ATE551352T1 - Peptidakzeptorbindungsverfahren - Google Patents
PeptidakzeptorbindungsverfahrenInfo
- Publication number
- ATE551352T1 ATE551352T1 AT07005917T AT07005917T ATE551352T1 AT E551352 T1 ATE551352 T1 AT E551352T1 AT 07005917 T AT07005917 T AT 07005917T AT 07005917 T AT07005917 T AT 07005917T AT E551352 T1 ATE551352 T1 AT E551352T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide acceptor
- binding method
- acceptor binding
- peptide
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14583499P | 1999-07-27 | 1999-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE551352T1 true ATE551352T1 (de) | 2012-04-15 |
Family
ID=22514769
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00947524T ATE360706T1 (de) | 1999-07-27 | 2000-07-19 | Peptidakzeptor ligationsverfahren |
AT07005917T ATE551352T1 (de) | 1999-07-27 | 2000-07-19 | Peptidakzeptorbindungsverfahren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00947524T ATE360706T1 (de) | 1999-07-27 | 2000-07-19 | Peptidakzeptor ligationsverfahren |
Country Status (16)
Country | Link |
---|---|
US (3) | US6429300B1 (de) |
EP (2) | EP1870417B9 (de) |
JP (2) | JP4766808B2 (de) |
KR (1) | KR20020033743A (de) |
AT (2) | ATE360706T1 (de) |
AU (2) | AU781783B2 (de) |
CA (2) | CA2377468C (de) |
CY (1) | CY1113185T1 (de) |
DE (1) | DE60034566T2 (de) |
DK (2) | DK1196637T3 (de) |
ES (2) | ES2383332T3 (de) |
HK (2) | HK1045334A1 (de) |
IL (1) | IL147037A0 (de) |
NO (1) | NO20020348D0 (de) |
PT (2) | PT1870417E (de) |
WO (1) | WO2001007657A1 (de) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4766808B2 (ja) * | 1999-07-27 | 2011-09-07 | ブリストル−マイヤーズ スクウィブ カンパニー | ペプチドアクセプターの連結法 |
JP4731781B2 (ja) | 2000-01-11 | 2011-07-27 | ナノゲン・レコグノミクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 基体表面に結合させるための複数の結合部分を有する生体分子 |
JP2003530094A (ja) * | 2000-03-31 | 2003-10-14 | メモレック シュトッフェル ゲゼルシャフト ミット ベシュレンクテル ハフツング メディツィニッシューモレクラー エントヴィクルンク,ケルン | 核酸の抽出方法 |
WO2003044194A1 (en) * | 2001-11-16 | 2003-05-30 | Proteonova, Inc. | Selection and evolution of nucleic acids and polypeptides |
US7410761B2 (en) * | 2000-05-19 | 2008-08-12 | Proteonova, Inc. | System for rapid identification and selection of nucleic acids and polypeptides, and method thereof |
US6962781B1 (en) | 2000-05-19 | 2005-11-08 | Proteonova, Inc. | In vitro evolution of nucleic acids and encoded polypeptide |
US20040229271A1 (en) | 2000-05-19 | 2004-11-18 | Williams Richard B. | Compositions and methods for the identification and selection of nucleic acids and polypeptides |
US7129229B2 (en) | 2000-08-11 | 2006-10-31 | Nanogen Recognomics Gmbh | Hydrazide building blocks and hydrazide modified biomolecules |
AU2001295005A1 (en) * | 2000-08-11 | 2002-02-25 | Nanogen, Inc. | Macromolecules having hydrazide attachment moieties and reagents for their production |
JP4963142B2 (ja) * | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
US7727713B2 (en) * | 2001-06-20 | 2010-06-01 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US20060234231A1 (en) * | 2001-06-20 | 2006-10-19 | Nuevolution A/S | Microarrays displaying encoded molecules |
US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
EP1419274A4 (de) * | 2001-07-31 | 2006-02-08 | Phylos Inc | Modulare konstruktion von nukleinsäure-protein-fusionsmultimeren |
DE10147074A1 (de) * | 2001-09-25 | 2003-05-08 | Beru Ag | Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung |
AU2002365404A1 (en) * | 2001-11-27 | 2003-06-10 | Compound Therapeutics, Inc. | Solid-phase immobilization of proteins and peptides |
DE20200926U1 (de) * | 2002-01-23 | 2002-04-18 | Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz | Festwalzgerät einer Festwalzmaschine für Kurbelwellen |
EP1487851A2 (de) * | 2002-03-15 | 2004-12-22 | Nuevolution A/S | Ein baustein geeignet zur funktionellen gruppe übertragung zum nucleophil |
EP1490384A2 (de) * | 2002-03-15 | 2004-12-29 | Nuevolution A/S | Ein baublock zur c-c bindungsbildung |
WO2003078446A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c or a c-hetero atom bond upon reaction |
NZ535144A (en) * | 2002-03-15 | 2006-03-31 | Nuevolution As | An improved method for synthesising templated molecules |
AU2003247266A1 (en) * | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
AU2003256857A1 (en) * | 2002-08-08 | 2004-02-25 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
HUE033651T2 (en) * | 2002-10-30 | 2017-12-28 | Nuevolution As | A method for producing two-function complexes |
EP2175019A3 (de) | 2002-12-19 | 2011-04-06 | Nuevolution A/S | Durch Quasizufallsstrukturen und Funktionen geführte Synthesemethoden |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
WO2004074501A2 (en) * | 2003-02-21 | 2004-09-02 | Nuevolution A/S | A method for obtaining structural information about an encoded molecule |
DE602004019764D1 (de) * | 2003-03-20 | 2009-04-16 | Nuevolution As | Ligationsvermittelnde codierung von kleinen molekülen |
WO2004110964A2 (en) * | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
US11118215B2 (en) * | 2003-09-18 | 2021-09-14 | Nuevolution A/S | Method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
WO2005051985A2 (en) * | 2003-11-20 | 2005-06-09 | Sanofi Pasteur, Inc. | Methods for purifying pertussis toxin and peptides useful therefor |
AU2004296376B2 (en) | 2003-12-05 | 2010-03-04 | Bristol-Myers Squibb Company | Inhibitors of type 2 vascular endothelial growth factor receptors |
EP1692155A4 (de) * | 2003-12-12 | 2008-08-06 | Proteonova Inc | System und verfahren zur auswahl von nukleinsäuren und polypeptiden |
EP1723255B1 (de) * | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung |
DK1730277T3 (da) * | 2004-03-22 | 2010-03-01 | Nuevolution As | Kodning ved ligering under anvendelse af byggebloksoligonukleotider |
CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
WO2006041194A1 (ja) | 2004-10-15 | 2006-04-20 | Japan Science And Technology Agency | mRNA-ピューロマイシン-タンパク質連結体作製用リンカー |
US10206998B2 (en) | 2005-01-12 | 2019-02-19 | Proteonova, Inc. | Modular targeted therapeutic agents and methods of making same |
EP2261257B1 (de) | 2005-01-12 | 2018-07-11 | Proteonova, Inc. | Verfahren zur Herstellung zielgerichteter Therapeutika |
US20090018029A1 (en) | 2005-11-16 | 2009-01-15 | Ambrx, Inc. | Methods and Compositions Comprising Non-Natural Amino Acids |
PT3305900T (pt) | 2005-12-01 | 2021-10-27 | Nuevolution As | Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes |
US7749957B2 (en) | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
CA2670471A1 (en) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
US9080256B2 (en) | 2007-02-12 | 2015-07-14 | Proteonova, Inc. | Generation of library of soluble random polypeptides linked to mRNA |
US7829311B2 (en) | 2007-07-25 | 2010-11-09 | E.I. Du Pont De Nemours And Company | Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate |
US7951559B2 (en) * | 2007-07-25 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Recombinant peptide production using a cross-linkable solubility tag |
US7678883B2 (en) * | 2007-07-25 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Solubility tags for the expression and purification of bioactive peptides |
US7794963B2 (en) | 2007-11-02 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins |
AU2008334099B2 (en) | 2007-11-30 | 2014-07-24 | Abbvie Biotechnology Ltd. | Protein formulations and methods of making same |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
US8524244B2 (en) | 2008-02-14 | 2013-09-03 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind EGFR |
JP5774474B2 (ja) * | 2008-05-02 | 2015-09-09 | エピセンター テクノロジーズ コーポレーションEpicentre Technologies Corporation | Rnaへの選択的な5’ライゲーションによるタグの付加 |
ES2620285T3 (es) | 2008-05-02 | 2017-06-28 | Novartis Ag | Moléculas de unión con base en fibronectina mejorada y usos de las mismas |
CN102099373A (zh) | 2008-05-22 | 2011-06-15 | 百时美施贵宝公司 | 基于纤连蛋白的多价支架结构域蛋白 |
EP3629022A1 (de) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Proteinscreeningverfahren |
RU2011117210A (ru) * | 2008-09-30 | 2012-11-10 | Эбботт Лэборетриз (Us) | Улучшенные способы рнк-дисплея |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
US20100158837A1 (en) | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Iron oxide-binding peptides |
US8287845B2 (en) * | 2008-12-18 | 2012-10-16 | E I Du Pont De Nemours And Company | Hair-binding peptides |
US20100158846A1 (en) * | 2008-12-18 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hair-binding peptides |
US20100158822A1 (en) * | 2008-12-18 | 2010-06-24 | E .I. Du Pont De Nemours And Company | Peptides that bind to silica-coated particles |
WO2010114638A1 (en) | 2009-03-30 | 2010-10-07 | E. I. Du Pont De Nemours And Company | Peptide-based tooth whitening reagents |
BRPI1014677A2 (pt) | 2009-03-30 | 2016-04-12 | Du Pont | sistemas baseados em peptídeos para distribuição de agentes cosméticos |
JP5733784B2 (ja) * | 2009-09-24 | 2015-06-10 | 国立大学法人埼玉大学 | cDNA/mRNA−タンパク質連結体の効率的合成法 |
WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
IN2012DN06588A (de) | 2010-02-10 | 2015-10-23 | Novartis Ag | |
US20130034578A1 (en) * | 2010-04-09 | 2013-02-07 | Petrus Josephus Marie Rottier | Recombinant multimeric influenza proteins |
EP3540059A1 (de) | 2010-04-16 | 2019-09-18 | Nuevolution A/S | Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
ES2573108T3 (es) | 2010-05-26 | 2016-06-06 | Bristol-Myers Squibb Company | Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada |
WO2012016245A2 (en) | 2010-07-30 | 2012-02-02 | Novartis Ag | Fibronectin cradle molecules and libraries thereof |
DE102010056289A1 (de) | 2010-12-24 | 2012-06-28 | Geneart Ag | Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken |
EP2686349B1 (de) | 2011-03-15 | 2020-12-09 | X-Body, Inc. | Antikörper-screening-verfahren |
DK3415619T3 (da) | 2011-04-28 | 2021-03-08 | Univ Leland Stanford Junior | Identifikation af polynukleotider forbundet med en prøve |
EP2742153B1 (de) | 2011-08-01 | 2018-09-05 | The General Hospital Corporation | Protein- und peptidbibliotheken |
MX367013B (es) | 2011-10-11 | 2019-08-02 | Medimmune Llc | Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo. |
CN104105708B (zh) | 2011-12-05 | 2018-04-03 | X博迪生物科学公司 | PDGF受体β结合多肽 |
EP2975121A4 (de) * | 2013-03-13 | 2016-07-20 | Univ Tokyo | Nukleinsäurelinker |
NZ716126A (en) | 2013-06-28 | 2021-12-24 | X Body Inc | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
CN103382579B (zh) * | 2013-07-06 | 2015-10-21 | 中国科学院成都生物研究所 | 一种体外筛选多肽的方法 |
CN105705947B (zh) | 2013-09-23 | 2019-04-02 | X博迪公司 | 用于生成对抗细胞表面抗原的结合剂的方法和组合物 |
EP3090049B1 (de) * | 2013-12-31 | 2017-10-18 | F. Hoffmann-La Roche AG | Anreicherung vollständiger oligonukleotide über transkriptions-/translationsvermittelte reinigung |
US10421958B2 (en) | 2014-02-05 | 2019-09-24 | Molecular Templates, Inc. | Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity |
KR20220162886A (ko) | 2014-03-20 | 2022-12-08 | 브리스톨-마이어스 스큅 컴퍼니 | 혈청 알부민-결합 피브로넥틴 유형 iii 도메인 |
JP6478392B2 (ja) * | 2014-12-26 | 2019-03-06 | 国立研究開発法人産業技術総合研究所 | 核酸リンカー |
JP6862348B2 (ja) | 2015-03-12 | 2021-04-21 | メディミューン,エルエルシー | アルブミン融合タンパク質を精製する方法 |
EP3708580B1 (de) | 2015-09-23 | 2023-11-01 | Bristol-Myers Squibb Company | Schnell ablaufende serumalbuminbindende fibronektin-typ-iii-domänen |
KR102516168B1 (ko) | 2016-05-02 | 2023-03-30 | 엔코디아, 인코포레이티드 | 암호화 핵산을 사용한 거대분자 분석 |
CA3027951A1 (en) * | 2016-06-15 | 2017-12-21 | Genecapture, Inc. | Compositions, methods and devices comprising stem-loop captor molecules |
MA45491A (fr) | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés |
EP3475446A1 (de) | 2016-06-27 | 2019-05-01 | Juno Therapeutics, Inc. | Verfahren zur identifizierung von peptidepitopen, moleküle zur bindung derartiger epitope und verwendungen davon |
AU2018238892B2 (en) | 2017-03-21 | 2020-07-23 | Fujifilm Corporation | Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound |
US11513126B2 (en) * | 2017-10-31 | 2022-11-29 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
IL297543A (en) | 2017-11-30 | 2022-12-01 | Arrakis Therapeutics Inc | Nucleic acid-binding photoprobes and their uses |
MX2020008017A (es) | 2018-02-02 | 2020-12-03 | Ripple Therapeutics Corp | Formulaciones de vidrio y usos de las mismas. |
TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
WO2019189591A1 (ja) * | 2018-03-30 | 2019-10-03 | 住友化学株式会社 | 一本鎖rnaの製造方法 |
WO2019236644A1 (en) * | 2018-06-05 | 2019-12-12 | Arrakis Therapeutics, Inc. | Encoded libraries and methods of use for screening nucleic acid targets |
WO2021220061A2 (en) | 2020-05-01 | 2021-11-04 | Ripple Therapeutics Corporation | Heterodimer compositions and methods for the treatment of ocular disorders |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5391723A (en) * | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
WO1995011922A1 (en) * | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
DE19646372C1 (de) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
DE69612013T2 (de) * | 1995-11-21 | 2001-08-02 | Yale University, New Haven | Unimolekulare segmentamplifikation und bestimmung |
US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
US5842701A (en) * | 1996-10-08 | 1998-12-01 | Smith International, Inc. | Dual functioning seal for rock bits |
CA2268353A1 (en) | 1996-10-10 | 1998-04-16 | Henrik Garoff | Alphavirus-retrovirus vectors |
EP1477561B1 (de) * | 1996-10-17 | 2008-12-10 | Mitsubishi Chemical Corporation | Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen |
ES2373110T3 (es) * | 1997-01-21 | 2012-01-31 | The General Hospital Corporation | Selección de proteínas usando fusiones de arn-proteína. |
US6261804B1 (en) * | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
US5935791A (en) * | 1997-09-23 | 1999-08-10 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
JP3889927B2 (ja) * | 1997-12-22 | 2007-03-07 | セローノ ジェネティクス インスティテュート ソシエテ アノニム | 前立腺癌遺伝子 |
US5985575A (en) * | 1998-05-20 | 1999-11-16 | Wisconsin Alumni Research Foundation | Tethered function assay for protein function |
JP4766808B2 (ja) * | 1999-07-27 | 2011-09-07 | ブリストル−マイヤーズ スクウィブ カンパニー | ペプチドアクセプターの連結法 |
JP4803933B2 (ja) * | 1999-08-27 | 2011-10-26 | ブリストル−マイヤーズ スクウィブ カンパニー | インビトロ翻訳タンパク質の符号化方法および選別方法 |
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2000
- 2000-07-19 JP JP2001512922A patent/JP4766808B2/ja not_active Expired - Lifetime
- 2000-07-19 PT PT07005917T patent/PT1870417E/pt unknown
- 2000-07-19 KR KR1020027001058A patent/KR20020033743A/ko not_active Application Discontinuation
- 2000-07-19 DK DK00947524T patent/DK1196637T3/da active
- 2000-07-19 AU AU61112/00A patent/AU781783B2/en not_active Expired
- 2000-07-19 WO PCT/US2000/019653 patent/WO2001007657A1/en active IP Right Grant
- 2000-07-19 CA CA2377468A patent/CA2377468C/en not_active Expired - Lifetime
- 2000-07-19 ES ES07005917T patent/ES2383332T3/es not_active Expired - Lifetime
- 2000-07-19 ES ES00947524T patent/ES2284508T3/es not_active Expired - Lifetime
- 2000-07-19 AT AT00947524T patent/ATE360706T1/de active
- 2000-07-19 AT AT07005917T patent/ATE551352T1/de active
- 2000-07-19 IL IL14703700A patent/IL147037A0/xx unknown
- 2000-07-19 DK DK07005917.5T patent/DK1870417T3/da active
- 2000-07-19 PT PT00947524T patent/PT1196637E/pt unknown
- 2000-07-19 DE DE60034566T patent/DE60034566T2/de not_active Expired - Lifetime
- 2000-07-19 US US09/619,103 patent/US6429300B1/en not_active Expired - Lifetime
- 2000-07-19 EP EP07005917A patent/EP1870417B9/de not_active Expired - Lifetime
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- 2000-07-19 CA CA2693274A patent/CA2693274C/en not_active Expired - Lifetime
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2002
- 2002-01-23 NO NO20020348A patent/NO20020348D0/no not_active Application Discontinuation
- 2002-07-30 US US10/208,357 patent/US7078197B2/en not_active Expired - Lifetime
- 2002-09-13 HK HK02106728.4A patent/HK1045334A1/zh unknown
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2005
- 2005-09-15 AU AU2005211548A patent/AU2005211548B2/en not_active Expired
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2006
- 2006-07-10 US US11/483,495 patent/US7790421B2/en not_active Expired - Fee Related
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2008
- 2008-06-26 HK HK08107091.5A patent/HK1112007A1/xx not_active IP Right Cessation
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2010
- 2010-08-24 JP JP2010186725A patent/JP5512463B2/ja not_active Expired - Lifetime
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2012
- 2012-06-08 CY CY20121100522T patent/CY1113185T1/el unknown
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