HUP9700884A2 - Tienil-etilamino-halogénfenil-acetamid intermedierek és eljárás előállításukra - Google Patents

Tienil-etilamino-halogénfenil-acetamid intermedierek és eljárás előállításukra

Info

Publication number
HUP9700884A2
HUP9700884A2 HU9700884A HUP9700884A HUP9700884A2 HU P9700884 A2 HUP9700884 A2 HU P9700884A2 HU 9700884 A HU9700884 A HU 9700884A HU P9700884 A HUP9700884 A HU P9700884A HU P9700884 A2 HUP9700884 A2 HU P9700884A2
Authority
HU
Hungary
Prior art keywords
ethylamino
halogen
phenyl
producing
thienyl
Prior art date
Application number
HU9700884A
Other languages
English (en)
Inventor
Mária Bakonyi
Nagy Marianna Csatáriné
Leventéné Molnár
Tiborné Bai
Piroska Jobb
Zoltán Makovi
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU9700884A priority Critical patent/HU225503B1/hu
Publication of HU9700884D0 publication Critical patent/HU9700884D0/hu
Priority to PCT/HU1998/000047 priority patent/WO1998051681A1/en
Priority to JP54895598A priority patent/JP4282770B2/ja
Priority to ES98921669T priority patent/ES2195335T3/es
Priority to DK98921669T priority patent/DK0981524T3/da
Priority to AU74447/98A priority patent/AU7444798A/en
Priority to DE69813792T priority patent/DE69813792T2/de
Priority to PT98921669T priority patent/PT981524E/pt
Priority to BRPI9809111-5A priority patent/BR9809111B1/pt
Priority to US09/423,801 priority patent/US6258961B1/en
Priority to EP98921669A priority patent/EP0981524B1/en
Priority to AT98921669T priority patent/ATE238294T1/de
Priority to CA002289545A priority patent/CA2289545C/en
Publication of HUP9700884A2 publication Critical patent/HUP9700884A2/hu
Priority to NO19995532A priority patent/NO324039B1/no
Publication of HUP9700884A3 publication Critical patent/HUP9700884A3/hu
Publication of HU225503B1 publication Critical patent/HU225503B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Press Drives And Press Lines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya (VII) általánős képletű[2-(2-tienil)-etilaminő]-(2-halőgénfenil)-acetamidők, és eljárás ezek előállítására az (I)általánős képletű nitrilekből kiindűlva. A (VII) általánős képletűvegyületek antitrőmbőlitikűs hatású vegyületek intermedierei. ŕ
HU9700884A 1997-05-13 1997-05-13 Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them HU225503B1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HU9700884A HU225503B1 (en) 1997-05-13 1997-05-13 Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
CA002289545A CA2289545C (en) 1997-05-13 1998-05-11 Process for the preparation of 2-[(2-thienyl)-ethylamino]-(2-halogenophenyl)acetamides
DE69813792T DE69813792T2 (de) 1997-05-13 1998-05-11 Zwischenprodukte und verfahren zu ihrer herstellung
BRPI9809111-5A BR9809111B1 (pt) 1997-05-13 1998-05-11 intermediários de [2-(2-tienil) etilamino]-(2-clorofenil) acetamida e processo para preparação dos mesmos.
ES98921669T ES2195335T3 (es) 1997-05-13 1998-05-11 Nuevos productos intermedios y procedimiento para la preparacion de los mismos.
DK98921669T DK0981524T3 (da) 1997-05-13 1998-05-11 Nye mellemprodukter og fremgangsmåde til fremstilling deraf
AU74447/98A AU7444798A (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof
PCT/HU1998/000047 WO1998051681A1 (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof
PT98921669T PT981524E (pt) 1997-05-13 1998-05-11 Novos intermediarios e processo para sua preparacao
JP54895598A JP4282770B2 (ja) 1997-05-13 1998-05-11 新規な中間体およびその製造方法
US09/423,801 US6258961B1 (en) 1997-05-13 1998-05-11 Intermediates and process for the preparation thereof
EP98921669A EP0981524B1 (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof
AT98921669T ATE238294T1 (de) 1997-05-13 1998-05-11 Zwischenprodukte und verfahren zu ihrer herstellung
NO19995532A NO324039B1 (no) 1997-05-13 1999-11-12 Nye mellomprodukter og fremgangsmate for fremstilling derav

