ATE517119T1 - Einzelketteninsulin - Google Patents
EinzelketteninsulinInfo
- Publication number
- ATE517119T1 ATE517119T1 AT04801167T AT04801167T ATE517119T1 AT E517119 T1 ATE517119 T1 AT E517119T1 AT 04801167 T AT04801167 T AT 04801167T AT 04801167 T AT04801167 T AT 04801167T AT E517119 T1 ATE517119 T1 AT E517119T1
- Authority
- AT
- Austria
- Prior art keywords
- chain
- insulin
- single chain
- chain insulin
- insulins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301786 | 2003-12-03 | ||
| PCT/DK2004/000843 WO2005054291A1 (en) | 2003-12-03 | 2004-12-03 | Single-chain insulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517119T1 true ATE517119T1 (de) | 2011-08-15 |
Family
ID=34639202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04801167T ATE517119T1 (de) | 2003-12-03 | 2004-12-03 | Einzelketteninsulin |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20070129284A1 (de) |
| EP (1) | EP1692168B1 (de) |
| JP (2) | JP5697831B2 (de) |
| CN (2) | CN1902226A (de) |
| AT (1) | ATE517119T1 (de) |
| AU (1) | AU2004295023A1 (de) |
| ES (1) | ES2369895T3 (de) |
| WO (1) | WO2005054291A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006097521A1 (en) * | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Pegylated single-chain insulin |
| US8343914B2 (en) | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| EP1996709A2 (de) * | 2006-03-13 | 2008-12-03 | Novo Nordisk A/S | Acyliertes, einkettiges insulin |
| US20090069215A1 (en) * | 2006-03-13 | 2009-03-12 | Novo Nordisk A/S | Acylated Single Chain Insulin |
| WO2007104736A2 (en) * | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
| WO2007104734A1 (en) * | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| EP2164466A1 (de) | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Spontan dispergierbare vorkonzentrate mit einem peptidwirkstoff in einem festen oder halbfesten träger |
| US20100190706A1 (en) | 2007-06-01 | 2010-07-29 | Novo Nordisk A/S | Stable Non-Aqueous Pharmaceutical Compositions |
| KR20100053561A (ko) * | 2007-08-15 | 2010-05-20 | 노보 노르디스크 에이/에스 | 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체 |
| US8946148B2 (en) | 2007-11-20 | 2015-02-03 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
| EP2249853A4 (de) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | Peptid-prodrugs auf esterbasis |
| EP2242767A4 (de) * | 2008-02-19 | 2011-04-06 | Biocon Ltd | Verfahren zur gewinnung von in hefe exprimierten gereinigten heterologen insulinen |
| US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| CN102065885A (zh) * | 2008-04-22 | 2011-05-18 | 卡斯西部储备大学 | 同种型特异性的胰岛素类似物 |
| KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
| US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
| WO2010019965A1 (en) * | 2008-08-15 | 2010-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection |
| CN106317164A (zh) | 2008-09-12 | 2017-01-11 | 诺沃—诺迪斯克有限公司 | 酰化肽或蛋白的方法 |
| CN102245624B (zh) | 2008-12-19 | 2016-08-10 | 印第安纳大学研究及科技有限公司 | 基于酰胺的胰岛素前药 |
| EP2376099A4 (de) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | Insulinähnliche wachstumsfaktoren auf yl-basis mit hoher aktivität am insulinrezeptor |
| WO2010080606A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Insulin analogs |
| US8399407B2 (en) | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| NZ600477A (en) | 2009-12-11 | 2014-07-25 | Univ Case Western Reserve | Insulin analogues with chlorinated amino acids |
| WO2011159895A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| EP2585484A1 (de) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Zusätzliche disulfidbindungen enthaltende insulinanaloga |
