FI910857A0 - Foerfarande foer framstaellning av oxetanoner. - Google Patents

Foerfarande foer framstaellning av oxetanoner.

Info

Publication number
FI910857A0
FI910857A0 FI910857A FI910857A FI910857A0 FI 910857 A0 FI910857 A0 FI 910857A0 FI 910857 A FI910857 A FI 910857A FI 910857 A FI910857 A FI 910857A FI 910857 A0 FI910857 A0 FI 910857A0
Authority
FI
Finland
Prior art keywords
oxetanoner
foer faring
faring framstaellning
framstaellning
foer
Prior art date
Application number
FI910857A
Other languages
English (en)
Other versions
FI910857A (fi
FI115458B (fi
Inventor
Martin Karpf
Ulrich Zutter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI910857A0 publication Critical patent/FI910857A0/fi
Publication of FI910857A publication Critical patent/FI910857A/fi
Application granted granted Critical
Publication of FI115458B publication Critical patent/FI115458B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Treatment Of Steel (AREA)
  • Examining Or Testing Airtightness (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI910857A 1990-02-23 1991-02-22 Menetelmä oksetanonien valmistamiseksi FI115458B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH58990 1990-02-23
CH58990 1990-02-23
CH392590 1990-12-12
CH392590 1990-12-12

Publications (3)

Publication Number Publication Date
FI910857A0 true FI910857A0 (fi) 1991-02-22
FI910857A FI910857A (fi) 1991-08-24
FI115458B FI115458B (fi) 2005-05-13

Family

ID=25685045

Family Applications (1)

Application Number Title Priority Date Filing Date
FI910857A FI115458B (fi) 1990-02-23 1991-02-22 Menetelmä oksetanonien valmistamiseksi

Country Status (18)

Country Link
US (2) US5245056A (fi)
EP (1) EP0443449B1 (fi)
JP (1) JP2912463B2 (fi)
KR (2) KR0183034B1 (fi)
AT (1) ATE153332T1 (fi)
AU (1) AU644846B2 (fi)
CA (1) CA2035972C (fi)
DE (1) DE59108707D1 (fi)
DK (1) DK0443449T3 (fi)
ES (1) ES2103751T3 (fi)
FI (1) FI115458B (fi)
GR (1) GR3024420T3 (fi)
HU (1) HU208686B (fi)
IE (1) IE910608A1 (fi)
NO (1) NO178764C (fi)
NZ (1) NZ237132A (fi)
PT (1) PT96857B (fi)
ZA (1) ZA911153B (fi)

