DK58285D0 - Peptider samt fremstilling og anvendelse deraf - Google Patents
Peptider samt fremstilling og anvendelse derafInfo
- Publication number
- DK58285D0 DK58285D0 DK58285A DK58285A DK58285D0 DK 58285 D0 DK58285 D0 DK 58285D0 DK 58285 A DK58285 A DK 58285A DK 58285 A DK58285 A DK 58285A DK 58285 D0 DK58285 D0 DK 58285D0
- Authority
- DK
- Denmark
- Prior art keywords
- chain
- human insulin
- bridging
- insulin
- lys
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
| GR851304A GR851304B (da) | 1984-05-30 | 1985-05-28 | |
| EP90121887A EP0427296B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors |
| CA000482722A CA1304022C (en) | 1984-05-30 | 1985-05-29 | Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors |
| FI852135A FI89183C (fi) | 1984-05-30 | 1985-05-29 | Dna-sekvens som kodar foer insulinprekursorer, vektorer innehaollande denna sekvens, insulinprekursorer och foerfarande foer framstaellning av dessa samt foerfarande foer framstaellning av humaninsulin |
| DE8585303775T DE3583824D1 (de) | 1984-05-30 | 1985-05-29 | Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins. |
| AT90121887T ATE143374T1 (de) | 1984-05-30 | 1985-05-29 | Insulin-vorläufer |
| IE133185A IE66387B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors process for their preparation and process for preparing human insulin from such insulin precursors |
| DK238585A DK157938C (da) | 1984-05-30 | 1985-05-29 | Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin |
| IE950351A IE80630B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors |
| JP60116297A JPH0630613B2 (ja) | 1984-05-30 | 1985-05-29 | インシュリンの製造方法 |
| PT80551A PT80551B (en) | 1984-05-30 | 1985-05-29 | Process for the preparation of insulin precursors useful for preparing human insulin |
| US06/739,123 US4916212A (en) | 1984-05-30 | 1985-05-29 | DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin |
| ES543594A ES8609483A1 (es) | 1984-05-30 | 1985-05-29 | Un procedimiento para producir un precursor de insulina |
| EP85303775A EP0163529B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors |
| DE3588125T DE3588125T2 (de) | 1984-05-30 | 1985-05-29 | Insulin-Vorläufer |
| AU43092/85A AU590197B2 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors |
| NO852132A NO174351C (no) | 1984-05-30 | 1985-05-29 | Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten |
| NZ212243A NZ212243A (en) | 1984-05-30 | 1985-05-29 | Yeast strains expressing modified recombinant insulin |
| AT85303775T ATE66490T1 (de) | 1984-05-30 | 1985-05-29 | Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins. |
| ES551941A ES8702488A1 (es) | 1984-05-30 | 1986-02-13 | Un procedimiento para preparar un precursor de insulina |
| DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
| JP5121694A JPH0746998B2 (ja) | 1984-05-30 | 1993-05-24 | インシュリン前駆体の製造方法 |
| JP5121649A JPH07121226B2 (ja) | 1984-05-30 | 1993-05-24 | インシュリン前駆体をコードするdna |
| JP7142085A JP2519023B2 (ja) | 1984-05-30 | 1995-06-08 | インシュリン前駆体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK266584A DK266584D0 (da) | 1984-05-30 | 1984-05-30 | Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren |
| DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK58285D0 true DK58285D0 (da) | 1985-02-08 |
Family
ID=26064247
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
| DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4916212A (da) |
| EP (2) | EP0163529B1 (da) |
| JP (4) | JPH0630613B2 (da) |
| AT (1) | ATE143374T1 (da) |
| AU (1) | AU590197B2 (da) |
| CA (1) | CA1304022C (da) |
| DE (2) | DE3583824D1 (da) |
| DK (2) | DK58285D0 (da) |
| ES (2) | ES8609483A1 (da) |
| FI (1) | FI89183C (da) |
| GR (1) | GR851304B (da) |
| IE (1) | IE66387B1 (da) |
| NO (1) | NO174351C (da) |
| NZ (1) | NZ212243A (da) |
| PT (1) | PT80551B (da) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
| DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
| DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
| DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
| ATE101620T1 (de) * | 1988-06-23 | 1994-03-15 | Hoechst Ag | Mini-proinsulin, seine herstellung und verwendung. |
| US6875589B1 (en) | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| AU9172991A (en) | 1990-12-07 | 1992-07-08 | Cnc Development, Inc. | Catalytic chemical reactor |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| CA2089541A1 (en) | 1992-02-18 | 1993-08-19 | Bruce H. Frank | Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 |
| US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
| WO1996029397A1 (en) | 1995-03-17 | 1996-09-26 | Novo Nordisk A/S | Novel endoglucanases |
| IL118127A0 (en) * | 1995-05-05 | 1996-09-12 | Lilly Co Eli | Single chain insulin with high bioactivity |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| US5840542A (en) * | 1995-07-28 | 1998-11-24 | Mogam Biotechnology Research Institute | Method for manufacture of proinsulin with high export yield |
| CZ297338B6 (cs) | 1996-03-01 | 2006-11-15 | Novo Nordisk A/S | Peptid potlacující chut k jídlu, farmaceutický prostredek jej obsahující a jeho pouzití |
| DK1066328T3 (da) * | 1998-03-31 | 2009-02-09 | Tonghua Gantech Biotechnology | Kimært protein, der indeholder en intramolekylær chaperon-lignende sekvens, og dets anvendelse til insulinproduktion |
| CN1125081C (zh) | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
| WO2001046453A1 (en) | 1999-12-22 | 2001-06-28 | Novo Nordisk A/S | Method for extractive refolding of scrambled single-chain polypeptides |
| US6521738B2 (en) | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| US7378390B2 (en) | 1999-12-29 | 2008-05-27 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| KR20030004315A (ko) | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 효모에서 개선된 발효 수율을 갖는 인슐린 선구물질 및인슐린 선구물질 유사체의 제조 방법 |
| HUP0203475A3 (en) * | 1999-12-29 | 2005-11-28 | Novo Nordisk As | Method for making insulin precursors and insulin precursor analogs |
| US6777207B2 (en) | 1999-12-29 | 2004-08-17 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| JP2003528149A (ja) | 2000-03-24 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 軟骨性疾患の治療のためのインスリンの使用 |
| US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2003530838A (ja) * | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
| KR100449454B1 (ko) * | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| US20020164712A1 (en) * | 2000-12-11 | 2002-11-07 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence |
| CZ20032454A3 (en) | 2001-03-22 | 2004-03-17 | Novo Nordisk Health Care Ag | Coagulation factor vii derivative |
| US7105314B2 (en) | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
| WO2002079250A1 (en) * | 2001-04-02 | 2002-10-10 | Novo Nordisk A/S | Insulin precursors and a process for their preparation |
| CA2446739A1 (en) * | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Chemokine beta-1 fusion proteins |
| ES2376694T3 (es) | 2001-09-27 | 2012-03-16 | Novo Nordisk Health Care Ag | Polipã‰ptidos del factor vii de coagulaciã“n humano. |
| AU2002364587A1 (en) * | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
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| EP1604008B1 (en) | 2002-09-13 | 2010-12-22 | Cornell Research Foundation, Inc. | Using mutations to improve aspergillus phytases |
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-
1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
-
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
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1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
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1993
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
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1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related
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