MX378753B - Dominios de fibronectina tipo iii que se unen a albúmina de suero. - Google Patents

Dominios de fibronectina tipo iii que se unen a albúmina de suero.

Info

Publication number
MX378753B
MX378753B MX2016011580A MX2016011580A MX378753B MX 378753 B MX378753 B MX 378753B MX 2016011580 A MX2016011580 A MX 2016011580A MX 2016011580 A MX2016011580 A MX 2016011580A MX 378753 B MX378753 B MX 378753B
Authority
MX
Mexico
Prior art keywords
serum albumin
type iii
fibronectin type
sup
iii domains
Prior art date
Application number
MX2016011580A
Other languages
English (en)
Other versions
MX2016011580A (es
Inventor
Dasa Lipovsek
David Fabrizio
Jonathan Davis
Michael L Gosselin
Ray Camphausen
Rex PARKER
Tracy S Mitchell
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2016011580A publication Critical patent/MX2016011580A/es
Publication of MX378753B publication Critical patent/MX378753B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere un polipéptido, caracterizado porque comprende un décimo dominio de fibronectina tipo III (10Fn3) en donde el dominio 10Fn3 comprende bucles AB, BC, CD, DE, EF, y FG, y el bucle CD comprende una secuencia de aminoácido de conformidad con la fórmula G-X1-X2-V-X3-X4-X5-S-X6-X7-G-G-X8-X9-Y-X10-X11-X12-E, en donde (a) X1 es R; (b) X2 es E; (c) X3 es Q; (d) X4 es K; ( e ) X5 es Y; (f) X6 es D; (g) X7 es L o W; (h) X8 es P; (i) X9 es L; (j) X10 es I; (k) X11 es Y; y (1) X12 es Q o N, y en donde el polipéptido se une a albúmina de suero humana (HSA) con una KD de menos de 500 nM, y a una o más albúmina de suero de Rhesus, albúmina de suero de cinomólogo, albúmina de suero de ratón y albúmina de suero de rata con un KD de menos de 500 nM.
MX2016011580A 2014-03-20 2015-03-19 Dominios de fibronectina tipo iii que se unen a albúmina de suero. MX378753B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461968181P 2014-03-20 2014-03-20
PCT/US2015/021535 WO2015143199A1 (en) 2014-03-20 2015-03-19 Serum albumin-binding fibronectin type iii domains

Publications (2)

Publication Number Publication Date
MX2016011580A MX2016011580A (es) 2016-11-29
MX378753B true MX378753B (es) 2025-03-10

Family

ID=52808189

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011580A MX378753B (es) 2014-03-20 2015-03-19 Dominios de fibronectina tipo iii que se unen a albúmina de suero.

Country Status (14)

Country Link
US (3) US10442851B2 (es)
EP (2) EP3129401B1 (es)
JP (2) JP6591437B2 (es)
KR (2) KR102472862B1 (es)
CN (2) CN106170494B (es)
AU (1) AU2015231170B2 (es)
CA (1) CA2943241C (es)
EA (2) EA034886B1 (es)
ES (2) ES2913840T3 (es)
IL (2) IL275497B (es)
MX (1) MX378753B (es)
SG (1) SG11201607820QA (es)
WO (1) WO2015143199A1 (es)
ZA (1) ZA201606321B (es)

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