DE602006020482D1 - 1,5-substituierte indol-2-yl amidderivative - Google Patents
1,5-substituierte indol-2-yl amidderivativeInfo
- Publication number
- DE602006020482D1 DE602006020482D1 DE602006020482T DE602006020482T DE602006020482D1 DE 602006020482 D1 DE602006020482 D1 DE 602006020482D1 DE 602006020482 T DE602006020482 T DE 602006020482T DE 602006020482 T DE602006020482 T DE 602006020482T DE 602006020482 D1 DE602006020482 D1 DE 602006020482D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted indol
- amid derivatives
- amid
- derivatives
- indol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111478 | 2005-11-30 | ||
PCT/EP2006/068655 WO2007062999A2 (en) | 2005-11-30 | 2006-11-20 | 1,5-substituted indol-2-yl amide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006020482D1 true DE602006020482D1 (de) | 2011-04-14 |
Family
ID=37814240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006020482T Active DE602006020482D1 (de) | 2005-11-30 | 2006-11-20 | 1,5-substituierte indol-2-yl amidderivative |
Country Status (18)
Country | Link |
---|---|
US (1) | US7745479B2 (de) |
EP (1) | EP1957479B1 (de) |
JP (1) | JP4879997B2 (de) |
KR (1) | KR101124156B1 (de) |
CN (1) | CN101316840B (de) |
AR (1) | AR057989A1 (de) |
AT (1) | ATE500244T1 (de) |
AU (1) | AU2006319234B2 (de) |
BR (1) | BRPI0619268A2 (de) |
CA (1) | CA2630314A1 (de) |
DE (1) | DE602006020482D1 (de) |
ES (1) | ES2359739T3 (de) |
IL (1) | IL191314A (de) |
NO (1) | NO20082136L (de) |
RU (1) | RU2008126391A (de) |
TW (1) | TWI333490B (de) |
WO (1) | WO2007062999A2 (de) |
ZA (1) | ZA200804301B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080076987A (ko) * | 2005-11-30 | 2008-08-20 | 에프. 호프만-라 로슈 아게 | 5-치환된 인돌-2-카복스아미드 유도체 |
CN101316838B (zh) * | 2005-11-30 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物 |
TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
EP2079694B1 (de) * | 2006-12-28 | 2017-03-01 | Rigel Pharmaceuticals, Inc. | N-substituierte heterocycloalkyloxybenzamidverbindungen und verfahren zu ihrer verwendung |
US7507736B2 (en) * | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
BRPI0820171B8 (pt) | 2007-11-16 | 2021-05-25 | Rigel Pharmaceuticals Inc | compostos de carboxamida, sulfonamida e amina para distúrbios metabólicos, composição farmacêutica, e, uso dos mesmos |
WO2009076631A1 (en) | 2007-12-12 | 2009-06-18 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
EP2276761B1 (de) | 2008-04-23 | 2015-07-29 | Rigel Pharmaceuticals, Inc. | Carboxamidverbindungen zur behandlung von stoffwechselerkrankungen |
US9394294B2 (en) * | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US8765737B1 (en) * | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
WO2012012764A1 (en) | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
EP2481740B1 (de) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
BR122022001219B1 (pt) * | 2011-10-07 | 2023-03-14 | Takeda Pharmaceutical Company Limited | Composição farmacêutica, uso da composição farmacêutica, combinação, e, uso da combinação |
WO2013085922A1 (en) | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Phosphate esters of noribogaine |
US8877921B2 (en) | 2012-01-25 | 2014-11-04 | Demerx, Inc. | Synthetic voacangine |
US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
LT3071203T (lt) | 2013-11-18 | 2021-05-25 | Forma Therapeutics, Inc. | Tetrahidrochinolino kompozicijos kaip bet bromodomeno inhibitoriai |
EP3071205B1 (de) | 2013-11-18 | 2020-02-05 | Forma Therapeutics, Inc. | Benzopiperazinzusammensetzungen als bet-bromdomänenhemmer |
CN105523986A (zh) * | 2015-12-30 | 2016-04-27 | 江汉大学 | 一种外排泵抑制剂n-氢-2-芳基吲哚及其衍生物的合成方法 |
CN115340460B (zh) * | 2022-09-21 | 2024-07-16 | 江西亚太科技发展有限公司 | 一种Reissert吲哚合成反应中间体的合成方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1247547A (en) | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
US5246960A (en) | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
CA1328881C (en) | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
CA2035972C (en) | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
US6004996A (en) | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
TR200100472T2 (tr) | 1998-08-14 | 2001-07-23 | F.Hoffmann-La Roche Ag | Lipaz inhibitörleri ile sitozan içeren farmasötik bileşimler |
EP1105122B1 (de) | 1998-08-14 | 2005-04-27 | F.Hoffmann-La Roche Ag | Lipasehemmer enthaltende pharmazeutische zusammensetzungen |
EP1169312B1 (de) | 1999-03-29 | 2004-10-06 | F. Hoffmann-La Roche Ag | Glukokinase aktivatoren |
GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
AU2003274053A1 (en) * | 2002-10-22 | 2004-05-13 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
RU2382778C2 (ru) * | 2004-06-21 | 2010-02-27 | Ф.Хоффманн-Ля Рош Аг | Производные индола в качестве антагонистов гистаминовых рецепторов |
CN101316838B (zh) * | 2005-11-30 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物 |
US7507736B2 (en) * | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
-
2006
- 2006-11-20 KR KR1020087015768A patent/KR101124156B1/ko not_active IP Right Cessation
- 2006-11-20 EP EP06830046A patent/EP1957479B1/de not_active Not-in-force
- 2006-11-20 ES ES06830046T patent/ES2359739T3/es active Active
- 2006-11-20 JP JP2008542716A patent/JP4879997B2/ja not_active Expired - Fee Related
- 2006-11-20 WO PCT/EP2006/068655 patent/WO2007062999A2/en active Application Filing
- 2006-11-20 RU RU2008126391/04A patent/RU2008126391A/ru unknown
- 2006-11-20 AT AT06830046T patent/ATE500244T1/de active
- 2006-11-20 CN CN2006800448399A patent/CN101316840B/zh not_active Expired - Fee Related
- 2006-11-20 DE DE602006020482T patent/DE602006020482D1/de active Active
- 2006-11-20 CA CA002630314A patent/CA2630314A1/en not_active Abandoned
- 2006-11-20 AU AU2006319234A patent/AU2006319234B2/en not_active Ceased
- 2006-11-20 BR BRPI0619268-8A patent/BRPI0619268A2/pt not_active IP Right Cessation
- 2006-11-27 US US11/604,412 patent/US7745479B2/en not_active Expired - Fee Related
- 2006-11-28 TW TW095144012A patent/TWI333490B/zh not_active IP Right Cessation
- 2006-11-28 AR ARP060105248A patent/AR057989A1/es not_active Application Discontinuation
-
2008
- 2008-05-07 IL IL191314A patent/IL191314A/en not_active IP Right Cessation
- 2008-05-07 NO NO20082136A patent/NO20082136L/no not_active Application Discontinuation
- 2008-05-19 ZA ZA200804301A patent/ZA200804301B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1957479B1 (de) | 2011-03-02 |
WO2007062999A2 (en) | 2007-06-07 |
CN101316840B (zh) | 2012-08-08 |
RU2008126391A (ru) | 2010-01-10 |
AU2006319234A1 (en) | 2007-06-07 |
US7745479B2 (en) | 2010-06-29 |
BRPI0619268A2 (pt) | 2011-09-20 |
KR101124156B1 (ko) | 2012-03-23 |
US20070123515A1 (en) | 2007-05-31 |
ES2359739T3 (es) | 2011-05-26 |
ATE500244T1 (de) | 2011-03-15 |
JP2009517433A (ja) | 2009-04-30 |
TWI333490B (en) | 2010-11-21 |
EP1957479A2 (de) | 2008-08-20 |
TW200804340A (en) | 2008-01-16 |
CA2630314A1 (en) | 2007-06-07 |
ZA200804301B (en) | 2009-04-29 |
CN101316840A (zh) | 2008-12-03 |
IL191314A (en) | 2012-06-28 |
NO20082136L (no) | 2008-06-30 |
KR20080076980A (ko) | 2008-08-20 |
JP4879997B2 (ja) | 2012-02-22 |
AR057989A1 (es) | 2008-01-09 |
AU2006319234B2 (en) | 2012-01-19 |
WO2007062999A3 (en) | 2007-07-26 |
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