ATE360706T1 - Peptidakzeptor ligationsverfahren - Google Patents

Peptidakzeptor ligationsverfahren

Info

Publication number
ATE360706T1
ATE360706T1 AT00947524T AT00947524T ATE360706T1 AT E360706 T1 ATE360706 T1 AT E360706T1 AT 00947524 T AT00947524 T AT 00947524T AT 00947524 T AT00947524 T AT 00947524T AT E360706 T1 ATE360706 T1 AT E360706T1
Authority
AT
Austria
Prior art keywords
peptide acceptor
ligation procedure
acceptor ligation
peptide
procedure
Prior art date
Application number
AT00947524T
Other languages
English (en)
Inventor
Markus Kurz
Peter Lohse
Richard Wagner
Original Assignee
Adnexus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adnexus Therapeutics Inc filed Critical Adnexus Therapeutics Inc
Application granted granted Critical
Publication of ATE360706T1 publication Critical patent/ATE360706T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00947524T 1999-07-27 2000-07-19 Peptidakzeptor ligationsverfahren ATE360706T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14583499P 1999-07-27 1999-07-27

Publications (1)

Publication Number Publication Date
ATE360706T1 true ATE360706T1 (de) 2007-05-15

Family

ID=22514769

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07005917T ATE551352T1 (de) 1999-07-27 2000-07-19 Peptidakzeptorbindungsverfahren
AT00947524T ATE360706T1 (de) 1999-07-27 2000-07-19 Peptidakzeptor ligationsverfahren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07005917T ATE551352T1 (de) 1999-07-27 2000-07-19 Peptidakzeptorbindungsverfahren

Country Status (16)

Country Link
US (3) US6429300B1 (de)
EP (2) EP1870417B9 (de)
JP (2) JP4766808B2 (de)
KR (1) KR20020033743A (de)
AT (2) ATE551352T1 (de)
AU (2) AU781783B2 (de)
CA (2) CA2377468C (de)
CY (1) CY1113185T1 (de)
DE (1) DE60034566T2 (de)
DK (2) DK1196637T3 (de)
ES (2) ES2383332T3 (de)
HK (1) HK1045334A1 (de)
IL (1) IL147037A0 (de)
NO (1) NO20020348D0 (de)
PT (2) PT1196637E (de)
WO (1) WO2001007657A1 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377468C (en) * 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
AU6769700A (en) 2000-01-11 2001-07-24 Nanogen, Inc. Biomolecules having multiple attachment moieties for binding to a substrate surface
EP1268769A2 (de) * 2000-03-31 2003-01-02 Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung Verfahren zur extraktion von nukleinsäuren
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
WO2003044194A1 (en) * 2001-11-16 2003-05-30 Proteonova, Inc. Selection and evolution of nucleic acids and polypeptides
US7129229B2 (en) 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
JP4880182B2 (ja) * 2000-08-11 2012-02-22 ナノジェン・レコグノミクス・ゲーエムベーハー ヒドラジド結合部分を有する巨大分子およびそれらの製造用試剤
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
US7727713B2 (en) * 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US20030027194A1 (en) * 2001-07-31 2003-02-06 Markus Kurz Modular assembly of nucleic acid-protein fusion multimers
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
US7125669B2 (en) 2001-11-27 2006-10-24 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
EP1490384A2 (de) * 2002-03-15 2004-12-29 Nuevolution A/S Ein baublock zur c-c bindungsbildung
EP1487851A2 (de) * 2002-03-15 2004-12-22 Nuevolution A/S Ein baustein geeignet zur funktionellen gruppe übertragung zum nucleophil
CA2518626A1 (en) 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
US20050247001A1 (en) * 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
EP1539980B1 (de) * 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
US20040058886A1 (en) * 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
EP1756277B1 (de) 2002-12-19 2009-12-02 Nuevolution A/S Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US20060269920A1 (en) * 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
EP1608748B1 (de) * 2003-03-20 2009-03-04 Nuevolution A/S Ligationsvermittelnde codierung von kleinen molekülen
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
ATE447626T1 (de) * 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
CN1906307B (zh) * 2003-11-20 2011-08-24 圣诺菲·帕斯图尔公司 纯化百日咳毒素的方法及其中有用的肽
BRPI0417302A (pt) 2003-12-05 2007-03-06 Compound Therapeutics Inc inibidores de receptores de fator de crescimento endotelial vascular do tipo 2
EP1692155A4 (de) * 2003-12-12 2008-08-06 Proteonova Inc System und verfahren zur auswahl von nukleinsäuren und polypeptiden
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
WO2005090566A2 (en) * 2004-03-22 2005-09-29 Nuevolution A/S Ligational encoding using building block oligonucleotides
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
US8445413B2 (en) 2004-10-15 2013-05-21 National Institute Of Advanced Industrial Science And Technology Linker for constructing mRNA-puromycin-protein conjugate
US20080199499A1 (en) 2005-01-12 2008-08-21 Proteonova, Inc. Method for Making Targeted Therapeutic Agents
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
CN101454461A (zh) 2005-11-16 2009-06-10 Ambrx公司 包括非天然氨基酸的方法和组合物
ES2897529T3 (es) 2005-12-01 2022-03-01 Nuevolution As Métodos de codificación enzimática para la síntesis eficiente de bibliotecas grandes
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
CA2670471A1 (en) 2006-11-22 2008-06-05 Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
WO2008100961A2 (en) 2007-02-12 2008-08-21 Proteonova, Inc. GENERATION OF LIBRARY OF SOLUBLE RANDOM POLYPEPTIDES LINKED TO mRNA
US7678883B2 (en) * 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
TWI543768B (zh) 2007-11-30 2016-08-01 艾伯維生物技術有限責任公司 蛋白質調配物及製造其之方法
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
JP2011517314A (ja) 2008-02-14 2011-06-02 ブリストル−マイヤーズ スクイブ カンパニー Ｅｇｆｒに結合する操作されたタンパク質に基づく標的化された治療薬
AU2009242484B2 (en) * 2008-05-02 2012-08-16 Epicentre Technologies Corporation Selective 5' ligation tagging of RNA
WO2009133208A1 (en) 2008-05-02 2009-11-05 Novartis Ag Improved fibronectin-based binding molecules and uses thereof
CN102099373A (zh) 2008-05-22 2011-06-15 百时美施贵宝公司 基于纤连蛋白的多价支架结构域蛋白
CN102177438A (zh) 2008-07-25 2011-09-07 理查德·W·瓦格纳 蛋白筛选方法
CA2737035A1 (en) * 2008-09-30 2010-04-08 Abbott Laboratories Improved method of rna display
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US20100158822A1 (en) 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
KR20120073161A (ko) 2009-03-30 2012-07-04 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 화장품 제제 운반용 펩티드계 시스템
JP5733784B2 (ja) * 2009-09-24 2015-06-10 国立大学法人埼玉大学 ｃＤＮＡ／ｍＲＮＡ−タンパク質連結体の効率的合成法
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
AU2011214465A1 (en) 2010-02-10 2012-08-30 Novartis Ag Methods and compounds for muscle growth
CN102939102A (zh) * 2010-04-09 2013-02-20 乌得勒支大学控股有限责任公司 重组多聚流感蛋白
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
EP2576615B1 (de) 2010-05-26 2016-03-30 Bristol-Myers Squibb Company Auf fibronectin basierende gerüstproteine mit erhöhter stabilität
JP6092773B2 (ja) 2010-07-30 2017-03-08 ノバルティス アーゲー フィブロネクチンクレードル分子及びそのライブラリ
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
ES2926988T3 (es) 2011-03-15 2022-10-31 X Body Inc Métodos de cribado de anticuerpos
ES2925799T3 (es) 2011-04-28 2022-10-19 Univ Leland Stanford Junior Identificación de polinucleótidos asociados a una muestra
US9422550B2 (en) 2011-08-01 2016-08-23 The General Hospital Corporation Protein and peptide libraries
CA2851667A1 (en) 2011-10-11 2013-04-18 Medimmune, Llc Cd40l-specific tn3-derived scaffolds and methods of use thereof
WO2013085972A1 (en) 2011-12-05 2013-06-13 X-Body, Inc. Pdgf receptor beta binding polypeptides
WO2014142020A1 (ja) * 2013-03-13 2014-09-18 国立大学法人東京大学 核酸リンカー
SG10201806428YA (en) 2013-06-28 2018-08-30 X Body Inc Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
CN103382579B (zh) * 2013-07-06 2015-10-21 中国科学院成都生物研究所 一种体外筛选多肽的方法
ES2827281T3 (es) 2013-09-23 2021-05-20 X Body Inc Métodos y composiciones para la generación de agentes de unión contra antígenos de superficie celular
US20150184214A1 (en) * 2013-12-31 2015-07-02 Roche Nimblegen, Inc. Enrichment of full length oligonucleotides via transcription/translation mediated purification
JP6814634B2 (ja) 2014-02-05 2021-01-20 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法
ES2913840T3 (es) 2014-03-20 2022-06-06 Bristol Myers Squibb Co Dominios de tipo III de fibronectina de unión a seroalbúmina
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
KR20240093725A (ko) 2015-03-12 2024-06-24 메디뮨 엘엘씨 알부민 융합 단백질의 정제 방법
JP6893504B2 (ja) 2015-09-23 2021-06-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 速い解離速度を有する血清アルブミン結合フィブロネクチンタイプｉｉｉドメイン
MX2018013341A (es) 2016-05-02 2019-09-18 Encodia Inc Analisis de macromoleculas que emplea la codificacion de acido nucleico.
US11713482B2 (en) 2016-06-15 2023-08-01 Genecapture, Inc. Compositions, methods and devices comprising stem-loop captor molecules
WO2018005559A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
JP6831903B2 (ja) 2017-03-21 2021-02-17 富士フイルム株式会社 ペプチド化合物およびその製造方法、スクリーニング用組成物、並びにペプチド化合物の選択方法
EP3704249B1 (de) * 2017-10-31 2025-05-21 Encodia, Inc. Kits zur analyse unter verwendung von nukleinsäurecodierung und/oder markierung
EP3717009A4 (de) 2017-11-30 2021-12-01 Arrakis Therapeutics, Inc. Nukleinsäurebindende photosonden und verwendungen davon
JP7502186B2 (ja) 2018-02-02 2024-06-18 リップル セラピューティクス コーポレーション ステロイド二量体を含むガラス製剤およびその使用
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
US20210115485A1 (en) * 2018-03-30 2021-04-22 Sumitomo Chemical Company, Limited Method for producing single-strand rna
WO2019236644A1 (en) * 2018-06-05 2019-12-12 Arrakis Therapeutics, Inc. Encoded libraries and methods of use for screening nucleic acid targets
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
CN115956083A (zh) 2020-05-01 2023-04-11 波纹疗法公司 异二聚体组合物及用于治疗眼部病症的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US6143495A (en) * 1995-11-21 2000-11-07 Yale University Unimolecular segment amplification and sequencing
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5842701A (en) * 1996-10-08 1998-12-01 Smith International, Inc. Dual functioning seal for rock bits
CA2268353A1 (en) 1996-10-10 1998-04-16 Henrik Garoff Alphavirus-retrovirus vectors
JP3683282B2 (ja) * 1996-10-17 2005-08-17 三菱化学株式会社 遺伝子型と表現型の対応付け分子及びその利用
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
DE69835143T2 (de) * 1997-01-21 2007-06-06 The General Hospital Corp., Boston Selektion von proteinen mittels rns-protein fusionen
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
ATE197817T1 (de) * 1997-12-22 2000-12-15 Genset Sa Prostatakrebs-gen
US5985575A (en) * 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function
CA2377468C (en) * 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
EP1212452B1 (de) * 1999-08-27 2013-07-17 Bristol-Myers Squibb Company Verfahren zur kodierung und sortierung von in vitro-translatierten proteinen

Also Published As

Publication number Publication date
JP5512463B2 (ja) 2014-06-04
WO2001007657A1 (en) 2001-02-01
ES2284508T3 (es) 2007-11-16
HK1112007A1 (en) 2008-08-22
ATE551352T1 (de) 2012-04-15
CA2377468C (en) 2010-04-20
CA2693274C (en) 2013-05-28
US7078197B2 (en) 2006-07-18
CA2693274A1 (en) 2001-02-01
EP1196637A1 (de) 2002-04-17
IL147037A0 (en) 2002-08-14
JP2003505094A (ja) 2003-02-12
EP1870417A3 (de) 2008-06-11
PT1870417E (pt) 2012-06-01
ES2383332T3 (es) 2012-06-20
US6429300B1 (en) 2002-08-06
AU2005211548B2 (en) 2007-11-29
HK1045334A1 (zh) 2002-11-22
JP4766808B2 (ja) 2011-09-07
DK1196637T3 (da) 2007-07-30
CA2377468A1 (en) 2001-02-01
KR20020033743A (ko) 2002-05-07
PT1196637E (pt) 2007-07-04
US7790421B2 (en) 2010-09-07
DE60034566T2 (de) 2008-01-03
US20020182687A1 (en) 2002-12-05
NO20020348L (no) 2002-01-23
NO20020348D0 (no) 2002-01-23
CY1113185T1 (el) 2016-04-13
AU2005211548A1 (en) 2005-10-13
EP1196637A4 (de) 2003-11-12
DE60034566D1 (de) 2007-06-06
EP1870417B9 (de) 2012-08-01
AU6111200A (en) 2001-02-13
EP1196637B1 (de) 2007-04-25
EP1870417A2 (de) 2007-12-26
DK1870417T3 (da) 2012-07-16
AU781783B2 (en) 2005-06-16
US20060246549A1 (en) 2006-11-02
JP2010284172A (ja) 2010-12-24
EP1870417B1 (de) 2012-03-28

Similar Documents

Publication Publication Date Title
ATE360706T1 (de) Peptidakzeptor ligationsverfahren
WO2003012119A3 (en) Nucleic acid amplification method
DK1032555T3 (da) Cykliske aminosyrer og derivater deraf, som er anvendelige som lægemidler
DK0788360T3 (da) Boronsyreester- og syreforbindelser, deres syntese og anvendelser
AU2003296151A1 (en) Process for producing dipeptide
UA84284C2 (ru) Способы лечения, профилактики и диагностики инфекции helicobacter cerdo
MA26804A1 (fr) Acides 3-propyl-gamma-aminobutyriques mono- et disubstitues.
TR199802289A3 (tr) Fosfonasit-ikame etmis benzazepinon-n-asetikasit türevleri.
DK1399590T3 (da) Happier kortlægning
AU1908100A (en) Isothermal nucleic acid amplification methods
IT1301737B1 (it) Premitallone per pneumatici.
PT1064265E (pt) Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona
DK1487802T3 (da) 2,3-diaryl-pyrazolidin-derivater som neurotensin-nedbrydende enzyminhibitorer
DK1123396T3 (da) Minimale promotorer og anvendelser deraf
NO20020328L (no) Fremgangsmåte for fremstilling av 4-cyano-2-aminometyltiazol
NL1012028A1 (nl) Aminozuursequentie.
FR2797443B1 (fr) Procede de prepartion de quinoleine-5,8-diones
ITBS990047V0 (it) Rubinetto per gas valvolato.
IT1303333B1 (it) Sottopiede per calzature.
TR199801514A3 (tr) N-Piruvil-L-Prolin üretimi için yöntem.
IT1317829B1 (it) Processo per la preparazione di cefonicid per via enzimatica.
IT1311584B1 (it) Metodo per la realizzazione di calzature, e calzature ottenute contale metodo.
DK0970030T3 (da) Fremgangsmåde til at oprense 1,3,5-triisopropylbenzen
NO20040693L (no) Fermenteringsmetode.
ITMI991227A0 (it) Apparecchio emettitore di gas anionico

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1196637

Country of ref document: EP

EEIH Change in the person of patent owner