ATE360706T1 - Peptidakzeptor ligationsverfahren - Google Patents
Peptidakzeptor ligationsverfahrenInfo
- Publication number
- ATE360706T1 ATE360706T1 AT00947524T AT00947524T ATE360706T1 AT E360706 T1 ATE360706 T1 AT E360706T1 AT 00947524 T AT00947524 T AT 00947524T AT 00947524 T AT00947524 T AT 00947524T AT E360706 T1 ATE360706 T1 AT E360706T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide acceptor
- ligation procedure
- acceptor ligation
- peptide
- procedure
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14583499P | 1999-07-27 | 1999-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360706T1 true ATE360706T1 (de) | 2007-05-15 |
Family
ID=22514769
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07005917T ATE551352T1 (de) | 1999-07-27 | 2000-07-19 | Peptidakzeptorbindungsverfahren |
| AT00947524T ATE360706T1 (de) | 1999-07-27 | 2000-07-19 | Peptidakzeptor ligationsverfahren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07005917T ATE551352T1 (de) | 1999-07-27 | 2000-07-19 | Peptidakzeptorbindungsverfahren |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6429300B1 (de) |
| EP (2) | EP1870417B9 (de) |
| JP (2) | JP4766808B2 (de) |
| KR (1) | KR20020033743A (de) |
| AT (2) | ATE551352T1 (de) |
| AU (2) | AU781783B2 (de) |
| CA (2) | CA2377468C (de) |
| CY (1) | CY1113185T1 (de) |
| DE (1) | DE60034566T2 (de) |
| DK (2) | DK1870417T3 (de) |
| ES (2) | ES2383332T3 (de) |
| HK (1) | HK1045334A1 (de) |
| IL (1) | IL147037A0 (de) |
| NO (1) | NO20020348D0 (de) |
| PT (2) | PT1870417E (de) |
| WO (1) | WO2001007657A1 (de) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1870417B9 (de) * | 1999-07-27 | 2012-08-01 | Bristol-Myers Squibb Company | Peptidakzeptorbindungsverfahren |
| EP1257695B1 (de) | 2000-01-11 | 2007-03-07 | Nanogen Recognomics GmbH | Biomoleküle mit multiplen anbindungsabschnitten zur bindung an eine substratoberfläche |
| AU2001262152A1 (en) * | 2000-03-31 | 2001-10-08 | Memorec Stoffel Gmbh | Method for extracting nucleic acids |
| US20040229271A1 (en) | 2000-05-19 | 2004-11-18 | Williams Richard B. | Compositions and methods for the identification and selection of nucleic acids and polypeptides |
| WO2003044194A1 (en) * | 2001-11-16 | 2003-05-30 | Proteonova, Inc. | Selection and evolution of nucleic acids and polypeptides |
| US6962781B1 (en) | 2000-05-19 | 2005-11-08 | Proteonova, Inc. | In vitro evolution of nucleic acids and encoded polypeptide |
| US7410761B2 (en) * | 2000-05-19 | 2008-08-12 | Proteonova, Inc. | System for rapid identification and selection of nucleic acids and polypeptides, and method thereof |
| DE60136715D1 (de) * | 2000-08-11 | 2009-01-08 | Nanogen Recognomics Gmbh | Hydrazidbausteine und hydratin-modifizierte biomoleküle |
| US7129229B2 (en) | 2000-08-11 | 2006-10-31 | Nanogen Recognomics Gmbh | Hydrazide building blocks and hydrazide modified biomolecules |
| JP4963142B2 (ja) * | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
| US20060234231A1 (en) * | 2001-06-20 | 2006-10-19 | Nuevolution A/S | Microarrays displaying encoded molecules |
| US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
| JP2004537312A (ja) * | 2001-07-31 | 2004-12-16 | フィロス インク. | 核酸−蛋白質融合多量体のモジュラーアッセンブリ |
| DE10147074A1 (de) * | 2001-09-25 | 2003-05-08 | Beru Ag | Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung |
| WO2003045975A2 (en) * | 2001-11-27 | 2003-06-05 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
| DE20200926U1 (de) * | 2002-01-23 | 2002-04-18 | Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz | Festwalzgerät einer Festwalzmaschine für Kurbelwellen |
