EA201491494A1 - Нацеливание на гликаны хондроитинсульфаты - Google Patents

Нацеливание на гликаны хондроитинсульфаты

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Publication number
EA201491494A1
EA201491494A1 EA201491494A EA201491494A EA201491494A1 EA 201491494 A1 EA201491494 A1 EA 201491494A1 EA 201491494 A EA201491494 A EA 201491494A EA 201491494 A EA201491494 A EA 201491494A EA 201491494 A1 EA201491494 A1 EA 201491494A1
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var2csa
binding fragments
nacelivanie
hondroitinsulfaty
glikany
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EA201491494A
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English (en)
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EA031876B1 (ru
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Али Саланти
Тор Грунттвиг Теаннер
Мадс Даугорд
Мортен Нильсен
Маделейне Дальбек
Томас Маннель Клаусен
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Вар2 Фармасьютикалз Апс
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Publication of EA201491494A1 publication Critical patent/EA201491494A1/ru
Publication of EA031876B1 publication Critical patent/EA031876B1/ru

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Abstract

Изобретение относится к функциональным связывающим фрагментам, содержащим минимальные связывающие фрагменты VAR2CSA, к антителам против указанных связывающих фрагментов VAR2CSA, нуклеиновым кислотам, кодирующим указанные фрагменты VAR2CSA, а также к способам их получения. Изобретение относится также к конъюгатам и слитым белкам полипептидов VAR2CSA, содержащим минимальные связывающие фрагменты, и к их применению, в частности, для лечения состояний, связанных с экспрессией хондроитинсульфата A (CSA), такой как патологическая экспрессия хондроитинсульфата A (CSA).
EA201491494A 2012-02-09 2013-02-08 Применения конъюгата, содержащего полипептид var2csa и эффекторную молекулу, для лечения и диагностики злокачественного новообразования EA031876B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596931P 2012-02-09 2012-02-09
PCT/EP2013/052557 WO2013117705A1 (en) 2012-02-09 2013-02-08 Targeting of chondroitin sulfate glycans

Publications (2)

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EA201491494A1 true EA201491494A1 (ru) 2015-01-30
EA031876B1 EA031876B1 (ru) 2019-03-29

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EA201491494A EA031876B1 (ru) 2012-02-09 2013-02-08 Применения конъюгата, содержащего полипептид var2csa и эффекторную молекулу, для лечения и диагностики злокачественного новообразования

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US (3) US11787844B2 (ru)
EP (1) EP2812024B1 (ru)
JP (2) JP6517018B2 (ru)
CN (1) CN104136041B (ru)
AU (1) AU2013217986B2 (ru)
BR (1) BR112014018630A2 (ru)
CA (1) CA2861051C (ru)
DK (1) DK2812024T3 (ru)
EA (1) EA031876B1 (ru)
ES (1) ES2676029T3 (ru)
IL (1) IL233594B (ru)
PL (1) PL2812024T3 (ru)
SG (2) SG11201403988WA (ru)
WO (1) WO2013117705A1 (ru)
ZA (1) ZA201405187B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2714933C2 (ru) * 2013-12-27 2020-02-21 Займворкс Инк. Конъюгаты var2csa-лекарственное средство

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY174813A (en) 2013-03-15 2020-05-16 Zymeworks Inc Cytotoxic and anti-mitotic compounds, and methods of using the same
JP6599334B2 (ja) * 2013-12-20 2019-10-30 ザ ジェネラル ホスピタル コーポレイション 血中循環腫瘍細胞に関する方法およびアッセイ
CA2935077C (en) 2013-12-27 2022-03-15 Geoffrey C. Winters Sulfonamide-containing linkage systems for drug conjugates
JP6246030B2 (ja) * 2014-03-12 2017-12-13 東芝メディカルシステムズ株式会社 病理染色装置及び病理染色方法
DK3194421T3 (da) 2014-09-17 2022-02-14 Zymeworks Inc Cytotoksiske og antimitotiske forbindelser samt fremgangsmåder til anvendelse heraf
CA2977434A1 (en) * 2015-02-26 2016-09-01 Var2 Pharmaceuticals Aps Immunotherapeutic targeting of placental-like chondroitin sulfate using chimeric antigen receptors (cars) and immunotherapeutic targeting of cancer using cars with split-protein binding systems
WO2017088623A1 (zh) * 2015-11-26 2017-06-01 广州中科蓝华生物科技有限公司 一种抗胎盘样硫酸软骨素的嵌合抗原受体及其应用
CN106459224B (zh) * 2015-11-26 2019-12-27 广州中科蓝华生物科技有限公司 一种抗胎盘样硫酸软骨素的嵌合抗原受体及其应用
CN105753991B (zh) * 2015-11-26 2019-12-27 广州中科蓝华生物科技有限公司 一种抗胎盘样硫酸软骨素的嵌合抗原受体及其应用
WO2017179015A1 (en) * 2016-04-15 2017-10-19 Glaxosmithkline Intellectual Property Development Limited Compositions for the treatment of cancer
US10517958B2 (en) 2016-10-04 2019-12-31 Zymeworks Inc. Compositions and methods for the treatment of platinum-drug resistant cancer
CN106512022B (zh) * 2016-10-12 2019-09-27 广东艾时代生物科技有限责任公司 羟基红花黄色素a-红细胞黏附硫酸软骨素a受体蛋白多肽复合物在制备抗肿瘤药物的应用
CN109982713A (zh) * 2016-12-14 2019-07-05 中国科学院上海巴斯德研究所 外周血循环肿瘤细胞检测体系及其应用
CN109568596B (zh) * 2017-09-28 2021-07-27 中国科学院深圳先进技术研究院 胎盘样硫酸软骨素a靶向运载体系及其制备方法和应用
CN109589416B (zh) * 2017-09-28 2021-07-27 中国科学院深圳先进技术研究院 胎盘样硫酸软骨素a靶向纳米投递系统及其制备方法和应用
CN109568598B (zh) * 2017-09-28 2021-07-27 中国科学院深圳先进技术研究院 用于药物流产的胎盘靶向纳米颗粒及其制备方法和应用
WO2019061648A1 (zh) * 2017-09-28 2019-04-04 中国科学院深圳先进技术研究院 靶向胎盘样硫酸软骨素a的多肽、靶向递送系统及其制备方法和应用
CN109589413B (zh) * 2017-09-28 2021-07-27 中国科学院深圳先进技术研究院 靶向胎盘样硫酸软骨素a的多肽、靶向纳米颗粒及其制备方法和应用
CN109568597B (zh) * 2017-09-28 2021-07-27 中国科学院深圳先进技术研究院 靶向胎盘样硫酸软骨素a的多肽药物偶联物及其制备方法和应用
CN108570118B (zh) * 2017-10-17 2020-07-03 中国科学院深圳先进技术研究院 一种胎盘样硫酸软骨素a或其衍生物的亲和层析纯化方法
WO2019104562A1 (zh) * 2017-11-29 2019-06-06 广州中科蓝华生物科技有限公司 一种嵌合抗原受体及其应用
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WO2020033398A1 (en) * 2018-08-06 2020-02-13 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating atii cell-dependent lung diseases
WO2020077532A1 (zh) * 2018-10-16 2020-04-23 中国科学院深圳先进技术研究院 一种基于胎盘样硫酸软骨素a的癌症筛查和早期诊断的试剂方法
CN109387627B (zh) * 2018-10-16 2021-09-24 中国科学院深圳先进技术研究院 一种基于胎盘样硫酸软骨素a的癌症筛查和早期诊断的试剂方法
KR102167443B1 (ko) * 2019-03-25 2020-10-19 주식회사 카티프라임 체외 골관절염 모델 및 이를 이용한 골관절염 치료제 스크리닝 방법
CN110124045A (zh) * 2019-04-30 2019-08-16 云南大学 疟原虫var2csa蛋白在抗肿瘤药物中的应用
AU2020318955A1 (en) * 2019-07-23 2022-03-03 Csts Health Care Inc. Platelet-facilitated delivery of therapeutic compounds
CN113318225B (zh) * 2020-02-28 2024-01-19 无锡派列博生物医药科技有限公司 肿瘤免疫增强剂及其制法和应用
CN113967268A (zh) * 2020-07-21 2022-01-25 深圳先进技术研究院 一种子宫内膜异位症病灶靶向纳米投递系统及其制备方法和应用
CN113956331A (zh) * 2020-07-21 2022-01-21 深圳先进技术研究院 异位子宫内膜识别多肽及其衍生物和应用
US20240009290A1 (en) * 2020-11-19 2024-01-11 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Novel var2csa immunogens and methods of use thereof
CN113740521A (zh) * 2021-08-27 2021-12-03 安徽贝铭生物科技有限公司 检测尿液中癌胚硫酸软骨素的制剂在制备诊断泌尿系统恶性肿瘤的制剂、试剂盒中的应用
WO2023118150A1 (en) * 2021-12-22 2023-06-29 Royal College Of Surgeons In Ireland A conjugate for use in localising a molecule to the vascular endothelium.
CN114075298B (zh) * 2022-01-07 2022-04-29 广州中科蓝华生物科技有限公司 一种索烃化的var2csa重组蛋白及其制备方法和应用
WO2023148398A1 (en) * 2022-02-07 2023-08-10 Var2 Pharmaceuticals Aps Antibodies and antibody fragments and analogues specific for chondroitin sulfate
CN116874578A (zh) * 2022-12-09 2023-10-13 中山大学肿瘤防治中心(中山大学附属肿瘤医院 中山大学肿瘤研究所) 一种var2csa重组蛋白及其制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203570A (en) 1978-08-23 1980-05-20 The Western States Machine Company Power-operated loading gate for centrifugal machines incorporating an auxiliary drive device
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
WO1984004330A1 (en) 1983-04-22 1984-11-08 Amgen Secretion of exogenous polypeptides from yeast
NZ207926A (en) 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4766073A (en) 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4885249A (en) 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0625577A1 (en) 1985-08-29 1994-11-23 Genencor International, Inc. Heterologous polypeptides expressed in filamentous fungi, processes for their preparation, and vectors for their preparation
AU6543286A (en) 1985-10-25 1987-05-19 Zymogenetics Inc. Method of using bar1 for secreting foreign proteins
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
NZ221259A (en) 1986-07-31 1990-05-28 Calgene Inc Seed specific transcriptional regulation
EP0832981A1 (en) 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
CA1309680C (en) 1987-07-24 1992-11-03 David Harano Airlift insect cell culture
US5024947A (en) 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
DE3886221T3 (de) 1987-09-04 2000-12-21 Novo Nordisk As VERFAHREN ZUR HERSTELLUNG VON PROTEINPRODUKTEN IN -i(ASPERGILLUS) UND PROMOTOREN ZUR VERWENDUNG IN -i(ASPERGILLUS).
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
AU4647889A (en) 1988-11-18 1990-06-12 Cetus Corporation Insect signal peptide mediated secretion of recombinant proteins
GB8910962D0 (en) 1989-05-12 1989-06-28 Natural Environment Res Novel baculovirus expression vectors and use thereof in the expression of foreign proteins in insects or insect cells
US5162222A (en) 1989-07-07 1992-11-10 Guarino Linda A Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
US5077214A (en) 1989-07-07 1991-12-31 The Texas A&M University System Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells
US5023328A (en) 1989-08-04 1991-06-11 The Texas A&M University System Lepidopteran AKH signal sequence
US5073964A (en) 1989-08-04 1991-12-17 Aware, Inc. Signal processing device and method
US5155037A (en) 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
US5225584A (en) * 1989-09-06 1993-07-06 Tropix, Inc. Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
DK300090D0 (da) 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
EP0591219B1 (en) 1991-01-11 2001-12-19 American Red Cross Expression of active human protein c in mammary tissue of transgenic animals
DK1212423T3 (da) * 1999-09-01 2009-04-27 Us Gov Health & Human Serv Identifikation af dom net af Plasmodium falciparum- erythrocytmembranprotein 1 (PfEMP1), der medierer adh sion til chondroitinsulfat
FR2805821B1 (fr) * 2000-03-01 2004-01-16 Diatos Sequences d'acides amines facilitant la penetration d'une substance d'interet a l'interieur des cellules et/ou des noyaux cellulaires
JP3932358B2 (ja) 2001-02-28 2007-06-20 独立行政法人産業技術総合研究所 ブラディオン遺伝子導入ショウジョウバエ株
AU2003296330A1 (en) 2002-12-10 2004-06-30 Epimmune Inc. Hla-a1, a2 -a3,-a24,-b7,and -b44 tumor associated antigen peptides and compositions
AU2003291977A1 (en) * 2003-01-27 2004-08-23 Kobenhavns Universitet Compounds useful in the diagnosis and treatment of pregnancy-associated malaria
WO2006039652A2 (en) * 2004-09-30 2006-04-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chondroitin sulfate a binding domains
JP5819307B2 (ja) * 2009-10-20 2015-11-24 ネステク ソシエテ アノニム 発癌性融合タンパク質を検出するための近接媒介性アッセイ
WO2012002069A1 (ja) * 2010-06-29 2012-01-05 富士フイルム株式会社 形状抽出方法及び装置、並びに寸法測定装置及び距離測定装置
FR2963241B1 (fr) * 2010-07-30 2014-10-24 Inst Rech Developpement Ird Vaccin contre le paludisme gestationnel
US20140294930A1 (en) * 2011-08-04 2014-10-02 The Regents Of The University Of California STREPTOCOCCAL GlcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2714933C2 (ru) * 2013-12-27 2020-02-21 Займворкс Инк. Конъюгаты var2csa-лекарственное средство

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