NO995532L - Nye mellomprodukter og fremgangsmåte for fremstilling derav - Google Patents
Nye mellomprodukter og fremgangsmåte for fremstilling deravInfo
- Publication number
- NO995532L NO995532L NO995532A NO995532A NO995532L NO 995532 L NO995532 L NO 995532L NO 995532 A NO995532 A NO 995532A NO 995532 A NO995532 A NO 995532A NO 995532 L NO995532 L NO 995532L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- processes
- new intermediates
- general formula
- vii
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Press Drives And Press Lines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700884A HU225503B1 (en) | 1997-05-13 | 1997-05-13 | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
PCT/HU1998/000047 WO1998051681A1 (en) | 1997-05-13 | 1998-05-11 | New intermediates and process for the preparation thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO995532D0 NO995532D0 (no) | 1999-11-12 |
NO995532L true NO995532L (no) | 1999-12-13 |
NO324039B1 NO324039B1 (no) | 2007-07-30 |
Family
ID=89995117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19995532A NO324039B1 (no) | 1997-05-13 | 1999-11-12 | Nye mellomprodukter og fremgangsmate for fremstilling derav |
Country Status (13)
Country | Link |
---|---|
US (1) | US6258961B1 (no) |
EP (1) | EP0981524B1 (no) |
JP (1) | JP4282770B2 (no) |
AT (1) | ATE238294T1 (no) |
AU (1) | AU7444798A (no) |
BR (1) | BR9809111B1 (no) |
CA (1) | CA2289545C (no) |
DE (1) | DE69813792T2 (no) |
ES (1) | ES2195335T3 (no) |
HU (1) | HU225503B1 (no) |
NO (1) | NO324039B1 (no) |
PT (1) | PT981524E (no) |
WO (1) | WO1998051681A1 (no) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU226421B1 (en) * | 1998-11-09 | 2008-12-29 | Sanofi Aventis | Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides |
US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
GB0125708D0 (en) * | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
US6800759B2 (en) * | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
WO2004081016A1 (en) | 2003-03-12 | 2004-09-23 | Cadila Healthcare Limited | Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate |
US6858734B2 (en) * | 2003-04-23 | 2005-02-22 | Rhodia Pharma Solutions Inc. | Preparation of (S)-Clopidogrel and related compounds |
WO2004108665A2 (en) * | 2003-04-24 | 2004-12-16 | Sun Pharmaceutical Industries Limited | A process for preparation of clopidogrel |
GB0321256D0 (en) | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
ES2339944T3 (es) | 2003-11-03 | 2010-05-27 | Cadila Healthcare Limited | Procedimientos para preparar la forma i de bisulfato de (s)-(+)-clopidogrel. |
DK1589019T3 (da) * | 2004-04-20 | 2008-11-17 | Ratiopharm Gmbh | Stereoselektiv fremgangsmåde til fremstilling af clopidogrel |
EP1704152A2 (en) * | 2004-09-21 | 2006-09-27 | Teva Pharmaceutical Industries Ltd | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
TW200640932A (en) * | 2005-02-24 | 2006-12-01 | Teva Pharma | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
JP2009543759A (ja) * | 2006-04-27 | 2009-12-10 | アイエヌディー−スイフト ラボラトリーズ リミテッド | クロピドグレル硫酸水素塩の多形相を調製するプロセス |
TW200825093A (en) * | 2006-08-03 | 2008-06-16 | Teva Pharma | Process for preparing clopidogrel bisulphate |
PL382055A1 (pl) * | 2007-03-23 | 2008-09-29 | Koźluk Tomasz Nobilus Ent | Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu |
EP1980563A1 (en) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
US20090264460A1 (en) * | 2008-04-21 | 2009-10-22 | Mamta Mishra | Clopidogrel pharmaceutical formulations |
WO2010046476A1 (en) * | 2008-10-24 | 2010-04-29 | Sandoz Ag | A process for the preparation of s-clopidogrel |
US8563690B2 (en) * | 2008-11-03 | 2013-10-22 | The Board Of Trustees Of The University Of Illinois | Modulation of platelet aggregation |
CN103483356B (zh) * | 2013-09-30 | 2016-01-13 | 浙江美诺华药物化学有限公司 | 一种(s)-氯吡格雷的硫酸盐或盐酸盐的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2530247B1 (fr) | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
FR2608607B1 (fr) | 1986-12-23 | 1989-04-28 | Sanofi Sa | Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2652575B1 (fr) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664596B1 (fr) | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
-
1997
- 1997-05-13 HU HU9700884A patent/HU225503B1/hu unknown
-
1998
- 1998-05-11 EP EP98921669A patent/EP0981524B1/en not_active Expired - Lifetime
- 1998-05-11 WO PCT/HU1998/000047 patent/WO1998051681A1/en active IP Right Grant
- 1998-05-11 ES ES98921669T patent/ES2195335T3/es not_active Expired - Lifetime
- 1998-05-11 CA CA002289545A patent/CA2289545C/en not_active Expired - Fee Related
- 1998-05-11 PT PT98921669T patent/PT981524E/pt unknown
- 1998-05-11 US US09/423,801 patent/US6258961B1/en not_active Expired - Lifetime
- 1998-05-11 BR BRPI9809111-5A patent/BR9809111B1/pt not_active IP Right Cessation
- 1998-05-11 AU AU74447/98A patent/AU7444798A/en not_active Abandoned
- 1998-05-11 DE DE69813792T patent/DE69813792T2/de not_active Expired - Lifetime
- 1998-05-11 JP JP54895598A patent/JP4282770B2/ja not_active Expired - Lifetime
- 1998-05-11 AT AT98921669T patent/ATE238294T1/de active
-
1999
- 1999-11-12 NO NO19995532A patent/NO324039B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT981524E (pt) | 2003-08-29 |
BR9809111B1 (pt) | 2009-05-05 |
EP0981524B1 (en) | 2003-04-23 |
DE69813792T2 (de) | 2004-01-29 |
CA2289545A1 (en) | 1998-11-19 |
WO1998051681A1 (en) | 1998-11-19 |
HU9700884D0 (en) | 1997-07-28 |
ES2195335T3 (es) | 2003-12-01 |
BR9809111A (pt) | 2000-08-01 |
NO324039B1 (no) | 2007-07-30 |
US6258961B1 (en) | 2001-07-10 |
CA2289545C (en) | 2006-12-12 |
JP2001525818A (ja) | 2001-12-11 |
HUP9700884A3 (en) | 2000-06-28 |
EP0981524A1 (en) | 2000-03-01 |
NO995532D0 (no) | 1999-11-12 |
HU225503B1 (en) | 2007-01-29 |
ATE238294T1 (de) | 2003-05-15 |
HUP9700884A2 (hu) | 1999-09-28 |
AU7444798A (en) | 1998-12-08 |
JP4282770B2 (ja) | 2009-06-24 |
DE69813792D1 (de) | 2003-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |