NO910712D0 - Fremgangsmaate ved fremstilling av oksetanoner. - Google Patents

Fremgangsmaate ved fremstilling av oksetanoner.

Info

Publication number
NO910712D0
NO910712D0 NO1991910712A NO910712A NO910712D0 NO 910712 D0 NO910712 D0 NO 910712D0 NO 1991910712 A NO1991910712 A NO 1991910712A NO 910712 A NO910712 A NO 910712A NO 910712 D0 NO910712 D0 NO 910712D0
Authority
NO
Norway
Prior art keywords
oxetanones
procedure
manufacture
beta
novel
Prior art date
Application number
NO1991910712A
Other languages
English (en)
Other versions
NO910712L (no
NO178764B (no
NO178764C (no
Inventor
Martin Karpf
Ulrich Zutter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO910712D0 publication Critical patent/NO910712D0/no
Publication of NO910712L publication Critical patent/NO910712L/no
Publication of NO178764B publication Critical patent/NO178764B/no
Publication of NO178764C publication Critical patent/NO178764C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Treatment Of Steel (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO910712A 1990-02-23 1991-02-22 Fremgangsmåte ved fremstilling av oksetanoner NO178764C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH392590 1990-12-12

Publications (4)

Publication Number Publication Date
NO910712D0 true NO910712D0 (no) 1991-02-22
NO910712L NO910712L (no) 1991-08-26
NO178764B NO178764B (no) 1996-02-19
NO178764C NO178764C (no) 1996-05-29

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
NO910712A NO178764C (no) 1990-02-23 1991-02-22 Fremgangsmåte ved fremstilling av oksetanoner

Country Status (18)

Country Link
US (2) US5245056A (no)
EP (1) EP0443449B1 (no)
JP (1) JP2912463B2 (no)
KR (2) KR0183034B1 (no)
AT (1) ATE153332T1 (no)
AU (1) AU644846B2 (no)
CA (1) CA2035972C (no)
DE (1) DE59108707D1 (no)
DK (1) DK0443449T3 (no)
ES (1) ES2103751T3 (no)
FI (1) FI115458B (no)
GR (1) GR3024420T3 (no)
HU (1) HU208686B (no)
IE (1) IE910608A1 (no)
NO (1) NO178764C (no)
NZ (1) NZ237132A (no)
PT (1) PT96857B (no)
ZA (1) ZA911153B (no)

Families Citing this family (61)

