EA201490825A1 - Tdp-43-специфически связывающие молекулы - Google Patents

Tdp-43-специфически связывающие молекулы

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Publication number
EA201490825A1
EA201490825A1 EA201490825A EA201490825A EA201490825A1 EA 201490825 A1 EA201490825 A1 EA 201490825A1 EA 201490825 A EA201490825 A EA 201490825A EA 201490825 A EA201490825 A EA 201490825A EA 201490825 A1 EA201490825 A1 EA 201490825A1
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Eurasian Patent Office
Prior art keywords
tdp
binding molecules
specific binding
specifically binding
variants
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EA201490825A
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English (en)
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EA201490825A8 (ru
EA032003B1 (ru
Inventor
Нитш Рожер
Кристоф Хок
Мария Грация Баренко Монтрасио
Фабио Монтрасио
Ян Гримм
Жан-Люк Берисвиль
Пол Вейнреб
Янаки Кумарасвами
Омар Куинтеро-Монзон
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Байоджен Айдек Интернэшнл Нейросайенз Гмбх
Юниверсити Оф Цюрих
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Application filed by Байоджен Айдек Интернэшнл Нейросайенз Гмбх, Юниверсити Оф Цюрих filed Critical Байоджен Айдек Интернэшнл Нейросайенз Гмбх
Publication of EA201490825A1 publication Critical patent/EA201490825A1/ru
Publication of EA201490825A8 publication Critical patent/EA201490825A8/ru
Publication of EA032003B1 publication Critical patent/EA032003B1/ru

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Abstract

Целью изобретения является создание новых TDP-43-специфически связывающих молекул, в том числе полипептидов, таких как человеческие антитела, а также фрагментов, производных и их вариантов. Предложены также способы, связанные с этими TDP-43-специфически связывающими молекулами. Анализы, наборы и твердые носители, связанные с TDP-43-специфически связывающими молекулами, в том числе полипептидами, такими как человеческие антитела, также раскрыты. TDP-43-специфически связывающие молекулы, антитела, цепь иммуноглобулина(ов), а также связывающие фрагменты, производные и их варианты могут быть использованы в фармацевтических и диагностических составов для TDP-43 ориентированной иммунотерапии и диагностики, соответственно.
EA201490825A 2011-10-28 2012-10-26 Анти-tdp-43 антитело EA032003B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161553113P 2011-10-28 2011-10-28
PCT/IB2012/002905 WO2013061163A2 (en) 2011-10-28 2012-10-26 Tdp-43 specific binding molecules

Publications (3)

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EA201490825A1 true EA201490825A1 (ru) 2015-01-30
EA201490825A8 EA201490825A8 (ru) 2016-09-30
EA032003B1 EA032003B1 (ru) 2019-03-29

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EA201490825A EA032003B1 (ru) 2011-10-28 2012-10-26 Анти-tdp-43 антитело

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US (3) US9587014B2 (ru)
EP (2) EP2771359B1 (ru)
JP (3) JP6240611B2 (ru)
KR (2) KR101961508B1 (ru)
CN (1) CN104159918B (ru)
AU (1) AU2012327211C9 (ru)
BR (1) BR112014010161B1 (ru)
CA (2) CA3112082A1 (ru)
CL (1) CL2014001074A1 (ru)
EA (1) EA032003B1 (ru)
ES (1) ES2883212T3 (ru)
HK (1) HK1201846A1 (ru)
IL (2) IL232219B (ru)
MX (2) MX357678B (ru)
MY (1) MY167795A (ru)
SG (1) SG11201401735WA (ru)
WO (1) WO2013061163A2 (ru)
ZA (1) ZA201403680B (ru)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses.
CN104159918B (zh) 2011-10-28 2019-09-13 生物国际神经系统科学公司 Tdp-43特异性结合分子
EP3008083B1 (en) 2013-06-11 2021-06-30 Paul Scherrer Institut Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr
EP3099712A4 (en) * 2014-01-31 2017-11-08 Arizona Board of Regents on behalf of Arizona State University Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein tdp-43
CN104497121A (zh) * 2014-08-29 2015-04-08 苏州顺升桥生物科技有限公司 淀粉样蛋白tdp-43及其用途
TWI592423B (zh) * 2014-10-03 2017-07-21 中央研究院 可辨識致病性ｔｄｐ－４３之抗體及其用途
JP2018503596A (ja) 2014-10-03 2018-02-08 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｔｄｐ−４３の病理学的形態に対する抗体及びその使用
WO2016053610A1 (en) * 2014-10-03 2016-04-07 Academia Sinica Antibodies against pathological forms of tdp-43 and uses thereof
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
WO2017111166A1 (ja) * 2015-12-25 2017-06-29 国立大学法人東京農工大学 Ｔｄｐ－４３細胞内存在量関連疾患治療剤
US11340225B2 (en) 2016-03-14 2022-05-24 Biogen International Neuroscience Gmbh Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins
US20190330318A1 (en) 2016-07-25 2019-10-31 Biogen Ma Inc. Anti-hspa5 (grp78) antibodies and uses thereof
WO2018112362A1 (en) 2016-12-16 2018-06-21 Biogen Ma Inc. Stabilized proteolytically activated growth differentiation factor 11
MY200609A (en) * 2017-03-14 2024-01-05 Five Prime Therapeutics Inc Antibodies binding to vista at acidic ph
JP2020522475A (ja) * 2017-05-30 2020-07-30 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア Ｔｄｐ−４３のｒｎａ認識モチーフ１（ｒｒｍ１）中のエピトープ、およびそれらに対するミスフォールディング選択的抗体
CA3073066A1 (en) 2017-08-22 2019-02-28 Biogen Ma Inc. Pharmaceutical compositions containing anti-beta amyloid antibodies
US11246857B2 (en) * 2017-12-14 2022-02-15 The Johns Hopkins University Anti-fungal inhibitors
EP3724232A4 (en) 2017-12-14 2021-12-15 The University of Ottawa EXOSOME PACKAGING AND TARGETED AUTOPHAGY
KR20200106525A (ko) * 2018-01-05 2020-09-14 에이씨 이뮨 에스.에이. 미스폴딩된 tdp-43 결합 분자
CN112236523A (zh) * 2018-03-16 2021-01-15 国立大学法人滋贺医科大学 降解和去除异常tdp-43的抗体片段
TW202019398A (zh) * 2018-06-28 2020-06-01 張翔毓 用於治療或預防構形疾病之方法及藥物篩選方法
CA3117409A1 (en) 2018-10-29 2020-05-07 Biogen Ma Inc. Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport
JP2022512388A (ja) * 2018-12-14 2022-02-03 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア ミスフォールドｔｄｐ－４３に対する抗体およびその使用方法
SG11202112453TA (en) 2019-05-23 2021-12-30 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
CA3150627A1 (en) * 2019-08-12 2021-02-18 Macquarie University Compositions and methods for treatment
GB202004863D0 (en) * 2020-04-02 2020-05-20 Univ Oxford Innovation Ltd Method
JP2023524414A (ja) 2020-04-28 2023-06-12 ソラ・バイオサイエンシズ・エルエルシー Ｔｄｐ－４３プロテイノパチーの処置のための組成物および方法
AU2021265165A1 (en) * 2020-04-29 2022-12-08 Promis Neurosciences Inc. Single chain antibodies and intrabodies to misfolded TDP-43 and methods of use
EP4196162A1 (en) 2020-08-14 2023-06-21 AC Immune SA Humanized anti-tdp-43 binding molecules and uses thereof
JP2023551542A (ja) 2020-11-30 2023-12-08 エニグマ バイオインテリジェンス，インコーポレイテッド アルツハイマー病の非侵襲的評価
CN112920264B (zh) * 2021-02-08 2022-07-05 武汉大学 Tdp-43蛋白的o-糖基化突变体及其应用
JP6961278B1 (ja) * 2021-03-10 2021-11-05 国立研究開発法人量子科学技術研究開発機構 生体試料中のｔｄｐ−４３を測定する方法及び装置
AU2022282368A1 (en) * 2021-05-27 2023-11-30 Mayo Foundation For Medical Education And Research Methods and materials for treating proteinopathies
US20230107901A1 (en) * 2021-10-01 2023-04-06 University Of Utah Research Foundation Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy
WO2023099788A1 (en) 2021-12-03 2023-06-08 Neurimmune Ag Novel potency assay for antibody-based drugs and useful means therefor
TW202342519A (zh) 2022-02-16 2023-11-01 瑞士商Ａｃ 免疫有限公司 人源化抗ｔｄｐ－４３結合分子及其用途
WO2023194565A1 (en) * 2022-04-08 2023-10-12 Ac Immune Sa Anti-tdp-43 binding molecules
WO2023205579A1 (en) * 2022-04-18 2023-10-26 The Regents Of The University Of California Compositions and methods for disrupting pathological aggregates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
CA2253633A1 (en) * 1997-12-03 1999-06-03 Boehringer Mannheim Corporation Complex specific antibodies, method of preparation and uses thereof
US8354236B2 (en) * 2006-09-29 2013-01-15 The Trustees Of The University Of Pennsylvania Detection of neurodegenerative disease
CA2764852C (en) 2007-01-05 2018-09-18 University Of Zurich Method of providing disease-specific binding molecules and targets
WO2008151055A1 (en) 2007-06-01 2008-12-11 Mayo Foundation For Medical Education And Research Diagnosing neurodegenerative diseases
JP5439176B2 (ja) 2007-07-06 2014-03-12 公益財団法人東京都医学総合研究所 Ｔｄｐ−４３凝集物に特異的に結合する抗体
CA2713871C (en) * 2008-02-01 2018-05-22 Washington University In St. Louis Sequences associated with tdp-43 proteinopathies and methods of using the same
SI2370466T1 (sl) 2008-12-19 2015-11-30 Biogen International Neuroscience Gmbh Človeška avtoprotitelesa proti alfa-sinukleinu
CN101634656A (zh) * 2009-08-21 2010-01-27 武汉三鹰生物技术有限公司 人tdp-43的单抗包被酶标板的制法及elisa检测试剂盒
CN104159918B (zh) 2011-10-28 2019-09-13 生物国际神经系统科学公司 Tdp-43特异性结合分子

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MX2018008680A (es) 2023-04-18
NZ624871A (en) 2016-06-24
US20140255304A1 (en) 2014-09-11
JP6240611B2 (ja) 2017-11-29
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IL232219A0 (en) 2014-06-30
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CL2014001074A1 (es) 2015-01-09
CA2853412A1 (en) 2013-05-02
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EA201490825A8 (ru) 2016-09-30
EP3964524A1 (en) 2022-03-09
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BR112014010161B1 (pt) 2022-02-08
ES2883212T3 (es) 2021-12-07
EA032003B1 (ru) 2019-03-29
AU2012327211B2 (en) 2016-03-10
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US9587014B2 (en) 2017-03-07
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US20170152308A1 (en) 2017-06-01
EP2771359B1 (en) 2021-05-19
MX2014005048A (es) 2014-11-10
US20200017577A1 (en) 2020-01-16
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BR112014010161A2 (pt) 2018-09-25
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