EA201000979A1 - Улучшенные связывающие молекулы на основе фибронектина и их применение - Google Patents

Улучшенные связывающие молекулы на основе фибронектина и их применение

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Publication number
EA201000979A1
EA201000979A1 EA201000979A EA201000979A EA201000979A1 EA 201000979 A1 EA201000979 A1 EA 201000979A1 EA 201000979 A EA201000979 A EA 201000979A EA 201000979 A EA201000979 A EA 201000979A EA 201000979 A1 EA201000979 A1 EA 201000979A1
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Eurasian Patent Office
Prior art keywords
binding molecules
fibronectin
methods
application
improved binding
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EA201000979A
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English (en)
Inventor
Франк Кольбингер
Карен Джейн Винсент
Барбара Браннетти
Штефан Эверт
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Новартис Аг
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Publication of EA201000979A1 publication Critical patent/EA201000979A1/ru

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Abstract

В заявке описаны связывающие молекулы на основе фибронектина и способы и методы включения донорских CDR в связывающие молекулы на основе фибронектина прежде всего на основе домена Fn3. Связывающие молекулы на основе фибронектина по изобретению можно также конъюгировать с другими частицами, например, ПЭГ, для повышения периода полураспада и стабильности. В изобретении также предлагаются способы тестирования таких связывающих молекул по связыванию с антигеном-мишенью, а также способы получения и очистки перспективных связывающих молекул.
EA201000979A 2007-12-27 2008-12-22 Улучшенные связывающие молекулы на основе фибронектина и их применение EA201000979A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US936107P 2007-12-27 2007-12-27
PCT/IB2008/003962 WO2009083804A2 (en) 2007-12-27 2008-12-22 Improved fibronectin-based binding molecules and their use

Publications (1)

Publication Number Publication Date
EA201000979A1 true EA201000979A1 (ru) 2011-02-28

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EA201000979A EA201000979A1 (ru) 2007-12-27 2008-12-22 Улучшенные связывающие молекулы на основе фибронектина и их применение

Country Status (11)

Country Link
US (1) US20100322930A1 (ru)
EP (1) EP2234646A2 (ru)
JP (1) JP2011507543A (ru)
KR (1) KR20100111283A (ru)
CN (1) CN101965198A (ru)
AU (1) AU2008345424A1 (ru)
BR (1) BRPI0821924A2 (ru)
CA (1) CA2710835A1 (ru)
EA (1) EA201000979A1 (ru)
IL (1) IL206356A0 (ru)
WO (1) WO2009083804A2 (ru)

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