AR241531A1 - Un procedimiento para la preparacion derivados de 2-indolinona, y sus sales farmaceuticamente aceptables. - Google Patents

Un procedimiento para la preparacion derivados de 2-indolinona, y sus sales farmaceuticamente aceptables.

Info

Publication number
AR241531A1
AR241531A1 AR85300328A AR30032885A AR241531A1 AR 241531 A1 AR241531 A1 AR 241531A1 AR 85300328 A AR85300328 A AR 85300328A AR 30032885 A AR30032885 A AR 30032885A AR 241531 A1 AR241531 A1 AR 241531A1
Authority
AR
Argentina
Prior art keywords
indoline
formula
indolinone derivatives
compound
indolinone
Prior art date
Application number
AR85300328A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of AR241531A1 publication Critical patent/AR241531A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 2-INDOLINONA DE FORMULA (I), DONDE R3, R6 Y RA SON H O METILO, R1, R2, R4 Y R5 SON H, ALQUILO, O LAS SALES FARMACEUTICAMENTE ACEPTABLES, QUE CONSISTE EN: HACER REACCIONAR UN COMPUESTO DE FORMULA (III) CON UN COMPUESTO DE FORMULA R2NHNH2. ESTOS COMPUESTOS SON AGENTES INOTROPICOS POSITIVOS.
AR85300328A 1984-05-14 1985-05-09 Un procedimiento para la preparacion derivados de 2-indolinona, y sus sales farmaceuticamente aceptables. AR241531A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61021084A 1984-05-14 1984-05-14

Publications (1)

Publication Number Publication Date
AR241531A1 true AR241531A1 (es) 1992-08-31

Family

ID=24444125

Family Applications (1)

Application Number Title Priority Date Filing Date
AR85300328A AR241531A1 (es) 1984-05-14 1985-05-09 Un procedimiento para la preparacion derivados de 2-indolinona, y sus sales farmaceuticamente aceptables.

Country Status (20)

Country Link
EP (1) EP0161918B1 (es)
JP (1) JPH0643417B2 (es)
KR (1) KR870000274B1 (es)
AR (1) AR241531A1 (es)
AT (1) ATE54915T1 (es)
AU (1) AU577372B2 (es)
CA (1) CA1248099A (es)
DE (1) DE3578822D1 (es)
DK (1) DK207785A (es)
EG (1) EG17342A (es)
ES (1) ES8609308A1 (es)
GR (1) GR851121B (es)
HU (1) HU194873B (es)
IL (1) IL75122A (es)
MY (1) MY101520A (es)
NZ (1) NZ212023A (es)
PH (1) PH21862A (es)
PT (1) PT80414B (es)
SU (1) SU1486060A3 (es)
ZA (1) ZA853440B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
DE3706427A1 (de) * 1987-02-27 1988-09-08 Boehringer Mannheim Gmbh Neue substituierte 3h-indole, zwischenprodukte, verfahren zu ihrer herstellung sowie arzneimittel
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
ES2037230T3 (es) * 1987-08-28 1993-06-16 Eli Lilly And Company Composiciones activadoras de la penetracion.
ATE110071T1 (de) * 1988-01-23 1994-09-15 Kyowa Hakko Kogyo Kk Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
GB8816944D0 (en) * 1988-07-15 1988-08-17 Sobio Lab Compounds
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス,インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
US20240308973A1 (en) * 2023-03-10 2024-09-19 Zoetis Services Llc Phosphodiesterase 3 (pde3) inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8101067A1 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS588016A (ja) * 1981-07-06 1983-01-18 Mitsubishi Chem Ind Ltd 強心剤

Also Published As

Publication number Publication date
AU577372B2 (en) 1988-09-22
IL75122A (en) 1989-02-28
EP0161918A2 (en) 1985-11-21
ES8609308A1 (es) 1986-09-01
NZ212023A (en) 1988-04-29
KR870000274B1 (ko) 1987-02-23
EP0161918B1 (en) 1990-07-25
PT80414A (en) 1985-06-01
EG17342A (en) 1991-03-30
SU1486060A3 (ru) 1989-06-07
HU194873B (en) 1988-03-28
MY101520A (en) 1991-11-30
AU4240585A (en) 1985-11-21
DK207785A (da) 1985-11-15
IL75122A0 (en) 1985-09-29
PH21862A (en) 1988-03-25
DK207785D0 (da) 1985-05-10
KR850008166A (ko) 1985-12-13
PT80414B (en) 1987-04-16
JPS6122080A (ja) 1986-01-30
HUT37783A (en) 1986-02-28
ES543078A0 (es) 1986-09-01
GR851121B (es) 1985-11-25
JPH0643417B2 (ja) 1994-06-08
CA1248099A (en) 1989-01-03
ATE54915T1 (de) 1990-08-15
EP0161918A3 (en) 1986-11-20
DE3578822D1 (de) 1990-08-30
ZA853440B (en) 1986-12-30

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