JO1184B1 - Thearapeutic agents - Google Patents

Thearapeutic agents

Info

Publication number
JO1184B1
JO1184B1 JO19821184A JOP19821184A JO1184B1 JO 1184 B1 JO1184 B1 JO 1184B1 JO 19821184 A JO19821184 A JO 19821184A JO P19821184 A JOP19821184 A JO P19821184A JO 1184 B1 JO1184 B1 JO 1184B1
Authority
JO
Jordan
Prior art keywords
alkyl
6alkenyl
formula
thearapeutic
agents
Prior art date
Application number
JO19821184A
Other languages
Arabic (ar)
Inventor
ادوارد جيفري جيمس
كوزليك انتونين
تشارلز ويلمهيرست ايريك
Original Assignee
ذي بوتس كومباني ليمتد
ادوارد جيفري جيمس
كوزليك انتونين
تشارلز ويلمهيرست ايريك
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26279045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO1184(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ذي بوتس كومباني ليمتد, ادوارد جيفري جيمس, كوزليك انتونين, تشارلز ويلمهيرست ايريك filed Critical ذي بوتس كومباني ليمتد
Application granted granted Critical
Publication of JO1184B1 publication Critical patent/JO1184B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/227—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen
    • C07C49/237—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

Compounds of formula I In which n=O, R1 is C1-6 alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-‎‎6cycloalkylalkyl or optionally substituted phenyl when n=O or R1 is H or C1-3 ‎alkyl, when n=1.R2 is H or C1-3 alkyl, R3 and or R4 are H, formyl, C1-3 alkyl, ‎C3-6alkenyl , C3-6 alkynyl, C3-7 cycloalkyl or R3 and R4 together with the ‎nitrogen atom form a heterocyclic ring system, R5 and / or R6 are H, halo, CF3, ‎C1-3 alkyl, C1-3alkoxy, C1-3alkylthio or R5 and R6 together with the carbon ‎atoms to which they are attached form a second benzene ring and R7 and / or R8 ‎are H or C1-3 alkyl, show therapeutic activity in the treatment of depression, ‎pharmaceutical compositions and processes for preparing compounds of formula I ‎are dis-closed.’‎
JO19821184A 1981-04-06 1982-04-05 Thearapeutic agents JO1184B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8110710 1981-04-06
GB8110709 1981-04-06

Publications (1)

Publication Number Publication Date
JO1184B1 true JO1184B1 (en) 1983-11-30

Family

ID=26279045

Family Applications (1)

Application Number Title Priority Date Filing Date
JO19821184A JO1184B1 (en) 1981-04-06 1982-04-05 Thearapeutic agents

Country Status (40)

Country Link
KR (1) KR900000274B1 (en)
AT (1) AT382612B (en)
AU (1) AU545595B2 (en)
BG (2) BG40651A3 (en)
CA (1) CA1248955A (en)
CH (1) CH652117A5 (en)
CS (1) CS244672B2 (en)
CY (1) CY1408A (en)
DD (1) DD208348A5 (en)
DE (1) DE3212682A1 (en)
DK (1) DK161770C (en)
ES (5) ES8305678A1 (en)
FI (1) FI77223C (en)
FR (1) FR2504920B1 (en)
GB (1) GB2098602B (en)
GE (1) GEP19970661B (en)
GR (1) GR76697B (en)
HK (1) HK13888A (en)
HU (1) HU186582B (en)
IE (1) IE52768B1 (en)
IL (1) IL65257A0 (en)
IN (1) IN155773B (en)
IT (1) IT1235758B (en)
JO (1) JO1184B1 (en)
KE (1) KE3753A (en)
LU (1) LU84070A1 (en)
MY (1) MY8800048A (en)
NL (1) NL192201C (en)
NO (1) NO156785C (en)
NZ (1) NZ200178A (en)
PH (1) PH22762A (en)
PL (2) PL139120B1 (en)
PT (1) PT74580B (en)
RO (2) RO89436A2 (en)
SE (1) SE452611B (en)
SG (1) SG67287G (en)
SU (2) SU1482522A3 (en)
UA (2) UA7589A1 (en)
YU (2) YU44336B (en)
ZW (1) ZW4982A1 (en)

Families Citing this family (45)

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IE56000B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylalkylamine compounds
GB8412480D0 (en) * 1984-05-16 1984-06-20 Elliott M Pesticides
DK58285D0 (en) * 1984-05-30 1985-02-08 Novo Industri As PEPTIDES AND MANUFACTURING AND USING THEREOF
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
US5157021A (en) * 1985-03-15 1992-10-20 Novo Nordisk A/S Insulin derivatives and pharmaceutical preparations containing these derivatives
DK119785D0 (en) * 1985-03-15 1985-03-15 Nordisk Gentofte INSULIN PREPARATION
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
GB2184122B (en) * 1985-12-17 1989-10-18 Boots Co Plc N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (en) * 1988-03-31 1997-11-12 科研製薬株式会社 Brain function improver
JPH08500093A (en) * 1992-06-23 1996-01-09 セプラコア インコーポレーテッド Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
GB9309749D0 (en) * 1993-05-12 1993-06-23 Boots Co Plc Therapeutic agents
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
DE19518988A1 (en) * 1995-05-29 1996-12-05 Basf Ag Use of aryl substituted cyclobutylalkylamines to treat obesity
GB9524681D0 (en) * 1995-12-02 1996-01-31 Knoll Ag Chemical process
GB9619757D0 (en) 1996-09-21 1996-11-06 Knoll Ag Chemical process
GB9619961D0 (en) 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9619962D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9727131D0 (en) 1997-12-24 1998-02-25 Knoll Ag Therapeutic agents
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
AU2007200334B8 (en) * 1998-08-24 2010-10-21 Sepracor, Inc. Methods of using and compositions comprising dopamine reuptake inhibitors
US6331571B1 (en) * 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
BG65170B1 (en) * 1999-03-17 2007-05-31 Knoll Gmbh Use of n-substituted derivatives of 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine for the production of a medicine for treating eating disorders
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KR100536750B1 (en) * 2002-10-05 2005-12-16 한미약품 주식회사 Pharmaceutical composition comprising crystalline hemihydrate of sibutramine methanesulfonate
FR2870537A1 (en) * 2004-05-19 2005-11-25 Servier Lab NOVEL PROCESS FOR SYNTHESIZING (1S) -4,5-DIMETHOXY-1- (METHYL AMINOMETHYL) BENZOCYCLOBUTANE AND ITS ADDITION SALTS AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS ADDITION SALTS PHARMACEUTICALLY ACCEPTABLE ACID
KR100606533B1 (en) 2004-08-27 2006-08-01 한올제약주식회사 An improved synthetic method of sibutramine
KR100606534B1 (en) 2004-11-01 2006-08-01 한올제약주식회사 An improved synthetic method of sibutramine
KR100618176B1 (en) * 2004-12-02 2006-09-01 휴먼팜 주식회사 Sibutramine tartrate, its preparation process and phamaceutical composition comprising it
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FR2935381B1 (en) * 2008-08-29 2010-12-17 Servier Lab NOVEL METHOD FOR THE RESOLUTION OF ENANTIOMERES OF (3,4-DIMETHOXY-BICYCLOO-4.2.0-OCTA-1,3,5-TRIEN-7-YL) NITRILE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE
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FR2993561B1 (en) * 2012-07-17 2014-10-31 Servier Lab PROCESS FOR ENZYMATIC SYNTHESIS OF (7S) -1- (3,4-DIMETHOXY BICYCLO [4.2.0] OCTA-1,3,5-TRIENE 7-YL) N-METHYL METHANAMINE, AND APPLICATION TO THE SYNTHESIS OF THE IVABRADINE AND ITS SALTS

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US3526656A (en) * 1967-05-25 1970-09-01 Parke Davis & Co (1-arylcyclobutyl)carbonyl carbamic acid derivatives

Also Published As

Publication number Publication date
PH22762A (en) 1988-12-12
LU84070A1 (en) 1983-06-07
RO89436A2 (en) 1986-06-30
DK161770C (en) 1992-02-10
ES519032A0 (en) 1984-03-01
YU6385A (en) 1985-08-31
DK161770B (en) 1991-08-12
NO156785B (en) 1987-08-17
ES511152A0 (en) 1983-04-16
CH652117A5 (en) 1985-10-31
DE3212682C2 (en) 1992-03-26
KE3753A (en) 1987-10-02
ES519029A0 (en) 1984-08-01
FI77223C (en) 1989-02-10
RO84802B (en) 1984-10-30
ES8305678A1 (en) 1983-04-16
YU44253B (en) 1990-04-30
UA7589A1 (en) 1995-09-29
HK13888A (en) 1988-02-26
ES519031A0 (en) 1984-08-16
GR76697B (en) 1984-08-28
IE820481L (en) 1982-10-06
NL192201C (en) 1997-03-04
ES8406413A1 (en) 1984-08-01
AU545595B2 (en) 1985-07-18
YU75082A (en) 1985-08-31
FR2504920A1 (en) 1982-11-05
CA1248955A (en) 1989-01-17
SE452611B (en) 1987-12-07
SG67287G (en) 1988-02-19
NZ200178A (en) 1985-07-31
KR900000274B1 (en) 1990-01-24
HU186582B (en) 1985-08-28
SU1482522A3 (en) 1989-05-23
PT74580A (en) 1982-04-01
BG40652A3 (en) 1986-01-15
ES8406414A1 (en) 1984-08-01
PL136242B1 (en) 1986-02-28
GB2098602A (en) 1982-11-24
AT382612B (en) 1987-03-25
IN155773B (en) 1985-03-09
YU44336B (en) 1990-06-30
IT8248157A0 (en) 1982-04-02
SE8202166L (en) 1982-11-25
ES8403097A1 (en) 1984-03-01
IE52768B1 (en) 1988-02-17
NL192201B (en) 1996-11-01
ES519030A0 (en) 1984-08-01
PL139120B1 (en) 1986-12-31
PT74580B (en) 1983-12-23
FR2504920B1 (en) 1985-06-28
FI77223B (en) 1988-10-31
KR830010065A (en) 1983-12-26
DK146482A (en) 1982-10-07
PL240079A1 (en) 1983-09-12
DD208348A5 (en) 1984-05-02
CY1408A (en) 1988-04-22
ATA132582A (en) 1986-08-15
SU1461372A3 (en) 1989-02-23
ZW4982A1 (en) 1982-11-03
CS245782A2 (en) 1985-08-15
GB2098602B (en) 1984-08-22
UA7838A1 (en) 1995-12-26
NL8201347A (en) 1982-11-01
FI821197A0 (en) 1982-04-05
IL65257A0 (en) 1983-12-30
NO821087L (en) 1982-10-07
CS244672B2 (en) 1986-08-14
RO84802A (en) 1984-09-29
BG40651A3 (en) 1986-01-15
FI821197L (en) 1982-10-07
MY8800048A (en) 1988-12-31
AU8221382A (en) 1982-10-14
DE3212682A1 (en) 1982-10-21
PL235832A1 (en) 1983-09-12
IT1235758B (en) 1992-09-28
NO156785C (en) 1987-11-25
GEP19970661B (en) 1997-01-04
ES8407002A1 (en) 1984-08-16

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