko) 2-(1,4-벤조디옥산-2-일알킬) 이미다졸류의 제조방법
KR850002459A (ko) 디히드록시벤즈아미드 유도체 및 그 제조방법
KR840001555A (ko) 치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법
KR840001152A (ko) 신규 복소환(複素環) 화합물의 제법
KR840006206A (ko) 이소퀴놀린 유도체의 제조방법
KR840004422A (ko) 사이프로헵타딘-3-카복실산의 에스테르 및 관련 화합물의 제조방법
KR830004320A (ko) 퀴나졸린 유도체의 제조방법
KR840004438A (ko) 세팔로스포린 유도체의 제조방법
KR850004470A (ko) 유기 화합물의 제조방법
KR830005191A (ko) 푸란유도체의 제조방법
KR840006238A (ko) 신규 α-아릴-α-피리딜알카노인산 유도체의 제조방법
KR840001160A (ko) 벤조디옥산-이미다졸린 유도체의 제조방법
KR830006293A (ko) 신규 폴리아자 헤테로고리 화합물의 제조방법
KR840001121A (ko) 데카복실라제- 저해제인 플루오르화 알칸디아민유도체의 제조방법
KR860006461A (ko) 항알레르기 작용을 갖는 화합물의 제조방법
DE58901277D1 (de) Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
SE7909157L (sv) Forfarande for framstellning av cyklo-1,3,2-oxazafosforylderivat
SE7706693L (sv) Sett att framstella hydrazinopyridazinderivat
KR830005157A (ko) 페녹시-아미노프로판올 유도체의 제조방법

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid