NO20082136L - 1,5-substituerte indol-2-yl-amidderivater - Google Patents
1,5-substituerte indol-2-yl-amidderivaterInfo
- Publication number
- NO20082136L NO20082136L NO20082136A NO20082136A NO20082136L NO 20082136 L NO20082136 L NO 20082136L NO 20082136 A NO20082136 A NO 20082136A NO 20082136 A NO20082136 A NO 20082136A NO 20082136 L NO20082136 L NO 20082136L
- Authority
- NO
- Norway
- Prior art keywords
- amide derivatives
- substituted indol
- compounds
- indol
- substituted
- Prior art date
Links
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical class C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004384 Histamine H3 receptors Human genes 0.000 abstract 1
- 108090000981 Histamine H3 receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111478 | 2005-11-30 | ||
| PCT/EP2006/068655 WO2007062999A2 (en) | 2005-11-30 | 2006-11-20 | 1,5-substituted indol-2-yl amide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082136L true NO20082136L (no) | 2008-06-30 |
Family
ID=37814240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082136A NO20082136L (no) | 2005-11-30 | 2008-05-07 | 1,5-substituerte indol-2-yl-amidderivater |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7745479B2 (de) |
| EP (1) | EP1957479B1 (de) |
| JP (1) | JP4879997B2 (de) |
| KR (1) | KR101124156B1 (de) |
| CN (1) | CN101316840B (de) |
| AR (1) | AR057989A1 (de) |
| AT (1) | ATE500244T1 (de) |
| AU (1) | AU2006319234B2 (de) |
| BR (1) | BRPI0619268A2 (de) |
| CA (1) | CA2630314A1 (de) |
| DE (1) | DE602006020482D1 (de) |
| ES (1) | ES2359739T3 (de) |
| IL (1) | IL191314A (de) |
| NO (1) | NO20082136L (de) |
| RU (1) | RU2008126391A (de) |
| TW (1) | TWI333490B (de) |
| WO (1) | WO2007062999A2 (de) |
| ZA (1) | ZA200804301B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007063000A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
| EP1968967B1 (de) * | 2005-11-30 | 2011-04-27 | F. Hoffmann-La Roche AG | 1,1-dioxo-thiomorpholinyl-indolyl-methanon-derivate zur verwendung als h3-modulatoren |
| TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
| WO2008083124A1 (en) * | 2006-12-28 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
| US7507736B2 (en) * | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
| JP5544296B2 (ja) * | 2007-11-16 | 2014-07-09 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物 |
| ES2553340T3 (es) | 2007-12-12 | 2015-12-07 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos |
| JP5658138B2 (ja) * | 2008-04-23 | 2015-01-21 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 代謝障害の処置のためのカルボキサミド化合物 |
| US9394294B2 (en) * | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8765737B1 (en) * | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| JP6049615B2 (ja) | 2010-07-23 | 2016-12-21 | デマークス・インコーポレイテッドＤｅｍｅｒｘ，Ｉｎｃ． | ノリボガイン組成物 |
| EP2481740B1 (de) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| CA2851087C (en) * | 2011-10-07 | 2019-09-24 | Takeda Pharmaceutical Company Limited | 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases |
| EP2788003A4 (de) | 2011-12-09 | 2015-05-27 | Demerx Inc | Phosphatester von noribogain |
| CA2858820C (en) | 2012-01-25 | 2021-08-17 | Demerx, Inc. | Synthetic voacangine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| CA2896133A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| PT3071203T (pt) | 2013-11-18 | 2021-03-11 | Forma Therapeutics Inc | Composições de tetra-hidroquinolina como inibidores de bromodomínio bet |
| WO2015074081A1 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Benzopiperazine compositions as bet bromodomain inhibitors |
| CN105523986A (zh) * | 2015-12-30 | 2016-04-27 | 江汉大学 | 一种外排泵抑制剂n-氢-2-芳基吲哚及其衍生物的合成方法 |
| JP7230240B2 (ja) | 2019-12-11 | 2023-02-28 | 富士フイルム株式会社 | 半月板投影面設定装置、方法およびプログラム |
| CN115340460B (zh) * | 2022-09-21 | 2024-07-16 | 江西亚太科技发展有限公司 | 一种Reissert吲哚合成反应中间体的合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| CA1270837A (en) * | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| CA1328881C (en) * | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DE69916288T2 (de) | 1998-08-14 | 2005-03-24 | F. Hoffmann-La Roche Ag | Lipasehemmer und chitosan enthaltende arzneimittel |
| BR9912980B1 (pt) | 1998-08-14 | 2013-10-22 | Composição farmacêutica administrável oralmente, tablete de mascar contendo a mesma e utilização da mesma | |
| CZ301366B6 (cs) | 1999-03-29 | 2010-02-03 | F. Hoffmann-La Roche Ag | 2-Fenyl-3-cykloalkylpropionamidová sloucenina, zpusob její prípravy a farmaceutický prostredek s jejím obsahem |
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| EP1554260A1 (de) * | 2002-10-22 | 2005-07-20 | Glaxo Group Limited | Aryloxyalkylamine derivate als h3 rezeptor liganden |
| ES2306170T3 (es) | 2004-06-21 | 2008-11-01 | F. Hoffmann-La Roche Ag | Derivados de indol como antagonistas redeptores de histamina. |
| EP1968967B1 (de) * | 2005-11-30 | 2011-04-27 | F. Hoffmann-La Roche AG | 1,1-dioxo-thiomorpholinyl-indolyl-methanon-derivate zur verwendung als h3-modulatoren |
| US7507736B2 (en) * | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
-
2006
- 2006-11-20 WO PCT/EP2006/068655 patent/WO2007062999A2/en not_active Ceased
- 2006-11-20 CN CN2006800448399A patent/CN101316840B/zh not_active Expired - Fee Related
- 2006-11-20 KR KR1020087015768A patent/KR101124156B1/ko not_active Expired - Fee Related
- 2006-11-20 ES ES06830046T patent/ES2359739T3/es active Active
- 2006-11-20 DE DE602006020482T patent/DE602006020482D1/de active Active
- 2006-11-20 BR BRPI0619268-8A patent/BRPI0619268A2/pt not_active IP Right Cessation
- 2006-11-20 CA CA002630314A patent/CA2630314A1/en not_active Abandoned
- 2006-11-20 RU RU2008126391/04A patent/RU2008126391A/ru unknown
- 2006-11-20 EP EP06830046A patent/EP1957479B1/de not_active Not-in-force
- 2006-11-20 AU AU2006319234A patent/AU2006319234B2/en not_active Ceased
- 2006-11-20 AT AT06830046T patent/ATE500244T1/de active
- 2006-11-20 JP JP2008542716A patent/JP4879997B2/ja not_active Expired - Fee Related
- 2006-11-27 US US11/604,412 patent/US7745479B2/en not_active Expired - Fee Related
- 2006-11-28 AR ARP060105248A patent/AR057989A1/es not_active Application Discontinuation
- 2006-11-28 TW TW095144012A patent/TWI333490B/zh not_active IP Right Cessation
-
2008
- 2008-05-07 NO NO20082136A patent/NO20082136L/no not_active Application Discontinuation
- 2008-05-07 IL IL191314A patent/IL191314A/en not_active IP Right Cessation
- 2008-05-19 ZA ZA200804301A patent/ZA200804301B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4879997B2 (ja) | 2012-02-22 |
| KR101124156B1 (ko) | 2012-03-23 |
| US20070123515A1 (en) | 2007-05-31 |
| ZA200804301B (en) | 2009-04-29 |
| AU2006319234A1 (en) | 2007-06-07 |
| US7745479B2 (en) | 2010-06-29 |
| WO2007062999A2 (en) | 2007-06-07 |
| IL191314A (en) | 2012-06-28 |
| CN101316840B (zh) | 2012-08-08 |
| CN101316840A (zh) | 2008-12-03 |
| TW200804340A (en) | 2008-01-16 |
| AR057989A1 (es) | 2008-01-09 |
| KR20080076980A (ko) | 2008-08-20 |
| AU2006319234B2 (en) | 2012-01-19 |
| ATE500244T1 (de) | 2011-03-15 |
| EP1957479A2 (de) | 2008-08-20 |
| CA2630314A1 (en) | 2007-06-07 |
| TWI333490B (en) | 2010-11-21 |
| RU2008126391A (ru) | 2010-01-10 |
| JP2009517433A (ja) | 2009-04-30 |
| EP1957479B1 (de) | 2011-03-02 |
| DE602006020482D1 (de) | 2011-04-14 |
| BRPI0619268A2 (pt) | 2011-09-20 |
| WO2007062999A3 (en) | 2007-07-26 |
| ES2359739T3 (es) | 2011-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |