HUP9900739A2 - Eljárás kinolinszármazékok előállítására és intermedierjeik - Google Patents

Eljárás kinolinszármazékok előállítására és intermedierjeik

Info

Publication number
HUP9900739A2
HUP9900739A2 HU9900739A HUP9900739A HUP9900739A2 HU P9900739 A2 HUP9900739 A2 HU P9900739A2 HU 9900739 A HU9900739 A HU 9900739A HU P9900739 A HUP9900739 A HU P9900739A HU P9900739 A2 HUP9900739 A2 HU P9900739A2
Authority
HU
Hungary
Prior art keywords
atom
general formula
compounds
carbon atoms
formula
Prior art date
Application number
HU9900739A
Other languages
English (en)
Inventor
James Edward Foy
Cletus Onwozurike Ugwuegbulam
Original Assignee
Smithkline Beecham Corporation
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation, Smithkline Beecham P.L.C. filed Critical Smithkline Beecham Corporation
Publication of HUP9900739A2 publication Critical patent/HUP9900739A2/hu
Publication of HUP9900739A3 publication Critical patent/HUP9900739A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány a maláriaellenes gyógyszerként ismert, (I) általánősképletű vegyületek új előállítási eljárására vőnatkőzik - a képletben R1 jelentése 1-6 szénatőmős alkilcsőpőrt; R2 és R3 jelentése egymástól függetlenül hidrőgénatőm, halőgénatőm,triflűőr-metil-csőpőrt vagy 1-6 szénatőmős alkőxicsőpőrt; R4 jelentése 1-6 szénatőmős alkilcsőpőrt; R5 jelentése hidrőgénatőm vagy 1-6 szénatőmős alkilcsőpőrt; és R6 jelentése nitrőcsőpőrt vagy aminőcsőpőrt. A találmány szerint úgyállítanak elő (I) általánős képletű vegyületeket, hőgy (II) általánősképletű vegyületeket - ahől a képletben R1, R4 és R5 jelentése afenti, és X jelentése kilépőcsőpőrt - egy (III) általánős képletűvegyülettel reagáltatnak - a képletben R2 és R3 jelentése a fenti. Atalálmány a fenti eljárásban használt új, közbenső termékekre isvőnatkőzik, tővábbá egyes, az (I) általánős képlet körébe eső újvegyületekre. ŕ
HU9900739A 1995-10-13 1996-10-11 Process for the preparation of quinoline derivatives, and the intermediates HUP9900739A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9521004.3A GB9521004D0 (en) 1995-10-13 1995-10-13 Process

Publications (2)

Publication Number Publication Date
HUP9900739A2 true HUP9900739A2 (hu) 1999-09-28
HUP9900739A3 HUP9900739A3 (en) 1999-11-29

Family

ID=10782264

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900739A HUP9900739A3 (en) 1995-10-13 1996-10-11 Process for the preparation of quinoline derivatives, and the intermediates

Country Status (28)

Country Link
US (1) US6479660B1 (hu)
EP (1) EP0871616B1 (hu)
JP (1) JP4083803B2 (hu)
KR (1) KR100453256B1 (hu)
CN (1) CN1147475C (hu)
AR (1) AR004015A1 (hu)
AT (1) ATE214372T1 (hu)
AU (1) AU709333B2 (hu)
BR (1) BR9611010A (hu)
CA (1) CA2231633C (hu)
CZ (1) CZ290380B6 (hu)
DE (1) DE69619863T2 (hu)
DK (1) DK0871616T3 (hu)
ES (1) ES2170874T3 (hu)
GB (1) GB9521004D0 (hu)
HK (1) HK1016180A1 (hu)
HU (1) HUP9900739A3 (hu)
IL (1) IL124060A (hu)
NO (1) NO313285B1 (hu)
NZ (1) NZ320209A (hu)
PL (1) PL186055B1 (hu)
PT (1) PT871616E (hu)
SA (1) SA97170574B1 (hu)
SI (1) SI0871616T1 (hu)
TR (1) TR199800637T2 (hu)
TW (1) TW450950B (hu)
WO (1) WO1997013753A1 (hu)
ZA (1) ZA968550B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08276712A (ja) * 1995-04-05 1996-10-22 Masao Tsuji チュ−ブレススパイクタイヤ
GB0210150D0 (en) 2002-05-03 2002-06-12 Smithkline Beecham Plc Process
JP2009507824A (ja) * 2005-09-12 2009-02-26 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 抗マラリアベイリス−ヒルマン付加物およびその調製方法
WO2007127930A2 (en) * 2006-04-28 2007-11-08 Kansas State University Research Foundation Compounds affecting gap junction activity
GB0620005D0 (en) 2006-10-10 2006-11-22 Glaxo Group Ltd Compounds
US20090076072A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched tafenoquine
ES2453206B1 (es) 2013-09-25 2015-01-12 Thyssenkrupp Elevator Innovation Center, S.A. Sistema de tracción para un sistema de transporte
CN113248431A (zh) * 2021-05-21 2021-08-13 重庆医药高等专科学校 一种磷酸伯氨喹的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431807A (en) * 1980-06-12 1984-02-14 The United States Of America As Represented By The Secretary Of The Army 4-Methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines
US4617394A (en) 1985-10-15 1986-10-14 The United States Of America As Represented By The Secretary Of The Army 4-methyl-5-(unsubstituted and substituted phenoxy)-2,6-dimethoxy-8-(aminoalkylamino) quinolines

Also Published As

Publication number Publication date
CA2231633A1 (en) 1997-04-17
ATE214372T1 (de) 2002-03-15
CA2231633C (en) 2006-10-03
JPH11513399A (ja) 1999-11-16
HUP9900739A3 (en) 1999-11-29
DE69619863T2 (de) 2002-11-21
AR004015A1 (es) 1998-09-30
PT871616E (pt) 2002-07-31
US6479660B1 (en) 2002-11-12
NZ320209A (en) 1999-08-30
AU7291096A (en) 1997-04-30
PL326194A1 (en) 1998-08-31
PL186055B1 (pl) 2003-09-30
EP0871616B1 (en) 2002-03-13
DK0871616T3 (da) 2002-07-01
NO313285B1 (no) 2002-09-09
GB9521004D0 (en) 1995-12-13
BR9611010A (pt) 1999-07-13
CN1147475C (zh) 2004-04-28
CN1199395A (zh) 1998-11-18
AU709333B2 (en) 1999-08-26
JP4083803B2 (ja) 2008-04-30
WO1997013753A1 (en) 1997-04-17
SA97170574B1 (ar) 2006-09-25
CZ290380B6 (cs) 2002-07-17
DE69619863D1 (de) 2002-04-18
TW450950B (en) 2001-08-21
KR19990064210A (ko) 1999-07-26
NO981537D0 (no) 1998-04-03
HK1016180A1 (en) 1999-10-29
TR199800637T2 (xx) 1998-07-21
KR100453256B1 (ko) 2004-12-17
ES2170874T3 (es) 2002-08-16
ZA968550B (en) 1998-04-14
SI0871616T1 (en) 2002-12-31
EP0871616A1 (en) 1998-10-21
NO981537L (no) 1998-04-03
CZ110398A3 (cs) 1998-09-16
IL124060A (en) 2003-07-31

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees