KR850008166A - 인돌린 및 2-인돌리논 유도체의 제조방법 - Google Patents
인돌린 및 2-인돌리논 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850008166A KR850008166A KR1019850003271A KR850003271A KR850008166A KR 850008166 A KR850008166 A KR 850008166A KR 1019850003271 A KR1019850003271 A KR 1019850003271A KR 850003271 A KR850003271 A KR 850003271A KR 850008166 A KR850008166 A KR 850008166A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- methyl
- alkyl
- formula
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 하기 일반식(Ⅳ)의 화합물을 일반식 R2NHNH2의 화합물과 반응시키거나, 또는 일반식(Ⅰ) (여기서 R2는 수소이다)의 화합물을 일반식 R2Y(여기서 Y는 이탈기이다)의 알킬화제로 알킬화시키거나 또는 일반식(Ⅰ)(여기서 R3와 R4및 R5중의 하나는 수소이다)의 화합물을 수소 이탈반응시키고, 임의로는 생성물을 염화시킴을 특징으로 하여, 하기 일반식(Ⅰ)의 인돌린 또는 2-인돌리논 유도체 또는 이의 약리학적으로 허용되는 염을 제조하는 방법.상기식에서, Ra는 수소 또는 메틸이고; B=C<는 O=C<또는 H2C< 이고; R1은 수소, C1-C4알킬, C2-C4알카노일, 메틸-또는 에틸-술포닐, 또는 할로, C1-C4알킬, 메톡시 또는 에톡시로부터 선택된 1 내지 3개의 치환분으로 페닐환에 임의로 치환된 벤조일이며; R2는 수소, C2-C22알킬, 히드록시-치환된 C1-C3알킬, 카르바모일-치환된 C1-C11알킬, 나프틸옥시-메틸 또는-에틸, 옥소-치환된 C1-C11알킬기, 또는 R6R7N-(CH2)n-(여기서 각각의 R6및 R7은 각각 수소 또는 C1-C4알킬이며, 부착되는 질소원자와 함께 취할 때 피롤리디노, 피페리디노, 모르폴리노, 피페라지노, 또는 N-메틸피페라지노 환을 형성하고, n은 2 또는 3이다)이며; R3는 수소이고; R4는 수소, C1-C4알킬, 히드록시메틸, 또는 C2-C4알카노일옥시메틸이고; R5는 수소 또는 C1-C4알킬이거나; 또는 R3와 R4및 R5중의 하나는 함께 결합되며; R6는 수소 또는 메틸이다.
- 제1항에 있어서, 일반식(Ⅳ)의 화합물(여기서 Ra는 메틸이고, R6는 수소이다)을 히드라진 또는 히드라진 수화물과 반응시키는 방법.
- 제1항에 있어서, 일반식(Ⅳ)의 화합물(여기서 B=C<는 O=C<이고, Ra는 메틸이며, R1, R3, R4및 R6는 수소이며, R5는 메틸이다)을 히드라진 또는 히드라진 수화물과 반응시키는 방법.
