CS410191A3 - Benzimidazoles, process of their preparation and medicaments comprising said compounds - Google Patents

Benzimidazoles, process of their preparation and medicaments comprising said compounds

Info

Publication number
CS410191A3
CS410191A3 CS914101A CS410191A CS410191A3 CS 410191 A3 CS410191 A3 CS 410191A3 CS 914101 A CS914101 A CS 914101A CS 410191 A CS410191 A CS 410191A CS 410191 A3 CS410191 A3 CS 410191A3
Authority
CS
Czechoslovakia
Prior art keywords
benzimidazoles
medicaments
compounds
preparation
Prior art date
Application number
CS914101A
Other languages
English (en)
Inventor
Volkhard Dr Dipl Chem Austel
Joachim Dr Dipl Chem Helder
Wolfgang Dr Dipl Chem Eberlein
Willi Dr Diederen
Walter Dr Haarmann
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782837161 external-priority patent/DE2837161A1/de
Priority claimed from DE19792922336 external-priority patent/DE2922336A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CS410191A3 publication Critical patent/CS410191A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS914101A 1978-08-25 1991-12-27 Benzimidazoles, process of their preparation and medicaments comprising said compounds CS410191A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung
DE19792922336 DE2922336A1 (de) 1979-06-01 1979-06-01 Neue in 5- oder 6-stellung durch einen pyridazinonring substituierte benzimidazole und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
CS410191A3 true CS410191A3 (en) 1992-05-13

Family

ID=25775527

Family Applications (1)

Application Number Title Priority Date Filing Date
CS914101A CS410191A3 (en) 1978-08-25 1991-12-27 Benzimidazoles, process of their preparation and medicaments comprising said compounds

Country Status (17)

Country Link
US (1) US4361563A (cs)
EP (1) EP0008391B1 (cs)
AU (1) AU528825B2 (cs)
BG (1) BG60428B2 (cs)
CA (1) CA1134362A (cs)
CS (1) CS410191A3 (cs)
DE (1) DE2962051D1 (cs)
DK (1) DK152496C (cs)
ES (2) ES8101067A1 (cs)
FI (1) FI66372C (cs)
GR (1) GR69998B (cs)
HK (1) HK50585A (cs)
IE (1) IE48814B1 (cs)
MX (1) MX9202731A (cs)
NL (1) NL980035I2 (cs)
PH (1) PH17515A (cs)
SG (1) SG285G (cs)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699909A (en) * 1981-07-25 1987-10-13 Dr. Karl Thomae Gmbh Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
AU572783B2 (en) * 1982-06-21 1988-05-19 Wellcome Foundation Limited, The Improvements in or relating to the production of antiviral agents
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
US4717730A (en) * 1982-12-03 1988-01-05 Warner-Lambert Company 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components
US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
GB8320005D0 (en) * 1983-07-25 1983-08-24 Fujisawa Pharmaceutical Co Benzothiazoline derivatives
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
ZA853440B (en) * 1984-05-14 1986-12-30 Lilly Co Eli Indoline and 2-indolinone derivatives
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
DE3505609A1 (de) * 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4725686A (en) * 1985-11-22 1988-02-16 William H. Rorer, Inc. Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE3704879A1 (de) * 1987-02-17 1988-08-25 Merck Patent Gmbh Pyridazinonderivate
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE110071T1 (de) * 1988-01-23 1994-09-15 Kyowa Hakko Kogyo Kk Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5338743A (en) * 1988-06-06 1994-08-16 Fujisawa Pharmaceutical Co., Ltd. New use of the adenosine antagonist
ATE128135T1 (de) * 1988-07-11 1995-10-15 Akzo Nobel Nv Pyridazinon-derivate.
DE3830054A1 (de) * 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE3908531A1 (de) * 1989-03-16 1990-09-20 Thomae Gmbh Dr K Arzneimittel mit einer positiv inotropen wirkung, enthaltend eine synergistisch wirkende mischung, bestehend aus einem benzimidazol und einem ss-blocker, deren herstellung und deren verwendung
DE3934436A1 (de) * 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
US5364646A (en) * 1990-01-10 1994-11-15 Dr. Karl Thomae Gmbh Oral pharmaceutical forms of pimobendan
ATE211384T1 (de) * 1991-01-29 2002-01-15 Fujisawa Pharmaceutical Co Verwendung von adenosinantagonisten zur vorbeugung und behandlung von pankreatitis und ulcera
EA002305B1 (ru) 1997-06-10 2002-02-28 Глэксо Гроуп Лимитед Производные бензимидазола
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
ES2215327T3 (es) 1998-10-23 2004-10-01 Toray Industries, Inc. Composicion de medicamento inmunomodulador.
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DK1304978T3 (da) * 2000-07-31 2008-02-04 Carl Ernest Alexander Sammensætning og anordning til personlig mundhygiejne
CA2451699A1 (en) * 2001-06-26 2003-01-09 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
DE10203086A1 (de) * 2002-01-28 2003-07-31 Bayer Ag 5-Ring Heterozyklen
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
CN101282929A (zh) * 2005-08-15 2008-10-08 Irm责任有限公司 用作tpo模拟物的化合物和组合物
JP5312034B2 (ja) * 2005-11-14 2013-10-09 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング 無症候性（潜在性）心不全の治療のためのｐｄｅｉｉｉ阻害剤の使用
EP1920785A1 (en) * 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
CN102223882B (zh) 2008-11-25 2016-02-03 贝林格尔.英格海姆维特梅迪卡有限公司 用于治疗肥厚型心肌病的III 型磷酸二酯酶(PPE III)抑制剂或Ca2+敏化剂
NL1037569C2 (en) * 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
AR089645A1 (es) 2011-08-12 2014-09-10 Boehringer Ingelheim Vetmed Particula multicapas de sabor enmascarado, metodo, uso, composicion farmaceutica
WO2013135852A1 (en) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
PL3021832T3 (pl) 2013-07-19 2021-08-23 Boehringer Ingelheim Vetmedica Gmbh Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny
PL3106150T3 (pl) 2013-12-04 2022-01-03 Boehringer Ingelheim Vetmedica Gmbh Ulepszone kompozycje farmaceutyczne pimobendanu
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106432095B (zh) * 2016-09-09 2019-04-16 东南大学 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备
CN106518850B (zh) * 2016-11-15 2019-04-09 青岛农业大学 一种匹莫苯丹的化学合成方法
WO2022073954A1 (en) 2020-10-08 2022-04-14 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan in the anaesthesia of non-human mammals
EP4633607A1 (en) 2022-12-15 2025-10-22 Boehringer Ingelheim Vetmedica GmbH Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers
JP2026508931A (ja) * 2023-03-10 2026-03-13 ゾエティス・サービシーズ・エルエルシー ホスホジエステラーゼ３（ｐｄｅ３）阻害剤
TW202508593A (zh) 2023-05-24 2025-03-01 德商百靈佳殷格翰維美迪加股份有限公司 包含一或多種sglt-2抑制劑及匹莫苯坦(pimobendan)及/或替米沙坦(telmisartan)之非人類哺乳動物心臟病之組合治療及/或預防

