US20030190740A1
(en)
|
1998-10-13 |
2003-10-09 |
The University Of Georgia Research Foundation, Inc |
Stabilized bioactive peptides and methods of identification, synthesis, and use
|
EP1121425B1
(de)
|
1998-10-13 |
2005-06-29 |
The University Of Georgia Research Foundation, Inc. |
Stabilisierte bioaktive peptide und methoden zu ihrer identifikation, synthese und verwendung
|
US20050287153A1
(en)
*
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
US20040001827A1
(en)
*
|
2002-06-28 |
2004-01-01 |
Dennis Mark S. |
Serum albumin binding peptides for tumor targeting
|
ATE337403T1
(de)
|
1999-12-24 |
2006-09-15 |
Genentech Inc |
Verfahren und verbindungen zur verlängerung der halbwertzeiten bei der ausscheidung von biowirksamen verbindungen
|
DE10012120A1
(de)
*
|
2000-03-13 |
2001-09-27 |
Ktb Tumorforschungs Gmbh |
Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel
|
AU2002217010A1
(en)
|
2000-11-08 |
2002-05-21 |
Affina Immuntechnik Gmbh |
Peptides, the production and use thereof for binding immunoglobulins
|
CA2440582A1
(en)
|
2001-03-09 |
2002-10-03 |
Dyax Corp. |
Serum albumin binding moieties
|
US20030157561A1
(en)
*
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
US20050271663A1
(en)
*
|
2001-06-28 |
2005-12-08 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
US20110045005A1
(en)
|
2001-10-19 |
2011-02-24 |
Craig Crowley |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
JP2005289809A
(ja)
*
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
US6916904B2
(en)
|
2002-04-24 |
2005-07-12 |
Zolaris Biosciences, Llc |
Inhibition of immune complex formation
|
US20090068178A1
(en)
*
|
2002-05-08 |
2009-03-12 |
Genentech, Inc. |
Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin
|
CA2489596A1
(en)
*
|
2002-06-14 |
2003-12-24 |
Dyax Corporation |
Protein analysis
|
US9321832B2
(en)
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
PT1517921E
(pt)
*
|
2002-06-28 |
2006-09-29 |
Domantis Ltd |
Ligandos duplamente especificos com semi-vida no soro aumentada
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
JP2006524036A
(ja)
|
2002-11-08 |
2006-10-26 |
アブリンクス エン.ヴェー. |
腫瘍壊死因子αを標的とする単一ドメイン抗体およびその使用
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
US7329725B1
(en)
*
|
2003-10-29 |
2008-02-12 |
Nastech Pharmaceutical Company Inc. |
Phage displayed Trp cage ligands
|
PT1718677E
(pt)
|
2003-12-19 |
2012-07-18 |
Genentech Inc |
Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos
|
US8754031B2
(en)
|
2004-03-08 |
2014-06-17 |
Oncolix, Inc. |
Use of prolactin receptor antagonists in combination with an agent that inactivates the HER2/neu signaling pathway
|
AU2005221187B2
(en)
*
|
2004-03-10 |
2011-09-01 |
Trinity Therapeutics, Inc. |
Method for inhibiting immune complex formation in a subjetc
|
AU2011253771B2
(en)
*
|
2004-03-10 |
2013-10-31 |
Trinity Therapeutics, Inc. |
Method for inhibiting immune complex formation in a subject
|
DE05733048T1
(de)
|
2004-04-06 |
2007-05-10 |
Affibody Ab |
Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung
|
NZ551180A
(en)
|
2004-06-01 |
2009-10-30 |
Genentech Inc |
Antibody drug conjugates and methods
|
CA2569240A1
(en)
|
2004-06-01 |
2005-12-15 |
Domantis Limited |
Drug fusion comprising a polypeptide drug and an immunoglobulin heavy chain variable domain specific for serum albumin
|
SI1773885T1
(sl)
|
2004-08-05 |
2010-08-31 |
Genentech Inc |
Humanizirani anti-CMET antagonisti
|
EP1791565B1
(de)
|
2004-09-23 |
2016-04-20 |
Genentech, Inc. |
Zystein-modifizierte Antikörper und Konjugate
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
GB0426146D0
(en)
|
2004-11-29 |
2004-12-29 |
Bioxell Spa |
Therapeutic peptides and method
|
JP4993645B2
(ja)
|
2004-12-01 |
2012-08-08 |
ジェネンテック, インコーポレイテッド |
抗体薬剤結合体および方法
|
WO2006059110A2
(en)
*
|
2004-12-02 |
2006-06-08 |
Domantis Limited |
Plad domain peptides with increased serum half life due to conjugation to domain antibodies
|
BRPI0518622A2
(pt)
*
|
2004-12-02 |
2008-12-02 |
Domantis Ltd |
usos de antagonistas de receptor do tipo 1 de interleucina-1(il-1r1) para a fabricaÇço de um medicamento para o tratamento de uma doenÇa respiratària; composiÇço farmacÊutica que compreende um antagonista do il-1r1 e um veÍculo fisiologicamente aceitÁvel e dispositivo de liberaÇço de medicamento
|
CN101128487B
(zh)
|
2004-12-02 |
2012-10-10 |
杜门蒂斯有限公司 |
靶向血清白蛋白和glp-1或pyy的双特异性结构域抗体
|
AU2006249144B2
(en)
|
2005-05-18 |
2011-11-17 |
Ablynx Nv |
Improved NanobodiesTM against Tumor Necrosis Factor-alpha
|
DE102005023617A1
(de)
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Verfahren zum Mischen von Farben in einem Display
|
WO2007094842A2
(en)
|
2005-12-02 |
2007-08-23 |
Genentech, Inc. |
Binding polypeptides and uses thereof
|
CA2621539C
(en)
*
|
2005-09-06 |
2019-03-05 |
Trinity Therapeutics, Inc. |
Methods for treating immune mediated neurological diseases
|
EP1940880A2
(de)
*
|
2005-10-14 |
2008-07-09 |
Novo Nordisk A/S |
Behandeln von diabetes durch verwenden von il-1-hemmern
|
US7704953B2
(en)
*
|
2006-02-17 |
2010-04-27 |
Mdrna, Inc. |
Phage displayed cell binding peptides
|
JP5252435B2
(ja)
|
2006-03-15 |
2013-07-31 |
ノボ・ノルデイスク・エー/エス |
アミリン誘導体
|
AR060978A1
(es)
|
2006-05-30 |
2008-07-23 |
Genentech Inc |
Anticuerpos e inmunoconjugados y sus usos
|
AU2007306340A1
(en)
*
|
2006-10-11 |
2008-04-17 |
Ablynx N.V. |
Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and use thereof
|
SI2502938T1
(sl)
|
2006-10-27 |
2015-05-29 |
Genentech, Inc. |
Protitelesa in imunokonjugati in njihove uporabe
|
JP2010512734A
(ja)
*
|
2006-12-13 |
2010-04-30 |
アブリンクス エン.ヴェー. |
Il−6/il−6受容体複合体等受容体介在性シグナル伝達に関与する複合体に特異的なポリペプチド
|
EP2514767A1
(de)
|
2006-12-19 |
2012-10-24 |
Ablynx N.V. |
Gegen Metalloproteinase der ADAM-Familie gerichtete Aminosäuren und Polypeptide damit zur Behandlung von Erkrankungen und Störungen im Zusammenhang mit ADAM
|
US9512236B2
(en)
|
2006-12-19 |
2016-12-06 |
Ablynx N.V. |
Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
SG10201503407WA
(en)
|
2006-12-19 |
2015-06-29 |
Genentech Inc |
Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
|
WO2008074839A2
(en)
|
2006-12-19 |
2008-06-26 |
Ablynx N.V. |
Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
|
CA2676766A1
(en)
|
2007-02-09 |
2008-08-21 |
Genentech, Inc. |
Anti-robo4 antibodies and uses therefor
|
TW200918089A
(en)
|
2007-07-16 |
2009-05-01 |
Genentech Inc |
Humanized anti-CD79b antibodies and immunoconjugates and methods of use
|
JP5469600B2
(ja)
|
2007-07-16 |
2014-04-16 |
ジェネンテック, インコーポレイテッド |
抗CD79b抗体及びイムノコンジュゲートとその使用方法
|
DE08786222T1
(de)
|
2007-07-31 |
2010-11-25 |
Affibody Ab |
Neue albuminbindende zusammensetzungen, verfahren und anwendungen
|
EP2036923A1
(de)
*
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Verbesserte Derivate von Amylin
|
EP2195341B1
(de)
|
2007-09-26 |
2017-03-22 |
UCB Biopharma SPRL |
Fusionsantikörper mit dualer spezifität
|
KR100920729B1
(ko)
*
|
2007-10-01 |
2009-10-07 |
한국생명공학연구원 |
펩타이드 혼성체를 사용한 배향성이 조절된 항체단분자막의 제조방법
|
EP2650311A3
(de)
|
2007-11-27 |
2014-06-04 |
Ablynx N.V. |
Gegen heterodimere Cytokine und/oder deren Rezeptoren gerichtete Aminosäuresequenzen und Polypeptide damit
