IE52768B1 - 1-arylcyclobutylalkylamine compounds useful as therapeutic agents - Google Patents

1-arylcyclobutylalkylamine compounds useful as therapeutic agents

Info

Publication number
IE52768B1
IE52768B1 IE481/82A IE48182A IE52768B1 IE 52768 B1 IE52768 B1 IE 52768B1 IE 481/82 A IE481/82 A IE 481/82A IE 48182 A IE48182 A IE 48182A IE 52768 B1 IE52768 B1 IE 52768B1
Authority
IE
Ireland
Prior art keywords
arylcyclobutylalkylamine
therapeutic agents
compounds useful
compounds
useful
Prior art date
Application number
IE481/82A
Other versions
IE820481L (en
Original Assignee
Boots Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to GB8110710 priority Critical
Priority to GB8110709 priority
Application filed by Boots Co Ltd filed Critical Boots Co Ltd
Publication of IE820481L publication Critical patent/IE820481L/en
Publication of IE52768B1 publication Critical patent/IE52768B1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26279045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE52768(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/50Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/237Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/40Unsaturated compounds containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
IE481/82A 1981-04-06 1982-03-03 1-arylcyclobutylalkylamine compounds useful as therapeutic agents IE52768B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB8110710 1981-04-06
GB8110709 1981-04-06

Publications (2)

Publication Number Publication Date
IE820481L IE820481L (en) 1982-10-06
IE52768B1 true IE52768B1 (en) 1988-02-17

Family

ID=26279045

Family Applications (1)

Application Number Title Priority Date Filing Date
IE481/82A IE52768B1 (en) 1981-04-06 1982-03-03 1-arylcyclobutylalkylamine compounds useful as therapeutic agents

Country Status (38)

Country Link
KR (1) KR900000274B1 (en)
AT (1) AT382612B (en)
AU (1) AU545595B2 (en)
BG (2) BG40652A3 (en)
CA (1) CA1248955A (en)
CH (1) CH652117A5 (en)
CS (1) CS244672B2 (en)
CY (1) CY1408A (en)
DD (1) DD208348A5 (en)
DE (1) DE3212682C2 (en)
DK (1) DK161770C (en)
ES (5) ES511152A0 (en)
FI (1) FI77223C (en)
FR (1) FR2504920B1 (en)
GB (1) GB2098602B (en)
GR (1) GR76697B (en)
HK (1) HK13888A (en)
HU (1) HU186582B (en)
IE (1) IE52768B1 (en)
IL (1) IL65257D0 (en)
IN (1) IN155773B (en)
IT (1) IT1235758B (en)
JO (1) JO1184B1 (en)
KE (1) KE3753A (en)
LU (1) LU84070A1 (en)
MY (1) MY8800048A (en)
NL (1) NL192201C (en)
NO (1) NO156785C (en)
NZ (1) NZ200178A (en)
PH (1) PH22762A (en)
PL (2) PL136242B1 (en)
PT (1) PT74580B (en)
RO (2) RO84802B (en)
SE (1) SE452611B (en)
SG (1) SG67287G (en)
SU (2) SU1482522A3 (en)
YU (2) YU44336B (en)
ZW (1) ZW4982A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56000B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylalkylamine compounds
IE56001B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylmethylamine compounds
GB8412480D0 (en) * 1984-05-16 1984-06-20 Elliott M Pesticides
DK58285D0 (en) * 1984-05-30 1985-02-08 Novo Industri As Peptides and manufacturing and using thereof
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
DK119785D0 (en) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
GB2184122B (en) * 1985-12-17 1989-10-18 Boots Co Plc N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (en) * 1988-03-31 1997-11-12 科研製薬株式会社 Brain function improver
AU4542893A (en) * 1992-06-23 1994-01-24 Sepracor, Inc. Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
GB9309749D0 (en) * 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
DE19518988A1 (en) * 1995-05-29 1996-12-05 Basf Ag Use of aryl substituted cyclobutylalkylamines to treat obesity
GB9524681D0 (en) 1995-12-02 1996-01-31 Knoll Ag Chemical process
GB9619757D0 (en) 1996-09-21 1996-11-06 Knoll Ag Chemical process
GB9619962D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9619961D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9727131D0 (en) 1997-12-24 1998-02-25 Knoll Ag Therapeutic agents
US6399826B1 (en) * 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
US6331571B1 (en) * 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
AU2007200334B8 (en) * 1998-08-24 2010-10-21 Sepracor, Inc. Methods of using and compositions comprising dopamine reuptake inhibitors
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
BG65170B1 (en) * 1999-03-17 2007-05-31 Knoll Gmbh Use of n-substituted derivatives of 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine for the production of a medicine for treating eating disorders
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
GB9915617D0 (en) 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
AU1081602A (en) * 2000-11-02 2002-05-15 Not Given Process for preparation of beta-phenethylamine derivative
WO2002083631A1 (en) 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
KR100536750B1 (en) * 2002-10-05 2005-12-16 한미약품 주식회사 Pharmaceutical composition comprising crystalline hemihydrate of sibutramine methanesulfonate
FR2870537A1 (en) * 2004-05-19 2005-11-25 Servier Lab Novel process for synthesizing (1s) -4,5-dimethoxy-1- (methyl aminomethyl) benzocyclobutane and its addition salts and application to the synthesis of ivabradine and its addition salts pharmaceutically acceptable acid
KR100606533B1 (en) 2004-08-27 2006-08-01 한올제약주식회사 An improved synthetic method of sibutramine
KR100606534B1 (en) 2004-11-01 2006-08-01 한올제약주식회사 An improved synthetic method of sibutramine
KR100618176B1 (en) * 2004-12-02 2006-09-01 휴먼팜 주식회사 Sibutramine tartrate, its preparation process and phamaceutical composition comprising it
JP2008526836A (en) 2005-01-06 2008-07-24 シージェー チェイルジェダン コーポレーション Sibutramine inorganic acid salt
EP2066329B1 (en) 2006-09-15 2017-09-06 Reviva Pharmaceuticals, Inc. Synthesis, methods of using, and compositions of cyclobutylmethylamines
CN101555214B (en) * 2008-04-08 2012-07-11 北京嘉事联博医药科技有限公司 Phenylcyclobutylacylamide derivative as well as optical isomer, preparation method and application thereof
FR2935381B1 (en) * 2008-08-29 2010-12-17 Servier Lab Novel method for the resolution of enantiomeres of (3,4-dimethoxy-bicycloo-4.2.0-octa-1,3,5-trien-7-yl) nitrile and application to the synthesis of ivabradine
WO2010082216A2 (en) * 2008-12-08 2010-07-22 Matrix Laboratories Ltd Novel salts of sibutramine and their crystal forms
AP3099A (en) 2009-11-02 2015-01-31 Pfizer Dioxa-bicyclo[3.2.1]octane-2,3,4-triol de derivatives
WO2012003501A2 (en) 2010-07-02 2012-01-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
AU2012362105B2 (en) * 2011-12-30 2017-09-07 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
FR2993561B1 (en) * 2012-07-17 2014-10-31 Servier Lab Process for enzymatic synthesis of (7s) -1- (3,4-dimethoxy bicyclo [4.2.0] octa-1,3,5-triene 7-yl) n-methyl methanamine, and application to the synthesis of the ivabradine and its salts