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2427943C2 (de) * 1974-06-10 1984-08-02 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2516040C2 (de) * 1974-06-10 1984-12-20 Dr. Karl Thomae Gmbh, 7950 Biberach Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
JPS5416485A (en) * 1977-07-08 1979-02-07 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivatives and their preparation

Also Published As

Publication number Publication date
FI66372C (fi) 1984-10-10
AU528825B2 (en) 1983-05-12
DE2962051D1 (en) 1982-03-11
ES482789A0 (es) 1980-12-01
DK152496C (da) 1988-07-25
GR69998B (cs) 1982-07-23
FI66372B (fi) 1984-06-29
SG285G (en) 1985-11-15
EP0008391B1 (de) 1982-02-03
CA1134362A (en) 1982-10-26
NL980035I1 (nl) 1999-02-01
HK50585A (en) 1985-07-12
NL980035I2 (nl) 1999-03-01
IE791629L (en) 1980-02-25
FI792628A7 (fi) 1980-02-26
DK354279A (da) 1980-02-26
ES8105001A1 (es) 1981-05-16
IE48814B1 (en) 1985-05-29
BG60428B2 (bg) 1995-03-31
ES8101067A1 (es) 1980-12-01
DK152496B (da) 1988-03-07
ES491970A0 (es) 1981-05-16
PH17515A (en) 1984-09-13
AU5027979A (en) 1980-02-28
US4361563A (en) 1982-11-30
MX9202731A (es) 1992-06-30
EP0008391A1 (de) 1980-03-05

Similar Documents

Publication Publication Date Title
CS410191A3 (en) Benzimidazoles, process of their preparation and medicaments comprising said compounds
DE2960222D1 (en) Phenoxyalkylcarboxylic-acid derivatives, process for their preparation and medicaments containing them
CS420091A3 (en) Derivatives of carbazol-4-yloxy-propanol amine, process of their preparation and medicament containing these compounds
ZA794472B (en) Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof
DE2960954D1 (en) 1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions
DE2960621D1 (en) Hydroxypropyl imidazoles, their preparation and medicaments containing them
DE2961983D1 (en) Pyrrolidine-2-methanol derivatives, process for their preparation and medicaments containing them
DE2960024D1 (en) Substituted diphenylmethyl-imidazoles, their preparation and medicaments containing them
IL57360A (en) Phenylaminothiophenacetic acids,processes for their preparation and medicaments containing them
GB2002763B (en) Derivatives of 1,3-phenoxypropane-2-one process of their preparation and their use as medicaments
DE2964198D1 (en) Indanamine derivatives, process for their preparation and medicaments containing them
EG14205A (en) Substituted alkanyl-asolyl oxime-carbamates,process for their preparation and their use as insecticides,acaricides and nematocides
DE2962567D1 (en) N-phenethylacetamide compounds, processes for their preparation and therapeutic compositions containing them
DE2962169D1 (en) Chromanon derivatives, process for their preparation, and their use as medicines and growth-promoting agents
ZA79271B (en) 1-naphthyl-acetic acid derivatives,process for their preparation and their therapeutic applications
DE2960037D1 (en) Isoquinolines, process for their preparation and their use for the preparation of medicines
HK96984A (en) Glucofuranosyl-nitrosourea derivatives,processes for their preparation and medicaments containing them
DE2960205D1 (en) 4-hydroxy-2-benzimidazolin-thion derivatives, process for their preparation and medicaments containing them
DE2962886D1 (en) Derivatives of l-cysteine, their use as medicaments and process for their preparation
HK58085A (en) Novel azathianaphthalene derivatives,process for their manufacture,pharmaceutical preparations containing them and their use
DE2967286D1 (en) 3-amino-cardenolide derivatives, process for their preparation and medicines containing them
DE2967433D1 (en) 3-amino-cardenolides, process for their preparation and medicines containing them
IL57105A (en) Benzimidazole and benzimidazolidine derivatives and process for their preparation
IL56617A0 (en) Benzimidazole derivatives,their manufacture and pharmaceutical compositions containing
DE2960521D1 (en) 2-amino-3a,4,5,6-tetrahydroperimidine derivatives, medicaments containing them and process for their preparation