|
SI2657253T1
(sl)
|
2008-01-31 |
2017-10-30 |
Genentech, Inc. |
Protitelesa proti CD79b in imunokonjugati in postopki za uporabo
|
CN102056945A
(zh)
|
2008-04-07 |
2011-05-11 |
埃博灵克斯股份有限公司 |
针对Notch途径的单可变结构域
|
JP6034023B2
(ja)
|
2008-05-16 |
2016-11-30 |
アブリンクス エン.ヴェー. |
Cxcr4及び他のgpcrに指向性を有するアミノ酸配列及びそれを含む化合物
|
DK2285408T3
(en)
|
2008-06-05 |
2019-02-04 |
Ablynx Nv |
AMINO ACID SEQUENCES AGAINST COATING PROTEINS IN A VIRUS AND POLYPEPTIDES INCLUDING THESE FOR TREATMENT OF VIRUSAL DISEASES
|
RU2016108598A
(ru)
|
2008-06-30 |
2018-11-23 |
ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи |
Функционализированные полипептиды
|
RU2522245C2
(ru)
|
2008-07-10 |
2014-07-10 |
ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи |
Способы и композиции для улучшенной доставки макромолекул
|
EP2320924B1
(de)
|
2008-07-18 |
2015-03-11 |
Trinity Therapeutics, Inc. |
Ein polypeptid zur verwendung in der behandlung von denguevirus-infektionen
|
HUE033438T2
(en)
|
2008-09-26 |
2017-11-28 |
Ucb Biopharma Sprl |
Biological products
|
EP2340261B1
(de)
|
2008-10-21 |
2017-12-20 |
Novo Nordisk A/S |
Amylinderivate
|
CA2739352C
(en)
|
2008-10-29 |
2021-07-13 |
Wyeth Llc |
Methods for purification of single domain antigen binding molecules
|
KR101581986B1
(ko)
|
2008-10-29 |
2016-01-04 |
아블린쓰 엔.브이. |
단일 도메인 항원 결합 분자의 제형
|
WO2010054699A1
(en)
*
|
2008-11-17 |
2010-05-20 |
Affibody Ab |
Conjugates of albumin binding domain
|
EP2752189B1
(de)
|
2008-11-22 |
2016-10-26 |
F. Hoffmann-La Roche AG |
Verwendung von anti-vegf antikörper in kombination mit chemotherapie zur behandlung von brustkrebs
|
WO2010070145A2
(en)
|
2008-12-19 |
2010-06-24 |
Ablynx N.V. |
Method for generation of immunoglobulin sequences
|
US8648046B2
(en)
*
|
2009-02-26 |
2014-02-11 |
Oncolix, Inc. |
Compositions and methods for visualizing and eliminating cancer stem cells
|
US8754035B2
(en)
*
|
2009-02-26 |
2014-06-17 |
Oncolix, Inc. |
Compositions and methods for visualizing and eliminating cancer stem cells
|
CA2754163C
(en)
|
2009-03-25 |
2019-04-09 |
Genentech, Inc. |
Anti-fgfr3 antibodies and methods using same
|
AU2010236787A1
(en)
|
2009-04-01 |
2011-11-10 |
Genentech, Inc. |
Anti-FcRH5 antibodies and immunoconjugates and methods of use
|
NZ595461A
(en)
|
2009-04-10 |
2013-01-25 |
Ablynx Nv |
Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
|
DK2438087T3
(en)
|
2009-06-05 |
2017-08-28 |
Ablynx Nv |
TRIVALENT NANOBODY CONSTRUCTIONS AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) FOR PREVENTION AND / OR TREATMENT OF AIR INFECTIONS
|
WO2011022264A1
(en)
|
2009-08-15 |
2011-02-24 |
Genentech, Inc. |
Anti-angiogenesis therapy for the treatment of previously treated breast cancer
|
JP2013504585A
(ja)
|
2009-09-09 |
2013-02-07 |
セントローズ, エルエルシー |
細胞外標的化薬物複合体
|
GB201005063D0
(en)
|
2010-03-25 |
2010-05-12 |
Ucb Pharma Sa |
Biological products
|
NZ599337A
(en)
|
2009-10-22 |
2013-05-31 |
Genentech Inc |
Anti-hepsin antibodies and methods using same
|
RU2585488C2
(ru)
|
2009-11-05 |
2016-05-27 |
Дженентек, Инк. |
Способы и композиция для секреции гетерологичных полипептидов
|
NZ600278A
(en)
|
2009-11-13 |
2014-04-30 |
Grifols Therapeutics Inc |
Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto
|
US9644022B2
(en)
|
2009-11-30 |
2017-05-09 |
Ablynx N.V. |
Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
|
EP2507381A4
(de)
|
2009-12-04 |
2016-07-20 |
Hoffmann La Roche |
Multispezifische antikörper, antikörperanaloge, zusammensetzungen und verfahren
|
EP2509997B1
(de)
|
2009-12-07 |
2017-08-30 |
i2 Pharmaceuticals, Inc. |
Konjugate mit einem antkörpersurrogatgerüst mit verbesserten pharmakokinetischen eigenschaften
|
US8962807B2
(en)
|
2009-12-14 |
2015-02-24 |
Ablynx N.V. |
Single variable domain antibodies against OX40L, constructs and therapeutic use
|
WO2011083140A1
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
AU2011221229B2
(en)
|
2010-02-23 |
2015-06-18 |
F. Hoffmann-La Roche Ag |
Anti-angiogenesis therapy for the treatment of ovarian cancer
|
US8937164B2
(en)
|
2010-03-26 |
2015-01-20 |
Ablynx N.V. |
Biological materials related to CXCR7
|
KR101738203B1
(ko)
|
2010-04-15 |
2017-05-19 |
메디뮨 리미티드 |
피롤로벤조디아제핀 및 그의 컨주게이트
|
RU2012149227A
(ru)
|
2010-05-20 |
2014-06-27 |
Аблинкс Нв |
Биологические материалы, относящиеся к her3
|
WO2011153243A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Anti-angiogenesis therapy for treating gastric cancer
|
BR112012029866A2
(pt)
|
2010-06-03 |
2017-03-07 |
Genentech Inc |
método para a determinação da presença de uma proteína steap-1
|
CA3220104A1
(en)
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
KR101884654B1
(ko)
|
2010-07-09 |
2018-08-02 |
애피바디 에이비 |
폴리펩타이드
|
CN103370083B
(zh)
|
2010-09-28 |
2016-11-16 |
艾米琳制药有限责任公司 |
具有增强的作用持续时间的工程化多肽
|
EP2621953B1
(de)
|
2010-09-30 |
2017-04-05 |
Ablynx N.V. |
Biologische stoffe im zusammenhang mit c-met
|
KR101832040B1
(ko)
|
2010-11-08 |
2018-04-04 |
노파르티스 아게 |
Cxcr2 결합 폴리펩티드
|
US20120121615A1
(en)
|
2010-11-17 |
2012-05-17 |
Flygare John A |
Alaninyl maytansinol antibody conjugates
|
KR20140032356A
(ko)
|
2010-11-26 |
2014-03-14 |
몰리큘라 파트너스 아게 |
설계된 안키린 반복 단백질에 대한 개선된 n-말단 캡핑 모듈
|
US20140088019A1
(en)
|
2011-02-11 |
2014-03-27 |
Zyngenia, Inc. |
Monovalent and Multivalent Multispecific Complexes and Uses Thereof
|
JP6181040B2
(ja)
|
2011-03-28 |
2017-08-16 |
アブリンクス エン.ヴェー. |
二特異性抗cxcr7免疫グロブリン単一可変ドメイン
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
JP5987053B2
(ja)
|
2011-05-12 |
2016-09-06 |
ジェネンテック, インコーポレイテッド |
フレームワークシグネチャーペプチドを用いて動物サンプルにおける治療抗体を検出するための多重反応モニタリングlc−ms/ms法
|
AU2012264809B2
(en)
|
2011-05-27 |
2017-05-04 |
Ablynx Nv |
Inhibition of bone resorption with RANKL binding peptides
|
IN2014CN00437A
(de)
|
2011-06-23 |
2015-04-03 |
Ablynx Nv |
|
WO2013003680A1
(en)
|
2011-06-30 |
2013-01-03 |
Genentech, Inc. |
Anti-c-met antibody formulations
|
CA2840552A1
(en)
|
2011-07-01 |
2013-01-10 |
Bayer Intellectual Property Gmbh |
Relaxin fusion polypeptides and uses thereof
|
US20140148390A1
(en)
|
2011-07-08 |
2014-05-29 |
Bayer Intellectual Property Gmbh |
Fusion proteins releasing relaxin and uses thereof
|
US20130022551A1
(en)
|
2011-07-22 |
2013-01-24 |
Trustees Of Boston University |
DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS
|
WO2013027796A1
(ja)
|
2011-08-24 |
2013-02-28 |
大塚化学株式会社 |
IgG結合性ペプチド及びそれによるIgGの検出および精製方法
|
AU2012310328A1
(en)
|
2011-09-23 |
2014-04-10 |
Technophage, Investigação E Desenvolvimento Em Biotecnologia, S.A. |
Anti-Tumor Necrosis Factor-alpha agents and uses thereof
|
EP3311837A1
(de)
|
2011-09-23 |
2018-04-25 |
Ablynx NV |
Verlängerte hemmung der interleukin-6-vermittelten signalisierung
|
EP2758422A1
(de)
|
2011-09-23 |
2014-07-30 |
Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA |
Modifizierte albuminbindende domänen und ihre verwendung zur verbesserung der pharmakokinetik
|
EP2747783B1
(de)
|
2011-09-30 |
2017-06-14 |
Ablynx N.V. |
Biologische stoffe im zusammenhang mit c-met
|
EP2750713B1
(de)
|
2011-10-14 |
2015-09-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine und konjugate daraus
|
