DK129385A - Peptider og fremstilling deraf - Google Patents

Peptider og fremstilling deraf Download PDF

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Publication number
DK129385A
DK129385A DK129385A DK129385A DK129385A DK 129385 A DK129385 A DK 129385A DK 129385 A DK129385 A DK 129385A DK 129385 A DK129385 A DK 129385A DK 129385 A DK129385 A DK 129385A
Authority
DK
Denmark
Prior art keywords
human insulin
precursors
prepared
insulin precursors
peptides
Prior art date
Application number
DK129385A
Other languages
English (en)
Other versions
DK129385D0 (da
Inventor
Lars Thim
Mogens Trier Hansen
Kjeld Norris
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK129385A priority Critical patent/DK129385A/da
Publication of DK129385D0 publication Critical patent/DK129385D0/da
Priority to ZA861953A priority patent/ZA861953B/xx
Priority to DK125786A priority patent/DK158270C/da
Priority to CA000504650A priority patent/CA1340823C/en
Priority to MX1947A priority patent/MX163837B/es
Priority to JP61060995A priority patent/JPH0648993B2/ja
Priority to AT86302133T priority patent/ATE69266T1/de
Priority to DE8686302133T priority patent/DE3682303D1/de
Priority to EP86302133A priority patent/EP0195691B1/en
Priority to NO861120A priority patent/NO172646C/no
Priority to IE73786A priority patent/IE58842B1/en
Priority to GR860764A priority patent/GR860764B/el
Priority to PT82241A priority patent/PT82241B/pt
Priority to FI861198A priority patent/FI87801C/fi
Priority to NZ215570A priority patent/NZ215570A/xx
Priority to ES553231A priority patent/ES8802402A1/es
Priority to AU55005/86A priority patent/AU586855B2/en
Publication of DK129385A publication Critical patent/DK129385A/da
Priority to ES557227A priority patent/ES8708251A1/es
Priority to JP5121394A priority patent/JPH088871B2/ja
Priority to JP7178875A priority patent/JP2553326B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
DK129385A 1985-03-22 1985-03-22 Peptider og fremstilling deraf DK129385A (da)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DK129385A DK129385A (da) 1985-03-22 1985-03-22 Peptider og fremstilling deraf
ZA861953A ZA861953B (en) 1985-03-22 1986-03-17 Insulin precursors,process for their preparation and process for the preparation of human insulin
DK125786A DK158270C (da) 1985-03-22 1986-03-19 Fremgangsmaade til fremstilling af human insulinprecursorer og af human insulin samt dna- sekvenser og plasmider til anvendelse i disse fremgangsmaader
CA000504650A CA1340823C (en) 1985-03-22 1986-03-20 Insulin precursors, process for their preparation and process for the preparation of human insulin
MX1947A MX163837B (es) 1985-03-22 1986-03-20 Procedimiento para la preparacion de insulina humana
JP61060995A JPH0648993B2 (ja) 1985-03-22 1986-03-20 インシュリンの製造方法
AU55005/86A AU586855B2 (en) 1985-03-22 1986-03-21 Insulin precursors, process for their preparation and process for the preparation of human insulin
EP86302133A EP0195691B1 (en) 1985-03-22 1986-03-21 Process for the preparation of insulin precursors and process for the preparation of human insulin
FI861198A FI87801C (fi) 1985-03-22 1986-03-21 Foerfarande foer framstaellning av maenniskoinsulinprekursorer samt i foerfarandet anvaenda dna-sekvensen och plasmider
AT86302133T ATE69266T1 (de) 1985-03-22 1986-03-21 Verfahren zum herstellung von insulin-vorlaeufern und verfahren zur herstellung von humaninsulin.
NO861120A NO172646C (no) 1985-03-22 1986-03-21 Dna-sekvens, repliserbart ekspresjonsplasmid, samt fremstilling av insulin og human-insulin-forloepere
IE73786A IE58842B1 (en) 1985-03-22 1986-03-21 Process for the preparation of insulin precursors and process for the preparation of human insulin
GR860764A GR860764B (en) 1985-03-22 1986-03-21 Insulin precursors process for their preparation and a process for the preparation of human insulin
PT82241A PT82241B (pt) 1985-03-22 1986-03-21 Processo para a preparacao de precursores de insulina e de insulina humana
DE8686302133T DE3682303D1 (de) 1985-03-22 1986-03-21 Verfahren zum herstellung von insulin-vorlaeufern und verfahren zur herstellung von humaninsulin.
NZ215570A NZ215570A (en) 1985-03-22 1986-03-21 Human insulin precursor, its preparation and conversion to insulin
ES553231A ES8802402A1 (es) 1985-03-22 1986-03-21 Un metodo para producir precursores de insulina humana.
ES557227A ES8708251A1 (es) 1985-03-22 1986-11-28 Un metodo de producir insulina humana
JP5121394A JPH088871B2 (ja) 1985-03-22 1993-05-24 インシュリン前駆体をコードするｄｎａ配列
JP7178875A JP2553326B2 (ja) 1985-03-22 1995-07-14 インシュリン前駆体をコードするｄｎａ配列

