FI852135L - Insulinprekursoser, foerfarande foer framstaellning daerav och foerfarande foer framstaellning av humaninsulin fraon dessa prekursorer. - Google Patents
Insulinprekursoser, foerfarande foer framstaellning daerav och foerfarande foer framstaellning av humaninsulin fraon dessa prekursorer.Info
- Publication number
- FI852135L FI852135L FI852135A FI852135A FI852135L FI 852135 L FI852135 L FI 852135L FI 852135 A FI852135 A FI 852135A FI 852135 A FI852135 A FI 852135A FI 852135 L FI852135 L FI 852135L
- Authority
- FI
- Finland
- Prior art keywords
- chain
- foerfarande foer
- foer framstaellning
- prekursorer
- insulinprekursoser
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK266584A DK266584D0 (da) | 1984-05-30 | 1984-05-30 | Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren |
DK266584 | 1984-05-30 | ||
DK58285 | 1985-02-08 | ||
DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
Publications (4)
Publication Number | Publication Date |
---|---|
FI852135A0 FI852135A0 (fi) | 1985-05-29 |
FI852135L true FI852135L (fi) | 1985-12-01 |
FI89183B FI89183B (fi) | 1993-05-14 |
FI89183C FI89183C (fi) | 1993-08-25 |
Family
ID=26064247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI852135A FI89183C (fi) | 1984-05-30 | 1985-05-29 | Dna-sekvens som kodar foer insulinprekursorer, vektorer innehaollande denna sekvens, insulinprekursorer och foerfarande foer framstaellning av dessa samt foerfarande foer framstaellning av humaninsulin |
Country Status (15)
Country | Link |
---|---|
US (1) | US4916212A (fi) |
EP (2) | EP0163529B1 (fi) |
JP (4) | JPH0630613B2 (fi) |
AT (1) | ATE143374T1 (fi) |
AU (1) | AU590197B2 (fi) |
CA (1) | CA1304022C (fi) |
DE (2) | DE3588125T2 (fi) |
DK (2) | DK58285D0 (fi) |
ES (2) | ES8609483A1 (fi) |
FI (1) | FI89183C (fi) |
GR (1) | GR851304B (fi) |
IE (1) | IE66387B1 (fi) |
NO (1) | NO174351C (fi) |
NZ (1) | NZ212243A (fi) |
PT (1) | PT80551B (fi) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
DE58906966D1 (de) * | 1988-06-23 | 1994-03-24 | Hoechst Ag | Mini-Proinsulin, seine Herstellung und Verwendung. |
US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
WO1992010284A2 (en) | 1990-12-07 | 1992-06-25 | Cnc Development, Inc. | Catalytic chemical reactor |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
CA2089541A1 (en) | 1992-02-18 | 1993-08-19 | Bruce H. Frank | Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 |
US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
EP1683860B1 (en) | 1995-03-17 | 2013-10-23 | Novozymes A/S | Novel endoglucanases |
AU5724996A (en) * | 1995-05-05 | 1996-11-21 | Eli Lilly And Company | Single chain insulin with high bioactivity |
GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
US5840542A (en) * | 1995-07-28 | 1998-11-24 | Mogam Biotechnology Research Institute | Method for manufacture of proinsulin with high export yield |
ATE227737T1 (de) | 1996-03-01 | 2002-11-15 | Novo Nordisk As | Gebrauch einer pharmazeutischen zusammensetzung, enthaltend ein appetitzügelndes peptid |
EP1066328B1 (en) * | 1998-03-31 | 2008-09-17 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production |
US20040010134A1 (en) * | 2000-04-12 | 2004-01-15 | Rosen Craig A. | Albumin fusion proteins |
CN1125081C (zh) | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
WO2001046453A1 (en) | 1999-12-22 | 2001-06-28 | Novo Nordisk A/S | Method for extractive refolding of scrambled single-chain polypeptides |
US6521738B2 (en) | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
US6777207B2 (en) | 1999-12-29 | 2004-08-17 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
KR20030004317A (ko) * | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법 |
US7378390B2 (en) * | 1999-12-29 | 2008-05-27 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
KR20030004315A (ko) | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 효모에서 개선된 발효 수율을 갖는 인슐린 선구물질 및인슐린 선구물질 유사체의 제조 방법 |
US6689747B2 (en) | 2000-03-24 | 2004-02-10 | Genentech, Inc. | Use of insulin for the treatment of cartilagenous disorders |
US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
KR100449454B1 (ko) * | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
US20020164712A1 (en) * | 2000-12-11 | 2002-11-07 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence |
HUP0401124A3 (en) | 2001-03-22 | 2006-01-30 | Novo Nordisk Healthcare Ag | Coagulation factor vii derivatives |
ES2333942T3 (es) * | 2001-04-02 | 2010-03-03 | Novo Nordisk A/S | Precursores de insulina y proceso para su preparacion. |
US7105314B2 (en) * | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
WO2002097038A2 (en) * | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Chemokine beta-1 fusion proteins |
JP4537059B2 (ja) | 2001-09-27 | 2010-09-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト凝固第vii因子ポリペプチド |
WO2003059934A2 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DK1463751T3 (da) * | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Albuminfusionsproteiner. |
AU2003255988A1 (en) * | 2002-09-13 | 2004-04-30 | Edupuganti B. Raju | Yeast protein expression secretion system |
EP1604008B1 (en) | 2002-09-13 | 2010-12-22 | Cornell Research Foundation, Inc. | Using mutations to improve aspergillus phytases |
EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
EP1633876B1 (en) | 2003-06-17 | 2008-08-20 | SemBioSys Genetics Inc. | Methods for the production of insulin in plants |
CN1863908B (zh) | 2003-09-09 | 2010-08-04 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
JP2007532096A (ja) * | 2003-11-14 | 2007-11-15 | ノボ ノルディスク アクティーゼルスカブ | アシル化されたインスリンの製造方法 |
JP5697831B2 (ja) * | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー/エス | 単鎖インシュリン |
WO2006082205A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
EP2256130B1 (en) | 2005-02-02 | 2013-09-25 | Novo Nordisk A/S | Novel insulin derivatives |
BRPI0609079A2 (pt) | 2005-04-18 | 2010-11-16 | Novo Nordisk As | peptìdeo, composição farmacêutica, método para o tratamento de cáncer, uso de um peptìdeo construto de ácido nucleico, vetor, hospedeiro, e, anticorpo |
JP5366546B2 (ja) | 2005-08-16 | 2013-12-11 | ノボ・ノルデイスク・エー/エス | 成熟インスリンポリペプチドの作製方法 |
WO2007031559A2 (en) | 2005-09-14 | 2007-03-22 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
EP1996709A2 (en) * | 2006-03-13 | 2008-12-03 | Novo Nordisk A/S | Acylated single chain insulin |
PL2074141T3 (pl) | 2006-09-22 | 2017-02-28 | Novo Nordisk A/S | Analogi insuliny oporne na proteazę |
ES2464282T3 (es) | 2006-09-27 | 2014-06-02 | Novo Nordisk A/S | Método para preparar polipéptidos de insulina madura |
ES2425413T3 (es) | 2006-11-22 | 2013-10-15 | Novo Nordisk A/S | Método para preparar carboxipeptidasa activada |
US10100098B2 (en) | 2006-12-13 | 2018-10-16 | Stelis Biopharma Private Limited | Insulin production methods and proinsulin constructs |
US7790677B2 (en) * | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
US8575096B2 (en) | 2007-08-13 | 2013-11-05 | Novo Nordisk A/S | Rapid acting insulin analogues |
EP2708554A1 (en) | 2007-08-15 | 2014-03-19 | Novo Nordisk A/S | Insulin analogues with an acyl and alkylene glycol moiety |
JP5721432B2 (ja) | 2007-08-15 | 2015-05-20 | ノボ・ノルデイスク・エー/エス | アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン |
JP4314332B1 (ja) * | 2008-02-12 | 2009-08-12 | Ils株式会社 | 高発現分泌インスリン前駆体を含む融合タンパク質、それをコードするdnaおよびインスリンの製造方法 |
JP5818681B2 (ja) | 2008-04-01 | 2015-11-18 | ノボ・ノルデイスク・エー/エス | インスリンアルブミンコンジュゲート |
EP2406282A1 (en) | 2009-03-11 | 2012-01-18 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
PL2612677T3 (pl) | 2009-06-26 | 2015-10-30 | Novo Nordisk As | Preparat zawierający insulinę, nikotynamid i argininę |
WO2011006982A2 (en) | 2009-07-17 | 2011-01-20 | Rigshospitalet | Inhibitors of complement activation |
ES2583259T3 (es) | 2009-12-01 | 2016-09-20 | Novo Nordisk A/S | Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina |
CA2791841C (en) | 2010-03-05 | 2023-01-03 | Rigshospitalet | Chimeric inhibitor molecules of complement activation |
JP5973427B2 (ja) * | 2010-06-23 | 2016-08-23 | ノヴォ ノルディスク アー/エス | 追加のジスルフィド結合を含有するインスリン類似体 |
WO2011161083A1 (en) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
CA2802510A1 (en) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin derivatives containing additional disulfide bonds |
CN103249427A (zh) | 2010-12-14 | 2013-08-14 | 诺沃—诺迪斯克有限公司 | 速效胰岛素联合长效胰岛素 |
AU2011343360A1 (en) | 2010-12-14 | 2013-06-06 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and an amino acid |
JP2014509603A (ja) | 2011-03-15 | 2014-04-21 | ノヴォ ノルディスク アー/エス | システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体 |
CN102675452B (zh) | 2011-03-17 | 2015-09-16 | 重庆富进生物医药有限公司 | 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物 |
CN103596584B (zh) | 2011-06-15 | 2016-12-14 | 诺沃—诺迪斯克有限公司 | 多取代的胰岛素 |
CN104136041B (zh) | 2012-02-09 | 2021-06-29 | Var2制药有限公司 | 靶向硫酸软骨素聚糖 |
WO2013186138A1 (en) | 2012-06-14 | 2013-12-19 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and arginine |
WO2014060401A1 (en) | 2012-10-15 | 2014-04-24 | Novo Nordisk Health Care Ag | Coagulation factor vii polypeptides |
JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | O−グリコシル化カルボキシ末端部分(ctp)ペプチド系のインスリンおよびインスリン類似体 |
WO2014093696A2 (en) | 2012-12-12 | 2014-06-19 | Massachusetts Institute Of Technology | Insulin derivatives for diabetes treatment |
WO2014195452A1 (en) | 2013-06-07 | 2014-12-11 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
PL233560B1 (pl) | 2014-12-05 | 2019-10-31 | Mabion Spolka Akcyjna | Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka |
EA037848B1 (ru) | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
AU2017322552B2 (en) | 2016-09-06 | 2021-12-02 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | Proinsulin derivatives |
AU2018317810A1 (en) | 2017-08-17 | 2020-03-19 | Novo Nordisk A/S | Novel acylated insulin analogues and uses thereof |
CN112789504A (zh) | 2018-07-13 | 2021-05-11 | 瓦克特诊断有限责任公司 | 使用重组疟疾蛋白var2csa分离胎儿来源的循环细胞 |
WO2020051812A1 (zh) | 2018-09-12 | 2020-03-19 | 美药星(南京)制药有限公司 | 一种新型门冬胰岛素原的结构和制备门冬胰岛素的方法 |
JP2023510218A (ja) | 2019-12-30 | 2023-03-13 | ガン アンド リー ファーマスゥーティカルズ カンパニー リミテッド | 長時間作用型glp-1化合物 |
KR20220119730A (ko) | 2019-12-30 | 2022-08-30 | 간 앤 리 파마슈티칼스 컴퍼니, 리미티드 | 인슐린 유도체 |
WO2022049409A1 (en) | 2020-09-02 | 2022-03-10 | Sia Terragen | Express diagnosticum for sars-cov-2 |
WO2023144240A1 (en) | 2022-01-26 | 2023-08-03 | Novo Nordisk Research Centre Oxford Limited | Glucose sensitive insulin derivatives and uses thereof |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4440859A (en) * | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
US4411994A (en) * | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
US4431740A (en) * | 1979-09-12 | 1984-02-14 | The Regents Of The University Of California | DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes |
IE50892B1 (en) * | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
CA1202581A (en) * | 1980-03-27 | 1986-04-01 | Saran A. Narang | Adaptor molecules for dna and their application to synthesis of gene-derived products |
RO81951B (ro) * | 1980-03-27 | 1984-02-28 | Eli Lilly And Company | Procedeu de preparare a unui precursor de insulina |
ZA811895B (en) * | 1980-04-07 | 1982-04-28 | Univ California | Expression of hormone genomic clones |
JPS5750948A (en) * | 1980-09-12 | 1982-03-25 | Shionogi & Co Ltd | Insulin analog and preparation |
NZ199391A (en) * | 1981-01-02 | 1985-12-13 | Genentech Inc | Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin |
NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
IE52768B1 (en) * | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
CA1204682A (en) * | 1981-06-19 | 1986-05-20 | Saran A. Narang | Adaptors, and synthesis and cloning of proinsulin genes |
ZA824218B (en) * | 1981-06-29 | 1983-04-27 | Cetus Corp | Plasmid for producing human insulin |
IE54046B1 (en) * | 1981-08-25 | 1989-05-24 | Celltech Ltd | Expression vectors |
AU1559483A (en) * | 1982-03-31 | 1983-10-24 | Genetics Institute Inc. | Creation of dna sequences encoding modified proinsulin precursors |
WO1983003413A1 (en) * | 1982-03-31 | 1983-10-13 | Genetics Inst | Creation of dna sequences encoding modified proinsulin precursors |
DK172738B1 (da) * | 1983-04-07 | 1999-06-21 | Chiron Corp | Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
WO1987002670A1 (en) * | 1985-10-25 | 1987-05-07 | Mackay Vivian L | Method of using bar1 for secreting foreign proteins |
-
1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
-
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
-
1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
-
1993
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related
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