HUP9800649A2 - Benzil-oxi-csoporttal helyettesített, kondenzált N-heterociklusos vegyületek, eljárás előállításukra és alkalmazásuk bradikinin receptorantagonistaként - Google Patents

Benzil-oxi-csoporttal helyettesített, kondenzált N-heterociklusos vegyületek, eljárás előállításukra és alkalmazásuk bradikinin receptorantagonistaként

Info

Publication number
HUP9800649A2
HUP9800649A2 HU9800649A HUP9800649A HUP9800649A2 HU P9800649 A2 HUP9800649 A2 HU P9800649A2 HU 9800649 A HU9800649 A HU 9800649A HU P9800649 A HUP9800649 A HU P9800649A HU P9800649 A2 HUP9800649 A2 HU P9800649A2
Authority
HU
Hungary
Prior art keywords
bradiquinin
condesed
benzyloxy
antagonists
receptor
Prior art date
Application number
HU9800649A
Other languages
English (en)
Inventor
Holger Heitsch
Bernward Schölkens
Adalbert Wagner
Klaus Wirth
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of HU9800649D0 publication Critical patent/HU9800649D0/hu
Publication of HUP9800649A2 publication Critical patent/HUP9800649A2/hu
Publication of HUP9800649A3 publication Critical patent/HUP9800649A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya az új, (I) általánős képletű vegyületek, ahől Djelentése (II) vagy (III) általánős képletű gyök, X1 jelentése N vagyC-R6, X2 jelentése N vagy C-R7, X3 jelentése N vagy C-R8, B jelentése(VIII) általánős képletű csőpőrt, R1, R2 jelentése, amelyek lehetnekazőnősak vagy különbözők: 1. hidrőgénatőm, 2. halőgénatőm, 3. (C1-C3)-alkilcsőpőrt. A találmány tárgya tővábbá ezeknek a vegyületeknek azelőállítása, valamint alkalmazásűk gyógyszerként májzsűgőr ésAlzheimer-kór kezelésére és megelőzésére. ŕ
HU9800649A 1997-03-27 1998-03-25 Condesed n-heterocyclic compounds substituted with benzyloxy-group, process for producing them, and their use as bradiquinin-receptor-antagonists HUP9800649A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712960A DE19712960A1 (de) 1997-03-27 1997-03-27 Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten

Publications (3)

Publication Number Publication Date
HU9800649D0 HU9800649D0 (en) 1998-05-28
HUP9800649A2 true HUP9800649A2 (hu) 1998-12-28
HUP9800649A3 HUP9800649A3 (en) 1999-01-28

Family

ID=7824838

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800649A HUP9800649A3 (en) 1997-03-27 1998-03-25 Condesed n-heterocyclic compounds substituted with benzyloxy-group, process for producing them, and their use as bradiquinin-receptor-antagonists

Country Status (16)

Country Link
US (1) US6211196B1 (hu)
EP (1) EP0867432B1 (hu)
JP (1) JPH10279563A (hu)
KR (1) KR19980080757A (hu)
CN (1) CN1194978A (hu)
AT (1) ATE268759T1 (hu)
AU (1) AU5965298A (hu)
BR (1) BR9801132A (hu)
CA (1) CA2232499A1 (hu)
CZ (1) CZ91498A3 (hu)
DE (2) DE19712960A1 (hu)
ES (1) ES2223090T3 (hu)
HU (1) HUP9800649A3 (hu)
NO (1) NO981383L (hu)
PL (1) PL325597A1 (hu)
TR (1) TR199800543A2 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10134721A1 (de) * 2001-07-17 2003-02-06 Bayer Ag Tetrahydrochinoxaline
US6492517B1 (en) 2001-07-19 2002-12-10 Air Products And Chemicals, Inc. Method for preparing halomethyl heterocyclic compounds
EP1495017A2 (en) * 2002-04-10 2005-01-12 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
US7183281B2 (en) * 2002-05-03 2007-02-27 Elan Pharmaceuticals, Inc. Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
US7700595B2 (en) 2005-03-01 2010-04-20 Wyeth Llc Cinnoline compounds
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
US10167296B2 (en) 2014-05-07 2019-01-01 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
AR113839A1 (es) 2017-11-24 2020-06-17 Pharvaris B V Antagonistas del receptor b2 de bradiquinina
AR118983A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
UY38706A (es) 2019-05-23 2020-12-31 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
RS65427B1 (sr) 2021-08-05 2024-05-31 Pharvaris Gmbh Kompozicija na bazi lipida za oralnu primenu antagonista receptora bradikinina b2
WO2023180575A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Solid composition comprising solubilised bradykinin b2-receptor antagonists
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物
WO2023180577A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Therapeutic uses of bradykinin b2-receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202336A (en) * 1986-09-24 1993-04-13 Bayer Aktiengesellschaft Antiflammatory quinolin methoxy phenylsulphonamides
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
ES2218554T3 (es) * 1994-10-27 2004-11-16 Fujisawa Pharmaceutical Co., Ltd. Piridopirimidonas, quinolinas y n-heterociclos condensados que son antagonistas de bradiquinina.
FR2735128B1 (fr) * 1995-06-07 1997-07-25 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique
GB9519077D0 (en) * 1995-09-18 1995-11-15 Fujisawa Pharmaceutical Co New heterocyclic compounds
DE19610784A1 (de) * 1996-03-19 1997-09-25 Hoechst Ag Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0808627A2 (de) 1996-05-22 1997-11-26 Hoechst Aktiengesellschaft Verwendung nicht-peptidischer Bradykinin-Antagonisten zur Behandlung und Prävention von chronisch-fibrogenetischen Lebererkrankungen, akuten Lebererkrankungen und den damit verbundenen Komplikationen
ES2230581T3 (es) * 1996-10-14 2005-05-01 Aventis Pharma Deutschland Gmbh Utilizacion de antagonistas no peptidicos de la bradiquinina en la preparacion de medicamentos para el tratamiento y prevencion de la enfermedad de alzheimer.

Also Published As

Publication number Publication date
US6211196B1 (en) 2001-04-03
CN1194978A (zh) 1998-10-07
HU9800649D0 (en) 1998-05-28
JPH10279563A (ja) 1998-10-20
MX9802372A (es) 1998-09-30
KR19980080757A (ko) 1998-11-25
NO981383L (no) 1998-09-28
PL325597A1 (en) 1998-09-28
EP0867432A3 (de) 1998-10-14
HUP9800649A3 (en) 1999-01-28
ES2223090T3 (es) 2005-02-16
ATE268759T1 (de) 2004-06-15
DE59811526D1 (de) 2004-07-15
DE19712960A1 (de) 1998-10-01
EP0867432B1 (de) 2004-06-09
CZ91498A3 (cs) 1998-10-14
BR9801132A (pt) 2000-03-21
AU5965298A (en) 1998-10-01
TR199800543A2 (xx) 1998-10-21
EP0867432A2 (de) 1998-09-30
CA2232499A1 (en) 1998-09-27
NO981383D0 (no) 1998-03-26

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