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK129385A DK129385A (da) 1985-03-22 1985-03-22 Peptider og fremstilling deraf

Publications (2)

Publication Number Publication Date
DK129385D0 DK129385D0 (da) 1985-03-22
DK129385A true DK129385A (da) 1986-09-23

Family

ID=8103207

Family Applications (1)

Application Number Title Priority Date Filing Date
DK129385A DK129385A (da) 1985-03-22 1985-03-22 Peptider og fremstilling deraf

Country Status (16)

Country Link
EP (1) EP0195691B1 (da)
JP (3) JPH0648993B2 (da)
AT (1) ATE69266T1 (da)
AU (1) AU586855B2 (da)
CA (1) CA1340823C (da)
DE (1) DE3682303D1 (da)
DK (1) DK129385A (da)
ES (2) ES8802402A1 (da)
FI (1) FI87801C (da)
GR (1) GR860764B (da)
IE (1) IE58842B1 (da)
MX (1) MX163837B (da)
NO (1) NO172646C (da)
NZ (1) NZ215570A (da)
PT (1) PT82241B (da)
ZA (1) ZA861953B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
ATE69062T1 (de) * 1985-06-12 1991-11-15 Lubrizol Genetics Inc Modifiziertes zein.
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
DE3837271A1 (de) * 1988-11-03 1990-05-10 Hoechst Ag Verfahren zur selektiven spaltung von fusionsproteinen
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
ATE101620T1 (de) * 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
US6875589B1 (en) 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
DE58909556D1 (de) * 1988-11-03 1996-02-15 Hoechst Ag Verfahren zur Herstellung eines Insulin-Vorprodukts in Streptomyceten
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
CA2051375C (en) * 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
NZ239652A (en) * 1990-09-05 1992-09-25 Hoechst Ag Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
TW224471B (da) * 1991-11-26 1994-06-01 Lilly Co Eli
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
JP4624495B2 (ja) * 1994-12-29 2011-02-02 フェリング・インターナショナル・センター・エス．・エー． ヒト・インスリンの生成
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
WO1996034882A1 (en) * 1995-05-05 1996-11-07 Eli Lilly And Company Single chain insulin with high bioactivity
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
KR100381494B1 (ko) * 1997-06-30 2003-07-22 바이오 테크놀로지 제네랄 코오포레이션 인간인슐린의제조방법
AU9162398A (en) * 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Process for producing insulin precursor proteins
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
JP2003528149A (ja) 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
AR025646A1 (es) 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
RU2458989C1 (ru) 2008-08-07 2012-08-20 Байокон Лимитид Способ получения аналогов инсулина из их соответствующих предшественников (варианты)
AR072563A1 (es) * 2009-07-15 2010-09-08 Beta Lab Sa Un procedimiento para obtener insulina aspartica que utiliza una cepa de levaduras de pichia pastoris
PL239062B1 (pl) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
US11230585B2 (en) 2016-09-06 2022-01-25 Chemical & Biopharmaceutical Laboratories Of Patra Proinsulin derivatives
KR102646845B1 (ko) 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법
KR102666154B1 (ko) * 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
US11524987B2 (en) * 2018-09-25 2022-12-13 Amphastar Pharmaceuticals, Inc. Highly purified recombinant human insulin (RHI) API and methods of producing the same
KR20200080747A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16156A (en) * 1980-03-27 1983-07-18 Lilly Co Eli Process for producing an insulin precursor
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
DK172738B1 (da) * 1983-04-07 1999-06-21 Chiron Corp Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf

Also Published As

Publication number Publication date
FI87801C (fi) 1993-02-25
JPS61221200A (ja) 1986-10-01
JPH0648993B2 (ja) 1994-06-29
ES8802402A1 (es) 1988-05-16
GR860764B (en) 1986-07-21
EP0195691A1 (en) 1986-09-24
ATE69266T1 (de) 1991-11-15
MX163837B (es) 1992-06-25
DE3682303D1 (de) 1991-12-12
AU586855B2 (en) 1989-07-27
ES553231A0 (es) 1988-05-16
JPH0823985A (ja) 1996-01-30
ES8708251A1 (es) 1987-10-01
ZA861953B (en) 1986-11-26
PT82241A (en) 1986-04-01
AU5500586A (en) 1986-09-25
DK129385D0 (da) 1985-03-22
JP2553326B2 (ja) 1996-11-13
PT82241B (pt) 1988-11-30
CA1340823C (en) 1999-11-16
NZ215570A (en) 1989-07-27
IE58842B1 (en) 1993-11-17
FI861198A0 (fi) 1986-03-21
JPH088871B2 (ja) 1996-01-31
FI87801B (fi) 1992-11-13
NO861120L (no) 1986-09-23
EP0195691B1 (en) 1991-11-06
IE860737L (en) 1986-09-22
NO172646B (no) 1993-05-10
FI861198A (fi) 1986-09-23
JPH06133777A (ja) 1994-05-17
ES557227A0 (es) 1987-10-01
NO172646C (no) 1993-08-18

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Legal Events

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AHS Application shelved for other reasons than non-payment
AHS Application shelved for other reasons than non-payment