EA201892796A1 - Связывающиеся с сывороточным альбумином домены фибронектина типа iii - Google Patents
Связывающиеся с сывороточным альбумином домены фибронектина типа iiiInfo
- Publication number
- EA201892796A1 EA201892796A1 EA201892796A EA201892796A EA201892796A1 EA 201892796 A1 EA201892796 A1 EA 201892796A1 EA 201892796 A EA201892796 A EA 201892796A EA 201892796 A EA201892796 A EA 201892796A EA 201892796 A1 EA201892796 A1 EA 201892796A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- domains
- serum albumin
- type iii
- fibronectin type
- albumin domains
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
- G01N2333/765—Serum albumin, e.g. HSA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Abstract
Домены фибронектина типа III (FN3), которые специфически связываются с сывороточным альбумином, имеющие к ним отношение полинуклеотиды, способные кодировать специфические в отношении сывороточного альбумина домены FN3, клетки, экспрессирующие домены FN3, а также ассоциированные векторы, помеченные детектируемым образом домены FN3 и домены FN3, слитые с гетерологичной составляющей, полезны для продления периода полужизни молекул при диагностических и терапевтических применениях.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662345190P | 2016-06-03 | 2016-06-03 | |
PCT/US2017/035442 WO2017210425A1 (en) | 2016-06-03 | 2017-06-01 | Serum albumin-binding fibronectin type iii domains |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201892796A1 true EA201892796A1 (ru) | 2019-06-28 |
Family
ID=60477987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892796A EA201892796A1 (ru) | 2016-06-03 | 2017-06-01 | Связывающиеся с сывороточным альбумином домены фибронектина типа iii |
Country Status (13)
Country | Link |
---|---|
US (3) | US10925932B2 (ru) |
EP (1) | EP3463430A4 (ru) |
JP (2) | JP7111627B2 (ru) |
KR (1) | KR102461666B1 (ru) |
CN (1) | CN109562146A (ru) |
AU (1) | AU2017273743B2 (ru) |
EA (1) | EA201892796A1 (ru) |
IL (2) | IL263347B (ru) |
MA (1) | MA45186A (ru) |
MX (1) | MX2018014876A (ru) |
SG (1) | SG11201810687SA (ru) |
UA (1) | UA126021C2 (ru) |
WO (1) | WO2017210425A1 (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112016008125B1 (pt) | 2013-10-14 | 2023-11-21 | Janssen Biotech, Inc. | Domínio proteico isolado de fibronectina tipo iii modificado com cisteína, seu método de produção e método para produzir uma molécula isolada de de fibronectina tipo iii biespecífica modificada com cisteína |
WO2017210425A1 (en) * | 2016-06-03 | 2017-12-07 | Janssen Biotech, Inc. | Serum albumin-binding fibronectin type iii domains |
CN109689080A (zh) * | 2016-06-21 | 2019-04-26 | 詹森生物科技公司 | 半胱氨酸工程化iii型纤连蛋白结构域结合分子 |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
AU2017378226A1 (en) | 2016-12-14 | 2019-06-20 | Janssen Biotech, Inc. | CD8A-binding fibronectin type III domains |
CN110724198B (zh) * | 2018-07-17 | 2023-05-26 | 上海一宸医药科技有限公司 | 长效纤连蛋白iii型结构域融合蛋白 |
WO2021076574A2 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
CN114786682A (zh) | 2019-10-14 | 2022-07-22 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
USD1021702S1 (en) * | 2021-10-20 | 2024-04-09 | GM Global Technology Operations LLC | Vehicle center grille |
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EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
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DK0669836T3 (da) | 1992-11-13 | 1996-10-14 | Idec Pharma Corp | Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom |
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SG11201607820QA (en) * | 2014-03-20 | 2016-10-28 | Bristol Myers Squibb Co | Serum albumin-binding fibronectin type iii domains |
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WO2017210425A1 (en) * | 2016-06-03 | 2017-12-07 | Janssen Biotech, Inc. | Serum albumin-binding fibronectin type iii domains |
CN109689080A (zh) * | 2016-06-21 | 2019-04-26 | 詹森生物科技公司 | 半胱氨酸工程化iii型纤连蛋白结构域结合分子 |
-
2017
- 2017-06-01 WO PCT/US2017/035442 patent/WO2017210425A1/en unknown
- 2017-06-01 EA EA201892796A patent/EA201892796A1/ru unknown
- 2017-06-01 MX MX2018014876A patent/MX2018014876A/es unknown
- 2017-06-01 EP EP17807478.7A patent/EP3463430A4/en active Pending
- 2017-06-01 KR KR1020187037937A patent/KR102461666B1/ko active IP Right Grant
- 2017-06-01 SG SG11201810687SA patent/SG11201810687SA/en unknown
- 2017-06-01 UA UAA201812826A patent/UA126021C2/uk unknown
- 2017-06-01 MA MA045186A patent/MA45186A/fr unknown
- 2017-06-01 US US15/611,296 patent/US10925932B2/en active Active
- 2017-06-01 AU AU2017273743A patent/AU2017273743B2/en active Active
- 2017-06-01 CN CN201780047969.6A patent/CN109562146A/zh active Pending
- 2017-06-01 JP JP2018562935A patent/JP7111627B2/ja active Active
-
2018
- 2018-11-28 IL IL263347A patent/IL263347B/en active IP Right Grant
-
2021
- 2021-01-20 US US17/153,229 patent/US11833190B2/en active Active
- 2021-05-05 IL IL282960A patent/IL282960B/en unknown
- 2021-12-08 JP JP2021199610A patent/JP2022046510A/ja not_active Withdrawn
-
2023
- 2023-10-27 US US18/496,397 patent/US20240100129A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN109562146A (zh) | 2019-04-02 |
KR102461666B1 (ko) | 2022-11-01 |
IL263347B (en) | 2021-05-31 |
EP3463430A4 (en) | 2020-02-12 |
MX2018014876A (es) | 2019-05-22 |
US10925932B2 (en) | 2021-02-23 |
UA126021C2 (uk) | 2022-08-03 |
US20240100129A1 (en) | 2024-03-28 |
US20170348397A1 (en) | 2017-12-07 |
US11833190B2 (en) | 2023-12-05 |
MA45186A (fr) | 2019-04-10 |
EP3463430A1 (en) | 2019-04-10 |
AU2017273743B2 (en) | 2021-12-02 |
US20210228688A1 (en) | 2021-07-29 |
IL282960A (en) | 2021-06-30 |
JP7111627B2 (ja) | 2022-08-02 |
WO2017210425A1 (en) | 2017-12-07 |
AU2017273743A1 (en) | 2019-01-03 |
JP2019521662A (ja) | 2019-08-08 |
JP2022046510A (ja) | 2022-03-23 |
SG11201810687SA (en) | 2018-12-28 |
IL282960B (en) | 2022-03-01 |
IL263347A (en) | 2018-12-31 |
KR20190013970A (ko) | 2019-02-11 |
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