| AU2003218629A1 (en) * | 2002-03-15 | 2003-09-29 | Nuevolution A/S | A building block forming a c-c or a c-hetero atom bond uponreaction |
| WO2003078627A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block capable of functional entity transfer to nucleophil |
| WO2003078050A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c bond upon reaction |
| EP2186897B1 (de) * | 2002-03-15 | 2016-02-17 | Nuevolution A/S | Eine verbesserte Methode zur Synthese von matritzenabhängigen Molekülen |
| US10730906B2 (en) * | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
| AU2003256857A1 (en) * | 2002-08-08 | 2004-02-25 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
| LT2348125T (lt) * | 2002-10-30 | 2017-09-11 | Nuevolution A/S | Bifunkcinio komplekso sintezės būdas |
| DE60330406D1 (de) * | 2002-12-19 | 2010-01-14 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| EP1597394A2 (de) * | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Eine methode zur erlangung struktureller information über ein kodiertes molekül |
| EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
| DK1608748T3 (da) * | 2003-03-20 | 2009-06-29 | Nuevolution As | Ligeringskodning af små molekyler |
| WO2004110964A2 (en) * | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
| US20050095627A1 (en) * | 2003-09-03 | 2005-05-05 | The Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| ATE447626T1 (de) | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
| KR101337320B1 (ko) * | 2003-11-20 | 2013-12-06 | 사노피 파스퇴르 인크 | 백일해 독소의 정제방법 및 이에 유용한 펩타이드 |
| EP1711196A4 (de) | 2003-12-05 | 2011-09-14 | Bristol Myers Squibb Co | Inhibitoren von typ-2 vaskulären endothelialen wachstumsfaktor-rezeptoren |
| JP2007513631A (ja) * | 2003-12-12 | 2007-05-31 | プロテオノヴァ、 インコーポレイテッド | 核酸およびポリペプチドを選択する系ならびに方法 |
| WO2005078122A2 (en) * | 2004-02-17 | 2005-08-25 | Nuevolution A/S | Method for enrichment involving elimination by mismatch hybridisation |
| ATE447020T1 (de) * | 2004-03-22 | 2009-11-15 | Nuevolution As | Ligationscodierung unter verwendung von oligonukleotidbausteinen |
| CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
| US8445413B2 (en) | 2004-10-15 | 2013-05-21 | National Institute Of Advanced Industrial Science And Technology | Linker for constructing mRNA-puromycin-protein conjugate |
| US10206998B2 (en) | 2005-01-12 | 2019-02-19 | Proteonova, Inc. | Modular targeted therapeutic agents and methods of making same |
| EP1846432A4 (de) | 2005-01-12 | 2008-11-19 | Proteonova Inc | Verfahren zur herstellung zielgerichteter therapeutischer mittel |
| CN101454461A (zh) | 2005-11-16 | 2009-06-10 | Ambrx公司 | 包括非天然氨基酸的方法和组合物 |
| DK1957644T3 (da) | 2005-12-01 | 2011-03-28 | Nuevolution As | Enzymatiske kodnings metoder til effektiv syntese af store biblioteker |
| US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
| US8470332B2 (en) | 2006-11-22 | 2013-06-25 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR |
| AU2008216303A1 (en) | 2007-02-12 | 2008-08-21 | Proteonova, Inc. | Generation of library of soluble random polypeptides linked to mRNA |
| US7678883B2 (en) | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
| US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
| US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
| US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| MX354100B (es) | 2007-11-30 | 2018-02-13 | Abbvie Biotechnology Ltd Star | Formulaciones de proteinas y metodos para elaborarlas. |
| WO2009102421A2 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
| PT2274331E (pt) | 2008-05-02 | 2014-02-27 | Novartis Ag | Moléculas de ligação baseadas em fibronectina melhoradas e suas utilizações |
| EP2283132B1 (de) * | 2008-05-02 | 2016-10-26 | Epicentre Technologies Corporation | Selektives 5 -ligations-tagging von rna |
| CN102099373A (zh) | 2008-05-22 | 2011-06-15 | 百时美施贵宝公司 | 基于纤连蛋白的多价支架结构域蛋白 |
| WO2010011944A2 (en) | 2008-07-25 | 2010-01-28 | Wagner Richard W | Protein screeing methods |
| NZ591544A (en) * | 2008-09-30 | 2013-01-25 | Abbott Lab | Improved method of rna display |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| US20100158822A1 (en) | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
| US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
| US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
| US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
| US8481678B2 (en) | 2009-03-30 | 2013-07-09 | E I Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
| EP2414045A2 (de) | 2009-03-30 | 2012-02-08 | Johnson & Johnson | Systeme auf peptidbasis zur abgabe von kosmetischen mitteln |
| JP5733784B2 (ja) * | 2009-09-24 | 2015-06-10 | 国立大学法人埼玉大学 | cDNA/mRNA−タンパク質連結体の効率的合成法 |
| WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
| WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
| WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
| CA2789125A1 (en) | 2010-02-10 | 2011-08-18 | Novartis Ag | Methods and compounds for muscle growth |
| HUE030724T2 (en) * | 2010-04-09 | 2017-06-28 | Univ Utrecht Holding Bv | Recombinant multimer influenza proteins |
| WO2011127933A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP3091028A1 (de) | 2010-05-26 | 2016-11-09 | Bristol-Myers Squibb Company | Auf fibronectin basierende gerüstproteine mit erhöhter stabilität |
| KR20130136443A (ko) | 2010-07-30 | 2013-12-12 | 노파르티스 아게 | 피브로넥틴 크레이들 분자 및 그의 라이브러리 |
| DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
| EP2686349B1 (de) | 2011-03-15 | 2020-12-09 | X-Body, Inc. | Antikörper-screening-verfahren |
| PT3415619T (pt) | 2011-04-28 | 2021-03-22 | Univ Leland Stanford Junior | Identificação de polinucleótidos associados a uma amostra |
| US9422550B2 (en) | 2011-08-01 | 2016-08-23 | The General Hospital Corporation | Protein and peptide libraries |
| AU2012323316B2 (en) | 2011-10-11 | 2017-08-10 | Viela Bio, Inc. | CD40L-specific Tn3-derived scaffolds and methods of use thereof |
| TWI591074B (zh) | 2011-12-05 | 2017-07-11 | X 染色體有限公司 | PDGF受體β結合多肽 |
| EP2975121A4 (de) * | 2013-03-13 | 2016-07-20 | Univ Tokyo | Nukleinsäurelinker |
| EP3739336B1 (de) | 2013-06-28 | 2022-05-11 | X-Body, Inc. | Zielantigenerkennung, phänotypische masken und verwendung davon zur identifikation zielzellspezifischer zielepitope |
| CN103382579B (zh) * | 2013-07-06 | 2015-10-21 | 中国科学院成都生物研究所 | 一种体外筛选多肽的方法 |
| AU2014321251B2 (en) | 2013-09-23 | 2020-04-16 | X-Body, Inc. | Methods and compositions for generation of binding agents against cell surface antigens |
| US20150184214A1 (en) * | 2013-12-31 | 2015-07-02 | Roche Nimblegen, Inc. | Enrichment of full length oligonucleotides via transcription/translation mediated purification |
| JP6814634B2 (ja) | 2014-02-05 | 2021-01-20 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法 |
| ES2736127T3 (es) | 2014-03-20 | 2019-12-26 | Bristol Myers Squibb Co | Dominios de tipo III de fibronectina de unión a seroalbúmina |
| JP6478392B2 (ja) * | 2014-12-26 | 2019-03-06 | 国立研究開発法人産業技術総合研究所 | 核酸リンカー |
| EP3268389B1 (de) | 2015-03-12 | 2020-09-30 | Medimmune, LLC | Verfahren zur aufreinigung von albuminfusionsproteinen |
| JP6893504B2 (ja) | 2015-09-23 | 2021-06-23 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 速い解離速度を有する血清アルブミン結合フィブロネクチンタイプiiiドメイン |
| EP3452591B1 (de) | 2016-05-02 | 2023-08-16 | Encodia, Inc. | Makromolekülanalyse mit verwendung von nukleinsäurecodierung |
| US11713482B2 (en) | 2016-06-15 | 2023-08-01 | Genecapture, Inc. | Compositions, methods and devices comprising stem-loop captor molecules |
| US20200182884A1 (en) | 2016-06-27 | 2020-06-11 | Juno Therapeutics, Inc. | Method of identifying peptide epitopes, molecules that bind such epitopes and related uses |
| MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
| SG11201908817WA (en) | 2017-03-21 | 2019-10-30 | Fujifilm Corp | Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound |
| SG11202003924YA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Kits for analysis using nucleic acid encoding and/or label |
| EP3717009A4 (de) | 2017-11-30 | 2021-12-01 | Arrakis Therapeutics, Inc. | Nukleinsäurebindende photosonden und verwendungen davon |
| CA3087898A1 (en) | 2018-02-02 | 2019-08-08 | Ripple Therapeutics Corporation | Glass formulations comprising steroid dimers and uses thereof |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| JP6817493B2 (ja) * | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖rnaの製造方法 |
| WO2019236644A1 (en) * | 2018-06-05 | 2019-12-12 | Arrakis Therapeutics, Inc. | Encoded libraries and methods of use for screening nucleic acid targets |
| US12473326B2 (en) | 2019-02-01 | 2025-11-18 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| EP4010347A4 (de) | 2019-08-07 | 2023-09-20 | Ripple Therapeutics Corporation | Zusammensetzungen und verfahren zur behandlung von schmerz und abhängigkeitserkrankungen |
| CN115956083A (zh) | 2020-05-01 | 2023-04-11 | 波纹疗法公司 | 异二聚体组合物及用于治疗眼部病症的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5391723A (en) * | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
| US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| DE19646372C1 (de) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
| AU714486B2 (en) * | 1995-11-21 | 2000-01-06 | Yale University | Unimolecular segment amplification and detection |
| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5842701A (en) * | 1996-10-08 | 1998-12-01 | Smith International, Inc. | Dual functioning seal for rock bits |
| EP0932693A1 (de) | 1996-10-10 | 1999-08-04 | Henrik Garoff | Alphavirus-retrovirus vektoren |
| WO1998016636A1 (en) * | 1996-10-17 | 1998-04-23 | Mitsubishi Chemical Corporation | Molecule that homologizes genotype and phenotype and utilization thereof |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| JP3692542B2 (ja) | 1997-01-21 | 2005-09-07 | ザ ジェネラル ホスピタル コーポレーション | Rna−蛋白質の融合体を用いた蛋白質の選抜 |
| US5935791A (en) * | 1997-09-23 | 1999-08-10 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
| JP3889927B2 (ja) * | 1997-12-22 | 2007-03-07 | セローノ ジェネティクス インスティテュート ソシエテ アノニム | 前立腺癌遺伝子 |
| US5985575A (en) * | 1998-05-20 | 1999-11-16 | Wisconsin Alumni Research Foundation | Tethered function assay for protein function |
| EP1870417B9 (de) * | 1999-07-27 | 2012-08-01 | Bristol-Myers Squibb Company | Peptidakzeptorbindungsverfahren |
| AU779653B2 (en) * | 1999-08-27 | 2005-02-03 | Bristol-Myers Squibb Company | Methods for encoding and sorting in vitro translated proteins |
-
2000
- 2000-07-19 EP EP07005917A patent/EP1870417B9/de not_active Expired - Lifetime
- 2000-07-19 AT AT07005917T patent/ATE551352T1/de active
- 2000-07-19 PT PT07005917T patent/PT1870417E/pt unknown
- 2000-07-19 PT PT00947524T patent/PT1196637E/pt unknown
