ZA794472B - Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof - Google Patents
Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereofInfo
- Publication number
- ZA794472B ZA794472B ZA00794472A ZA794472A ZA794472B ZA 794472 B ZA794472 B ZA 794472B ZA 00794472 A ZA00794472 A ZA 00794472A ZA 794472 A ZA794472 A ZA 794472A ZA 794472 B ZA794472 B ZA 794472B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyridazinone
- processes
- preparation
- pharmaceutical compositions
- substituted benzimidazoles
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F8/00—Arrangements for software engineering
- G06F8/30—Creation or generation of source code
- G06F8/31—Programming languages or programming paradigms
- G06F8/313—Logic programming, e.g. PROLOG programming language
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Software Systems (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Engineering & Computer Science (AREA)
- Computing Systems (AREA)
- Theoretical Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782837161 DE2837161A1 (en) | 1978-08-25 | 1978-08-25 | 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA794472B true ZA794472B (en) | 1981-04-29 |
Family
ID=6047905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00794472A ZA794472B (en) | 1978-08-25 | 1979-08-24 | Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS5533479A (en) |
DE (1) | DE2837161A1 (en) |
ZA (1) | ZA794472B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3505609A1 (en) * | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | BENZIMIDAZOLYL PYRIDAZINONE |
DE3804490A1 (en) * | 1988-02-12 | 1989-08-24 | Heumann Pharma Gmbh & Co | SUBSTITUTED 6-PHENYLDIHYDRO-3 (2H) -PYRIDAZINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE3805635A1 (en) * | 1988-02-24 | 1989-09-07 | Thomae Gmbh Dr K | USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT WITH ANTI-MIXIC EFFECTS ON THE HEART AND ITS COMBINATIONS WITH SS-BLOCKERS OR BRADYCARDICA |
DE3814057A1 (en) * | 1988-04-26 | 1989-11-09 | Heumann Pharma Gmbh & Co | 6-OXO-PYRIDAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE3913597A1 (en) * | 1989-04-25 | 1990-11-08 | Heumann Pharma Gmbh & Co | DIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE4001622A1 (en) * | 1990-01-20 | 1991-07-25 | Thomae Gmbh Dr K | ORAL DRUGS OF PIMOBENDAN |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
JP4714921B2 (en) * | 2005-02-14 | 2011-07-06 | トーアエイヨー株式会社 | Production method of pimobendan and its intermediate |
BRPI0616994A2 (en) * | 2005-08-15 | 2011-07-05 | Irm Llc | tpo mimetic compounds and compositions |
ZA200804550B (en) | 2005-11-09 | 2009-08-26 | Combinatorx Inc | Methods, compositions, and kits for the treatment of medical conditions |
EA020466B1 (en) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2624828T3 (en) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EA201391254A1 (en) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | METHOD FOR OBTAINING GUANYLATZCLAZE AGONISTS C |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
PT3004138T (en) | 2013-06-05 | 2024-06-18 | Bausch Health Ireland Ltd | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
-
1978
- 1978-08-25 DE DE19782837161 patent/DE2837161A1/en not_active Withdrawn
-
1979
- 1979-08-24 ZA ZA00794472A patent/ZA794472B/en unknown
- 1979-08-24 JP JP10730779A patent/JPS5533479A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6324996B2 (en) | 1988-05-23 |
DE2837161A1 (en) | 1980-03-06 |
JPS5533479A (en) | 1980-03-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2962051D1 (en) | Benzimidazoles, their preparation and pharmaceutical compositions containing them | |
DE2965062D1 (en) | Imidazole derivatives, their preparation and pharmaceutical compositions | |
CY1250A (en) | N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them | |
PH21386A (en) | Platinum-diamine complexes, their pharmaceutical compositions and process for the preparation thereof | |
ZA794472B (en) | Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof | |
IL57708A0 (en) | Aminopropoxyindole derivatives,their preparation and pharmaceutical compositions containing them | |
DE2960954D1 (en) | 1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions | |
ZA783829B (en) | 1-acyl-2-cyanoaziridines,processes for their preparation and pharmaceutical compositions thereof | |
DE2964209D1 (en) | Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them | |
DE2965287D1 (en) | Bis-imidazoles, their preparation and pharmaceutical compositions containing them | |
IL57599A0 (en) | Indolealkylamines,pharmaceutical formulations containing these and processes for their preparation | |
IL57297A (en) | 4-amino-2-piperidinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them | |
ZA793131B (en) | Indolealkylamines,pharmaceutical formulations containing these,and processes for their preparation | |
ZA793682B (en) | New piperidylbenzimidazolinone derivatives,processes for their preparation and pharmaceutical compositions containing them | |
IL58620A (en) | Aryltrifluoroethanol derivatives,their preparation and pharmaceutical compositions containing them | |
IL56816A0 (en) | N-phenylaniline derivatives,their preparation and pharmaceutical compositions containing them | |
IL56686A0 (en) | Acylaminoalkyl-syanoguanidines,their preparation and pharmaceutical compositions containing them | |
IL57891A (en) | Alkylthiophenoxyalkylamines,their preparation and pharmaceutical compositions containing them | |
DE3060079D1 (en) | Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof | |
IL57219A (en) | 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them | |
IL56890A0 (en) | 2-amino-carbazole derivatives,their preparation and pharmaceutical compositions containing them | |
IL56913A (en) | Sprio-steroid-oxazolidinone derivatives,their preparation and pharmaceutical compositions containing them | |
IL57754A0 (en) | Benzopyranotriazoles,their preparation and pharmaceutical compositions containing them | |
DE2960503D1 (en) | Novel androstadienes, processes for their preparation and pharmaceutical compositions containing them | |
DE2963868D1 (en) | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them |