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US5481008A (en) * 1993-09-13 1996-01-02 Hoffmann-La Roche Inc. Process for the preparation of optically active compounds
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AU9198698A (en) * 1997-09-15 1999-04-05 Warner-Lambert Company Process for the preparation of substituted 5,6-dihydro-2h-pyran-2-ones
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
US6552204B1 (en) * 2000-02-04 2003-04-22 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
EP1307263B1 (en) * 2000-07-28 2005-04-20 F. Hoffmann-La Roche Ag New use of lipase inhibitors
WO2002011719A2 (en) 2000-08-09 2002-02-14 F. Hoffmann-La Roche Ag Lipase inhibitors for the treatment of dyspepsia
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
EP1328515B1 (en) 2000-10-16 2008-08-06 F. Hoffmann-La Roche AG Indoline derivatives and their use as 5-ht2 receptor ligands
GB0030710D0 (en) * 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
CN1250549C (zh) 2000-12-27 2006-04-12 霍夫曼-拉罗奇有限公司 吲哚衍生物及其作为5－ht2b和5－ht2c受体配体的应用
GB0106177D0 (en) 2001-03-13 2001-05-02 Hoffmann La Roche Piperazine derivatives
US6730319B2 (en) 2001-06-06 2004-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions having depressed melting points
US20030027786A1 (en) 2001-06-06 2003-02-06 Karsten Maeder Lipase inhibiting composition
US6787558B2 (en) 2001-09-28 2004-09-07 Hoffmann-La Roche Inc. Quinoline derivatives
WO2003050124A1 (en) * 2001-12-13 2003-06-19 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
GB0202015D0 (en) * 2002-01-29 2002-03-13 Hoffmann La Roche Piperazine Derivatives
JP4216196B2 (ja) 2002-02-04 2009-01-28 エフ．ホフマン−ラ ロシュ アーゲー Ｎｐｙアンタゴニストとしてのキノリン誘導体
ES2292992T3 (es) 2002-02-28 2008-03-16 F. Hoffmann-La Roche Ag Derivados de tiazol como antagonistas del receptor npy.
US7728153B2 (en) * 2002-04-17 2010-06-01 The Burnham Institute For Medical Research Method for the asymmetric synthesis of beta-lactone compounds
WO2003088975A1 (en) * 2002-04-17 2003-10-30 The Burnham Institute Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
CA2489251A1 (en) 2002-07-05 2004-01-15 F. Hoffmann-La Roche Ag Quinazoline derivatives
US8861667B1 (en) 2002-07-12 2014-10-14 Rambus Inc. Clock data recovery circuit with equalizer clock calibration
CA2493712A1 (en) 2002-08-07 2004-02-19 F. Hoffmann-La Roche Ag Aminothiazole derivatives as npy5 receptor inhibitors
KR100645684B1 (ko) 2002-09-12 2006-11-15 에프. 호프만-라 로슈 아게 당뇨병 치료에 유용한 ｐｐａｒ 작동제로서 ｎ-치환된-1ｈ-인돌-5-프로파이온산 화합물
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
EP1567523B1 (en) 2002-11-25 2008-08-20 F.Hoffmann-La Roche Ag Indolyl derivatives
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
MXPA06001570A (es) * 2003-08-12 2006-05-15 Hoffmann La Roche Antagonistas del receptor de neuropeptido y (npy) 2-amino-5-benzoiltiazol.
JP2007501824A (ja) * 2003-08-12 2007-02-01 エフ．ホフマン−ラ　ロシュ　アーゲー Ｎｐｙアンタゴニストとしてのチアゾール誘導体
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
KR100895758B1 (ko) * 2005-05-03 2009-04-30 에프. 호프만-라 로슈 아게 5-ｈｔ2 리간드로서 테트라사이클릭 아자피라지노인돌린
BRPI0614834A2 (pt) 2005-08-18 2011-04-19 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e usos destas
AU2006319234B2 (en) 2005-11-30 2012-01-19 F. Hoffmann-La Roche Ag 1,5-substituted indol-2-yl amide derivatives
JP2009517434A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ５−置換インドール−２−カルボキサミド誘導体
KR101047204B1 (ko) 2005-11-30 2011-07-06 에프. 호프만-라 로슈 아게 Ｈ3 조절제로서 사용하기 위한1,1-다이옥소-싸이오모폴린일 인돌일 메탄온 유도체
DE602006010433D1 (de) 2005-12-09 2009-12-24 Hoffmann La Roche Für die behandlung von obesitas geeignete tricyclische amidderivate
DE602006010738D1 (de) 2005-12-15 2010-01-07 Hoffmann La Roche Pyrroloä2,3-cüpyridinderivate
BRPI0619985A2 (pt) 2005-12-16 2011-10-25 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos
EP1976840A1 (en) * 2006-01-13 2008-10-08 F.Hoffmann-La Roche Ag Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
AU2007206997B2 (en) * 2006-01-23 2011-11-24 F. Hoffmann-La Roche Ag Cyclohexyl sulfonamide derivatives having H3 receptor activity
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
MX2008014532A (es) 2006-05-30 2008-11-27 Hoffmann La Roche Derivados de piperidinil pirimidinas.
US7514433B2 (en) 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US20080146559A1 (en) 2006-12-08 2008-06-19 Li Chen 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
CN101348475B (zh) * 2007-07-20 2011-03-30 重庆人本药物研究院 一种奥利司他合成方法、中间体化合物及其制备方法
AU2008280257A1 (en) * 2007-07-25 2009-01-29 F. Hoffmann-La Roche Ag Benzofuran- and benzo[B]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
WO2012075147A2 (en) * 2010-11-30 2012-06-07 Board Of Trustees Of The University Of Illinois Stable helical ionic polypeptides
CN103588735A (zh) * 2013-11-13 2014-02-19 大连九信生物化工科技有限公司 一种奥利司他的结晶提纯方法
FR3017878B1 (fr) * 2014-02-27 2017-12-08 Charabot Procede de production de lactones a partir d'une souche d'aureobasidium pullulans
US11225507B2 (en) 2017-01-25 2022-01-18 The Board Of Trustees Of The University Of Illinois Conformation switchable antimicrobial peptides and methods of using the same
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法

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Also Published As

Publication number Publication date
US5245056A (en) 1993-09-14
KR0183034B1 (ko) 1999-05-01
IE910608A1 (en) 1991-08-28
PT96857B (pt) 1998-07-31
NZ237132A (en) 1993-04-28
US5399720A (en) 1995-03-21
NO178764C (no) 1996-05-29
NO178764B (no) 1996-02-19
AU644846B2 (en) 1993-12-23
HUT56558A (en) 1991-09-30
KR910021393A (ko) 1991-12-20
HU208686B (en) 1993-12-28
EP0443449B1 (de) 1997-05-21
GR3024420T3 (en) 1997-11-28
ATE153332T1 (de) 1997-06-15
CA2035972C (en) 2006-07-11
ES2103751T3 (es) 1997-10-01
JPH04211675A (ja) 1992-08-03
AU7116691A (en) 1991-08-29
CA2035972A1 (en) 1991-08-24
NO910712L (no) 1991-08-26
KR100191365B1 (ko) 1999-06-15
EP0443449A3 (en) 1991-12-04
NO910712D0 (no) 1991-02-22
EP0443449A2 (de) 1991-08-28
DK0443449T3 (da) 1997-11-24
DE59108707D1 (de) 1997-06-26
FI910857A (fi) 1991-08-24
FI115458B (fi) 2005-05-13
PT96857A (pt) 1991-10-31
ZA911153B (en) 1991-11-27
JP2912463B2 (ja) 1999-06-28

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