KR840001555A - 치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법 - Google Patents

치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법 Download PDF

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KR840001555A
KR840001555A KR1019820004342A KR820004342A KR840001555A KR 840001555 A KR840001555 A KR 840001555A KR 1019820004342 A KR1019820004342 A KR 1019820004342A KR 820004342 A KR820004342 A KR 820004342A KR 840001555 A KR840001555 A KR 840001555A
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acid addition
ethylamine
phenyl
addition salts
general formula
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KR1019820004342A
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KR880002705B1 (ko
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쉬나이더 클라우스 (외 4)
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페터 페에르호프,기셀라 베엘만
베링거 인겔하임 케이지
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

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  • Chemical & Material Sciences (AREA)
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  • Pyridine Compounds (AREA)
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Abstract

내용 없음

Description

치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅱ)의 페닐에틸아민 또는 그의 산부가염을 하기 일반식(Ⅲ)의 피리딘 유도체와 반응시키고, 필요에 따라서는 수득되는 목적물을 약학적으로 허용되는 그의 산부가염으로 전환시킴을 특징으로 하여 하기 일반식(Ⅰ)의 치환된 2-페닐-2-(피리딜옥시)-에틸아민과 그의 동배전자 화합물 및 그들의 산부가염을 제조하는 방법.
  3. 상기 식들에 있어서, R1과 R2는 동일 또는 상이한 것으로서 수소, 할로겐원자, 메틸, 메톡시, 아미노 또는 니트로를 나타내고; R3는 수소, 할로겐 또는 메틸을 나타내며; R4와 R5는 동일 또는 상이한 것으로서 수소 또는 1-2개의 탄소원자를 갖는 알킬기를 나타내거나 또는 질소원자와 함께 피롤리디노 또는 모르폴리노환을 형성하며; X는 O, NH 또는 S를 나타내며; Y는 할로겐원자 또는 히드록시기를 나타내며; Z는 히드록시, 아미노 또는 메르캅토기를 나타낸다.
  4. 제1항에 있어서, 일반식(Ⅰ)의 R4및(또는 R5)가 수소를 나타내는 화합물을 그 자체 공지의 방법에 의해 알킬화시킴을 특징으로 하는 방법.
  5. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8204342A 1981-09-28 1982-09-27 치환된 2-페닐-2-(피리딜옥시)-에틸아민, 그의 등배전자 화합물 및 그의 산부가염의 제조방법 KR880002705B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3138550.8 1981-09-28
DEP.3138550.8 1981-09-28
DE19813138550 DE3138550A1 (de) 1981-09-28 1981-09-28 Substituierte 2-phenyl-2-(pyridyloxy)-ethylamine und isostere verbindungen, verfahren zu ihrer herstellung und verwendung

Publications (2)

Publication Number Publication Date
KR840001555A true KR840001555A (ko) 1984-05-07
KR880002705B1 KR880002705B1 (ko) 1988-12-26

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KR8204342A KR880002705B1 (ko) 1981-09-28 1982-09-27 치환된 2-페닐-2-(피리딜옥시)-에틸아민, 그의 등배전자 화합물 및 그의 산부가염의 제조방법

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US (1) US4666910A (ko)
EP (1) EP0075752B1 (ko)
JP (1) JPS5869865A (ko)
KR (1) KR880002705B1 (ko)
AR (1) AR231534A1 (ko)
AT (1) ATE18551T1 (ko)
AU (1) AU550614B2 (ko)
CA (1) CA1171086A (ko)
DE (2) DE3138550A1 (ko)
DK (1) DK156718C (ko)
ES (1) ES8308543A1 (ko)
FI (1) FI78074C (ko)
GB (1) GB2106902B (ko)
GR (1) GR77657B (ko)
IE (1) IE53959B1 (ko)
IL (1) IL66870A (ko)
NO (1) NO159999C (ko)
NZ (1) NZ202015A (ko)
PH (1) PH23219A (ko)
PT (1) PT75611B (ko)
ZA (1) ZA827055B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320699D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Ethylenediamines
GB0004151D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004153D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
AR035700A1 (es) * 2001-05-08 2004-06-23 Astrazeneca Ab Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados
SE0102641D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0102639D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
US6800652B2 (en) * 2002-08-16 2004-10-05 Pfizer Inc. Diaryl compounds
GB0219154D0 (en) * 2002-08-16 2002-09-25 Pfizer Ltd Diaryl compounds
SE0203304D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Coumpounds
EP1678161B1 (en) * 2003-10-09 2009-12-30 Millennium Pharmaceuticals, Inc. Thioether-substituted benzamides as inhibitors of factor xa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734846A (en) * 1956-02-14 Aqueous suspension of procaine penicil-
US2734845A (en) * 1956-02-14 Aqueous suspension of procaine penicil-
FR1511398A (fr) * 1966-02-16 1968-01-26 Takeda Chemical Industries Ltd Procédé de préparation de nouveaux dérivés de picoline
BE790592A (ko) * 1971-10-28 1973-04-26 Oreal
US4011324A (en) * 1976-01-20 1977-03-08 Pfizer Inc. Esters and amides of pyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylic acids as antiulcer agents
JPS53141271A (en) * 1977-05-13 1978-12-08 Yamanouchi Pharmaceut Co Ltd Heterocyclic compounds and process for their preparation

Also Published As

Publication number Publication date
EP0075752B1 (de) 1986-03-12
IL66870A (en) 1986-02-28
GB2106902A (en) 1983-04-20
KR880002705B1 (ko) 1988-12-26
PT75611B (de) 1985-12-09
PT75611A (de) 1982-10-01
ZA827055B (en) 1984-05-30
NO159999B (no) 1988-11-21
PH23219A (en) 1989-06-06
NZ202015A (en) 1985-11-08
IE822330L (en) 1983-03-28
DK156718B (da) 1989-09-25
DE3138550A1 (de) 1983-04-07
ES515972A0 (es) 1983-09-16
DE3269839D1 (en) 1986-04-17
FI823246L (fi) 1983-03-29
JPS5869865A (ja) 1983-04-26
ATE18551T1 (de) 1986-03-15
GR77657B (ko) 1984-09-25
AU550614B2 (en) 1986-03-27
DK428582A (da) 1983-03-29
FI78074B (fi) 1989-02-28
IL66870A0 (en) 1982-12-31
GB2106902B (en) 1985-08-07
IE53959B1 (en) 1989-04-26
AU8873882A (en) 1983-04-14
NO159999C (no) 1989-03-01
EP0075752A2 (de) 1983-04-06
AR231534A1 (es) 1984-12-28
CA1171086A (en) 1984-07-17
FI78074C (fi) 1989-06-12
US4666910A (en) 1987-05-19
FI823246A0 (fi) 1982-09-22
JPH0316952B2 (ko) 1991-03-06
ES8308543A1 (es) 1983-09-16
NO823253L (no) 1983-03-29
DK156718C (da) 1990-03-05
EP0075752A3 (en) 1984-03-21

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