DK58285D0 - Peptider samt fremstilling og anvendelse deraf - Google Patents
Peptider samt fremstilling og anvendelse derafInfo
- Publication number
- DK58285D0 DK58285D0 DK58285A DK58285A DK58285D0 DK 58285 D0 DK58285 D0 DK 58285D0 DK 58285 A DK58285 A DK 58285A DK 58285 A DK58285 A DK 58285A DK 58285 D0 DK58285 D0 DK 58285D0
- Authority
- DK
- Denmark
- Prior art keywords
- chain
- human insulin
- bridging
- insulin
- lys
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 3
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
| GR851304A GR851304B (da) | 1984-05-30 | 1985-05-28 | |
| EP85303775A EP0163529B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors |
| DE8585303775T DE3583824D1 (de) | 1984-05-30 | 1985-05-29 | Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins. |
| DE3588125T DE3588125T2 (de) | 1984-05-30 | 1985-05-29 | Insulin-Vorläufer |
| PT80551A PT80551B (en) | 1984-05-30 | 1985-05-29 | Process for the preparation of insulin precursors useful for preparing human insulin |
| AU43092/85A AU590197B2 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors |
| EP90121887A EP0427296B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors |
| FI852135A FI89183C (fi) | 1984-05-30 | 1985-05-29 | Dna-sekvens som kodar foer insulinprekursorer, vektorer innehaollande denna sekvens, insulinprekursorer och foerfarande foer framstaellning av dessa samt foerfarande foer framstaellning av humaninsulin |
| CA000482722A CA1304022C (en) | 1984-05-30 | 1985-05-29 | Insulin precursors, process for their preparation and process for preparing human insulin from such insulin precursors |
| US06/739,123 US4916212A (en) | 1984-05-30 | 1985-05-29 | DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin |
| IE133185A IE66387B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors process for their preparation and process for preparing human insulin from such insulin precursors |
| DK238585A DK157938C (da) | 1984-05-30 | 1985-05-29 | Dna-sekvens for insulinprecursorer, vektorer indeholdende denne sekvens, gaerstammer transformeret med disse vektorer samt en fremgangsmaade til fremstilling af insulinprecursorerne og en fremgangsmaade til fremstilling af humaninsulin |
| AT90121887T ATE143374T1 (de) | 1984-05-30 | 1985-05-29 | Insulin-vorläufer |
| NZ212243A NZ212243A (en) | 1984-05-30 | 1985-05-29 | Yeast strains expressing modified recombinant insulin |
| NO852132A NO174351C (no) | 1984-05-30 | 1985-05-29 | Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten |
| IE950351A IE80630B1 (en) | 1984-05-30 | 1985-05-29 | Insulin precursors |
| JP60116297A JPH0630613B2 (ja) | 1984-05-30 | 1985-05-29 | インシュリンの製造方法 |
| AT85303775T ATE66490T1 (de) | 1984-05-30 | 1985-05-29 | Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins. |
| ES543594A ES8609483A1 (es) | 1984-05-30 | 1985-05-29 | Un procedimiento para producir un precursor de insulina |
| ES551941A ES8702488A1 (es) | 1984-05-30 | 1986-02-13 | Un procedimiento para preparar un precursor de insulina |
| DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
| JP5121694A JPH0746998B2 (ja) | 1984-05-30 | 1993-05-24 | インシュリン前駆体の製造方法 |
| JP5121649A JPH07121226B2 (ja) | 1984-05-30 | 1993-05-24 | インシュリン前駆体をコードするdna |
| JP7142085A JP2519023B2 (ja) | 1984-05-30 | 1995-06-08 | インシュリン前駆体 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK266584A DK266584D0 (da) | 1984-05-30 | 1984-05-30 | Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren |
| DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK58285D0 true DK58285D0 (da) | 1985-02-08 |
Family
ID=26064247
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
| DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4916212A (da) |
| EP (2) | EP0427296B1 (da) |
| JP (4) | JPH0630613B2 (da) |
| AT (1) | ATE143374T1 (da) |
| AU (1) | AU590197B2 (da) |
| CA (1) | CA1304022C (da) |
| DE (2) | DE3583824D1 (da) |
| DK (2) | DK58285D0 (da) |
| ES (2) | ES8609483A1 (da) |
| FI (1) | FI89183C (da) |
| GR (1) | GR851304B (da) |
| IE (1) | IE66387B1 (da) |
| NO (1) | NO174351C (da) |
| NZ (1) | NZ212243A (da) |
| PT (1) | PT80551B (da) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
| DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
| DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
| DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
| US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| DE58906966D1 (de) * | 1988-06-23 | 1994-03-24 | Hoechst Ag | Mini-Proinsulin, seine Herstellung und Verwendung. |
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| AU9172991A (en) | 1990-12-07 | 1992-07-08 | Cnc Development, Inc. | Catalytic chemical reactor |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| CA2089541A1 (en) | 1992-02-18 | 1993-08-19 | Bruce H. Frank | Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 |
| US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
| CN101955921A (zh) | 1995-03-17 | 2011-01-26 | 诺沃奇梅兹有限公司 | 新的内切葡聚糖酶 |
| EP0741188A3 (en) * | 1995-05-05 | 1999-07-14 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| US5840542A (en) * | 1995-07-28 | 1998-11-24 | Mogam Biotechnology Research Institute | Method for manufacture of proinsulin with high export yield |
| ES2306685T3 (es) | 1996-03-01 | 2008-11-16 | Novo Nordisk A/S | Peptido supresor del apetito, su composicion y uso. |
| EP1066328B1 (en) * | 1998-03-31 | 2008-09-17 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production |
| CN1125081C (zh) | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
| WO2001046453A1 (en) | 1999-12-22 | 2001-06-28 | Novo Nordisk A/S | Method for extractive refolding of scrambled single-chain polypeptides |
| US6521738B2 (en) | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| US7378390B2 (en) * | 1999-12-29 | 2008-05-27 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| US6777207B2 (en) | 1999-12-29 | 2004-08-17 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| HUP0203475A3 (en) * | 1999-12-29 | 2005-11-28 | Novo Nordisk As | Method for making insulin precursors and insulin precursor analogs |
| BR0016860A (pt) | 1999-12-29 | 2002-10-01 | Novo Nordisk As | Precursor da insulina ou análogo de precursor de insulina, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, e, processos para fabricar um precursor da insulina ou análogo de precursor de insulina, e, insulina ou um análogo de insulina |
| WO2001072323A2 (en) | 2000-03-24 | 2001-10-04 | Genentech, Inc. | Use of insulin for the treatment of cartilagenous disorders |
| US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1278767A4 (en) | 2000-04-12 | 2003-11-12 | Principia Pharmaceutical Corp | ALBUMIN FUSED PROTEINS |
| AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
| KR100449454B1 (ko) * | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| US20020164712A1 (en) * | 2000-12-11 | 2002-11-07 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence |
| IL157842A0 (en) | 2001-03-22 | 2004-03-28 | Novo Nordisk Healthcare Ag | Coagulation factor vii derivatives |
| ES2333942T3 (es) * | 2001-04-02 | 2010-03-03 | Novo Nordisk A/S | Precursores de insulina y proceso para su preparacion. |
| US7105314B2 (en) * | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
| CA2446739A1 (en) * | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Chemokine beta-1 fusion proteins |
| CZ2004427A3 (cs) | 2001-09-27 | 2004-08-18 | Novoánordiskáhealthácareáag | Polypeptidy lidského koagulačního faktoru VII |
| EP2277889B1 (en) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusion proteins of albumin and interferon beta |
| AU2002364587A1 (en) * | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ATE492631T1 (de) | 2002-09-13 | 2011-01-15 | Cornell Res Foundation Inc | Verwendung von mutationen zur verbesserung von aspergillus-phytasen |
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| US4440859A (en) * | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
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| DK172738B1 (da) * | 1983-04-07 | 1999-06-21 | Chiron Corp | Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden |
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| UA41863C2 (uk) * | 1985-10-25 | 2001-10-15 | Займодженетікс Інк. | Спосіб одержання гетерологічного поліпептиду в еукаріотичних мікроорганізмах |
-
1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
-
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
-
1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
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1993
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
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1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related
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