| WO2011161125A1 (en) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin derivatives containing additional disulfide bonds |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US9006176B2 (en) | 2011-10-18 | 2015-04-14 | AmideBio LLC | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| CN108383902A (zh) | 2012-09-26 | 2018-08-10 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| MX2015005662A (es) * | 2012-11-05 | 2015-08-20 | Univ Case Western Reserve | Analogos de insulina de una sola cadena de larga accion. |
| JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | O−グリコシル化カルボキシ末端部分(ctp)ペプチド系のインスリンおよびインスリン類似体 |
| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| US9163073B2 (en) | 2013-04-17 | 2015-10-20 | Amidebio, Llc | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
| GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| US9884125B2 (en) | 2013-10-04 | 2018-02-06 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| US9402876B2 (en) * | 2013-11-27 | 2016-08-02 | Industrial Technology Research Institute | Method and pharmaceutical composition for hair growth |
| GB201321489D0 (en) * | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080149A1 (de) | 2013-12-13 | 2016-10-19 | Sanofi | Duale glp-1-/glucagon-rezeptoragonisten |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| EP3197912B1 (de) | 2014-09-24 | 2023-01-04 | Indiana University Research & Technology Corporation | Lipdierte amidbasierte insulin-prodrugs |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| CN107108716A (zh) * | 2014-10-06 | 2017-08-29 | 卡斯西部储备大学 | 双相性单链胰岛素类似物 |
| CA2964918A1 (en) * | 2014-10-20 | 2016-04-28 | Case Western Reserve University | Halogenated insulin analogues of enhanced biological potency |
| SG10201809457YA (en) | 2014-11-21 | 2018-11-29 | Merck Sharp & Dohme | Insulin receptor partial agonists |
| WO2016144658A1 (en) | 2015-03-10 | 2016-09-15 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| CN104805091B (zh) * | 2015-05-13 | 2018-01-30 | 武汉真福医药股份有限公司 | 重组人胰岛素的表达方法及专用表达载体、工程菌和应用 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| CA2996455A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| EP3344651B1 (de) | 2015-09-02 | 2022-03-02 | Merck Sharp & Dohme Corp. | Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen |
| SG11201803911PA (en) | 2015-12-23 | 2018-07-30 | Univ Case Western Reserve | Encapsulation of ultra-stable insulin analogues with polymer melts |
| EP3448417B1 (de) | 2016-04-26 | 2025-11-12 | Merck Sharp & Dohme LLC | Insulin-dimer-inkretin-konjugate |
| EP3922260A3 (de) | 2016-05-24 | 2022-06-15 | Merck Sharp & Dohme Corp. | Insulinrezeptorteilagonisten und glp-1-analoga |
| WO2017205309A1 (en) | 2016-05-25 | 2017-11-30 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
| KR20190026786A (ko) | 2016-07-18 | 2019-03-13 | 에테하 취리히 | β-세포-모방 세포 |
| EP3272877A1 (de) | 2016-07-18 | 2018-01-24 | ETH Zurich | B-zell-mimetische zellen |
| US11230585B2 (en) | 2016-09-06 | 2022-01-25 | Chemical & Biopharmaceutical Laboratories Of Patra | Proinsulin derivatives |
| EP3600381A4 (de) | 2017-03-23 | 2021-06-16 | Merck Sharp & Dohme Corp. | Glucosereaktives insulin mit einem dreiwertigen zuckercluster zur behandlung von diabetes |
| PE20211264A1 (es) | 2017-08-17 | 2021-07-15 | Novo Nordisk As | Analogos de insulina acilados novedosos y usos de estos |
| WO2020072181A1 (en) * | 2018-10-01 | 2020-04-09 | University Of Houston System | Engineered active single-polypeptide chain insulin analogs |
| WO2020247297A1 (en) | 2019-06-06 | 2020-12-10 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CA3149925A1 (en) * | 2019-08-02 | 2021-02-11 | Case Western Reserve University | Premixed ultra-stable single-chain insulin analogue formulations |
| FI4073097T3 (fi) | 2019-12-11 | 2024-08-13 | Novo Nordisk As | Uusia insuliinianalogeja ja niiden käyttötapoja |
| EP4255469A4 (de) * | 2020-12-07 | 2025-01-22 | Case Western Reserve University | Acylierte einkettige insulinanaloga |
| CZ310198B6 (cs) * | 2021-07-07 | 2024-11-13 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Deriváty inzulínu se zvýšenou tepelnou stabilitou |
| TW202342552A (zh) * | 2022-03-16 | 2023-11-01 | 大陸商北京拓界生物醫藥科技有限公司 | 人胰島素類似物、其融合蛋白及醫藥用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| AU600885B2 (en) | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
| DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| HUT56857A (en) | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| IL93282A (en) | 1989-02-09 | 1995-08-31 | Lilly Co Eli | Insulin analogues |
| DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| US5304473A (en) | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
| DK82893D0 (da) | 1993-07-08 | 1993-07-08 | Novo Nordisk As | Peptid |
| SI0792290T1 (en) | 1993-09-17 | 2001-12-31 | Novo Nordisk As | Acylated insulin |
| AU1272295A (en) * | 1993-12-17 | 1995-07-03 | Novo Nordisk A/S | Proinsulin-like compounds |
| US5639642A (en) | 1994-06-16 | 1997-06-17 | Novo Nordisk A/S | Synthetic leader peptide sequences |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| IL118127A0 (en) * | 1995-05-05 | 1996-09-12 | Lilly Co Eli | Single chain insulin with high bioactivity |
| US5905140A (en) | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
| EP0954589A1 (de) | 1997-01-24 | 1999-11-10 | Novo Nordisk A/S | Sythetische signalpeptid-sequenzen. |
| SV1998000125A (es) * | 1997-10-24 | 1999-05-24 | Lilly Co Eli | Composiciones de insulina insoluble ref. x-11232 |
| DE19947456A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga |
| HUP0203475A3 (en) * | 1999-12-29 | 2005-11-28 | Novo Nordisk As | Method for making insulin precursors and insulin precursor analogs |
| KR20030004315A (ko) | 1999-12-29 | 2003-01-14 | 노보 노르디스크 에이/에스 | 효모에서 개선된 발효 수율을 갖는 인슐린 선구물질 및인슐린 선구물질 유사체의 제조 방법 |
| EP1193272B1 (de) | 2000-10-02 | 2004-06-30 | Yonsei University | Einkettige Insulinanaloge |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| WO2002079250A1 (en) * | 2001-04-02 | 2002-10-10 | Novo Nordisk A/S | Insulin precursors and a process for their preparation |
| HUP0401492A3 (en) | 2001-09-14 | 2008-05-28 | Novo Nordisk As | Novel ligands for the hisb10 zn2+ sites of r-state insulin hexa |
| KR100508616B1 (ko) * | 2003-06-20 | 2005-08-17 | 신항철 | 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그 |
-
2004
- 2004-12-03 JP JP2006541803A patent/JP5697831B2/ja not_active Expired - Fee Related
- 2004-12-03 ES ES04801167T patent/ES2369895T3/es not_active Expired - Lifetime
- 2004-12-03 CN CNA2004800388416A patent/CN1902226A/zh active Pending
- 2004-12-03 WO PCT/DK2004/000843 patent/WO2005054291A1/en not_active Ceased
- 2004-12-03 CN CN2012103042454A patent/CN102816228A/zh not_active Withdrawn
- 2004-12-03 EP EP04801167A patent/EP1692168B1/de not_active Expired - Lifetime
- 2004-12-03 AT AT04801167T patent/ATE517119T1/de not_active IP Right Cessation
- 2004-12-03 AU AU2004295023A patent/AU2004295023A1/en not_active Abandoned
-
2006
- 2006-05-24 US US11/439,897 patent/US20070129284A1/en not_active Abandoned
-
2008
- 2008-10-15 US US12/251,901 patent/US8883449B2/en not_active Expired - Fee Related
-
2012
- 2012-08-03 JP JP2012173151A patent/JP2012254086A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2369895T3 (es) | 2011-12-07 |
| EP1692168B1 (de) | 2011-07-20 |
| US20090170750A1 (en) | 2009-07-02 |
| JP2008502313A (ja) | 2008-01-31 |
| WO2005054291A1 (en) | 2005-06-16 |
| AU2004295023A1 (en) | 2005-06-16 |
| EP1692168A1 (de) | 2006-08-23 |
| US8883449B2 (en) | 2014-11-11 |
| US20070129284A1 (en) | 2007-06-07 |
| CN102816228A (zh) | 2012-12-12 |
| CN1902226A (zh) | 2007-01-24 |
| JP5697831B2 (ja) | 2015-04-08 |
| JP2012254086A (ja) | 2012-12-27 |
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