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700884A HU225503B1 (en) 1997-05-13 1997-05-13 Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them

Publications (4)

Publication Number Publication Date
HU9700884D0 HU9700884D0 (en) 1997-07-28
HUP9700884A2 true HUP9700884A2 (hu) 1999-09-28
HUP9700884A3 HUP9700884A3 (en) 2000-06-28
HU225503B1 HU225503B1 (en) 2007-01-29

Family

ID=89995117

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700884A HU225503B1 (en) 1997-05-13 1997-05-13 Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them

Country Status (13)

Country Link
US (1) US6258961B1 (hu)
EP (1) EP0981524B1 (hu)
JP (1) JP4282770B2 (hu)
AT (1) ATE238294T1 (hu)
AU (1) AU7444798A (hu)
BR (1) BR9809111B1 (hu)
CA (1) CA2289545C (hu)
DE (1) DE69813792T2 (hu)
ES (1) ES2195335T3 (hu)
HU (1) HU225503B1 (hu)
NO (1) NO324039B1 (hu)
PT (1) PT981524E (hu)
WO (1) WO1998051681A1 (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226421B1 (en) 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
US7872019B2 (en) 2003-03-12 2011-01-18 Cadila Healthcare Limited Polymorphs and amorphous form of (S)-(+)-clopidogrel bisulfate
US6858734B2 (en) * 2003-04-23 2005-02-22 Rhodia Pharma Solutions Inc. Preparation of (S)-Clopidogrel and related compounds
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
ATE455778T1 (de) 2003-11-03 2010-02-15 Cadila Healthcare Ltd Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
DE502004007831D1 (de) * 2004-04-20 2008-09-25 Ratiopharm Gmbh Stereoselektives Verfahren zur Herstellung von Clopidogrel
JP2007513889A (ja) * 2004-09-21 2007-05-31 テバ ファーマシューティカル インダストリーズ リミティド 結晶性クロピドグレル臭酸塩及びその調製方法
CA2594763A1 (en) * 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
KR20090013794A (ko) * 2006-04-27 2009-02-05 인드-스위프트 래버러토리즈 리미티드 클로피도그렐 히드로겐 설페이트의 다형태의 제조방법
TW200825093A (en) * 2006-08-03 2008-06-16 Teva Pharma Process for preparing clopidogrel bisulphate
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
CN102186858A (zh) * 2008-10-24 2011-09-14 桑多斯股份公司 制备s-氯吡格雷的方法
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CN103483356B (zh) * 2013-09-30 2016-01-13 浙江美诺华药物化学有限公司 一种（s）-氯吡格雷的硫酸盐或盐酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr) 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.

Also Published As

Publication number Publication date
NO995532D0 (no) 1999-11-12
NO995532L (no) 1999-12-13
CA2289545C (en) 2006-12-12
JP2001525818A (ja) 2001-12-11
US6258961B1 (en) 2001-07-10
PT981524E (pt) 2003-08-29
AU7444798A (en) 1998-12-08
HUP9700884A3 (en) 2000-06-28
DE69813792D1 (de) 2003-05-28
EP0981524A1 (en) 2000-03-01
HU225503B1 (en) 2007-01-29
ES2195335T3 (es) 2003-12-01
DE69813792T2 (de) 2004-01-29
BR9809111A (pt) 2000-08-01
WO1998051681A1 (en) 1998-11-19
BR9809111B1 (pt) 2009-05-05
JP4282770B2 (ja) 2009-06-24
ATE238294T1 (de) 2003-05-15
CA2289545A1 (en) 1998-11-19
EP0981524B1 (en) 2003-04-23
NO324039B1 (no) 2007-07-30
HU9700884D0 (en) 1997-07-28

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