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AT398579B (de) * 1992-07-06 1994-12-27 Chemie Linz Gmbh Enzymatisches verfahren zur trennung racemischer gemische von delta-valerolactonen
DE4225817A1 (de) * 1992-08-05 1994-02-10 Chemie Linz Deutschland Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen
US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
KR100479968B1 (ko) * 1997-02-05 2005-03-30 에프. 호프만-라 로슈 아게 위장 리파아제 억제제의 용도
AU9198698A (en) * 1997-09-15 1999-04-05 Warner-Lambert Company Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
ES2240516T3 (es) * 2000-07-28 2005-10-16 F. Hoffmann-La Roche Ag Nuevo uso de los inhibidores de lipasa.
CA2417607C (en) 2000-08-09 2008-01-29 Christine Feinle Lipase inhibitors for the treatment of dyspepsia
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
CA2422698C (en) 2000-10-16 2009-12-15 F. Hoffmann-La Roche Ag Indoline derivatives and their use as 5-ht2 receptor ligands
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
CA2432085C (en) 2000-12-27 2009-02-24 F. Hoffmann-La Roche Ag Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
JP2005516011A (ja) * 2001-12-13 2005-06-02 ランバクシー ラボラトリーズ リミテッド 結晶二水化セフニディールカリウム
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
PL372295A1 (en) 2002-02-04 2005-07-11 F.Hoffmann-La Roche Ag Quinoline derivatives as npy antagonists
JP2005526732A (ja) 2002-02-28 2005-09-08 エフ．ホフマン−ラ　ロシュ　アーゲー Ｎｐｙ受容体拮抗剤としてのチアゾール誘導体
AU2003226370A1 (en) * 2002-04-17 2003-11-03 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) * 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
BR0312461A (pt) 2002-07-05 2005-04-26 Hoffmann La Roche Compostos, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, sua utilização e métodos para tratamento e profilaxia
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
EP1539722A1 (en) 2002-08-07 2005-06-15 F. Hoffmann-La Roche Ag Thiazole derivatives
MXPA05002704A (es) 2002-09-12 2005-05-05 Hoffmann La Roche Compuestos de acido n-sustituido-1h-indol-5-propionico como agonistas de los receptores activados proliferadores de peroxisomas (ppar) utiles para el tratamiento de diabetes.
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
ES2312819T3 (es) 2002-11-25 2009-03-01 F. Hoffmann-La Roche Ag Derivados de indolilo.
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
ES2297437T3 (es) * 2003-08-12 2008-05-01 F. Hoffmann-La Roche Ag Npy-antagonistas de 2-amino-5-benzoiltiazol.
BRPI0413458A (pt) * 2003-08-12 2006-10-17 Hoffmann La Roche compostos, processo para a sua preparação, composição farmacêutica que compreende os mesmos, utilização de um composto, métodos para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
ATE514698T1 (de) * 2005-05-03 2011-07-15 Hoffmann La Roche Tetracyclische azapyrazinoindoline als 5-ht2- liganden
EP1945635B1 (en) 2005-08-18 2009-05-06 F.Hoffmann-La Roche Ag Thiazolyl piperidine derivatives useful as h3 receptor modulators
JP4879996B2 (ja) 2005-11-30 2012-02-22 エフ．ホフマン−ラ ロシュ アーゲー Ｈ３調節剤として使用するための１，１−ジオキソ−チオモルホリニルインドリルメタノン誘導体
ES2342979T3 (es) 2005-11-30 2010-07-20 F. Hoffmann-La Roche Ag Derivados de indol-2-carboxamida sustituidos en 5.
DE602006020482D1 (de) 2005-11-30 2011-04-14 Hoffmann La Roche 1,5-substituierte indol-2-yl amidderivative
ATE448230T1 (de) 2005-12-09 2009-11-15 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
AU2006326135A1 (en) 2005-12-15 2007-06-21 F. Hoffmann-La Roche Ag Pyrrolo[2,3-c]pyridine derivatives
CN101331131A (zh) 2005-12-16 2008-12-24 霍夫曼-拉罗奇有限公司 用作H3受体调节剂的吡咯并[2,3-b]吡啶衍生物
JP2009523150A (ja) * 2006-01-13 2009-06-18 エフ．ホフマン−ラ ロシュ アーゲー シクロヘキシルピペラジニルメタノン誘導体及びｈ３受容体調節剤としてのそれらの使用
WO2007082840A1 (en) * 2006-01-23 2007-07-26 F. Hoffmann-La Roche Ag Cyclohexyl sulfonamide derivatives having h3 receptor activity
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
EP2032554A1 (en) 2006-05-30 2009-03-11 F. Hoffmann-Roche AG Piperidinyl pyrimidine derivatives
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
EP2183237A1 (en) * 2007-07-25 2010-05-12 F. Hoffmann-Roche AG Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
US9243040B2 (en) 2010-11-30 2016-01-26 The Board Of Trustees Of The University Of Illinois Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
WO2018140613A1 (en) 2017-01-25 2018-08-02 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

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US5149835A (en) * 1989-04-27 1992-09-22 University Of New Mexico Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof
US5036008A (en) * 1989-07-12 1991-07-30 Bristol-Myers Company Antitumor antibiotic BU-3285T
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
IL97148A (en) * 1990-02-26 1996-11-14 Hoffmann La Roche Oxtanones, the process for their preparation and the pharmaceutical preparations containing them

Also Published As

Publication number Publication date
NO910712L (no) 1991-08-26
EP0443449A2 (de) 1991-08-28
ZA911153B (en) 1991-11-27
GR3024420T3 (en) 1997-11-28
EP0443449B1 (de) 1997-05-21
IE910608A1 (en) 1991-08-28
EP0443449A3 (en) 1991-12-04
CA2035972A1 (en) 1991-08-24
ES2103751T3 (es) 1997-10-01
ATE153332T1 (de) 1997-06-15
JP2912463B2 (ja) 1999-06-28
DE59108707D1 (de) 1997-06-26
FI910857A (fi) 1991-08-24
KR0183034B1 (ko) 1999-05-01
JPH04211675A (ja) 1992-08-03
KR100191365B1 (ko) 1999-06-15
FI115458B (fi) 2005-05-13
US5245056A (en) 1993-09-14
CA2035972C (en) 2006-07-11
PT96857B (pt) 1998-07-31
US5399720A (en) 1995-03-21
FI910857A0 (fi) 1991-02-22
HU208686B (en) 1993-12-28
HUT56558A (en) 1991-09-30
PT96857A (pt) 1991-10-31
AU644846B2 (en) 1993-12-23
NO178764B (no) 1996-02-19
NZ237132A (en) 1993-04-28
DK0443449T3 (da) 1997-11-24
NO178764C (no) 1996-05-29
AU7116691A (en) 1991-08-29
KR910021393A (ko) 1991-12-20

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