ES2195335T3 - Nuevos productos intermedios y procedimiento para la preparacion de los mismos. - Google Patents
Nuevos productos intermedios y procedimiento para la preparacion de los mismos.Info
- Publication number
- ES2195335T3 ES2195335T3 ES98921669T ES98921669T ES2195335T3 ES 2195335 T3 ES2195335 T3 ES 2195335T3 ES 98921669 T ES98921669 T ES 98921669T ES 98921669 T ES98921669 T ES 98921669T ES 2195335 T3 ES2195335 T3 ES 2195335T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- intermediate products
- procedure
- same
- new intermediate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013067 intermediate product Substances 0.000 title abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Press Drives And Press Lines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se presenta un proceso par la preparación de 2-[(2-tienil)-etilamino]-2(2-halogenofenil)-acetamidas de la fórmula general (VII) comenzando a partir de nitrilos de la fórmula general (I). Los compuestos de la fórmula general (VII) son productos intermedios de gran valor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700884A HU225503B1 (en) | 1997-05-13 | 1997-05-13 | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195335T3 true ES2195335T3 (es) | 2003-12-01 |
Family
ID=89995117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98921669T Expired - Lifetime ES2195335T3 (es) | 1997-05-13 | 1998-05-11 | Nuevos productos intermedios y procedimiento para la preparacion de los mismos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6258961B1 (es) |
EP (1) | EP0981524B1 (es) |
JP (1) | JP4282770B2 (es) |
AT (1) | ATE238294T1 (es) |
AU (1) | AU7444798A (es) |
BR (1) | BR9809111B1 (es) |
CA (1) | CA2289545C (es) |
DE (1) | DE69813792T2 (es) |
ES (1) | ES2195335T3 (es) |
HU (1) | HU225503B1 (es) |
NO (1) | NO324039B1 (es) |
PT (1) | PT981524E (es) |
WO (1) | WO1998051681A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU226421B1 (en) | 1998-11-09 | 2008-12-29 | Sanofi Aventis | Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides |
US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
US6800759B2 (en) * | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
IL166593A0 (en) * | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
WO2004081016A1 (en) | 2003-03-12 | 2004-09-23 | Cadila Healthcare Limited | Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate |
US6858734B2 (en) * | 2003-04-23 | 2005-02-22 | Rhodia Pharma Solutions Inc. | Preparation of (S)-Clopidogrel and related compounds |
WO2004108665A2 (en) * | 2003-04-24 | 2004-12-16 | Sun Pharmaceutical Industries Limited | A process for preparation of clopidogrel |
GB0321256D0 (en) | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
CA2676121A1 (en) | 2003-11-03 | 2005-07-14 | Cadila Healthcare Limited | Processes for preparing different forms of (s)-(+)-clopidogrel bisulfate |
PL1589019T3 (pl) * | 2004-04-20 | 2008-12-31 | Ratiopharm Gmbh | Stereoselektywny sposób wytwarzania klopidogrelu |
WO2006034451A2 (en) * | 2004-09-21 | 2006-03-30 | Teva Pharmaceutical Industries Ltd. | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
MX2007010267A (es) * | 2005-02-24 | 2007-09-11 | Teva Pharma | Base de clopidogrel adecuada para formulacion farmaceutica y preparacion de ella. |
CA2650471A1 (en) * | 2006-04-27 | 2007-11-08 | Ind-Swift Laboratories Limited | Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate |
CA2655844A1 (en) * | 2006-08-03 | 2008-02-14 | Teva Pharmaceutical Industries Ltd. | Process for preparing clopidogrel bisulphate |
PL382055A1 (pl) * | 2007-03-23 | 2008-09-29 | Koźluk Tomasz Nobilus Ent | Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu |
EP1980563A1 (en) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
US20090264460A1 (en) * | 2008-04-21 | 2009-10-22 | Mamta Mishra | Clopidogrel pharmaceutical formulations |
EP2346879A1 (en) * | 2008-10-24 | 2011-07-27 | Sandoz AG | A process for the preparation of s-clopidogrel |
US8563690B2 (en) * | 2008-11-03 | 2013-10-22 | The Board Of Trustees Of The University Of Illinois | Modulation of platelet aggregation |
CN103483356B (zh) * | 2013-09-30 | 2016-01-13 | 浙江美诺华药物化学有限公司 | 一种(s)-氯吡格雷的硫酸盐或盐酸盐的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
FR2608607B1 (fr) | 1986-12-23 | 1989-04-28 | Sanofi Sa | Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues |
FR2623810B2 (fr) | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2652575B1 (fr) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
-
1997
- 1997-05-13 HU HU9700884A patent/HU225503B1/hu unknown
-
1998
- 1998-05-11 JP JP54895598A patent/JP4282770B2/ja not_active Expired - Lifetime
- 1998-05-11 AU AU74447/98A patent/AU7444798A/en not_active Abandoned
- 1998-05-11 CA CA002289545A patent/CA2289545C/en not_active Expired - Fee Related
- 1998-05-11 AT AT98921669T patent/ATE238294T1/de active
- 1998-05-11 ES ES98921669T patent/ES2195335T3/es not_active Expired - Lifetime
- 1998-05-11 DE DE69813792T patent/DE69813792T2/de not_active Expired - Lifetime
- 1998-05-11 EP EP98921669A patent/EP0981524B1/en not_active Expired - Lifetime
- 1998-05-11 US US09/423,801 patent/US6258961B1/en not_active Expired - Lifetime
- 1998-05-11 PT PT98921669T patent/PT981524E/pt unknown
- 1998-05-11 WO PCT/HU1998/000047 patent/WO1998051681A1/en active IP Right Grant
- 1998-05-11 BR BRPI9809111-5A patent/BR9809111B1/pt not_active IP Right Cessation
-
1999
- 1999-11-12 NO NO19995532A patent/NO324039B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9809111B1 (pt) | 2009-05-05 |
WO1998051681A1 (en) | 1998-11-19 |
JP2001525818A (ja) | 2001-12-11 |
HUP9700884A3 (en) | 2000-06-28 |
BR9809111A (pt) | 2000-08-01 |
NO324039B1 (no) | 2007-07-30 |
AU7444798A (en) | 1998-12-08 |
NO995532L (no) | 1999-12-13 |
HU225503B1 (en) | 2007-01-29 |
DE69813792T2 (de) | 2004-01-29 |
NO995532D0 (no) | 1999-11-12 |
EP0981524B1 (en) | 2003-04-23 |
CA2289545C (en) | 2006-12-12 |
US6258961B1 (en) | 2001-07-10 |
HU9700884D0 (en) | 1997-07-28 |
EP0981524A1 (en) | 2000-03-01 |
JP4282770B2 (ja) | 2009-06-24 |
PT981524E (pt) | 2003-08-29 |
DE69813792D1 (de) | 2003-05-28 |
ATE238294T1 (de) | 2003-05-15 |
CA2289545A1 (en) | 1998-11-19 |
HUP9700884A2 (hu) | 1999-09-28 |
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