ATE517119T1 - Einzelketteninsulin - Google Patents

Einzelketteninsulin

Info

Publication number
ATE517119T1
ATE517119T1 AT04801167T AT04801167T ATE517119T1 AT E517119 T1 ATE517119 T1 AT E517119T1 AT 04801167 T AT04801167 T AT 04801167T AT 04801167 T AT04801167 T AT 04801167T AT E517119 T1 ATE517119 T1 AT E517119T1
Authority
AT
Austria
Prior art keywords
chain
insulin
single chain
chain insulin
insulins
Prior art date
Application number
AT04801167T
Other languages
English (en)
Inventor
Thomas Kjeldsen
Asser Andersen
Morten Schlein
Anders Syrensen
Peter Madsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE517119T1 publication Critical patent/ATE517119T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04801167T 2003-12-03 2004-12-03 Einzelketteninsulin ATE517119T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301786 2003-12-03
PCT/DK2004/000843 WO2005054291A1 (en) 2003-12-03 2004-12-03 Single-chain insulin

Publications (1)

Publication Number Publication Date
ATE517119T1 true ATE517119T1 (de) 2011-08-15

Family

ID=34639202

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04801167T ATE517119T1 (de) 2003-12-03 2004-12-03 Einzelketteninsulin

Country Status (8)

Country Link
US (2) US20070129284A1 (de)
EP (1) EP1692168B1 (de)
JP (2) JP5697831B2 (de)
CN (2) CN1902226A (de)
AT (1) ATE517119T1 (de)
AU (1) AU2004295023A1 (de)
ES (1) ES2369895T3 (de)
WO (1) WO2005054291A1 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006097521A1 (en) * 2005-03-18 2006-09-21 Novo Nordisk A/S Pegylated single-chain insulin
US8343914B2 (en) 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
EP1996709A2 (de) * 2006-03-13 2008-12-03 Novo Nordisk A/S Acyliertes, einkettiges insulin
US20090069215A1 (en) * 2006-03-13 2009-03-12 Novo Nordisk A/S Acylated Single Chain Insulin
WO2007104736A2 (en) * 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
WO2007104734A1 (en) * 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
EP2164466A1 (de) 2007-06-01 2010-03-24 Novo Nordisk A/S Spontan dispergierbare vorkonzentrate mit einem peptidwirkstoff in einem festen oder halbfesten träger
US20100190706A1 (en) 2007-06-01 2010-07-29 Novo Nordisk A/S Stable Non-Aqueous Pharmaceutical Compositions
KR20100053561A (ko) * 2007-08-15 2010-05-20 노보 노르디스크 에이/에스 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체
US8946148B2 (en) 2007-11-20 2015-02-03 Ambrx, Inc. Modified insulin polypeptides and their uses
EP2249853A4 (de) 2008-01-30 2012-12-26 Univ Indiana Res & Tech Corp Peptid-prodrugs auf esterbasis
EP2242767A4 (de) * 2008-02-19 2011-04-06 Biocon Ltd Verfahren zur gewinnung von in hefe exprimierten gereinigten heterologen insulinen
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
CN102065885A (zh) * 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
WO2010019965A1 (en) * 2008-08-15 2010-02-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection
CN106317164A (zh) 2008-09-12 2017-01-11 诺沃—诺迪斯克有限公司 酰化肽或蛋白的方法
CN102245624B (zh) 2008-12-19 2016-08-10 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
EP2376099A4 (de) * 2008-12-19 2012-04-25 Univ Indiana Res & Tech Corp Insulinähnliche wachstumsfaktoren auf yl-basis mit hoher aktivität am insulinrezeptor
WO2010080606A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
NZ600477A (en) 2009-12-11 2014-07-25 Univ Case Western Reserve Insulin analogues with chlorinated amino acids
WO2011159895A2 (en) 2010-06-16 2011-12-22 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
EP2585484A1 (de) 2010-06-23 2013-05-01 Novo Nordisk A/S Zusätzliche disulfidbindungen enthaltende insulinanaloga
WO2011161125A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
US8946147B2 (en) 2010-06-24 2015-02-03 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
US9006176B2 (en) 2011-10-18 2015-04-14 AmideBio LLC Chemically and thermodynamically stable insulin analogues and improved methods for their production
US9573987B2 (en) 2011-12-20 2017-02-21 Indiana University Research And Technology Corporation CTP-based insulin analogs for treatment of diabetes
CN108383902A (zh) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
MX2015005662A (es) * 2012-11-05 2015-08-20 Univ Case Western Reserve Analogos de insulina de una sola cadena de larga accion.
JP6735561B2 (ja) 2012-12-03 2020-08-05 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. O−グリコシル化カルボキシ末端部分(ctp)ペプチド系のインスリンおよびインスリン類似体
SG10201705097PA (en) 2012-12-21 2017-07-28 Sanofi Sa Functionalized exendin-4 derivatives
WO2014158900A1 (en) 2013-03-14 2014-10-02 Indiana University Research And Technology Corporation Insulin-incretin conjugates
US9163073B2 (en) 2013-04-17 2015-10-20 Amidebio, Llc Chemically and thermodynamically stable insulin analogues and improved methods for their production
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US9884125B2 (en) 2013-10-04 2018-02-06 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
US9402876B2 (en) * 2013-11-27 2016-08-02 Industrial Technology Research Institute Method and pharmaceutical composition for hair growth
GB201321489D0 (en) * 2013-12-05 2014-01-22 Chemical & Biopharmaceutical Lab Of Patras S A Biologically active insulin derivatives
WO2015086729A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/gip receptor agonists
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
EP3080149A1 (de) 2013-12-13 2016-10-19 Sanofi Duale glp-1-/glucagon-rezeptoragonisten
TW201609795A (zh) 2013-12-13 2016-03-16 賽諾菲公司 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
EP3197912B1 (de) 2014-09-24 2023-01-04 Indiana University Research & Technology Corporation Lipdierte amidbasierte insulin-prodrugs
ES2822994T3 (es) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Conjugados de incretina-insulina
CN107108716A (zh) * 2014-10-06 2017-08-29 卡斯西部储备大学 双相性单链胰岛素类似物
CA2964918A1 (en) * 2014-10-20 2016-04-28 Case Western Reserve University Halogenated insulin analogues of enhanced biological potency
SG10201809457YA (en) 2014-11-21 2018-11-29 Merck Sharp & Dohme Insulin receptor partial agonists
WO2016144658A1 (en) 2015-03-10 2016-09-15 Merck Sharp & Dohme Corp. Process for preparing recombinant insulin using microfiltration
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
CN104805091B (zh) * 2015-05-13 2018-01-30 武汉真福医药股份有限公司 重组人胰岛素的表达方法及专用表达载体、工程菌和应用
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
CA2996455A1 (en) 2015-08-25 2017-03-02 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
EP3344651B1 (de) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen
SG11201803911PA (en) 2015-12-23 2018-07-30 Univ Case Western Reserve Encapsulation of ultra-stable insulin analogues with polymer melts
EP3448417B1 (de) 2016-04-26 2025-11-12 Merck Sharp & Dohme LLC Insulin-dimer-inkretin-konjugate
EP3922260A3 (de) 2016-05-24 2022-06-15 Merck Sharp & Dohme Corp. Insulinrezeptorteilagonisten und glp-1-analoga
WO2017205309A1 (en) 2016-05-25 2017-11-30 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
KR20190026786A (ko) 2016-07-18 2019-03-13 에테하 취리히 β-세포-모방 세포
EP3272877A1 (de) 2016-07-18 2018-01-24 ETH Zurich B-zell-mimetische zellen
US11230585B2 (en) 2016-09-06 2022-01-25 Chemical & Biopharmaceutical Laboratories Of Patra Proinsulin derivatives
EP3600381A4 (de) 2017-03-23 2021-06-16 Merck Sharp & Dohme Corp. Glucosereaktives insulin mit einem dreiwertigen zuckercluster zur behandlung von diabetes
PE20211264A1 (es) 2017-08-17 2021-07-15 Novo Nordisk As Analogos de insulina acilados novedosos y usos de estos
WO2020072181A1 (en) * 2018-10-01 2020-04-09 University Of Houston System Engineered active single-polypeptide chain insulin analogs
WO2020247297A1 (en) 2019-06-06 2020-12-10 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
CA3149925A1 (en) * 2019-08-02 2021-02-11 Case Western Reserve University Premixed ultra-stable single-chain insulin analogue formulations
FI4073097T3 (fi) 2019-12-11 2024-08-13 Novo Nordisk As Uusia insuliinianalogeja ja niiden käyttötapoja
EP4255469A4 (de) * 2020-12-07 2025-01-22 Case Western Reserve University Acylierte einkettige insulinanaloga
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
TW202342552A (zh) * 2022-03-16 2023-11-01 大陸商北京拓界生物醫藥科技有限公司 人胰島素類似物、其融合蛋白及醫藥用途

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
HUT56857A (en) 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
IL93282A (en) 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
DK300090D0 (da) 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
US5304473A (en) 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
DK82893D0 (da) 1993-07-08 1993-07-08 Novo Nordisk As Peptid
SI0792290T1 (en) 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
AU1272295A (en) * 1993-12-17 1995-07-03 Novo Nordisk A/S Proinsulin-like compounds
US5639642A (en) 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
IL118127A0 (en) * 1995-05-05 1996-09-12 Lilly Co Eli Single chain insulin with high bioactivity
US5905140A (en) 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
EP0954589A1 (de) 1997-01-24 1999-11-10 Novo Nordisk A/S Sythetische signalpeptid-sequenzen.
SV1998000125A (es) * 1997-10-24 1999-05-24 Lilly Co Eli Composiciones de insulina insoluble ref. x-11232
DE19947456A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
HUP0203475A3 (en) * 1999-12-29 2005-11-28 Novo Nordisk As Method for making insulin precursors and insulin precursor analogs
KR20030004315A (ko) 1999-12-29 2003-01-14 노보 노르디스크 에이/에스 효모에서 개선된 발효 수율을 갖는 인슐린 선구물질 및인슐린 선구물질 유사체의 제조 방법
EP1193272B1 (de) 2000-10-02 2004-06-30 Yonsei University Einkettige Insulinanaloge
KR100449454B1 (ko) 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
WO2002079250A1 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Insulin precursors and a process for their preparation
HUP0401492A3 (en) 2001-09-14 2008-05-28 Novo Nordisk As Novel ligands for the hisb10 zn2+ sites of r-state insulin hexa
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그

Also Published As

Publication number Publication date
ES2369895T3 (es) 2011-12-07
EP1692168B1 (de) 2011-07-20
US20090170750A1 (en) 2009-07-02
JP2008502313A (ja) 2008-01-31
WO2005054291A1 (en) 2005-06-16
AU2004295023A1 (en) 2005-06-16
EP1692168A1 (de) 2006-08-23
US8883449B2 (en) 2014-11-11
US20070129284A1 (en) 2007-06-07
CN102816228A (zh) 2012-12-12
CN1902226A (zh) 2007-01-24
JP5697831B2 (ja) 2015-04-08
JP2012254086A (ja) 2012-12-27

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