ES2103751T3 - Procedimiento para la obtencion de oxetanonas. - Google Patents

Procedimiento para la obtencion de oxetanonas.

Info

Publication number
ES2103751T3
ES2103751T3 ES91102150T ES91102150T ES2103751T3 ES 2103751 T3 ES2103751 T3 ES 2103751T3 ES 91102150 T ES91102150 T ES 91102150T ES 91102150 T ES91102150 T ES 91102150T ES 2103751 T3 ES2103751 T3 ES 2103751T3
Authority
ES
Spain
Prior art keywords
oxetanonas
procedure
obtaining
beta
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91102150T
Other languages
English (en)
Inventor
Martin Dr Karpf
Ulrich Dr Zutter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2103751T3 publication Critical patent/ES2103751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Heat Treatment Of Steel (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

EL DESCUBRIMIENTO CONSISTE EN UN NUEVO PROCEDIMIENTO PARA LA FABRICACION DE OXETANONA SEGUN LA FORMULA DONDE R ELEVADO A 1, R (AL CUADRADO) Y X SEGUN LA DESCRIPCION DEL SIGNIFICADO DADA TIENEN EL CORRESPONDIENTE (BETA)-KETO LTA)-LACTONA, ASI COMO LOS PRODUCTOS INTERMEDIOS EXISTENTES EN ESTE PROCESO.
ES91102150T 1990-02-23 1991-02-15 Procedimiento para la obtencion de oxetanonas. Expired - Lifetime ES2103751T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH392590 1990-12-12

Publications (1)

Publication Number Publication Date
ES2103751T3 true ES2103751T3 (es) 1997-10-01

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91102150T Expired - Lifetime ES2103751T3 (es) 1990-02-23 1991-02-15 Procedimiento para la obtencion de oxetanonas.

Country Status (18)

Country Link
US (2) US5245056A (es)
EP (1) EP0443449B1 (es)
JP (1) JP2912463B2 (es)
KR (2) KR0183034B1 (es)
AT (1) ATE153332T1 (es)
AU (1) AU644846B2 (es)
CA (1) CA2035972C (es)
DE (1) DE59108707D1 (es)
DK (1) DK0443449T3 (es)
ES (1) ES2103751T3 (es)
FI (1) FI115458B (es)
GR (1) GR3024420T3 (es)
HU (1) HU208686B (es)
IE (1) IE910608A1 (es)
NO (1) NO178764C (es)
NZ (1) NZ237132A (es)
PT (1) PT96857B (es)
ZA (1) ZA911153B (es)

