EA202090216A2 - Связывающие сывороточный альбумин домены фибронектина iii типа - Google Patents
Связывающие сывороточный альбумин домены фибронектина iii типаInfo
- Publication number
- EA202090216A2 EA202090216A2 EA202090216A EA202090216A EA202090216A2 EA 202090216 A2 EA202090216 A2 EA 202090216A2 EA 202090216 A EA202090216 A EA 202090216A EA 202090216 A EA202090216 A EA 202090216A EA 202090216 A2 EA202090216 A2 EA 202090216A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- serum albumin
- iii type
- fibronectin iii
- binding serum
- domains
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Abstract
Настоящее изобретение относится к полипептидам, которые включают десятые домены фибронектина III типа (Fn3), которые связываются с сывороточным альбумином, с заменами в петле "южного полюса". Настоящее изобретение дополнительно относится к гибридным молекулам, содержащим связывающий сывороточный альбуминFn3, соединенный с гетерологичным белком, для применения в диагностических и терапевтических целях.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461968181P | 2014-03-20 | 2014-03-20 |
Publications (2)
Publication Number | Publication Date |
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EA202090216A2 true EA202090216A2 (ru) | 2020-05-31 |
EA202090216A3 EA202090216A3 (ru) | 2020-07-31 |
Family
ID=52808189
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090216A EA202090216A3 (ru) | 2014-03-20 | 2015-03-19 | Связывающие сывороточный альбумин домены фибронектина iii типа |
EA201691669A EA034886B1 (ru) | 2014-03-20 | 2015-03-19 | Связывающие сывороточный альбумин домены фибронектина iii типа |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691669A EA034886B1 (ru) | 2014-03-20 | 2015-03-19 | Связывающие сывороточный альбумин домены фибронектина iii типа |
Country Status (14)
Country | Link |
---|---|
US (3) | US10442851B2 (ru) |
EP (2) | EP3129401B1 (ru) |
JP (2) | JP6591437B2 (ru) |
KR (2) | KR20220162886A (ru) |
CN (2) | CN106170494B (ru) |
AU (1) | AU2015231170B2 (ru) |
BR (1) | BR112016020175A2 (ru) |
CA (1) | CA2943241C (ru) |
EA (2) | EA202090216A3 (ru) |
ES (2) | ES2736127T3 (ru) |
IL (2) | IL275497B (ru) |
MX (1) | MX2016011580A (ru) |
SG (1) | SG11201607820QA (ru) |
WO (1) | WO2015143199A1 (ru) |
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