- 제1항에 있어서, 일반식(Ⅳ)의 화합물(여기서 B=C<는 O=C<이고, Ra는 메틸이고, R1, R3및 R6는 수소이며 R4및 R5는 메틸이다)을 히드라진 또는 히드라진 수화물과 반응시키는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61021084A | 1984-05-14 | 1984-05-14 | |
US610,210 | 1984-05-14 | ||
US610210 | 1984-05-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850008166A true KR850008166A (ko) | 1985-12-13 |
KR870000274B1 KR870000274B1 (ko) | 1987-02-23 |
Family
ID=24444125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850003271A KR870000274B1 (ko) | 1984-05-14 | 1985-05-14 | 인돌린 및 2-인돌리논 유도체의 제조방법 |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0161918B1 (ko) |
JP (1) | JPH0643417B2 (ko) |
KR (1) | KR870000274B1 (ko) |
AR (1) | AR241531A1 (ko) |
AT (1) | ATE54915T1 (ko) |
AU (1) | AU577372B2 (ko) |
CA (1) | CA1248099A (ko) |
DE (1) | DE3578822D1 (ko) |
DK (1) | DK207785A (ko) |
EG (1) | EG17342A (ko) |
ES (1) | ES8609308A1 (ko) |
GR (1) | GR851121B (ko) |
HU (1) | HU194873B (ko) |
IL (1) | IL75122A (ko) |
MY (1) | MY101520A (ko) |
NZ (1) | NZ212023A (ko) |
PH (1) | PH21862A (ko) |
PT (1) | PT80414B (ko) |
SU (1) | SU1486060A3 (ko) |
ZA (1) | ZA853440B (ko) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4591591A (en) * | 1984-03-08 | 1986-05-27 | Eli Lilly And Company | Pyridazinone derivatives as inotropic agents |
DE3631085A1 (de) * | 1986-09-12 | 1988-03-24 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte |
DE3706427A1 (de) * | 1987-02-27 | 1988-09-08 | Boehringer Mannheim Gmbh | Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel |
US5196416A (en) * | 1987-08-28 | 1993-03-23 | Eli Lilly And Company | Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water |
DE3871464D1 (de) * | 1987-08-28 | 1992-07-02 | Lilly Co Eli | Die permeation verbessernde zusammensetzung. |
EP0326307B1 (en) * | 1988-01-23 | 1994-08-17 | Kyowa Hakko Kogyo Co., Ltd. | Novel pyridazinone derivatives and pharmaceutical preparations containing them |
GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CN101772513B (zh) | 2007-06-04 | 2013-11-13 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2012118972A2 (en) | 2011-03-01 | 2012-09-07 | Synegy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2913737A1 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
WO2024191714A1 (en) * | 2023-03-10 | 2024-09-19 | Zoetis Services Llc | Phosphodiesterase 3 (pde3) inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES482789A0 (es) * | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
DE3124699A1 (de) * | 1981-06-24 | 1983-01-13 | Basf Ag, 6700 Ludwigshafen | Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
JPS588016A (ja) * | 1981-07-06 | 1983-01-18 | Mitsubishi Chem Ind Ltd | 強心剤 |
-
1985
- 1985-05-07 CA CA000480903A patent/CA1248099A/en not_active Expired
- 1985-05-07 IL IL75122A patent/IL75122A/xx unknown
- 1985-05-07 ZA ZA853440A patent/ZA853440B/xx unknown
- 1985-05-08 GR GR851121A patent/GR851121B/el unknown
- 1985-05-08 PT PT80414A patent/PT80414B/pt not_active IP Right Cessation
- 1985-05-09 PH PH32245A patent/PH21862A/en unknown
- 1985-05-09 AR AR85300328A patent/AR241531A1/es active
- 1985-05-09 NZ NZ212023A patent/NZ212023A/en unknown
- 1985-05-10 AT AT85303310T patent/ATE54915T1/de not_active IP Right Cessation
- 1985-05-10 DE DE8585303310T patent/DE3578822D1/de not_active Expired - Lifetime
- 1985-05-10 DK DK207785A patent/DK207785A/da not_active Application Discontinuation
- 1985-05-10 EP EP85303310A patent/EP0161918B1/en not_active Expired - Lifetime
- 1985-05-12 EG EG296/85D patent/EG17342A/xx active
- 1985-05-13 ES ES543078A patent/ES8609308A1/es not_active Expired
- 1985-05-13 HU HU851801A patent/HU194873B/hu not_active IP Right Cessation
- 1985-05-13 AU AU42405/85A patent/AU577372B2/en not_active Ceased
- 1985-05-13 JP JP60102499A patent/JPH0643417B2/ja not_active Expired - Lifetime
- 1985-05-13 SU SU853911552A patent/SU1486060A3/ru active
- 1985-05-14 KR KR1019850003271A patent/KR870000274B1/ko not_active IP Right Cessation
-
1987
- 1987-09-22 MY MYPI87001859A patent/MY101520A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUT37783A (en) | 1986-02-28 |
PT80414A (en) | 1985-06-01 |
PH21862A (en) | 1988-03-25 |
HU194873B (en) | 1988-03-28 |
SU1486060A3 (ru) | 1989-06-07 |
ATE54915T1 (de) | 1990-08-15 |
AU4240585A (en) | 1985-11-21 |
CA1248099A (en) | 1989-01-03 |
ES8609308A1 (es) | 1986-09-01 |
DK207785A (da) | 1985-11-15 |
EP0161918B1 (en) | 1990-07-25 |
DE3578822D1 (de) | 1990-08-30 |
EP0161918A3 (en) | 1986-11-20 |
IL75122A (en) | 1989-02-28 |
JPH0643417B2 (ja) | 1994-06-08 |
DK207785D0 (da) | 1985-05-10 |
ZA853440B (en) | 1986-12-30 |
EG17342A (en) | 1991-03-30 |
GR851121B (ko) | 1985-11-25 |
EP0161918A2 (en) | 1985-11-21 |
JPS6122080A (ja) | 1986-01-30 |
AU577372B2 (en) | 1988-09-22 |
PT80414B (en) | 1987-04-16 |
KR870000274B1 (ko) | 1987-02-23 |
ES543078A0 (es) | 1986-09-01 |
NZ212023A (en) | 1988-04-29 |
AR241531A1 (es) | 1992-08-31 |
MY101520A (en) | 1991-11-30 |
IL75122A0 (en) | 1985-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR850008166A (ko) | 인돌린 및 2-인돌리논 유도체의 제조방법 | |
KR860001793A (ko) | 벤즈 이미다졸 유도체의 제조방법 | |
KR850003402A (ko) | 2-아미노-5-하이드록시-4-메틸 피리미딘 유도체의 제조방법 | |
KR850001171A (ko) | 퀴놀린 화합물의 제조방법 | |
KR850003890A (ko) | 1H-이미다조[4,5c]-퀴놀린-4-아민의 제조방법 | |
KR840001949A (ko) | 신규 펩티드 화합물의 제법 | |
KR840000508A (ko) | 4-아닐리노피리미딘 유도체의 제조방법 | |
KR830002699A (ko) | 신규의 안트라센-9,10-비스-카르보닐-히드라존 및 그 유도체 제조방법 | |
KR850001184A (ko) | 1,5-벤조티아제핀 유도체의 제조방법 | |
KR840001555A (ko) | 치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법 | |
KR870004027A (ko) | 디하이드로리제르그산의 n-알킬화 방법 | |
ES455909A1 (es) | Procedimiento para preparar derivados de piperacina. | |
KR860001108A (ko) | 페닐-나프티리딘의 제조방법 | |
KR840004065A (ko) | 2-시아노-2-프로페노산 및 그 유도체의 제조방법 | |
KR830006243A (ko) | 헤테로고리화합물 유도체의 제조방법 | |
KR840001974A (ko) | 1-[3-(6-플루오로-1,2-벤즈이속사졸-3-일)프로필]-4-(치환된)-피페라진 및-피레리딘의 제조방법 | |
HUP9900739A2 (hu) | Eljárás kinolinszármazékok előállítására és intermedierjeik | |
KR840005449A (ko) | 벤조티오 피라노 피리디논 | |
KR840003627A (ko) | 4-피페라지닐-4-페닐 퀴나졸린 유도체의 제조방법 | |
KR860002474A (ko) | 치환된 페닐술포닐아졸의 제조방법 | |
ES451067A1 (es) | Un procedimiento de preparacion de derivados de fenotiazina. | |
KR840005107A (ko) | 피리미디온 및 그의 산부가염의 제조방법 | |
KR830003460A (ko) | 면역조절 활성을 갖는 치환된 피페라진 및 피페리딘 | |
KR840006238A (ko) | 신규 α-아릴-α-피리딜알카노인산 유도체의 제조방법 | |
KR840002821A (ko) | N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19930121 Year of fee payment: 7 |
|
LAPS | Lapse due to unpaid annual fee |