MX370535B - Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer. - Google Patents

Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.

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Publication number
MX370535B
MX370535B MX2016006438A MX2016006438A MX370535B MX 370535 B MX370535 B MX 370535B MX 2016006438 A MX2016006438 A MX 2016006438A MX 2016006438 A MX2016006438 A MX 2016006438A MX 370535 B MX370535 B MX 370535B
Authority
MX
Mexico
Prior art keywords
bromodomain inhibitors
bet bromodomain
tetrahydroquinoline
compositions
tetrahydroquinoline compositions
Prior art date
Application number
MX2016006438A
Other languages
English (en)
Other versions
MX2016006438A (es
Inventor
W Bair Kenneth
Herbertz Torsten
Stryker Kauffman Goss
J Kayser-Bricker Katherine
P Luke George
W Martin Matthew
S Millan David
E R Schiller Shawn
c talbot Adam
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MX2016006438A publication Critical patent/MX2016006438A/es
Publication of MX370535B publication Critical patent/MX370535B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a inhibidores de bromodominios de terminal extra y bromo (BET) que son útiles para el tratamiento de cáncer, enfermedades inflamatorias, diabetes y obesidad, que tienen la formula (I): Formula (I) en donde W, X, Y, Z, R1, R2, R5 y R8 son como se describe aquí.
MX2016006438A 2013-11-18 2014-11-18 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer. MX370535B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361905639P 2013-11-18 2013-11-18
US201462054811P 2014-09-24 2014-09-24
PCT/US2014/066198 WO2015074064A2 (en) 2013-11-18 2014-11-18 Tetrahydroquinoline compositions as bet bromodomain inhibitors

Publications (2)

Publication Number Publication Date
MX2016006438A MX2016006438A (es) 2016-10-21
MX370535B true MX370535B (es) 2019-12-17

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MX2016006438A MX370535B (es) 2013-11-18 2014-11-18 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
MX2019015068A MX2019015068A (es) 2013-11-18 2016-05-17 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo ( bet ) y el uso de los mismos en el tratamiento de cancer.

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MX2019015068A MX2019015068A (es) 2013-11-18 2016-05-17 Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo ( bet ) y el uso de los mismos en el tratamiento de cancer.

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