- 2000-07-19 US US09/619,103 patent/US6429300B1/en not_active Expired - Lifetime
- 2000-07-19 DK DK07005917.5T patent/DK1870417T3/da active
- 2000-07-19 AU AU61112/00A patent/AU781783B2/en not_active Expired
- 2000-07-19 ES ES07005917T patent/ES2383332T3/es not_active Expired - Lifetime
- 2000-07-19 IL IL14703700A patent/IL147037A0/xx unknown
- 2000-07-19 JP JP2001512922A patent/JP4766808B2/ja not_active Expired - Lifetime
- 2000-07-19 CA CA2377468A patent/CA2377468C/en not_active Expired - Lifetime
- 2000-07-19 KR KR1020027001058A patent/KR20020033743A/ko not_active Withdrawn
- 2000-07-19 DK DK00947524T patent/DK1196637T3/da active
- 2000-07-19 WO PCT/US2000/019653 patent/WO2001007657A1/en not_active Ceased
- 2000-07-19 HK HK02106728.4A patent/HK1045334A1/zh unknown
- 2000-07-19 ES ES00947524T patent/ES2284508T3/es not_active Expired - Lifetime
- 2000-07-19 AT AT00947524T patent/ATE360706T1/de active
- 2000-07-19 EP EP00947524A patent/EP1196637B1/de not_active Expired - Lifetime
- 2000-07-19 CA CA2693274A patent/CA2693274C/en not_active Expired - Lifetime
- 2000-07-19 DE DE60034566T patent/DE60034566T2/de not_active Expired - Lifetime
-
2002
- 2002-01-23 NO NO20020348A patent/NO20020348D0/no not_active Application Discontinuation
- 2002-07-30 US US10/208,357 patent/US7078197B2/en not_active Expired - Lifetime
-
2005
- 2005-09-15 AU AU2005211548A patent/AU2005211548B2/en not_active Expired
-
2006
- 2006-07-10 US US11/483,495 patent/US7790421B2/en not_active Expired - Fee Related
-
2010
- 2010-08-24 JP JP2010186725A patent/JP5512463B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-08 CY CY20121100522T patent/CY1113185T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE360706T1 (de) | Peptidakzeptor ligationsverfahren | |
| DE60010098D1 (de) | 28-epirapaloge | |
| WO2003012119A3 (en) | Nucleic acid amplification method | |
| DK0788360T3 (da) | Boronsyreester- og syreforbindelser, deres syntese og anvendelser | |
| AU2003296151A1 (en) | Process for producing dipeptide | |
| MA26782A1 (fr) | Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2. | |
| UA84284C2 (ru) | Способы лечения, профилактики и диагностики инфекции helicobacter cerdo | |
| MA26804A1 (fr) | Acides 3-propyl-gamma-aminobutyriques mono- et disubstitues. | |
| TR199802289A3 (tr) | Fosfonasit-ikame etmis benzazepinon-n-asetikasit türevleri. | |
| DK1399590T3 (da) | Happier kortlægning | |
| EP1615946A4 (de) | Proteolytische und kovalente antikörper | |
| AU1908100A (en) | Isothermal nucleic acid amplification methods | |
| IT1301737B1 (it) | Premitallone per pneumatici. | |
| PT1064265E (pt) | Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona | |
| TR200000441A3 (tr) | Organik azitlerin imali için islem. | |
| NO975534D0 (no) | Imidazo-£1,5|-pyridin-avledete serinproteaseinhibitorer | |
| DK1123396T3 (da) | Minimale promotorer og anvendelser deraf | |
| NO20020328L (no) | Fremgangsmåte for fremstilling av 4-cyano-2-aminometyltiazol | |
| NL1012028A1 (nl) | Aminozuursequentie. | |
| FR2797443B1 (fr) | Procede de prepartion de quinoleine-5,8-diones | |
| ITBS990047V0 (it) | Rubinetto per gas valvolato. | |
| TR199801514A3 (tr) | N-Piruvil-L-Prolin üretimi için yöntem. | |
| IT1317829B1 (it) | Processo per la preparazione di cefonicid per via enzimatica. | |
| IT1311584B1 (it) | Metodo per la realizzazione di calzature, e calzature ottenute contale metodo. | |
| DK0970030T3 (da) | Fremgangsmåde til at oprense 1,3,5-triisopropylbenzen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1196637 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |