HUP9902157A2 - Eljárás és intermedierek 4'-trifluor-metil-bifenil-2-karbonsav-[2-(2H-[1,2,4]-triazol-3-il-metil)-1,2,3,4-tetrahidro-izokinolin-6-il]-amid előállítására - Google Patents
Eljárás és intermedierek 4'-trifluor-metil-bifenil-2-karbonsav-[2-(2H-[1,2,4]-triazol-3-il-metil)-1,2,3,4-tetrahidro-izokinolin-6-il]-amid előállításáraInfo
- Publication number
- HUP9902157A2 HUP9902157A2 HU9902157A HUP9902157A HUP9902157A2 HU P9902157 A2 HUP9902157 A2 HU P9902157A2 HU 9902157 A HU9902157 A HU 9902157A HU P9902157 A HUP9902157 A HU P9902157A HU P9902157 A2 HUP9902157 A2 HU P9902157A2
- Authority
- HU
- Hungary
- Prior art keywords
- atom
- compound
- formula
- carbon
- trifluoromethylbiphenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- WNDIAFXQKOHFLV-UHFFFAOYSA-N n-[2-(1h-1,2,4-triazol-5-ylmethyl)-3,4-dihydro-1h-isoquinolin-6-yl]-2-[4-(trifluoromethyl)phenyl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(CN(CC2=NNC=N2)CC2)C2=C1 WNDIAFXQKOHFLV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya eljárás (I) képletű vegyület előállítására őlymódőn, hőgy egy (III) képletű vegyületet, ahől R hidrőgénatőm vagy R2,és R2 jelentése allil- vagy szűbsztitűált metilcsőpőrt, ahől aszűbsztitűens lehet egy-hárőm 6-10 szénatőmős arilcsőpőrt, ahől azarilcsőpőrt adőtt esetben egy vagy több nitrő- és/vagy 1-6 szénatőmősalkőxicsőpőrttal szűbsztitűált arilcsőpőrt; a) egy (X) képletűvegyülettel kezelik, ahől J jelentése kilépőcsőpőrt, pl. halőgénatőm,azidő-, 1-6 szénatőmős acilőxi- vagy 6-10 szénatőmős arőilőxicsőpőrt,előnyösen klór- vagy brómatőm; és b) ha R jelentése R2, akkőr az a)lépés szerinti terméket tővább kezelik egy savval. A (II) képletűvegyületre is kiterjed a találmány, ahől R jelentése R2 és R2jelentése a fenti, előnyösen CH3OC6H4CH2-csőpőrt. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1649596P | 1996-04-30 | 1996-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9902157A2 true HUP9902157A2 (hu) | 2000-04-28 |
| HUP9902157A3 HUP9902157A3 (en) | 2000-07-28 |
Family
ID=21777423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902157A HUP9902157A3 (en) | 1996-04-30 | 1997-03-13 | Process and intermediates for preparing 4'trifluoromethylbiphenyl-2-carboxylic acid [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5998623A (hu) |
| EP (1) | EP0902785B1 (hu) |
| JP (1) | JPH11507959A (hu) |
| KR (1) | KR20000065152A (hu) |
| CN (1) | CN1216988A (hu) |
| AR (1) | AR006876A1 (hu) |
| AT (1) | ATE223400T1 (hu) |
| AU (1) | AU711279B2 (hu) |
| BR (1) | BR9709137A (hu) |
| CA (1) | CA2252621C (hu) |
| CZ (1) | CZ346498A3 (hu) |
| DE (1) | DE69715188T2 (hu) |
| DK (1) | DK0902785T3 (hu) |
| ES (1) | ES2180935T3 (hu) |
| HU (1) | HUP9902157A3 (hu) |
| ID (1) | ID17294A (hu) |
| IL (1) | IL126202A0 (hu) |
| PL (1) | PL329739A1 (hu) |
| PT (1) | PT902785E (hu) |
| TR (1) | TR199802163T2 (hu) |
| WO (1) | WO1997041111A1 (hu) |
| YU (1) | YU16297A (hu) |
| ZA (1) | ZA973696B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
| IL139450A0 (en) * | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Methods of administering apo b-secretion/mtp inhibitors |
| CA2324801A1 (en) * | 1999-11-10 | 2001-05-10 | Andrew Gordon Swick | Use of apo b secretion/mtp inhibitors and anti-obesity agents |
| IL139449A0 (en) * | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Use of apo b secretion/mtp inhibitors |
| CA2324800A1 (en) * | 1999-11-10 | 2001-05-10 | Mary Anne Hickman | Use of apo b secretion/mtp inhibitors |
| PT1259484E (pt) * | 2000-01-18 | 2005-09-30 | Novartis Ag | Carboxamidas uteis como inibidores de proteina de transferencia de triglicerido microsomal e de secrecao de apolipoproteina b |
| AU2001277728A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| AU2001277727A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof |
| ES2399721T5 (es) | 2004-03-05 | 2016-05-25 | Univ Pennsylvania | Métodos para tratar trastornos o enfermedades asociados a la hiperlipidemia e hipercolesterolemia minimizando los efectos adversos |
| WO2008075949A1 (en) * | 2006-12-20 | 2008-06-26 | Friesland Brands B.V. | Modulation of human microsomal triglyceride transfer protein (mtp or mttp) gene expression by food-grade/ingested dietary microorganisms |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU218419B (hu) * | 1992-03-06 | 2000-08-28 | E.R. Squibb And Sons, Inc. | Mikroszomális triglicerid transzfer protein (MTP) nagy molekulatömegű alegységének rekombináns úton történő előállítására és a protein és inhibitorainak kimutatására szolgáló eljárások |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
| DK0832069T3 (da) * | 1995-06-07 | 2003-04-22 | Pfizer | Biphenyl-2-carboxylsyre-tetrahydroisoquinolin-6-ylamidderivater, deres fremstilling og deres anvendelse som inhibitorer af sekretion af mikrosomalt triglyceridoverførselsprotein og/eller apolipoprotein B (Apo B) |
| EP0832069B1 (en) * | 1995-06-07 | 2003-03-05 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
-
1997
- 1997-03-13 EP EP97905354A patent/EP0902785B1/en not_active Expired - Lifetime
- 1997-03-13 ES ES97905354T patent/ES2180935T3/es not_active Expired - Lifetime
- 1997-03-13 CZ CZ983464A patent/CZ346498A3/cs unknown
- 1997-03-13 PT PT97905354T patent/PT902785E/pt unknown
- 1997-03-13 WO PCT/IB1997/000254 patent/WO1997041111A1/en active IP Right Grant
- 1997-03-13 US US09/147,197 patent/US5998623A/en not_active Expired - Fee Related
- 1997-03-13 AT AT97905354T patent/ATE223400T1/de not_active IP Right Cessation
- 1997-03-13 HU HU9902157A patent/HUP9902157A3/hu unknown
- 1997-03-13 AU AU22266/97A patent/AU711279B2/en not_active Ceased
- 1997-03-13 JP JP9538686A patent/JPH11507959A/ja active Pending
- 1997-03-13 BR BR9709137A patent/BR9709137A/pt not_active Application Discontinuation
- 1997-03-13 KR KR1019980708760A patent/KR20000065152A/ko not_active Application Discontinuation
- 1997-03-13 CN CN97194209A patent/CN1216988A/zh active Pending
- 1997-03-13 DE DE69715188T patent/DE69715188T2/de not_active Expired - Fee Related
- 1997-03-13 IL IL12620297A patent/IL126202A0/xx unknown
- 1997-03-13 PL PL97329739A patent/PL329739A1/xx unknown
- 1997-03-13 DK DK97905354T patent/DK0902785T3/da active
- 1997-03-13 TR TR1998/02163T patent/TR199802163T2/xx unknown
- 1997-03-13 CA CA002252621A patent/CA2252621C/en not_active Expired - Fee Related
- 1997-04-25 AR ARP970101731A patent/AR006876A1/es unknown
- 1997-04-28 ID IDP971403A patent/ID17294A/id unknown
- 1997-04-29 YU YU16297A patent/YU16297A/sh unknown
- 1997-04-29 ZA ZA973696A patent/ZA973696B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT902785E (pt) | 2002-12-31 |
| IL126202A0 (en) | 1999-05-09 |
| JPH11507959A (ja) | 1999-07-13 |
| AR006876A1 (es) | 1999-09-29 |
| ID17294A (id) | 1997-12-18 |
| EP0902785A1 (en) | 1999-03-24 |
| DK0902785T3 (da) | 2002-10-07 |
| YU16297A (sh) | 1999-09-27 |
| HUP9902157A3 (en) | 2000-07-28 |
| BR9709137A (pt) | 1999-08-03 |
| DE69715188T2 (de) | 2003-01-02 |
| ES2180935T3 (es) | 2003-02-16 |
| CN1216988A (zh) | 1999-05-19 |
| CZ346498A3 (cs) | 1999-09-15 |
| KR20000065152A (ko) | 2000-11-06 |
| ZA973696B (en) | 1998-10-29 |
| PL329739A1 (en) | 1999-04-12 |
| CA2252621A1 (en) | 1997-11-06 |
| TR199802163T2 (xx) | 1999-02-22 |
| DE69715188D1 (de) | 2002-10-10 |
| US5998623A (en) | 1999-12-07 |
| AU2226697A (en) | 1997-11-19 |
| AU711279B2 (en) | 1999-10-07 |
| CA2252621C (en) | 2002-09-03 |
| EP0902785B1 (en) | 2002-09-04 |
| ATE223400T1 (de) | 2002-09-15 |
| WO1997041111A1 (en) | 1997-11-06 |
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