ES482789A0 - Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona - Google Patents

Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona

Info

Publication number
ES482789A0
ES482789A0 ES482789A ES482789A ES482789A0 ES 482789 A0 ES482789 A0 ES 482789A0 ES 482789 A ES482789 A ES 482789A ES 482789 A ES482789 A ES 482789A ES 482789 A0 ES482789 A0 ES 482789A0
Authority
ES
Spain
Prior art keywords
benzhimidazoles
replaced
procedure
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES482789A
Other languages
English (en)
Other versions
ES8101067A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782837161 external-priority patent/DE2837161A1/de
Priority claimed from DE19792922336 external-priority patent/DE2922336A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8101067A1 publication Critical patent/ES8101067A1/es
Publication of ES482789A0 publication Critical patent/ES482789A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
ES482789A 1978-08-25 1979-07-24 Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona Granted ES482789A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung
DE19792922336 DE2922336A1 (de) 1979-06-01 1979-06-01 Neue in 5- oder 6-stellung durch einen pyridazinonring substituierte benzimidazole und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8101067A1 ES8101067A1 (es) 1980-12-01
ES482789A0 true ES482789A0 (es) 1980-12-01

Family

ID=25775527

Family Applications (2)

Application Number Title Priority Date Filing Date
ES482789A Granted ES482789A0 (es) 1978-08-25 1979-07-24 Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
ES491970A Expired ES8105001A1 (es) 1978-08-25 1980-05-29 Procedimiento para la preparacion de nuevos bencimidazoles, sustituidos en posicion 5 o 6 con un anillo de piridazinona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES491970A Expired ES8105001A1 (es) 1978-08-25 1980-05-29 Procedimiento para la preparacion de nuevos bencimidazoles, sustituidos en posicion 5 o 6 con un anillo de piridazinona

Country Status (17)

Country Link
US (1) US4361563A (es)
EP (1) EP0008391B1 (es)
AU (1) AU528825B2 (es)
BG (1) BG60428B2 (es)
CA (1) CA1134362A (es)
CS (1) CS410191A3 (es)
DE (1) DE2962051D1 (es)
DK (1) DK152496C (es)
ES (2) ES482789A0 (es)
FI (1) FI66372C (es)
GR (1) GR69998B (es)
HK (1) HK50585A (es)
IE (1) IE48814B1 (es)
MX (1) MX9202731A (es)
NL (1) NL980035I2 (es)
PH (1) PH17515A (es)
SG (1) SG285G (es)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699909A (en) * 1981-07-25 1987-10-13 Dr. Karl Thomae Gmbh Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
IL69027A (en) * 1982-06-21 1988-08-31 Wellcome Found Process for the production of interferon
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
US4717730A (en) * 1982-12-03 1988-01-05 Warner-Lambert Company 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components
US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
GB8320005D0 (en) * 1983-07-25 1983-08-24 Fujisawa Pharmaceutical Co Benzothiazoline derivatives
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
CA1248099A (en) * 1984-05-14 1989-01-03 David W. Robertson Indoline and 2-indolinone derivatives
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
DE3505609A1 (de) * 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4725686A (en) * 1985-11-22 1988-02-16 William H. Rorer, Inc. Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE110071T1 (de) * 1988-01-23 1994-09-15 Kyowa Hakko Kogyo Kk Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5338743A (en) * 1988-06-06 1994-08-16 Fujisawa Pharmaceutical Co., Ltd. New use of the adenosine antagonist
EP0350990B1 (en) * 1988-07-11 1995-09-20 Akzo Nobel N.V. Pyridazinone derivatives
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3908531A1 (de) * 1989-03-16 1990-09-20 Thomae Gmbh Dr K Arzneimittel mit einer positiv inotropen wirkung, enthaltend eine synergistisch wirkende mischung, bestehend aus einem benzimidazol und einem ss-blocker, deren herstellung und deren verwendung
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
US5364646A (en) * 1990-01-10 1994-11-15 Dr. Karl Thomae Gmbh Oral pharmaceutical forms of pimobendan
EP0497258B1 (en) * 1991-01-29 2002-01-02 Fujisawa Pharmaceutical Co., Ltd. Use of adenosine antagonists in the prevention and treatment of pancreatitis and ulcer
CA2293470C (en) * 1997-06-10 2008-05-13 Glaxo Group Limited Benzimidazole derivatives
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
CA2347939C (en) 1998-10-23 2006-10-10 Akira Matsumori Composition for the treatment of rheumatism, hepatitis or pancreatitis
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
EP1304978B1 (en) * 2000-07-31 2007-10-03 Carl Ernest Alexander Personal oral hygiene composition and device
WO2003001968A2 (en) * 2001-06-26 2003-01-09 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
DE10203086A1 (de) * 2002-01-28 2003-07-31 Bayer Ag 5-Ring Heterozyklen
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) * 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
MX2008002166A (es) * 2005-08-15 2008-04-22 Irm Llc Compuestos y composiciones como mimeticos de trombopoietina (tpo).
ES2631879T3 (es) * 2005-11-14 2017-09-05 Boehringer Ingelheim Vetmedica Gmbh Uso de pimobendano para el tratamiento de la insuficiencia cardíaca asintomática (oculta)
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
PL2370070T3 (pl) 2008-11-25 2014-02-28 Boehringer Ingelheim Vetmedica Gmbh Pimobendan do zastosowania w leczeniu kardiomiopatii przerostowej u kotów
NL1037569C2 (en) * 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
CN103796638A (zh) 2011-08-12 2014-05-14 勃林格殷格翰动物保健有限公司 遮味药物组合物
US10398705B2 (en) 2012-03-15 2019-09-03 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
HUE054186T2 (hu) 2013-07-19 2021-08-30 Boehringer Ingelheim Vetmedica Gmbh Éterezett ciklodextrin-származékokat tartalmazó, tartósított, folyékony, vizes gyógyászati készítmény
KR102308973B1 (ko) 2013-12-04 2021-10-08 베링거잉겔하임베트메디카게엠베하 개선된 피모벤단의 약제학적 조성물
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106432095B (zh) * 2016-09-09 2019-04-16 东南大学 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备
CN106518850B (zh) * 2016-11-15 2019-04-09 青岛农业大学 一种匹莫苯丹的化学合成方法
WO2022073954A1 (en) 2020-10-08 2022-04-14 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan in the anaesthesia of non-human mammals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2516040C2 (de) * 1974-06-10 1984-12-20 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2427943C2 (de) * 1974-06-10 1984-08-02 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
JPS5416485A (en) * 1977-07-08 1979-02-07 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivatives and their preparation

Also Published As

Publication number Publication date
DK152496C (da) 1988-07-25
DK152496B (da) 1988-03-07
ES8101067A1 (es) 1980-12-01
EP0008391B1 (de) 1982-02-03
CS410191A3 (en) 1992-05-13
US4361563A (en) 1982-11-30
AU528825B2 (en) 1983-05-12
PH17515A (en) 1984-09-13
IE791629L (en) 1980-02-25
DE2962051D1 (en) 1982-03-11
BG60428B2 (bg) 1995-03-31
SG285G (en) 1985-11-15
FI66372C (fi) 1984-10-10
ES491970A0 (es) 1981-05-16
EP0008391A1 (de) 1980-03-05
ES8105001A1 (es) 1981-05-16
AU5027979A (en) 1980-02-28
DK354279A (da) 1980-02-26
FI792628A (fi) 1980-02-26
GR69998B (es) 1982-07-23
CA1134362A (en) 1982-10-26
FI66372B (fi) 1984-06-29
MX9202731A (es) 1992-06-30
IE48814B1 (en) 1985-05-29
NL980035I2 (nl) 1999-03-01
NL980035I1 (nl) 1999-02-01
HK50585A (en) 1985-07-12

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