DK323687D0 - Insulinprecursorer og fremgangsmaade til fremstilling deraf - Google Patents
Insulinprecursorer og fremgangsmaade til fremstilling derafInfo
- Publication number
- DK323687D0 DK323687D0 DK323687A DK323687A DK323687D0 DK 323687 D0 DK323687 D0 DK 323687D0 DK 323687 A DK323687 A DK 323687A DK 323687 A DK323687 A DK 323687A DK 323687 D0 DK323687 D0 DK 323687D0
- Authority
- DK
- Denmark
- Prior art keywords
- chain
- insulin
- human insulin
- bridging
- lys
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK266584A DK266584D0 (da) | 1984-05-30 | 1984-05-30 | Dna-sekvens, der koder for en biosyntetisk insulinprecursor og fremgangsmaade til fremstilling af insulinprecursoren |
DK266584 | 1984-05-30 | ||
DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
DK58285 | 1985-02-08 | ||
DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
DK323687 | 1987-06-25 |
Publications (4)
Publication Number | Publication Date |
---|---|
DK323687D0 true DK323687D0 (da) | 1987-06-25 |
DK323687A DK323687A (da) | 1987-06-25 |
DK157933B DK157933B (da) | 1990-03-05 |
DK157933C DK157933C (da) | 1990-08-27 |
Family
ID=26064247
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
DK323687A DK157933C (da) | 1984-05-30 | 1987-06-25 | Insulinprecursorer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK58285A DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Peptider samt fremstilling og anvendelse deraf |
Country Status (15)
Country | Link |
---|---|
US (1) | US4916212A (da) |
EP (2) | EP0163529B1 (da) |
JP (4) | JPH0630613B2 (da) |
AT (1) | ATE143374T1 (da) |
AU (1) | AU590197B2 (da) |
CA (1) | CA1304022C (da) |
DE (2) | DE3588125T2 (da) |
DK (2) | DK58285D0 (da) |
ES (2) | ES8609483A1 (da) |
FI (1) | FI89183C (da) |
GR (1) | GR851304B (da) |
IE (1) | IE66387B1 (da) |
NO (1) | NO174351C (da) |
NZ (1) | NZ212243A (da) |
PT (1) | PT80551B (da) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
DK450187D0 (da) * | 1987-08-28 | 1987-08-28 | Novo Industri As | Fremgangsmaade til fremstilling af proteiner |
DK463887D0 (da) * | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
DE58906966D1 (de) * | 1988-06-23 | 1994-03-24 | Hoechst Ag | Mini-Proinsulin, seine Herstellung und Verwendung. |
US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
WO1992010284A2 (en) | 1990-12-07 | 1992-06-25 | Cnc Development, Inc. | Catalytic chemical reactor |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
IL104727A (en) | 1992-02-18 | 1997-01-10 | Lilly Co Eli | Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 |
US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
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IL118127A0 (en) * | 1995-05-05 | 1996-09-12 | Lilly Co Eli | Single chain insulin with high bioactivity |
GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
US5840542A (en) * | 1995-07-28 | 1998-11-24 | Mogam Biotechnology Research Institute | Method for manufacture of proinsulin with high export yield |
CZ297338B6 (cs) | 1996-03-01 | 2006-11-15 | Novo Nordisk A/S | Peptid potlacující chut k jídlu, farmaceutický prostredek jej obsahující a jeho pouzití |
MXPA00009564A (es) * | 1998-03-31 | 2004-03-10 | Thongua Gantech Biotechnology | Proteina quimerica que contiene una secuencia similar a la caperona intramolecular y su aplicacion a la produccion de insulina. |
CN1125081C (zh) | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
EP1242610A1 (en) | 1999-12-22 | 2002-09-25 | Novo Nordisk A/S | Method for extractive refolding of scrambledsingle-chain polypeptides |
US6777207B2 (en) | 1999-12-29 | 2004-08-17 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
DE60039074D1 (de) * | 1999-12-29 | 2008-07-10 | Novo Nordisk As | Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern |
AU1995701A (en) | 1999-12-29 | 2001-07-16 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
US7378390B2 (en) | 1999-12-29 | 2008-05-27 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
US6521738B2 (en) | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
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US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20030171267A1 (en) * | 2000-04-12 | 2003-09-11 | Rosen Craig A. | Albumin fusion proteins |
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NZ199391A (en) * | 1981-01-02 | 1985-12-13 | Genentech Inc | Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin |
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IE52768B1 (en) * | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
CA1204682A (en) * | 1981-06-19 | 1986-05-20 | Saran A. Narang | Adaptors, and synthesis and cloning of proinsulin genes |
ZA824218B (en) * | 1981-06-29 | 1983-04-27 | Cetus Corp | Plasmid for producing human insulin |
US4615974A (en) * | 1981-08-25 | 1986-10-07 | Celltech Limited | Yeast expression vectors |
JPS58183659A (ja) * | 1982-03-31 | 1983-10-26 | ジェネテイックス、インスチチュ−ト、インコ−ポレ−テッド | 修飾プロインシュリン前駆体、これを暗号化するdna配列およびそれらの産生方法 |
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EP0243465A1 (en) * | 1985-10-25 | 1987-11-04 | Vivian L. Mackay | Method of using bar1 for secreting foreign proteins |
-
1985
- 1985-02-08 DK DK58285A patent/DK58285D0/da unknown
- 1985-05-28 GR GR851304A patent/GR851304B/el unknown
- 1985-05-29 US US06/739,123 patent/US4916212A/en not_active Expired - Lifetime
- 1985-05-29 DE DE3588125T patent/DE3588125T2/de not_active Expired - Fee Related
- 1985-05-29 PT PT80551A patent/PT80551B/pt not_active IP Right Cessation
- 1985-05-29 AU AU43092/85A patent/AU590197B2/en not_active Ceased
- 1985-05-29 EP EP85303775A patent/EP0163529B1/en not_active Expired - Lifetime
- 1985-05-29 FI FI852135A patent/FI89183C/fi not_active IP Right Cessation
- 1985-05-29 NO NO852132A patent/NO174351C/no not_active IP Right Cessation
- 1985-05-29 IE IE133185A patent/IE66387B1/en not_active IP Right Cessation
- 1985-05-29 ES ES543594A patent/ES8609483A1/es not_active Expired
- 1985-05-29 EP EP90121887A patent/EP0427296B1/en not_active Expired - Lifetime
- 1985-05-29 NZ NZ212243A patent/NZ212243A/en unknown
- 1985-05-29 CA CA000482722A patent/CA1304022C/en not_active Expired - Lifetime
- 1985-05-29 AT AT90121887T patent/ATE143374T1/de active
- 1985-05-29 DE DE8585303775T patent/DE3583824D1/de not_active Expired - Lifetime
- 1985-05-29 JP JP60116297A patent/JPH0630613B2/ja not_active Expired - Lifetime
-
1986
- 1986-02-13 ES ES551941A patent/ES8702488A1/es not_active Expired
-
1987
- 1987-06-25 DK DK323687A patent/DK157933C/da not_active IP Right Cessation
-
1993
- 1993-05-24 JP JP5121649A patent/JPH07121226B2/ja not_active Expired - Fee Related
- 1993-05-24 JP JP5121694A patent/JPH0746998B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-08 JP JP7142085A patent/JP2519023B2/ja not_active Expired - Fee Related
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