ATE466007T1 - 5-substituierte indol-2-carbonsäureamidderivate - Google Patents
5-substituierte indol-2-carbonsäureamidderivateInfo
- Publication number
- ATE466007T1 ATE466007T1 AT06819609T AT06819609T ATE466007T1 AT E466007 T1 ATE466007 T1 AT E466007T1 AT 06819609 T AT06819609 T AT 06819609T AT 06819609 T AT06819609 T AT 06819609T AT E466007 T1 ATE466007 T1 AT E466007T1
- Authority
- AT
- Austria
- Prior art keywords
- acid amide
- carbonic acid
- amide derivatives
- substituted indole
- sup
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111477 | 2005-11-30 | ||
PCT/EP2006/068658 WO2007063000A1 (en) | 2005-11-30 | 2006-11-20 | 5-substituted indole-2-carboxamide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE466007T1 true ATE466007T1 (de) | 2010-05-15 |
Family
ID=37943787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06819609T ATE466007T1 (de) | 2005-11-30 | 2006-11-20 | 5-substituierte indol-2-carbonsäureamidderivate |
Country Status (12)
Country | Link |
---|---|
US (1) | US7388095B2 (de) |
EP (1) | EP1960383B1 (de) |
JP (1) | JP2009517434A (de) |
KR (1) | KR20080076987A (de) |
CN (1) | CN101316835A (de) |
AT (1) | ATE466007T1 (de) |
AU (1) | AU2006319235A1 (de) |
BR (1) | BRPI0619233A2 (de) |
CA (1) | CA2630270A1 (de) |
DE (1) | DE602006014022D1 (de) |
ES (1) | ES2342979T3 (de) |
WO (1) | WO2007063000A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5650404B2 (ja) | 2006-12-28 | 2015-01-07 | ライジェル ファーマシューティカルズ, インコーポレイテッド | N−置換−ヘテロシクロアルキルオキシベンズアミド化合物およびその使用方法 |
US7507736B2 (en) * | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
JP5544296B2 (ja) * | 2007-11-16 | 2014-07-09 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 代謝障害のためのカルボキサミド、スルホンアミド、およびアミン化合物 |
CA2707047C (en) | 2007-12-12 | 2017-11-28 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
ES2552549T3 (es) | 2008-04-23 | 2015-11-30 | Rigel Pharmaceuticals, Inc. | Compuestos de carboxamida para el tratamiento de trastornos metabólicos |
FR2953521B1 (fr) * | 2009-12-09 | 2011-11-18 | Servier Lab | Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN110627770A (zh) | 2013-11-18 | 2019-12-31 | 福马疗法公司 | 作为bet溴域抑制剂的四氢喹啉组成物 |
WO2015074081A1 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Benzopiperazine compositions as bet bromodomain inhibitors |
KR101658174B1 (ko) | 2016-04-04 | 2016-09-20 | 김강석 | 웹 사이트를 통한 지능형 지속위협 대응시스템 및 방법 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4183857A (en) | 1978-07-06 | 1980-01-15 | Shell Oil Company | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione |
CA1247547A (en) | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
CA1328881C (en) | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
US5246960A (en) | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
CA2035972C (en) | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
FR2705095B1 (fr) * | 1993-05-12 | 1995-06-23 | Adir | Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US6004996A (en) | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
DE69924999T2 (de) | 1998-08-14 | 2006-05-04 | F. Hoffmann-La Roche Ag | Lipasehemmer enthaltende pharmazeutische zusammensetzungen |
CA2340052C (en) | 1998-08-14 | 2007-05-29 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions containing lipase inhibitors and chitosan |
KR100455635B1 (ko) | 1999-03-29 | 2004-11-06 | 에프. 호프만-라 로슈 아게 | 글루코키나제 활성화제 |
DE60138605D1 (de) * | 2000-03-31 | 2009-06-18 | Ortho Mcneil Pharm Inc | Phenyl-substituierte indole als h3 histaminrezeptorantagonisten |
WO2002072548A2 (en) * | 2001-03-09 | 2002-09-19 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
PT1539742E (pt) * | 2002-06-24 | 2007-01-31 | Schering Corp | Derivados de índole úteis como antagonistas h3 de histamina |
MXPA05002578A (es) * | 2002-09-06 | 2005-09-20 | Johnson & Johnson | Uso de derivados de indolilo para la fabricacion de un medicamento para el tratamiento de rinitis. |
US20040224952A1 (en) * | 2003-05-07 | 2004-11-11 | Cowart Marlon D. | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
US6995183B2 (en) | 2003-08-01 | 2006-02-07 | Bristol Myers Squibb Company | Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods |
MXPA06014810A (es) * | 2004-06-21 | 2007-02-12 | Hoffmann La Roche | Derivados de indol como antagonistas receptores de histamina. |
AR056690A1 (es) * | 2005-10-14 | 2007-10-17 | Athersys Inc | Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc |
BRPI0619266A2 (pt) * | 2005-11-30 | 2011-09-27 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, obesidade, diabetes do tipo ii e seu uso |
CA2630314A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 1,5-substituted indol-2-yl amide derivatives |
-
2006
- 2006-11-20 DE DE602006014022T patent/DE602006014022D1/de active Active
- 2006-11-20 BR BRPI0619233-5A patent/BRPI0619233A2/pt not_active IP Right Cessation
- 2006-11-20 EP EP06819609A patent/EP1960383B1/de not_active Not-in-force
- 2006-11-20 AT AT06819609T patent/ATE466007T1/de not_active IP Right Cessation
- 2006-11-20 ES ES06819609T patent/ES2342979T3/es active Active
- 2006-11-20 KR KR1020087015995A patent/KR20080076987A/ko active IP Right Grant
- 2006-11-20 AU AU2006319235A patent/AU2006319235A1/en not_active Abandoned
- 2006-11-20 CA CA002630270A patent/CA2630270A1/en not_active Abandoned
- 2006-11-20 CN CNA2006800445901A patent/CN101316835A/zh active Pending
- 2006-11-20 JP JP2008542717A patent/JP2009517434A/ja active Pending
- 2006-11-20 WO PCT/EP2006/068658 patent/WO2007063000A1/en active Application Filing
- 2006-11-27 US US11/604,563 patent/US7388095B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1960383A1 (de) | 2008-08-27 |
JP2009517434A (ja) | 2009-04-30 |
CA2630270A1 (en) | 2007-06-07 |
US20070123525A1 (en) | 2007-05-31 |
BRPI0619233A2 (pt) | 2011-09-20 |
CN101316835A (zh) | 2008-12-03 |
EP1960383B1 (de) | 2010-04-28 |
DE602006014022D1 (de) | 2010-06-10 |
KR20080076987A (ko) | 2008-08-20 |
ES2342979T3 (es) | 2010-07-20 |
AU2006319235A1 (en) | 2007-06-07 |
US7388095B2 (en) | 2008-06-17 |
WO2007063000A1 (en) | 2007-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |