NO910712L - Fremgangsmaate ved fremstilling av oksetanoner. - Google Patents

Fremgangsmaate ved fremstilling av oksetanoner.

Info

Publication number
NO910712L
NO910712L NO91910712A NO910712A NO910712L NO 910712 L NO910712 L NO 910712L NO 91910712 A NO91910712 A NO 91910712A NO 910712 A NO910712 A NO 910712A NO 910712 L NO910712 L NO 910712L
Authority
NO
Norway
Prior art keywords
oxetanones
procedure
manufacture
beta
novel
Prior art date
Application number
NO91910712A
Other languages
English (en)
Other versions
NO910712D0 (no
NO178764C (no
NO178764B (no
Inventor
Martin Karpf
Ulrich Zutter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO910712D0 publication Critical patent/NO910712D0/no
Publication of NO910712L publication Critical patent/NO910712L/no
Publication of NO178764B publication Critical patent/NO178764B/no
Publication of NO178764C publication Critical patent/NO178764C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Treatment Of Steel (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO910712A 1990-02-23 1991-02-22 Fremgangsmåte ved fremstilling av oksetanoner NO178764C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH392590 1990-12-12

Publications (4)

Publication Number Publication Date
NO910712D0 NO910712D0 (no) 1991-02-22
NO910712L true NO910712L (no) 1991-08-26
NO178764B NO178764B (no) 1996-02-19
NO178764C NO178764C (no) 1996-05-29

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
NO910712A NO178764C (no) 1990-02-23 1991-02-22 Fremgangsmåte ved fremstilling av oksetanoner

Country Status (18)

Country Link
US (2) US5245056A (no)
EP (1) EP0443449B1 (no)
JP (1) JP2912463B2 (no)
KR (2) KR0183034B1 (no)
AT (1) ATE153332T1 (no)
AU (1) AU644846B2 (no)
CA (1) CA2035972C (no)
DE (1) DE59108707D1 (no)
DK (1) DK0443449T3 (no)
ES (1) ES2103751T3 (no)
FI (1) FI115458B (no)
GR (1) GR3024420T3 (no)
HU (1) HU208686B (no)
IE (1) IE910608A1 (no)
NO (1) NO178764C (no)
NZ (1) NZ237132A (no)
PT (1) PT96857B (no)
ZA (1) ZA911153B (no)

Families Citing this family (61)

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AT398579B (de) * 1992-07-06 1994-12-27 Chemie Linz Gmbh Enzymatisches verfahren zur trennung racemischer gemische von delta-valerolactonen
DE4225817A1 (de) * 1992-08-05 1994-02-10 Chemie Linz Deutschland Enzymatisches Verfahren zur Trennung racemischer Gemische von delta-Valerolactonen
US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
PL191222B1 (pl) * 1997-02-05 2006-03-31 Hoffmann La Roche Zastosowanie tetrahydrolipstatyny do wytwarzania doustnego farmaceutycznego preparatu do leczenia cukrzycy typu II
WO1999014210A1 (en) * 1997-09-15 1999-03-25 Warner-Lambert Company Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
US6545165B1 (en) * 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
BR0112800A (pt) 2000-07-28 2003-07-01 Hoffmann La Roche Utilização de um inibidor de lìpases e de um sequestrante de ácido de bìlis farmaceuticamente aceitáveis e processo para a prevenção e tratamento de enfermidades associadas com altos nìveis de colesterol de plasma
CN1323661C (zh) 2000-08-09 2007-07-04 霍夫曼-拉罗奇有限公司 脂酶抑制剂的用途
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
KR100545435B1 (ko) 2000-10-16 2006-01-24 에프. 호프만-라 로슈 아게 인돌린 유도체 및 5-ｈｔ2 수용체 리간드로서의 이들의 용도
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
KR100539143B1 (ko) 2000-12-27 2005-12-26 에프. 호프만-라 로슈 아게 인돌 유도체 및 그의 5-ｈｔ2ｂ 및 5-ｈｔ2ｃ 수용체리간드로서의 용도
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
AU2002347539A1 (en) * 2001-12-13 2003-06-23 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
ATE392897T1 (de) 2002-02-04 2008-05-15 Hoffmann La Roche Chinolinderivate als npy antagonisten
CN100363362C (zh) 2002-02-28 2008-01-23 霍夫曼-拉罗奇有限公司 用作npy受体拮抗剂的噻唑衍生物
WO2003088975A1 (en) * 2002-04-17 2003-10-30 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
US7728153B2 (en) 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
JP2005535648A (ja) 2002-07-05 2005-11-24 エフ．ホフマン−ラ　ロシュ　アーゲー キナゾリン誘導体
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
MXPA05001328A (es) 2002-08-07 2005-04-28 Hoffmann La Roche Derivados de tiazol.
PL375878A1 (en) 2002-09-12 2005-12-12 F.Hoffmann-La Roche Ag N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
MXPA05005445A (es) 2002-11-25 2005-08-26 Hoffmann La Roche Derivados de indolilo.
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
RU2006107444A (ru) * 2003-08-12 2007-09-20 Ф.Хоффманн-Ля Рош Аг (Ch) 2-амино-5-бензоилтиазолы в качестве антагонистов npy
EP1656374B1 (en) * 2003-08-12 2009-03-11 F. Hoffmann-La Roche Ag Thiazole derivatives as npy antagonists
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
KR100895758B1 (ko) * 2005-05-03 2009-04-30 에프. 호프만-라 로슈 아게 5-ｈｔ2 리간드로서 테트라사이클릭 아자피라지노인돌린
MX2008002061A (es) 2005-08-18 2008-04-16 Hoffmann La Roche Derivados de tiazolil piperidina utiles como moduladores del receptor h3.
ES2362929T3 (es) 2005-11-30 2011-07-15 F. Hoffmann-La Roche Ag Derivados de 1,1-dioxo-tiomorfolinil-indolil-metanona para uso como moduladores de h3.
KR20080076987A (ko) 2005-11-30 2008-08-20 에프. 호프만-라 로슈 아게 5-치환된 인돌-2-카복스아미드 유도체
CA2630314A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 1,5-substituted indol-2-yl amide derivatives
ATE448230T1 (de) 2005-12-09 2009-11-15 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
ATE449776T1 (de) 2005-12-15 2009-12-15 Hoffmann La Roche Pyrroloä2,3-cüpyridinderivate
ATE467632T1 (de) 2005-12-16 2010-05-15 Hoffmann La Roche Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
RU2008132966A (ru) * 2006-01-13 2010-02-20 Ф.Хоффманн-Ля Рош Аг (Ch) Производные циклогексилпиперазинилметанона и их применение в качестве модуляторов гистамин н3 рецептора
AU2007206997B2 (en) * 2006-01-23 2011-11-24 F. Hoffmann-La Roche Ag Cyclohexyl sulfonamide derivatives having H3 receptor activity
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
CA2652158A1 (en) 2006-05-30 2007-12-06 Matthias Heinrich Nettekoven Piperidinyl pyrimidine derivatives
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
JP2010534217A (ja) * 2007-07-25 2010-11-04 エフ．ホフマン−ラ ロシュ アーゲー ベンゾフラン−及びベンゾ［ｂ］チオフェン−２−カルボン酸アミド誘導体ならびにヒスタミン３受容体モジュレータとしてのその使用
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
WO2012075147A2 (en) * 2010-11-30 2012-06-07 Board Of Trustees Of The University Of Illinois Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
US11225507B2 (en) 2017-01-25 2022-01-18 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

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US5149835A (en) * 1989-04-27 1992-09-22 University Of New Mexico Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof
US5036008A (en) * 1989-07-12 1991-07-30 Bristol-Myers Company Antitumor antibiotic BU-3285T
US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
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Also Published As

Publication number Publication date
GR3024420T3 (en) 1997-11-28
DE59108707D1 (de) 1997-06-26
NZ237132A (en) 1993-04-28
NO910712D0 (no) 1991-02-22
US5399720A (en) 1995-03-21
JPH04211675A (ja) 1992-08-03
KR0183034B1 (ko) 1999-05-01
CA2035972A1 (en) 1991-08-24
AU7116691A (en) 1991-08-29
FI910857A0 (fi) 1991-02-22
KR910021393A (ko) 1991-12-20
NO178764C (no) 1996-05-29
NO178764B (no) 1996-02-19
US5245056A (en) 1993-09-14
ATE153332T1 (de) 1997-06-15
FI910857A (fi) 1991-08-24
HUT56558A (en) 1991-09-30
EP0443449A3 (en) 1991-12-04
KR100191365B1 (ko) 1999-06-15
ES2103751T3 (es) 1997-10-01
FI115458B (fi) 2005-05-13
IE910608A1 (en) 1991-08-28
DK0443449T3 (da) 1997-11-24
PT96857B (pt) 1998-07-31
HU208686B (en) 1993-12-28
EP0443449A2 (de) 1991-08-28
EP0443449B1 (de) 1997-05-21
CA2035972C (en) 2006-07-11
ZA911153B (en) 1991-11-27
AU644846B2 (en) 1993-12-23
JP2912463B2 (ja) 1999-06-28
PT96857A (pt) 1991-10-31

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