DE2837161A1 - 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors - Google Patents

5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors

Info

Publication number
DE2837161A1
DE2837161A1 DE19782837161 DE2837161A DE2837161A1 DE 2837161 A1 DE2837161 A1 DE 2837161A1 DE 19782837161 DE19782837161 DE 19782837161 DE 2837161 A DE2837161 A DE 2837161A DE 2837161 A1 DE2837161 A1 DE 2837161A1
Authority
DE
Germany
Prior art keywords
alkyl
6c
substd
opt
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782837161
Other languages
German (de)
Inventor
Volkhard Dipl Chem Dr Austel
Joachim Dipl Chem Dr Heider
Wolfgang Dipl Chem Dr Eberlein
Willi Dr Diederen
Walter Dr Haarmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Karl Thomae GmbH
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19782837161 priority Critical patent/DE2837161A1/en
Priority claimed from ES482789A external-priority patent/ES8101067A1/en
Priority claimed from AT79102758T external-priority patent/AT646T/en
Priority claimed from DE19792962051 external-priority patent/DE2962051D1/en
Publication of DE2837161A1 publication Critical patent/DE2837161A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F8/00Arrangements for software engineering
    • G06F8/30Creation or generation of source code
    • G06F8/31Programming languages or programming paradigms
    • G06F8/313Logic programming, e.g. PROLOG programming language
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Abstract

Benzimidazole derivs. of formula (I) and their optical antipodes when A = B = H, and their physiologically acceptable salts with organic or inorganic acids are new: (A and B are each H, or together make a double bond; R1 = H, CF3, 1-11C alkyl, 3-7C cycloalkyl, OH or SH (both opt. etherified with 1-6C alkyl), phenyl (1-3C) alkyl, or phenyl (opt. substd. by 1-3 same or different halo, 1-4C alkyl, 1-6C alkylsulphinyl, OH or SH, both the latter opt. etherified with 1-6C alkyl); R2 = H, 1-5C alkyl, 3-6C cycloalkyl or phenyl (1-3C) alkyl; R3 = 1-6C alkyl). (I) have antiviral, interferon-inducing, ulcer-inhibiting and esp. cardiovascular (cardiotonic, hypotensive and/or antithrombotic) activities.
DE19782837161 1978-08-25 1978-08-25 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors Withdrawn DE2837161A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (en) 1978-08-25 1978-08-25 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (en) 1978-08-25 1978-08-25 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors
ES482789A ES8101067A1 (en) 1978-08-25 1979-07-24 Process for preparing new substituted benzimidazole in position 5 or 6 ring pyridazinone
GR59689A GR69998B (en) 1978-08-25 1979-07-25
EP19790102758 EP0008391B1 (en) 1978-08-25 1979-08-01 Benzimidazoles, their preparation and pharmaceutical compositions containing them
AT79102758T AT646T (en) 1978-08-25 1979-08-01 Benzimidazoles, their preparation and these compounds containing drug.
DE19792962051 DE2962051D1 (en) 1978-08-25 1979-08-01 Benzimidazoles, their preparation and pharmaceutical compositions containing them
CA000334357A CA1134362A (en) 1978-08-25 1979-08-23 Benzimidazoles, their preparation and their use as pharmaceutical compositions
FI792628A FI66372C (en) 1978-08-25 1979-08-23 Foerfarande Foer framstaellning of pharmacologically verkande i 5- or 6-staellning with a pyridazinonring and substituted besimidazoler
ZA00794472A ZA7904472B (en) 1978-08-25 1979-08-24 Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof
AU50279/79A AU528825B2 (en) 1978-08-25 1979-08-24 (3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
DK354279A DK152496C (en) 1978-08-25 1979-08-24 Analogifremgangsmaade for the preparation of the 5- or 6-position with a pyridazinonring substituted benzimidazoles or their physiologically acceptable acid addition salts
IE162979A IE48814B1 (en) 1978-08-25 1979-08-24 New benzimidazoles,their preparation and their use as pharmaceutical compositions
JP54107307A JPS6324996B2 (en) 1978-08-25 1979-08-24
ES491970A ES8105001A1 (en) 1978-08-25 1980-05-29 Process for the preparation of novel benzimidazoles substituted in position 5 or 6 ring pyridazinone
US06/259,537 US4361563A (en) 1978-08-25 1981-05-01 Pyridazinone-substituted benzimidazoles and salts
PH25674A PH17515A (en) 1978-08-25 1981-05-26 Pyridazinone-substituted benzimidazoles and salts thereof
SG285A SG285G (en) 1978-08-25 1985-01-03 Benzimidazoles,their preparation and pharmaceutical compositions containing them
HK50585A HK50585A (en) 1978-08-25 1985-07-04 Benzimidazoles,their preparation and pharmaceutical compositions containing them
MY8501118A MY111885A (en) 1978-08-25 1985-12-30 Benzimidazole deren herstellung und diese verbindungen enthaltende arznelmittel
CS914101A CS410191A3 (en) 1978-08-25 1991-12-27 Benzimidazoles, process of their preparation and medicaments comprising said compounds
MX9202731A MX9202731A (en) 1978-08-25 1992-06-08 Bencimadizoles new 5-substituted or 6 with a pyridazinone ring.
BG98420A BG60428B2 (en) 1978-08-25 1994-01-25 Benzimidazoles, method for their preparation and medicaments containing them
NL980035C NL980035I2 (en) 1978-08-25 1998-11-19 Benzimidazoles, their preparation and medicines containing these compounds.

Publications (1)

Publication Number Publication Date
DE2837161A1 true DE2837161A1 (en) 1980-03-06

Family

ID=6047905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782837161 Withdrawn DE2837161A1 (en) 1978-08-25 1978-08-25 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors

Country Status (3)

Country Link
JP (1) JPS6324996B2 (en)
DE (1) DE2837161A1 (en)
ZA (1) ZA7904472B (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339208A1 (en) * 1988-04-26 1989-11-02 HEUMANN PHARMA GMBH & CO 6-Oxopyridazine derivatives, process for their preparation and medicaments containing these compounds
US4954501A (en) * 1988-02-12 1990-09-04 Heumann Pharma Gmbh & Co. Piperazine substituted 6-phenyldihydro-3(2H)-pyridazinones, and pharmaceutical preparations containing these
US5026705A (en) * 1985-02-19 1991-06-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Benzimidazolylpyridazinones
US5108998A (en) * 1989-04-25 1992-04-28 Heumann Pharma Gmbh & Co. Cardiotonic thiadiazine derivatives
EP2088154A1 (en) 2004-03-09 2009-08-12 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
WO2011069038A2 (en) 2009-12-03 2011-06-09 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013138352A1 (en) 2012-03-15 2013-09-19 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase c agonists and methods of use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2810951A2 (en) 2008-06-04 2014-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP2998314A1 (en) 2007-06-04 2016-03-23 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839A1 (en) 2008-07-16 2017-11-08 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805635A1 (en) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Use of benzimidazoles for the manufacture of a medicament with anti-mixic effects on the heart and its combinations with ss-blockers or bradycardica
DE4001622A1 (en) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Oral drugs of pimobendan
JP4714921B2 (en) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 Production method of pimobendan and its intermediate
WO2007022269A2 (en) * 2005-08-15 2007-02-22 Irm Llc Compounds and compositions as tpo mimetics

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026705A (en) * 1985-02-19 1991-06-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Benzimidazolylpyridazinones
US4954501A (en) * 1988-02-12 1990-09-04 Heumann Pharma Gmbh & Co. Piperazine substituted 6-phenyldihydro-3(2H)-pyridazinones, and pharmaceutical preparations containing these
EP0339208A1 (en) * 1988-04-26 1989-11-02 HEUMANN PHARMA GMBH & CO 6-Oxopyridazine derivatives, process for their preparation and medicaments containing these compounds
US4968683A (en) * 1988-04-26 1990-11-06 Heumann Pharma Gmbh & Co. 6-oxo-pyridazine derivatives, a process for their preparation and medicaments containing these compounds
US5108998A (en) * 1989-04-25 1992-04-28 Heumann Pharma Gmbh & Co. Cardiotonic thiadiazine derivatives
EP2088154A1 (en) 2004-03-09 2009-08-12 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
EP2998314A1 (en) 2007-06-04 2016-03-23 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951A2 (en) 2008-06-04 2014-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839A1 (en) 2008-07-16 2017-11-08 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2011069038A2 (en) 2009-12-03 2011-06-09 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2923706A1 (en) 2009-12-03 2015-09-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013138352A1 (en) 2012-03-15 2013-09-19 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase c agonists and methods of use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3492106A1 (en) 2013-08-09 2019-06-05 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport

Also Published As

Publication number Publication date
JPS5533479A (en) 1980-03-08
JPS6324996B2 (en) 1988-05-23
ZA7904472B (en) 1981-04-29

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Legal Events

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8139 Disposal/non-payment of the annual fee