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1124485B (en) * 1960-02-12 1962-03-01 Hoechst Ag A process for preparing analeptisch effective Phenylcycloalkylmethylaminen
US3526656A (en) * 1967-05-25 1970-09-01 Parke Davis & Co (1-arylcyclobutyl)carbonyl carbamic acid derivatives

Also Published As

Publication number Publication date
DD208348A5 (en) 1984-05-02
ES8403097A1 (en) 1984-03-01
SE8202166L (en) 1982-11-25
CA1248955A (en) 1989-01-17
IT1235758B (en) 1992-09-28
ES511152D0 (en)
FI77223B (en) 1988-10-31
DK161770C (en) 1992-02-10
ES519031D0 (en)
ES519031A0 (en) 1984-08-16
IE820481L (en) 1982-10-06
NO156785B (en) 1987-08-17
BG40651A3 (en) 1986-01-15
ES8407002A1 (en) 1984-08-16
FI77223C (en) 1989-02-10
YU44253B (en) 1990-04-30
YU75082A (en) 1985-08-31
ES8406414A1 (en) 1984-08-01
IL65257D0 (en) 1983-12-30
NL192201B (en) 1996-11-01
IT8248157D0 (en) 1982-04-02
NZ200178A (en) 1985-07-31
ES8305678A1 (en) 1983-04-16
SU1482522A3 (en) 1989-05-23
ES519030D0 (en)
SE452611B (en) 1987-12-07
SG67287G (en) 1988-02-19
SU1461372A3 (en) 1989-02-23
ES519030A0 (en) 1984-08-01
PL235832A1 (en) 1983-09-12
FI821197A0 (en) 1982-04-05
FI821197D0 (en)
HU186582B (en) 1985-08-28
CH652117A5 (en) 1985-10-31
PL136242B1 (en) 1986-02-28
ES519029D0 (en)
AU545595B2 (en) 1985-07-18
ES511152A0 (en) 1983-04-16
NL192201C (en) 1997-03-04
ATA132582A (en) 1986-08-15
YU6385A (en) 1985-08-31
DK146482A (en) 1982-10-07
ES519029A0 (en) 1984-08-01
GB2098602A (en) 1982-11-24
ES519032A0 (en) 1984-03-01
DE3212682A1 (en) 1982-10-21
BG40652A3 (en) 1986-01-15
AT382612B (en) 1987-03-25
PT74580B (en) 1983-12-23
RO89436A2 (en) 1986-06-30
RO84802A (en) 1984-09-29
CA1248955A1 (en)
PT74580A (en) 1982-04-01
FR2504920A1 (en) 1982-11-05
ES8406413A1 (en) 1984-08-01
FI821197L (en) 1982-10-07
PH22762A (en) 1988-12-12
ZW4982A1 (en) 1982-11-03
LU84070A1 (en) 1983-06-07
PL139120B1 (en) 1986-12-31
IN155773B (en) 1985-03-09
NO156785C (en) 1987-11-25
HK13888A (en) 1988-02-26
CY1408A (en) 1988-04-22
NO821087L (en) 1982-10-07
KE3753A (en) 1987-10-02
ES519032D0 (en)
NL8201347A (en) 1982-11-01
YU44336B (en) 1990-06-30
FR2504920B1 (en) 1985-06-28
GB2098602B (en) 1984-08-22
DK161770B (en) 1991-08-12
DE3212682C2 (en) 1992-03-26
FI821197A (en)
KR900000274B1 (en) 1990-01-24
CS244672B2 (en) 1986-08-14
CS245782A2 (en) 1985-08-15
MY8800048A (en) 1988-12-31
JO1184B1 (en) 1983-11-30
AU8221382A (en) 1982-10-14
KR830010065A (en) 1983-12-26
PL240079A1 (en) 1983-09-12
GR76697B (en) 1984-08-28
RO84802B (en) 1984-10-30

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