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DE4225817A1 (de) * 1992-08-05 1994-02-10 Chemie Linz Deutschland Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen
US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
DK1017408T3 (da) * 1997-02-05 2005-08-01 Hoffmann La Roche Anvendelse af tetrahydrolipstatin i behandling af diabetes type II
AU9198698A (en) * 1997-09-15 1999-04-05 Warner-Lambert Company Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
EP1307263B1 (en) 2000-07-28 2005-04-20 F. Hoffmann-La Roche Ag New use of lipase inhibitors
PT1311260E (pt) 2000-08-09 2008-05-02 Hoffmann La Roche Utilização de inibidores de lipase para o tratamento da dispepsia
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
JP4047723B2 (ja) 2000-10-16 2008-02-13 エフ．ホフマン−ラ ロシュ アーゲー インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
MXPA03005915A (es) 2000-12-27 2003-09-10 Hoffmann La Roche Derivados de indol y su uso como ligandos receptores de 5-ht2b y 5-ht2c.
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
EP1458728A1 (en) * 2001-12-13 2004-09-22 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
DE60320529T2 (de) 2002-02-04 2009-06-10 F. Hoffmann-La Roche Ag Chinolinderivate als npy antagonisten
AU2003210305B2 (en) 2002-02-28 2006-07-06 F. Hoffmann-La Roche Ag Thiazole derivatives as NPY receptor antagonists
AU2003226370A1 (en) * 2002-04-17 2003-11-03 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
CA2489251A1 (en) 2002-07-05 2004-01-15 F. Hoffmann-La Roche Ag Quinazoline derivatives
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
CA2493712A1 (en) 2002-08-07 2004-02-19 F. Hoffmann-La Roche Ag Aminothiazole derivatives as npy5 receptor inhibitors
KR100645684B1 (ko) 2002-09-12 2006-11-15 에프. 호프만-라 로슈 아게 당뇨병 치료에 유용한 ｐｐａｒ 작동제로서 ｎ-치환된-1ｈ-인돌-5-프로파이온산 화합물
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
JP4384052B2 (ja) 2002-11-25 2009-12-16 エフ．ホフマン−ラ ロシュ アーゲー インドリル誘導体
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
WO2005014593A1 (en) * 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
ATE380189T1 (de) * 2003-08-12 2007-12-15 Hoffmann La Roche 2-amino-5-benzoylthiazol npy-antagonisten
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
ATE514698T1 (de) * 2005-05-03 2011-07-15 Hoffmann La Roche Tetracyclische azapyrazinoindoline als 5-ht2- liganden
CA2618568A1 (en) 2005-08-18 2007-02-22 F. Hoffmann-La Roche Ag Thiazolyl piperidine derivatives useful as h3 receptor modulators
EP1957479B1 (en) 2005-11-30 2011-03-02 F. Hoffmann-La Roche AG 1,5-substituted indol-2-yl amide derivatives
AU2006319232B2 (en) 2005-11-30 2012-09-13 F. Hoffmann-La Roche Ag 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as H3 modulators
BRPI0619233A2 (pt) 2005-11-30 2011-09-20 Hoffmann La Roche compostos, processo para a sua manufatura, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal
ATE448230T1 (de) 2005-12-09 2009-11-15 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
JP2009519290A (ja) 2005-12-15 2009-05-14 エフ．ホフマン−ラ ロシュ アーゲー ピロロ［２，３−ｃ］ピリジン誘導体
KR101015666B1 (ko) 2005-12-16 2011-02-22 에프. 호프만-라 로슈 아게 Ｈ3 수용체 조절제로서 피롤로[2,3-ｂ]피리딘 유도체
WO2007080140A1 (en) * 2006-01-13 2007-07-19 F. Hoffmann-La Roche Ag Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
CA2637449A1 (en) * 2006-01-23 2007-07-26 F. Hoffmann-La Roche Ag Cyclohexyl sulfonamide derivatives having h3 receptor activity
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
JP2009538859A (ja) 2006-05-30 2009-11-12 エフ．ホフマン−ラ ロシュ アーゲー ピペリジニルピリミジン誘導体
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
BRPI0814532A2 (pt) * 2007-07-25 2015-01-27 Hoffmann La Roche Compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação dos receptores de h3, e uso desses compostos para a preparação de medicamentos.
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
EP2646048B1 (en) * 2010-11-30 2017-11-01 The Board of Trustees of the University of Illionis Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
US11225507B2 (en) 2017-01-25 2022-01-18 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

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Also Published As

Publication number Publication date
FI910857A0 (fi) 1991-02-22
US5399720A (en) 1995-03-21
JPH04211675A (ja) 1992-08-03
NZ237132A (en) 1993-04-28
NO910712D0 (no) 1991-02-22
US5245056A (en) 1993-09-14
CA2035972A1 (en) 1991-08-24
HUT56558A (en) 1991-09-30
PT96857B (pt) 1998-07-31
KR100191365B1 (ko) 1999-06-15
IE910608A1 (en) 1991-08-28
ATE153332T1 (de) 1997-06-15
FI115458B (fi) 2005-05-13
KR910021393A (ko) 1991-12-20
CA2035972C (en) 2006-07-11
JP2912463B2 (ja) 1999-06-28
KR0183034B1 (ko) 1999-05-01
NO910712L (no) 1991-08-26
NO178764C (no) 1996-05-29
EP0443449B1 (de) 1997-05-21
ZA911153B (en) 1991-11-27
NO178764B (no) 1996-02-19
HU208686B (en) 1993-12-28
DE59108707D1 (de) 1997-06-26
AU644846B2 (en) 1993-12-23
DK0443449T3 (da) 1997-11-24
EP0443449A3 (en) 1991-12-04
GR3024420T3 (en) 1997-11-28
FI910857A (fi) 1991-08-24
PT96857A (pt) 1991-10-31
AU7116691A (en) 1991-08-29
EP0443449A2 (de) 1991-08-28

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