CY1113185T1 - Μεθοδοι συνενωσης αποδεκτη πεπτιδιου - Google Patents

Μεθοδοι συνενωσης αποδεκτη πεπτιδιου

Info

Publication number
CY1113185T1
CY1113185T1 CY20121100522T CY121100522T CY1113185T1 CY 1113185 T1 CY1113185 T1 CY 1113185T1 CY 20121100522 T CY20121100522 T CY 20121100522T CY 121100522 T CY121100522 T CY 121100522T CY 1113185 T1 CY1113185 T1 CY 1113185T1
Authority
CY
Cyprus
Prior art keywords
methods
acceptance
peptide
accepted
accepted peptide
Prior art date
Application number
CY20121100522T
Other languages
English (en)
Inventor
Markus Kurz
Peter Lohse
Richard Wagner
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1113185T1 publication Critical patent/CY1113185T1/el

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1062Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Abstract

Στο παρόν κείμενο περιγράφονται μέθοδοι και αντιδραστήρια για τη συνένωση αποδέκτη πεπτιδίου με RΝΑ, καθώς και προϊόντα του RΝΑ-αποδέκτη πεπτιδίου.
CY20121100522T 1999-07-27 2012-06-08 Μεθοδοι συνενωσης αποδεκτη πεπτιδιου CY1113185T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14583499P 1999-07-27 1999-07-27
EP07005917A EP1870417B9 (en) 1999-07-27 2000-07-19 Peptide acceptor ligation methods

Publications (1)

Publication Number Publication Date
CY1113185T1 true CY1113185T1 (el) 2016-04-13

Family

ID=22514769

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100522T CY1113185T1 (el) 1999-07-27 2012-06-08 Μεθοδοι συνενωσης αποδεκτη πεπτιδιου

Country Status (16)

Country Link
US (3) US6429300B1 (el)
EP (2) EP1196637B1 (el)
JP (2) JP4766808B2 (el)
KR (1) KR20020033743A (el)
AT (2) ATE360706T1 (el)
AU (2) AU781783B2 (el)
CA (2) CA2693274C (el)
CY (1) CY1113185T1 (el)
DE (1) DE60034566T2 (el)
DK (2) DK1196637T3 (el)
ES (2) ES2284508T3 (el)
HK (2) HK1045334A1 (el)
IL (1) IL147037A0 (el)
NO (1) NO20020348D0 (el)
PT (2) PT1196637E (el)
WO (1) WO2001007657A1 (el)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU781783B2 (en) * 1999-07-27 2005-06-16 Bristol-Myers Squibb Company Peptide acceptor ligation methods
DE60033851T2 (de) 2000-01-11 2007-11-08 Nanogen Recognomics Gmbh Biomoleküle mit multiplen anbindungsabschnitten zur bindung an eine substratoberfläche
EP1268769A2 (de) * 2000-03-31 2003-01-02 Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung Verfahren zur extraktion von nukleinsäuren
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US6962781B1 (en) * 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
DE60136715D1 (de) * 2000-08-11 2009-01-08 Nanogen Recognomics Gmbh Hydrazidbausteine und hydratin-modifizierte biomoleküle
US7129229B2 (en) 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
WO2003012146A1 (en) * 2001-07-31 2003-02-13 Phylos, Inc. Modular assembly of nucleic acid-protein fusion multimers
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
AU2002356984A1 (en) * 2001-11-16 2003-06-10 Proteonova, Inc. Selection and evolution of nucleic acids and polypeptides
WO2003045975A2 (en) * 2001-11-27 2003-06-05 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt Mfd Gmbh & Co Kg Festwalzgerät einer Festwalzmaschine für Kurbelwellen
US20060166197A1 (en) * 2002-03-15 2006-07-27 Gouliaev Alex H Building block capable of transferring a functional entity
AU2003253069A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S A building block forming a c-c bond upon reaction
WO2003078446A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
WO2003078625A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
US20040058886A1 (en) * 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
EP1597394A2 (en) * 2003-02-21 2005-11-23 Nuevolution A/S A method for obtaining structural information about an encoded molecule
EP2236606B1 (en) * 2003-03-20 2013-11-06 Nuevolution A/S Ligational encoding of small molecules
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
KR101320905B1 (ko) * 2003-11-20 2013-11-06 사노피 파스퇴르 인크 백일해 독소의 정제방법 및 이에 유용한 펩타이드
EP1711196A4 (en) 2003-12-05 2011-09-14 Bristol Myers Squibb Co INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
CA2548465A1 (en) * 2003-12-12 2005-08-11 Proteonova, Inc. System and methods for nucleic acid and polypeptide selection
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
ATE447020T1 (de) * 2004-03-22 2009-11-15 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
US8445413B2 (en) 2004-10-15 2013-05-21 National Institute Of Advanced Industrial Science And Technology Linker for constructing mRNA-puromycin-protein conjugate
EP2261257B1 (en) 2005-01-12 2018-07-11 Proteonova, Inc. Method for making targeted therapeutic agents
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
AU2006315347A1 (en) 2005-11-16 2007-05-24 Ambrx, Inc. Methods and compositions comprising non-natural amino acids
ES2897529T3 (es) 2005-12-01 2022-03-01 Nuevolution As Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
EP2727936B1 (en) 2006-11-22 2016-09-07 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR
EP2118344B1 (en) 2007-02-12 2014-07-23 Proteonova, Inc. GENERATION OF LIBRARY OF SOLUBLE RANDOM POLYPEPTIDES LINKED TO mRNA
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
KR20190045414A (ko) 2007-11-30 2019-05-02 애브비 바이오테크놀로지 리미티드 단백질 제형 및 이의 제조방법
KR20100128291A (ko) 2008-02-14 2010-12-07 브리스톨-마이어스 스큅 컴퍼니 Egfr에 결합하는 조작된 단백질을 기초로 하는 표적화된 치료제
EP2283132B1 (en) * 2008-05-02 2016-10-26 Epicentre Technologies Corporation Selective 5' ligation tagging of rna
US9296810B2 (en) 2008-05-02 2016-03-29 Novartis Ag Fibronectin-based binding molecules and uses thereof
WO2009142773A2 (en) 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Multivalent fibronectin based scaffold domain proteins
ES2752025T3 (es) 2008-07-25 2020-04-02 Wagner Richard W Métodos de cribado de proteínas
MX2011003381A (es) * 2008-09-30 2011-04-21 Abbott Lab Metodo mejorado para despliegue de arn.
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之egfr/igfir結合分子
US20100158822A1 (en) * 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US20100247590A1 (en) * 2009-03-30 2010-09-30 Johnson & Johnson Peptide-Based Systems For Delivery Of Cosmetic Agents
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
JP5733784B2 (ja) * 2009-09-24 2015-06-10 国立大学法人埼玉大学 cDNA/mRNA−タンパク質連結体の効率的合成法
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
JP2013519869A (ja) 2010-02-10 2013-05-30 ノバルティス アーゲー 筋肉成長のための方法および化合物
WO2011126370A1 (en) * 2010-04-09 2011-10-13 Universiteit Utrecht Holding B.V. Recombinant multimeric influenza proteins
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
WO2011150133A2 (en) 2010-05-26 2011-12-01 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
MX345300B (es) 2010-07-30 2017-01-24 Novartis Ag * Moléculas andamio de fibronectina y bibliotecas de las mismas.
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
ES2926988T3 (es) 2011-03-15 2022-10-31 X Body Inc Métodos de cribado de anticuerpos
SI3418380T1 (sl) 2011-04-28 2022-10-28 The Board Of Trustees Of The Leland Stanford Junior University Identifikacija polinukleotidov, povezanih z vzorcem
WO2013019794A1 (en) 2011-08-01 2013-02-07 The General Hospital Corporation Protein and peptide libraries
RS60828B1 (sr) 2011-10-11 2020-10-30 Viela Bio Inc Cd40l-specifične konstrukcije izvedene iz tn3 i metode za njihovu primenu
EP2788379B1 (en) 2011-12-05 2020-02-05 X-Body, Inc. Pdgf receptor beta binding polypeptides
EP2975121A4 (en) * 2013-03-13 2016-07-20 Univ Tokyo NUCLEIC ACID BINDING SEQUENCE
US10370651B2 (en) 2013-06-28 2019-08-06 X-Body, Inc. Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
CN103382579B (zh) * 2013-07-06 2015-10-21 中国科学院成都生物研究所 一种体外筛选多肽的方法
EP3049811B1 (en) 2013-09-23 2020-09-09 X-Body, Inc. Methods and compositions for generation of binding agents against cell surface antigens
EP3090049B1 (en) * 2013-12-31 2017-10-18 F. Hoffmann-La Roche AG Enrichment of full-length oligonucleotides via transcription/translation-mediated purification
WO2015120058A2 (en) 2014-02-05 2015-08-13 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
KR20220162886A (ko) 2014-03-20 2022-12-08 브리스톨-마이어스 스큅 컴퍼니 혈청 알부민-결합 피브로넥틴 유형 iii 도메인
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
CA2977675A1 (en) 2015-03-12 2016-09-15 Medimmune, Llc Method of purifying albumin-fusion proteins
KR20180056701A (ko) 2015-09-23 2018-05-29 브리스톨-마이어스 스큅 컴퍼니 패스트-오프 레이트 혈청 알부민 결합 피브로넥틴 유형 iii 도메인
KR102379048B1 (ko) 2016-05-02 2022-03-28 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
CN109790565A (zh) * 2016-06-15 2019-05-21 基因捕获公司 包含茎-环捕获分子的组合物、方法和装置
WO2018005559A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
SG11201908817WA (en) 2017-03-21 2019-10-30 Fujifilm Corp Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
SG11202003924YA (en) * 2017-10-31 2020-05-28 Encodia Inc Kits for analysis using nucleic acid encoding and/or label
RU2020112854A (ru) 2017-11-30 2021-12-30 Арракис Терапьютикс, Инк. Фотозонды, связывающие нуклеиновые кислоты, и способы их применения
CA3087898A1 (en) 2018-02-02 2019-08-08 Ripple Therapeutics Corporation Glass formulations comprising steroid dimers and uses thereof
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
CN111971396A (zh) * 2018-03-30 2020-11-20 住友化学株式会社 单链rna的制造方法
WO2019236644A1 (en) * 2018-06-05 2019-12-12 Arrakis Therapeutics, Inc. Encoded libraries and methods of use for screening nucleic acid targets
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
EP0862656B1 (en) * 1995-11-21 2001-03-07 Yale University Unimolecular segment amplification and detection
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5842701A (en) * 1996-10-08 1998-12-01 Smith International, Inc. Dual functioning seal for rock bits
CA2268353A1 (en) 1996-10-10 1998-04-16 Henrik Garoff Alphavirus-retrovirus vectors
DE69730157T2 (de) * 1996-10-17 2005-07-28 Mitsubishi Chemical Corp. Molekül, welches genotyp und phänotyp zusammenführt und dessen anwendungen
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
DE69835143T2 (de) * 1997-01-21 2007-06-06 The General Hospital Corp., Boston Selektion von proteinen mittels rns-protein fusionen
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
PT1052292E (pt) * 1997-12-22 2003-06-30 Genset Sa Gene associado ao cancro da prostata
US5985575A (en) * 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function
AU781783B2 (en) * 1999-07-27 2005-06-16 Bristol-Myers Squibb Company Peptide acceptor ligation methods
WO2001016352A1 (en) * 1999-08-27 2001-03-08 Phylos, Inc. Methods for encoding and sorting in vitro translated proteins

Also Published As

Publication number Publication date
PT1870417E (pt) 2012-06-01
DE60034566T2 (de) 2008-01-03
EP1870417B9 (en) 2012-08-01
DE60034566D1 (de) 2007-06-06
EP1870417A3 (en) 2008-06-11
AU2005211548B2 (en) 2007-11-29
ATE360706T1 (de) 2007-05-15
WO2001007657A1 (en) 2001-02-01
JP4766808B2 (ja) 2011-09-07
EP1196637A4 (en) 2003-11-12
NO20020348L (no) 2002-01-23
CA2377468C (en) 2010-04-20
DK1196637T3 (da) 2007-07-30
US20060246549A1 (en) 2006-11-02
EP1196637A1 (en) 2002-04-17
JP5512463B2 (ja) 2014-06-04
AU781783B2 (en) 2005-06-16
US6429300B1 (en) 2002-08-06
AU2005211548A1 (en) 2005-10-13
JP2010284172A (ja) 2010-12-24
JP2003505094A (ja) 2003-02-12
CA2377468A1 (en) 2001-02-01
KR20020033743A (ko) 2002-05-07
DK1870417T3 (da) 2012-07-16
ATE551352T1 (de) 2012-04-15
AU6111200A (en) 2001-02-13
US20020182687A1 (en) 2002-12-05
CA2693274A1 (en) 2001-02-01
EP1196637B1 (en) 2007-04-25
US7790421B2 (en) 2010-09-07
ES2383332T3 (es) 2012-06-20
US7078197B2 (en) 2006-07-18
PT1196637E (pt) 2007-07-04
EP1870417A2 (en) 2007-12-26
HK1112007A1 (en) 2008-08-22
CA2693274C (en) 2013-05-28
NO20020348D0 (no) 2002-01-23
HK1045334A1 (zh) 2002-11-22
IL147037A0 (en) 2002-08-14
EP1870417B1 (en) 2012-03-28
ES2284508T3 (es) 2007-11-16

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