PT2776466T
(pt)
|
2011-11-11 |
2017-11-30 |
Ucb Biopharma Sprl |
Anticorpos de ligação a albumina e seus fragmentos de ligação
|
JP6407726B2
(ja)
*
|
2012-03-01 |
2018-10-24 |
アムゲン リサーチ (ミュンヘン) ゲーエムベーハーAMGEN Research(Munich)GmbH |
長寿命ポリペプチド結合分子
|
WO2013130093A1
(en)
|
2012-03-02 |
2013-09-06 |
Genentech, Inc. |
Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
|
WO2013143890A1
(en)
|
2012-03-28 |
2013-10-03 |
Affibody Ab |
Oral administration
|
JP2020033372A
(ja)
*
|
2012-03-28 |
2020-03-05 |
アフィボディ・アーベー |
経口投与
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
US8822423B2
(en)
*
|
2012-05-17 |
2014-09-02 |
Janssen Biotech, Inc. |
Affinity peptides toward infliximab
|
KR102238317B1
(ko)
|
2012-05-17 |
2021-04-12 |
익스텐드 바이오사이언시즈, 인크. |
개선된 약물 전달용 캐리어
|
CA2874646C
(en)
|
2012-05-25 |
2020-12-01 |
Janssen Biotech, Inc. |
Non-natural consensus albumin binding domains
|
WO2013177481A1
(en)
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
WO2013192546A1
(en)
*
|
2012-06-22 |
2013-12-27 |
Cytomx Therapeutics, Inc. |
Activatable antibodies having non-binding steric moieties and mehtods of using the same
|
WO2014003176A1
(ja)
*
|
2012-06-29 |
2014-01-03 |
旭化成メディカル株式会社 |
プロテインaのbドメイン変異体を含むポリペプチドが結合された担体からなる吸着材
|
US10155792B2
(en)
|
2012-09-25 |
2018-12-18 |
Affibody Ab |
Albumin binding polypeptide
|
HUE042731T2
(hu)
|
2012-10-12 |
2019-07-29 |
Adc Therapeutics Sa |
Pirrolobenzodiazepin-antitest konjugátumok
|
ES2680153T3
(es)
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
WO2014057120A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
EP2906248B1
(de)
|
2012-10-12 |
2018-12-05 |
MedImmune Limited |
Pyrrolobenzodiazepine und konjugate davon
|
AU2013328625B2
(en)
|
2012-10-12 |
2016-12-15 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine-antibody conjugates
|
BR112015008238A2
(pt)
|
2012-10-12 |
2017-11-28 |
Adc Therapeutics Sarl |
conjugados de pirrolbenzodiazepina-anticorpo anti-cd22
|
HUE045435T2
(hu)
|
2012-10-12 |
2019-12-30 |
Medimmune Ltd |
Pirrolobenzodiazepinek és konjugátumaik
|
SI2906253T1
(sl)
|
2012-10-12 |
2018-11-30 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin-protitelo proti PSMA
|
WO2014064237A1
(en)
|
2012-10-25 |
2014-05-01 |
Affibody Ab |
Abd binding polypeptide
|
PL2912051T3
(pl)
|
2012-10-25 |
2018-08-31 |
Affibody Ab |
Sposób rozdzielania białek zawierających domenę wiążącą albuminę
|
JP6307519B2
(ja)
|
2012-12-21 |
2018-04-04 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピンおよびその結合体
|
EA032986B1
(ru)
|
2012-12-21 |
2019-08-30 |
Медимьюн Лимитед |
Пирролобензодиазепины
|
EP2752426A1
(de)
|
2013-01-03 |
2014-07-09 |
Covagen AG |
Humane Serumalbumin bindende Verbindungen und Fusionsproteine daraus
|
US9605029B2
(en)
|
2013-01-28 |
2017-03-28 |
National Institute Of Advanced Industrial Science And Technology |
Antibody-binding peptide
|
JP6340019B2
(ja)
|
2013-03-13 |
2018-06-06 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピン及びそのコンジュゲート
|
CA2905181C
(en)
|
2013-03-13 |
2020-06-02 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy
|
WO2014165093A2
(en)
|
2013-03-13 |
2014-10-09 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto
|
EA027910B1
(ru)
|
2013-03-13 |
2017-09-29 |
Медимьюн Лимитед |
Пирролобензодиазепины и их конъюгаты
|
AR095596A1
(es)
|
2013-03-15 |
2015-10-28 |
Amgen Res (Munich) Gmbh |
Moléculas de unión de cadena única comprendiendo n-terminal abp
|
MX2016001862A
(es)
|
2013-08-12 |
2016-08-03 |
Genentech Inc |
Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo[e]indol, y metodos de uso y tratamiento.
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
EP3054983B1
(de)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepin-antikörper-konjugate
|
US9956299B2
(en)
|
2013-10-11 |
2018-05-01 |
Medimmune Limited |
Pyrrolobenzodiazepine—antibody conjugates
|
WO2015052534A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
RU2689388C1
(ru)
|
2013-12-16 |
2019-05-28 |
Дженентек, Инк. |
Пептидомиметические соединения и их конъюгаты антител с лекарственными средствами
|
EP3082875B1
(de)
|
2013-12-16 |
2020-11-25 |
Genentech, Inc. |
Peptidomimetische verbindungen und antikörper-wirkstoff-konjugate davon
|
JP6980384B2
(ja)
|
2013-12-16 |
2021-12-15 |
ジェネンテック, インコーポレイテッド |
1−(クロロメチル)−2,3−ジヒドロ−1h−ベンゾ[e]インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法
|
EP3083675B1
(de)
|
2013-12-20 |
2018-03-07 |
Affibody AB |
Engineered albumin bindendes polypeptid
|
WO2015132248A2
(en)
*
|
2014-03-03 |
2015-09-11 |
Vrije Universiteit Brussel (Vub) |
Sequamers - a novel non-natural type of peptide libraries randomly constrained by their primary sequences
|
MA39746A
(fr)
|
2014-03-14 |
2021-04-28 |
Hoffmann La Roche |
Compositions de sécrétion de polypeptides hétérologues et procédés associés
|
BR112016021383A2
(pt)
|
2014-03-24 |
2017-10-03 |
Genentech Inc |
Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo
|
EP2940128A1
(de)
|
2014-04-30 |
2015-11-04 |
Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) |
Adenovirus mit einem albuminbindenden Teil
|
EP4299595A3
(de)
|
2014-05-02 |
2024-03-13 |
Momenta Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren im zusammenhang mit manipulierten fc-konstrukten
|
NL2013661B1
(en)
|
2014-10-21 |
2016-10-05 |
Ablynx Nv |
KV1.3 Binding immunoglobulins.
|
US10188746B2
(en)
|
2014-09-10 |
2019-01-29 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
CA2957354A1
(en)
|
2014-09-12 |
2016-03-17 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
EP3191134B1
(de)
|
2014-09-12 |
2019-11-20 |
Genentech, Inc. |
Anthracyclindisulfidzwischenprodukte, antikörper-wirkstoff-konjugate und verfahren
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
MX2017003523A
(es)
|
2014-09-17 |
2017-11-08 |
Genentech Inc |
Pirrolobenzodiazepinas y conjugados de anticuerpo-disulfuro de las mismas.
|
PL3262071T3
(pl)
|
2014-09-23 |
2020-08-10 |
F. Hoffmann-La Roche Ag |
Sposób stosowania immunokoniugatów anty-CD79b
|
WO2016065052A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Insulin vitamin d conjugates
|
WO2016065042A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Therapeutic vitamin d conjugates
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
CA2961439A1
(en)
|
2014-11-05 |
2016-05-12 |
Genentech, Inc. |
Anti-fgfr2/3 antibodies and methods using same
|
CN107148285B
(zh)
|
2014-11-25 |
2022-01-04 |
Adc治疗股份有限公司 |
吡咯并苯并二氮杂䓬-抗体缀合物
|
EP3226909A1
(de)
|
2014-12-03 |
2017-10-11 |
Genentech, Inc. |
Quaternäre aminverbindungen und antikörper-wirkstoff-konjugate davon
|
EP3234116B1
(de)
|
2014-12-19 |
2021-09-08 |
Alexion Pharmaceuticals, Inc. |
Verfahren zur behandlung von gewebeverkalkung
|
US10273305B2
(en)
|
2015-04-02 |
2019-04-30 |
Ablynx N.V. |
Bispecific CXCR4-CD4 polypeptides with potent anti-HIV activity
|
MX2017012679A
(es)
|
2015-04-06 |
2018-02-09 |
Subdomain Llc |
Polipeptidos que contienen dominios de union de novo y usos de los mismos.
