IL104727A - Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 - Google Patents

Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1

Info

Publication number
IL104727A
IL104727A IL10472793A IL10472793A IL104727A IL 104727 A IL104727 A IL 104727A IL 10472793 A IL10472793 A IL 10472793A IL 10472793 A IL10472793 A IL 10472793A IL 104727 A IL104727 A IL 104727A
Authority
IL
Israel
Prior art keywords
aminopeptidase
dipeptidyl
selective removal
terminal extensions
insulin precursors
Prior art date
Application number
IL10472793A
Other versions
IL104727A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL104727A0 publication Critical patent/IL104727A0/en
Publication of IL104727A publication Critical patent/IL104727A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL10472793A 1992-02-18 1993-02-15 Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 IL104727A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83701392A 1992-02-18 1992-02-18

Publications (2)

Publication Number Publication Date
IL104727A0 IL104727A0 (en) 1993-06-10
IL104727A true IL104727A (en) 1997-01-10

Family

ID=25273264

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10472793A IL104727A (en) 1992-02-18 1993-02-15 Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1

Country Status (7)

Country Link
EP (1) EP0557076A1 (en)
JP (1) JPH05308991A (en)
AU (1) AU670562B2 (en)
CA (1) CA2089541A1 (en)
HU (1) HU216099B (en)
IL (1) IL104727A (en)
MX (1) MX9300816A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
PT871474E (en) * 1994-12-29 2007-02-28 Ferring Int Ct Sa Generation of human insulin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430266A (en) 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
JPS582660U (en) * 1981-06-30 1983-01-08 三菱重工業株式会社 Heating furnace for analytical equipment
DK58285D0 (en) 1984-05-30 1985-02-08 Novo Industri As PEPTIDES AND MANUFACTURING AND USING THEREOF
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
JPH0461051U (en) * 1990-09-29 1992-05-26

Also Published As

Publication number Publication date
HUT68361A (en) 1995-06-28
AU670562B2 (en) 1996-07-25
HU9300435D0 (en) 1993-05-28
AU3307993A (en) 1993-08-19
EP0557076A1 (en) 1993-08-25
HU216099B (en) 1999-04-28
JPH05308991A (en) 1993-11-22
IL104727A0 (en) 1993-06-10
CA2089541A1 (en) 1993-08-19
MX9300816A (en) 1993-08-01

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Legal Events

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FF Patent granted
KB Patent renewed
RH Patent void