DK1086114T3 - Morfin-6-glucuronidsyntese - Google Patents
Morfin-6-glucuronidsynteseInfo
- Publication number
- DK1086114T3 DK1086114T3 DK99925205T DK99925205T DK1086114T3 DK 1086114 T3 DK1086114 T3 DK 1086114T3 DK 99925205 T DK99925205 T DK 99925205T DK 99925205 T DK99925205 T DK 99925205T DK 1086114 T3 DK1086114 T3 DK 1086114T3
- Authority
- DK
- Denmark
- Prior art keywords
- morphine
- glucuronidsyntese
- pivaloyloxymorphine
- pivaloylglucouronate
- ethylorthopivalate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/127—Preparation from compounds containing pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812097.5A GB9812097D0 (en) | 1998-06-06 | 1998-06-06 | Morphine-6-glucuronide synthesis |
| GB9900833 | 1999-01-15 | ||
| PCT/GB1999/001777 WO1999064430A2 (en) | 1998-06-06 | 1999-06-04 | Morphine-6-glucuronide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1086114T3 true DK1086114T3 (da) | 2003-02-10 |
Family
ID=26313798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99925205T DK1086114T3 (da) | 1998-06-06 | 1999-06-04 | Morfin-6-glucuronidsyntese |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6566510B1 (da) |
| EP (1) | EP1086114B1 (da) |
| JP (1) | JP2002517504A (da) |
| AT (1) | ATE225363T1 (da) |
| AU (1) | AU762800B2 (da) |
| CA (1) | CA2332974C (da) |
| DE (1) | DE69903291T2 (da) |
| DK (1) | DK1086114T3 (da) |
| ES (1) | ES2185350T3 (da) |
| HU (1) | HUP0102333A3 (da) |
| IL (1) | IL139773A0 (da) |
| NO (1) | NO316876B1 (da) |
| PL (1) | PL194362B1 (da) |
| PT (1) | PT1086114E (da) |
| WO (1) | WO1999064430A2 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9914382D0 (en) * | 1999-06-21 | 1999-08-18 | Ufc Limited | New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries |
| FR2907121B1 (fr) | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
| FR2939436B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
| FR2939437B1 (fr) | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| FR2939796B1 (fr) | 2008-12-11 | 2010-12-17 | Sanofi Aventis | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| CA3041309A1 (en) | 2016-10-21 | 2018-04-26 | Somniferum Labs LLC | Compositions, methods and kits for the safe inhaled delivery of targeted opioids for the treatment of pain and addiction |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| GB9325065D0 (en) * | 1993-12-07 | 1994-02-02 | Salford Ultrafine Chem & Res | An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| FR2680786B1 (fr) * | 1991-09-04 | 1995-03-10 | Irepa | Procede de synthese de glucuronides d'epoxy-4,5 morphinanes. |
| WO1996028451A1 (en) * | 1995-03-14 | 1996-09-19 | Euroceltique S.A. | Morphine-3-esters |
| DE19508664C2 (de) * | 1995-03-14 | 2001-08-23 | Christian Mignat | Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung |
-
1999
- 1999-06-04 AU AU41584/99A patent/AU762800B2/en not_active Ceased
- 1999-06-04 CA CA002332974A patent/CA2332974C/en not_active Expired - Fee Related
- 1999-06-04 WO PCT/GB1999/001777 patent/WO1999064430A2/en active IP Right Grant
- 1999-06-04 JP JP2000553438A patent/JP2002517504A/ja active Pending
- 1999-06-04 HU HU0102333A patent/HUP0102333A3/hu unknown
- 1999-06-04 US US09/700,909 patent/US6566510B1/en not_active Expired - Fee Related
- 1999-06-04 ES ES99925205T patent/ES2185350T3/es not_active Expired - Lifetime
- 1999-06-04 AT AT99925205T patent/ATE225363T1/de active
- 1999-06-04 PL PL99345195A patent/PL194362B1/pl not_active IP Right Cessation
- 1999-06-04 EP EP99925205A patent/EP1086114B1/en not_active Expired - Lifetime
- 1999-06-04 IL IL13977399A patent/IL139773A0/xx not_active IP Right Cessation
- 1999-06-04 DE DE69903291T patent/DE69903291T2/de not_active Expired - Lifetime
- 1999-06-04 DK DK99925205T patent/DK1086114T3/da active
- 1999-06-04 PT PT99925205T patent/PT1086114E/pt unknown
-
2000
- 2000-12-06 NO NO20006205A patent/NO316876B1/no not_active IP Right Cessation
-
2002
- 2002-10-04 US US10/263,693 patent/US6693179B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU762800B2 (en) | 2003-07-03 |
| JP2002517504A (ja) | 2002-06-18 |
| DE69903291T2 (de) | 2003-06-26 |
| ES2185350T3 (es) | 2003-04-16 |
| AU4158499A (en) | 1999-12-30 |
| NO316876B1 (no) | 2004-06-07 |
| NO20006205L (no) | 2000-12-06 |
| PL345195A1 (en) | 2001-12-03 |
| US6693179B2 (en) | 2004-02-17 |
| PT1086114E (pt) | 2003-02-28 |
| NO20006205D0 (no) | 2000-12-06 |
| EP1086114A2 (en) | 2001-03-28 |
| US6566510B1 (en) | 2003-05-20 |
| IL139773A0 (en) | 2002-02-10 |
| US20030083476A1 (en) | 2003-05-01 |
| EP1086114B1 (en) | 2002-10-02 |
| CA2332974C (en) | 2009-03-10 |
| WO1999064430A3 (en) | 2000-02-03 |
| DE69903291D1 (en) | 2002-11-07 |
| HUP0102333A3 (en) | 2003-07-28 |
| WO1999064430A2 (en) | 1999-12-16 |
| HUP0102333A2 (hu) | 2001-11-28 |
| ATE225363T1 (de) | 2002-10-15 |
| CA2332974A1 (en) | 1999-12-16 |
| PL194362B1 (pl) | 2007-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20003139L (no) | FremgangsmÕte for syntese av 1,3-dioler | |
| CY1113185T1 (el) | Μεθοδοι συνενωσης αποδεκτη πεπτιδιου | |
| IT1302347B1 (it) | Procedimento per la produzione diretta di perossido di idrogeno. | |
| EA200001129A3 (ru) | Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина | |
| DK1015466T3 (da) | Derivater af 9-hydrazon og 9-azinerythromycin og en fremgangsmåde til fremstilling af samme | |
| NO20004738D0 (no) | FremgangsmÕte for fremstilling av et epoksyd | |
| IT1283232B1 (it) | Procedimento per la sintesi di 2-buten-1, 4-diesteri | |
| CY1107635T1 (el) | Μεθοδος για την παρασκευη σιταλοπραμης | |
| IT1303694B1 (it) | Produzione di perfluoroalchilvinileteri. | |
| IT1315237B1 (it) | Metodo di produzione di tagliolini secchi. | |
| AU1817902A (en) | Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op) | |
| DK1086114T3 (da) | Morfin-6-glucuronidsyntese | |
| IT1305122B1 (it) | Procedimento di produzione di trimetilolalcano. | |
| AU1278801A (en) | Method for generating information related to the molecular structure of a biomolecule | |
| ZA9810063B (en) | Process for the manufacture of an organic compound. | |
| DK0975601T3 (da) | Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor | |
| PT1064265E (pt) | Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona | |
| DE59801691D1 (de) | Beschichtungsverfahren länglicher, metallischer rohlinge | |
| PL336480A1 (en) | Novel method of obtaining 3-n-,n-dicyclobutylamino-8-fluoro-3,4-dihydro-2h-1-benzopirane-5-carboxamide | |
| TR199900757A3 (tr) | Fenoksifenilsülfonil halidlerin hazirlanmasi için islem. | |
| NO986190D0 (no) | FremgangsmÕte for syntetisering av stumme konsonanter | |
| TR199801514A3 (tr) | N-Piruvil-L-Prolin üretimi için yöntem. | |
| DK1192308T3 (da) | Fremgangsmåde til fremstilling af elastiske bånd til beklædningsindustrien | |
| ZA989954B (en) | Process for the manufacture of an organic compound. | |
| IS5523A (is) | Aðferð til að framleiða ísóprópýl-metýl-[2-(3-n-própoxýfenoxý)-etýl]amín |