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
ES2754427T3
(es)
|
2015-05-13 |
2020-04-17 |
Ablynx Nv |
Polipéptidos de reclutamiento de células T basados en la reactividad de TCR alfa/beta
|
CA2985700C
(en)
|
2015-05-13 |
2022-06-28 |
Ablynx N.V. |
T cell recruiting polypeptides based on cd3 reactivity
|
ES2784603T3
(es)
|
2015-06-02 |
2020-09-29 |
Novo Nordisk As |
Insulinas con extensiones recombinantes polares
|
MA43348A
(fr)
|
2015-10-01 |
2018-08-08 |
Novo Nordisk As |
Conjugués de protéines
|
AU2016340472B2
(en)
*
|
2015-10-23 |
2019-02-28 |
Fujifilm Corporation |
Cyclic peptide, affinity chromatography support, labeled antibody, antibody-drug conjugate, and pharmaceutical preparation
|
SG11201803976VA
(en)
|
2015-11-27 |
2018-06-28 |
Ablynx Nv |
Polypeptides inhibiting cd40l
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
CA3011894A1
(en)
|
2016-01-31 |
2017-08-03 |
University Of Massachusetts |
Branched oligonucleotides
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
US10821160B2
(en)
|
2016-03-01 |
2020-11-03 |
The Board Of Trustees Of The University Of Illinois |
L-asparaginase variants and fusion proteins with reduced L-glutaminase activity and enhanced stability
|
JP6943872B2
(ja)
|
2016-03-25 |
2021-10-06 |
ジェネンテック, インコーポレイテッド |
多重全抗体及び抗体複合体化薬物定量化アッセイ
|
EP3446102A4
(de)
|
2016-04-15 |
2020-01-15 |
Berkeley Lights, Inc. |
Verfahren, systeme und kits für in-pen-tests
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
US11623964B2
(en)
|
2016-05-23 |
2023-04-11 |
Momenta Pharmaceuticals, Inc. |
Compositions and methods related to engineered Fc constructs
|
JP7022080B2
(ja)
|
2016-05-27 |
2022-02-17 |
ジェネンテック, インコーポレイテッド |
部位特異的抗体-薬物複合体の特徴付けのための生化学分析的方法
|
UA126021C2
(uk)
|
2016-06-03 |
2022-08-03 |
Янссен Байотек, Інк. |
Домен фібронектину типу ііі, що зв'язується із сироватковим альбуміном
|
WO2017218786A1
(en)
|
2016-06-16 |
2017-12-21 |
Alexion Pharmaceuticals, Inc. |
Methods of treating myointimal proliferation
|
WO2018007442A1
(en)
|
2016-07-06 |
2018-01-11 |
Ablynx N.V. |
Treatment of il-6r related diseases
|
WO2018029182A1
(en)
|
2016-08-08 |
2018-02-15 |
Ablynx N.V. |
Il-6r single variable domain antibodies for treatment of il-6r related diseases
|
CA3033368A1
(en)
|
2016-08-12 |
2018-02-15 |
University Of Massachusetts |
Conjugated oligonucleotides
|
JP6818305B2
(ja)
|
2016-09-01 |
2021-01-20 |
国立研究開発法人産業技術総合研究所 |
非天然型立体構造を形成した抗体に親和性を示すポリペプチド
|
WO2018050833A1
(en)
|
2016-09-15 |
2018-03-22 |
Ablynx Nv |
Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
|
CN109790202B
(zh)
*
|
2016-09-30 |
2022-09-13 |
富士胶片株式会社 |
环肽、亲和层析载体、标记抗体、抗体药物复合体及药物制剂
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
JP2019535267A
(ja)
*
|
2016-11-10 |
2019-12-12 |
ケロス セラピューティクス インコーポレイテッドKeros Therapeutics,Inc. |
Gdnf融合ポリペプチド及びその使用方法
|
CA3043515A1
(en)
|
2016-11-16 |
2018-05-24 |
Ablynx Nv |
T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
|
SG11201906139VA
(en)
|
2017-01-06 |
2019-08-27 |
Momenta Pharmaceuticals Inc |
Compositions and methods related to engineered fc constructs
|
JP6671555B2
(ja)
|
2017-02-08 |
2020-03-25 |
アーデーセー セラピューティクス ソシエテ アノニム |
ピロロベンゾジアゼピン抗体複合体
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
WO2018185131A2
(en)
|
2017-04-05 |
2018-10-11 |
Novo Nordisk A/S |
Oligomer extended insulin-fc conjugates
|
AU2018255876B2
(en)
|
2017-04-18 |
2020-04-30 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
AU2018253948A1
(en)
|
2017-04-20 |
2019-09-19 |
Adc Therapeutics Sa |
Combination therapy with an anti-AXL Antibody-Drug Conjugate
|
AU2018259856A1
(en)
|
2017-04-28 |
2019-11-14 |
Ajinomoto Co., Inc. |
Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof
|
JP7249961B2
(ja)
|
2017-06-02 |
2023-03-31 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Adamts5、mmp13およびアグリカンに結合するポリペプチド
|
US11261260B2
(en)
|
2017-06-02 |
2022-03-01 |
Merck Patent Gmbh |
ADAMTS binding immunoglobulins
|
AR112069A1
(es)
|
2017-06-02 |
2019-09-18 |
Ablynx Nv |
Inmunoglobulinas que fijan aggrecan
|
WO2018220235A1
(en)
|
2017-06-02 |
2018-12-06 |
Merck Patent Gmbh |
Mmp13 binding immunoglobulins
|
MX2019015042A
(es)
|
2017-06-14 |
2020-08-06 |
Adc Therapeutics Sa |
Regimen de dosificacion.
|
CA3067247A1
(en)
|
2017-07-11 |
2019-01-17 |
Alexion Pharmaceuticals, Inc. |
Polypeptides that bind complement component c5 or serum albumin and fusion proteins thereof
|
WO2019032827A1
(en)
*
|
2017-08-09 |
2019-02-14 |
Massachusetts Institute Of Technology |
PEPTIDE ALBUMIN BINDING CONJUGATES AND METHODS THEREOF
|
CN111050784B
(zh)
|
2017-08-11 |
2024-03-19 |
伊利诺伊大学理事会 |
截短的豚鼠l-天冬酰胺酶变体及其使用方法
|
KR102270107B1
(ko)
|
2017-08-18 |
2021-06-30 |
메디뮨 리미티드 |
피롤로벤조디아제핀 컨쥬게이트
|
CA3096821A1
(en)
|
2017-09-27 |
2019-04-04 |
Inozyme Pharma, Inc. |
Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1)
|
US20230192897A1
(en)
|
2017-10-10 |
2023-06-22 |
Numab Therapeutics AG |
Multispecific antibody
|
EP3721209B1
(de)
|
2017-10-15 |
2024-02-07 |
Berkeley Lights, Inc. |
Verfahren für in-pen-tests
|
WO2019099440A1
(en)
|
2017-11-14 |
2019-05-23 |
Arcellx, Inc. |
Multifunctional immune cell therapies
|
WO2019107962A2
(ko)
*
|
2017-11-29 |
2019-06-06 |
아주대학교 산학협력단 |
항체와 생리활성물질의 접합방법
|
KR102037336B1
(ko)
*
|
2017-11-29 |
2019-10-29 |
아주대학교산학협력단 |
항체와 생리활성물질의 접합방법
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
CN112261954A
(zh)
|
2018-06-14 |
2021-01-22 |
味之素株式会社 |
具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐
|
JP2021533762A
(ja)
|
2018-08-10 |
2021-12-09 |
ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts |
Snpを標的化する修飾オリゴヌクレオチド
|
JP2022502088A
(ja)
|
2018-09-27 |
2022-01-11 |
エクシリオ デベロップメント, インコーポレイテッド |
マスクされたサイトカインポリペプチド
|
CN113227124A
(zh)
|
2018-10-31 |
2021-08-06 |
味之素株式会社 |
具有针对抗体的亲和性物质、切割性部分及反应性基团的化合物或其盐
|
CN113227119A
(zh)
|
2018-12-10 |
2021-08-06 |
基因泰克公司 |
用于与含Fc的蛋白质进行位点特异性缀合的光交联肽
|
CN113454124A
(zh)
*
|
2018-12-20 |
2021-09-28 |
克莱奥药品有限公司 |
Arm和自然杀伤细胞的组合疗法
|
CN113614232A
(zh)
*
|
2019-01-18 |
2021-11-05 |
马萨诸塞大学 |
动态药代动力学修饰锚
|
EP3816185A1
(de)
|
2019-11-04 |
2021-05-05 |
Numab Therapeutics AG |
Multispezifischer antikörper gegen pd-l1 und ein tumorassoziiertes antigen
|
GB201919061D0
(en)
|
2019-12-20 |
2020-02-05 |
Ucb Biopharma Sprl |
Multi-specific antibody
|
EP3915580A1
(de)
|
2020-05-29 |
2021-12-01 |
Numab Therapeutics AG |
Multispezifischer antikörper
|
WO2022004805A1
(ja)
|
2020-06-30 |
2022-01-06 |
株式会社ガイアバイオメディシン |
Nk細胞と抗体との結合を安定化する方法、及びその利用
|
EP3988568A1
(de)
|
2020-10-21 |
2022-04-27 |
Numab Therapeutics AG |
Kombinationsbehandlung
|
WO2022098745A1
(en)
|
2020-11-03 |
2022-05-12 |
Indi Molecular, Inc. |
Compositions, delivery systems, and methods useful in tumor therapy
|
WO2022098743A1
(en)
|
2020-11-03 |
2022-05-12 |
Indi Molecular, Inc. |
Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
|
MX2023006650A
(es)
|
2020-12-07 |
2023-06-21 |
UCB Biopharma SRL |
Anticuerpos multiespecificos y combinaciones de anticuerpos.
|
AU2022215847A1
(en)
|
2021-02-02 |
2023-08-10 |
Numab Therapeutics AG |
Multispecific antibodies having specificity for ror1 and cd3
|
CN117321076A
(zh)
|
2021-02-19 |
2023-12-29 |
美国卫生及公众服务部代表 |
中和SARS-CoV-2的单结构域抗体
|
EP4359539A1
(de)
|
2021-06-23 |
2024-05-01 |
University Of Massachusetts |
Optimierte anti-flt1-oligonukleotidverbindungen zur behandlung von präeklampsie und anderen angiogenen erkrankungen
|
EP4183800A1
(de)
|
2021-11-19 |
2023-05-24 |
Medizinische Hochschule Hannover |
Neue sars-cov-2-neutralisierende antikörper
|
WO2024008904A2
(en)
|
2022-07-08 |
2024-01-11 |
Novo Nordisk A/S |
Highly potent isvd compounds capable of substituting for fviii(a)
|
WO2024038095A1
(en)
|
2022-08-16 |
2024-02-22 |
Iome Bio |
NOVEL ANTI-RGMb ANTIBODIES
|