US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US5336603A
(en)
*
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
US5567584A
(en)
*
|
1988-01-22 |
1996-10-22 |
Zymogenetics, Inc. |
Methods of using biologically active dimerized polypeptide fusions to detect PDGF
|
US5750375A
(en)
*
|
1988-01-22 |
1998-05-12 |
Zymogenetics, Inc. |
Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
|
US6018026A
(en)
|
1988-01-22 |
2000-01-25 |
Zymogenetics, Inc. |
Biologically active dimerized and multimerized polypeptide fusions
|
US6685941B1
(en)
|
1988-11-23 |
2004-02-03 |
The Regents Of The University Of Michigan |
Methods of treating autoimmune disease via CTLA-4Ig
|
US6406697B1
(en)
|
1989-02-23 |
2002-06-18 |
Genentech, Inc. |
Hybrid immunoglobulins
|
US5225538A
(en)
*
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
US5242687A
(en)
*
|
1989-03-15 |
1993-09-07 |
Tkb Associates Limited Partnership |
Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells
|
US7264944B1
(en)
|
1989-04-21 |
2007-09-04 |
Amgen Inc. |
TNF receptors, TNF binding proteins and DNAs coding for them
|
DE59010941D1
(de)
*
|
1989-04-21 |
2005-03-24 |
Amgen Inc |
TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
|
US6143866A
(en)
*
|
1989-07-18 |
2000-11-07 |
Amgen, Inc. |
Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
A method of producing a recombinant human necrotic factor absorber
|
US6267964B1
(en)
*
|
1989-08-01 |
2001-07-31 |
Affibody Technology Sweden Ab |
Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
|
US5395760A
(en)
*
|
1989-09-05 |
1995-03-07 |
Immunex Corporation |
DNA encoding tumor necrosis factor-α and -β receptors
|
NZ235148A
(en)
*
|
1989-09-05 |
1991-12-23 |
Immunex Corp |
Tumour necrosis factor receptor protein and dna sequences
|
US5605690A
(en)
*
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
US6541610B1
(en)
|
1989-09-05 |
2003-04-01 |
Immunex Corporation |
Fusion proteins comprising tumor necrosis factor receptor
|
US5945397A
(en)
*
|
1989-09-05 |
1999-08-31 |
Immunex Corporation |
Purified p75 (type II) tumor necrosis factor receptor polypeptides
|
DK0939121T4
(da)
*
|
1989-09-12 |
2008-02-04 |
Ahp Mfg B V |
TNF-bindende proteiner
|
US5216132A
(en)
*
|
1990-01-12 |
1993-06-01 |
Protein Design Labs, Inc. |
Soluble t-cell antigen receptor chimeric antigens
|
US6552170B1
(en)
*
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
GB9022543D0
(en)
*
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Antibody production
|
DE4037837A1
(de)
*
|
1990-11-28 |
1992-06-04 |
Behringwerke Ag |
Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
|
US7070991B2
(en)
*
|
1991-02-08 |
2006-07-04 |
Progenics Pharmaceuticals, Inc. |
Cells expressing a CD4-IgG2 chimeric heterotetramer
|
WO1992013947A1
(en)
|
1991-02-08 |
1992-08-20 |
Progenics Pharmaceuticals, Inc. |
CD4-GAMMA2 AND CD4-IgG2 CHIMERAS
|
CA2081028C
(en)
*
|
1991-03-12 |
1999-12-14 |
Barbara P. Wallner |
Cd2 binding domain of lymphocyte function associated antigen 3
|
MX9203138A
(es)
*
|
1991-03-12 |
1992-09-01 |
Biogen Inc |
Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos.
|
US6582959B2
(en)
*
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
US20030206899A1
(en)
*
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
US5318890A
(en)
*
|
1991-05-06 |
1994-06-07 |
The Regents Of The University Of California |
Assays for inhibitors of leukocyte adhesion
|
US6797492B2
(en)
|
1991-05-17 |
2004-09-28 |
Merck & Co., Inc. |
Method for reducing the immunogenicity of antibody variable domains
|
US5851795A
(en)
*
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
US5844095A
(en)
*
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
EP0533006A1
(en)
*
|
1991-09-18 |
1993-03-24 |
F.Hoffmann-La Roche & Co. Aktiengesellschaft |
Chimaeric interleukin 5-receptor/immunoglobulin polypeptides
|
US6764681B2
(en)
*
|
1991-10-07 |
2004-07-20 |
Biogen, Inc. |
Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
|
US5871734A
(en)
*
|
1992-01-13 |
1999-02-16 |
Biogen, Inc. |
Treatment for asthma with VLA-4 blocking agents
|
US6399368B1
(en)
|
1992-01-17 |
2002-06-04 |
Board Of Regents, The University Of Texas System |
Secretion of T cell receptor fragments from recombinant Escherichia coli cells
|
FR2686899B1
(fr)
*
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
US5932214A
(en)
*
|
1994-08-11 |
1999-08-03 |
Biogen, Inc. |
Treatment for inflammatory bowel disease with VLA-4 blockers
|
WO1993019777A1
(en)
*
|
1992-03-30 |
1993-10-14 |
Immunex Corporation |
Fusion proteins comprising tumor necrosis factor receptor
|
WO1993022332A2
(en)
*
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
US5540926A
(en)
*
|
1992-09-04 |
1996-07-30 |
Bristol-Myers Squibb Company |
Soluble and its use in B cell stimulation
|
WO1994005314A1
(en)
*
|
1992-09-08 |
1994-03-17 |
Centocor, Inc. |
Peptide inhibitors of leukocyte adhesion
|
WO1994006476A1
(en)
*
|
1992-09-15 |
1994-03-31 |
Immunex Corporation |
Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
|
CA2144081C
(en)
*
|
1992-09-16 |
2004-11-30 |
Filip Roos |
Protection against liver damage by hgf
|
WO1994006469A1
(en)
*
|
1992-09-18 |
1994-03-31 |
La Jolla Institute For Allergy And Immunology |
Hiv fusion polypeptide
|
US6270766B1
(en)
|
1992-10-08 |
2001-08-07 |
The Kennedy Institute Of Rheumatology |
Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
|
US5474766A
(en)
*
|
1992-12-18 |
1995-12-12 |
Washington University |
Methods and compositions for inhibition of hepatic clearance of tissue-type plasminogen activator
|
US5710123A
(en)
*
|
1992-12-18 |
1998-01-20 |
Centocor, Inc. |
Peptide inhibitors of selectin binding
|
SG48892A1
(en)
*
|
1993-01-25 |
1998-05-18 |
Dana Faber Cancer Inst Inc |
Chimeric L- and P-selectin by exchange of domains-uses thereof
|
US7537932B1
(en)
|
1993-05-19 |
2009-05-26 |
Schering Corporation |
Antibodies that bind purified mammalian FLT3 ligands
|
US20050129670A1
(en)
*
|
1993-07-26 |
2005-06-16 |
Genetics Institute, Llc. |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
US5861310A
(en)
*
|
1993-11-03 |
1999-01-19 |
Dana-Farber Cancer Institute |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
US6084067A
(en)
*
|
1993-07-26 |
2000-07-04 |
Dana-Farber Cancer Institute |
CTLA4/CD28 ligands and uses therefor
|
US6130316A
(en)
*
|
1993-07-26 |
2000-10-10 |
Dana Farber Cancer Institute |
Fusion proteins of novel CTLA4/CD28 ligands and uses therefore
|
US6723705B1
(en)
|
1993-08-19 |
2004-04-20 |
Gentics Institute, Inc. |
Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
|
US6824779B1
(en)
|
1993-07-26 |
2004-11-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for inhibiting the interaction of B7-2 with its natural ligand
|
SE9302855D0
(sv)
*
|
1993-09-06 |
1993-09-06 |
Martin Lindberg |
Method and means for producing plasmaproteinase inhibitor binding proteins
|
WO1995014787A1
(en)
*
|
1993-11-22 |
1995-06-01 |
Centocor, Inc. |
Peptide inhibitors of selecting binding
|
DE69521789T2
(de)
*
|
1994-02-01 |
2002-04-25 |
Us Health |
Fusionierte proteine die antikörper-teile und nicht-antikörper-teile enthalten
|
US7294331B2
(en)
*
|
1994-03-07 |
2007-11-13 |
Immunex Corporation |
Methods of using flt3-ligand in hematopoietic cell transplantation
|
EP0749323B1
(en)
*
|
1994-03-08 |
2000-11-29 |
Dana-Farber Cancer Institute |
Methods for modulating t cell anergy
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
IL113484A0
(en)
*
|
1994-04-28 |
1995-07-31 |
Immunex Corp |
Viral proteins pharmaceutical compositions containing them their preparation and use
|
USRE38313E1
(en)
|
1994-05-06 |
2003-11-11 |
Institut Gustave Roussy |
Soluble polypeptide fractions of the LAG-3 protein, production method, therapeutic composition, anti-idiotype antibodies
|
US6001968A
(en)
|
1994-08-17 |
1999-12-14 |
The Rockefeller University |
OB polypeptides, modified forms and compositions
|
US6471956B1
(en)
|
1994-08-17 |
2002-10-29 |
The Rockefeller University |
Ob polypeptides, modified forms and compositions thereto
|
US6429290B1
(en)
|
1994-08-17 |
2002-08-06 |
The Rockefeller University |
OB polypeptides, modified forms and derivatives
|
US6048837A
(en)
*
|
1994-08-17 |
2000-04-11 |
The Rockefeller University |
OB polypeptides as modulators of body weight
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
US6350730B1
(en)
|
1994-08-17 |
2002-02-26 |
The Rockefeller University |
OB polypeptides and modified forms as modulators of body weight
|
US6124448A
(en)
*
|
1994-08-17 |
2000-09-26 |
The Rockfeller University |
Nucleic acid primers and probes for the mammalian OB gene
|
US5541087A
(en)
*
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
US5814464A
(en)
*
|
1994-10-07 |
1998-09-29 |
Regeneron Pharma |
Nucleic acids encoding TIE-2 ligand-2
|
US6410008B1
(en)
*
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
CA2205572A1
(en)
*
|
1994-12-12 |
1996-06-20 |
Beth Israel Hospital Association |
Chimeric cytokines and uses thereof
|
US6808709B1
(en)
*
|
1994-12-30 |
2004-10-26 |
The Regents Of The University Of California |
Immunoglobulins containing protection proteins and their use
|
US6086875A
(en)
*
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
US6485726B1
(en)
*
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6030613A
(en)
*
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
US6455685B1
(en)
|
1995-03-03 |
2002-09-24 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
US20030069196A1
(en)
*
|
1995-03-03 |
2003-04-10 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
US6066322A
(en)
|
1995-03-03 |
2000-05-23 |
Millennium Pharmaceuticals, Inc. |
Methods for the treatment of immune disorders
|
US6211142B1
(en)
*
|
1995-03-10 |
2001-04-03 |
Genentech, Inc. |
Compositions comprising gas6 polypeptides and articles of manufacture comprising the same
|
US6680057B1
(en)
*
|
1995-03-23 |
2004-01-20 |
Immunex Corporation |
Methods of treating autoimmune disease by administering interleukin-17 receptor
|
JP4373495B2
(ja)
*
|
1995-03-23 |
2009-11-25 |
イミュネックス・コーポレーション |
Il−17受容体
|
IL117645A
(en)
*
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
US20060193862A1
(en)
*
|
1995-03-30 |
2006-08-31 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
US7153508B2
(en)
*
|
1995-06-07 |
2006-12-26 |
Biogen Idec Inc. |
Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4
|
US6113898A
(en)
*
|
1995-06-07 |
2000-09-05 |
Idec Pharmaceuticals Corporation |
Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
|
US7175847B1
(en)
*
|
1995-06-07 |
2007-02-13 |
Biogen Idec Inc. |
Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4
|
US7150992B1
(en)
|
1995-10-04 |
2006-12-19 |
Innunex Corporation |
Methods of preparing dendritic cells with flt3-ligand and antigen
|
US7361330B2
(en)
*
|
1995-10-04 |
2008-04-22 |
Immunex Corporation |
Methods of using flt3-ligand in the treatment of fibrosarcoma
|
US20020034517A1
(en)
*
|
1995-10-04 |
2002-03-21 |
Kenneth Brasel |
Dendritic cell stimulatory factor
|
US6936439B2
(en)
*
|
1995-11-22 |
2005-08-30 |
Amgen Inc. |
OB fusion protein compositions and methods
|
US20030040467A1
(en)
*
|
1998-06-15 |
2003-02-27 |
Mary Ann Pelleymounter |
Ig/ob fusions and uses thereof.
|
US20030026779A1
(en)
*
|
1999-10-15 |
2003-02-06 |
Liming Yu |
Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc
|
GB9526733D0
(en)
*
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
EP1619250B1
(en)
|
1996-01-08 |
2009-11-25 |
Genentech, Inc. |
OB receptor variant and ligands
|
US6750334B1
(en)
*
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
US5917026A
(en)
*
|
1996-02-05 |
1999-06-29 |
Loewenadler; Bjoern |
Fusion proteins of immunopotentiating activity
|
NZ503548A
(en)
|
1996-02-09 |
2001-09-28 |
Amgen Inc |
A fusion protein comprising an IL-1ra receptor antagonist with a constant domain of human immunoglobulin at the carboxy terminus
|
EA002474B1
(ru)
*
|
1996-02-20 |
2002-06-27 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Гибридный белок, образующий гетеродимеры, способ его получения и использования
|
US6194177B1
(en)
*
|
1996-02-20 |
2001-02-27 |
Applied Research Systems Ars Holding N.V. |
DNA encoding a hybrid heterodimeric protein
|
GB9604518D0
(en)
*
|
1996-03-02 |
1996-05-01 |
Smithkline Beecham Plc |
Novel compounds
|
JPH11507843A
(ja)
*
|
1996-03-28 |
1999-07-13 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
タンパク質の可溶性二価および多価ヘテロ二量体類縁体
|
US6458354B1
(en)
|
1996-03-28 |
2002-10-01 |
The Johns Hopkins University |
Molecular complexes which modify immune responses
|
US7026116B1
(en)
*
|
1996-04-04 |
2006-04-11 |
Bio-Rad Laboratories, Inc. |
Polymorphisms in the region of the human hemochromatosis gene
|
US6140305A
(en)
*
|
1996-04-04 |
2000-10-31 |
Bio-Rad Laboratories, Inc. |
Hereditary hemochromatosis gene products
|
US7063965B2
(en)
*
|
1996-04-05 |
2006-06-20 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acid encoding TIE-2 ligand
|
US6060054A
(en)
*
|
1996-04-10 |
2000-05-09 |
National Jewish Medical And Research Center |
Product for T lymphocyte immunosuppression
|
US6117977A
(en)
*
|
1996-04-24 |
2000-09-12 |
Genentech, Inc. |
Type C lectins
|
US6451308B1
(en)
*
|
1996-04-26 |
2002-09-17 |
Beth Israel Deaconess Medical Center |
Antagonists of interleukin-15
|
WO1997041232A1
(en)
*
|
1996-04-26 |
1997-11-06 |
Beth Israel Deaconess Medical Center |
Antagonists of interleukin-15
|
DE69733773T2
(de)
|
1996-05-02 |
2006-04-20 |
Mochida Pharmaceutical Co. Ltd. |
Fas ANTIGEN-DERIVATE
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
US6849399B1
(en)
|
1996-05-23 |
2005-02-01 |
Bio-Rad Laboratories, Inc. |
Methods and compositions for diagnosis and treatment of iron misregulation diseases
|
TW555765B
(en)
*
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
NZ333325A
(en)
*
|
1996-07-12 |
2000-06-23 |
Genentech Inc |
Recombinant chimeric heteromultimer adhesins comprising extracellular domains of ErbB receptors
|
AU727606B2
(en)
*
|
1996-07-12 |
2000-12-14 |
Genentech Inc. |
Gamma-heregulin
|
US5851984A
(en)
*
|
1996-08-16 |
1998-12-22 |
Genentech, Inc. |
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
|
US6159462A
(en)
*
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
EP2002846B1
(en)
|
1996-12-06 |
2017-01-25 |
Amgen Inc. |
Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases
|
DE69724451T2
(de)
|
1996-12-06 |
2004-03-18 |
Amgen Inc., Thousand Oaks |
Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen
|
AU737910B2
(en)
*
|
1997-01-31 |
2001-09-06 |
Regents Of The University Of California, The |
Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
|
US6268411B1
(en)
|
1997-09-11 |
2001-07-31 |
The Johns Hopkins University |
Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
|
US7435793B2
(en)
*
|
1998-05-15 |
2008-10-14 |
Genentech, Inc. |
Peptides that induce chondrocyte redifferentiation
|
US20020137890A1
(en)
*
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
DE69842225D1
(de)
|
1997-04-16 |
2011-05-26 |
Millennium Pharm Inc |
Zusammensetzung, umfassend einen Antikörper, der selektiv an ein cysteinreiches sekretiertes Protein (CRSP) bindet
|
US6190909B1
(en)
*
|
1997-04-17 |
2001-02-20 |
Millennium Pharmaceuticals, Inc. |
TH2-specific gene
|
EP0980432A1
(en)
*
|
1997-05-01 |
2000-02-23 |
Amgen, Inc. |
Chimeric opg polypeptides
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
US20030207346A1
(en)
*
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
AU751659B2
(en)
|
1997-05-02 |
2002-08-22 |
Genentech Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
US20020062010A1
(en)
*
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
ATE462717T1
(de)
|
1997-06-13 |
2010-04-15 |
Bio Rad Laboratories |
Verfahren und zusammensetzungen für die diagnose und die behandlung von krankheiten, die mit eisenüberschuss oder eisenmangel assoziiert sind
|
US20030083461A1
(en)
*
|
1997-06-16 |
2003-05-01 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US20040191256A1
(en)
*
|
1997-06-24 |
2004-09-30 |
Genentech, Inc. |
Methods and compositions for galactosylated glycoproteins
|
KR100220645B1
(ko)
*
|
1997-07-04 |
1999-09-15 |
구광시 |
벤젠유도체의 제조방법
|
US6187564B1
(en)
|
1997-07-10 |
2001-02-13 |
Beth Israel Deaconess Medical Center |
DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
|
US6165476A
(en)
*
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
US6242570B1
(en)
|
1997-07-10 |
2001-06-05 |
Beth Israel Deaconess Medical Center |
Production and use of recombinant protein multimers with increased biological activity
|
US20030073169A1
(en)
*
|
1997-09-18 |
2003-04-17 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US6391311B1
(en)
*
|
1998-03-17 |
2002-05-21 |
Genentech, Inc. |
Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
|
WO1999020758A1
(en)
*
|
1997-10-21 |
1999-04-29 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2
|
US6503184B1
(en)
|
1997-10-21 |
2003-01-07 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
US6689607B2
(en)
|
1997-10-21 |
2004-02-10 |
Human Genome Sciences, Inc. |
Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
US20040136986A1
(en)
*
|
1997-10-31 |
2004-07-15 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
US6576743B1
(en)
*
|
1997-11-26 |
2003-06-10 |
Zymogenetics, Inc. |
Mammalian cytokine-like polypeptide-10
|
WO1999029732A2
(en)
|
1997-12-08 |
1999-06-17 |
Lexigen Pharmaceuticals Corporation |
Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
|
US6207413B1
(en)
*
|
1998-01-22 |
2001-03-27 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acids encoding novel orphan cytokine receptors
|
US20030105294A1
(en)
*
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
US7198789B2
(en)
*
|
1998-03-17 |
2007-04-03 |
Genetics Institute, Llc |
Methods and compositions for modulating interleukin-21 receptor activity
|
US6057128A
(en)
|
1998-03-17 |
2000-05-02 |
Genetics Institute, Inc. |
MU-1, member of the cytokine receptor family
|
US7189400B2
(en)
*
|
1998-03-17 |
2007-03-13 |
Genetics Institute, Llc |
Methods of treatment with antagonists of MU-1
|
US7371836B2
(en)
*
|
1998-03-27 |
2008-05-13 |
Genentech, Inc. |
PRO526 nucleic acids
|
US7723488B2
(en)
*
|
1998-03-27 |
2010-05-25 |
Genentech, Inc. |
Monoclonal antibodies to secreted and transmembrane polypeptides
|
DE69931908T2
(de)
*
|
1998-04-15 |
2007-01-11 |
Lexigen Pharmaceuticals Corp., Lexington |
Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor
|
US7256039B2
(en)
*
|
1998-05-15 |
2007-08-14 |
Genentech, Inc. |
PRO4405 nucleic acids
|
JP3577586B2
(ja)
*
|
1998-05-15 |
2004-10-13 |
ジェネンテック・インコーポレーテッド |
Il−17相同的ポリペプチドとその治療用途
|
CA2328498A1
(en)
|
1998-06-12 |
1999-12-16 |
Genentech, Inc. |
Monoclonal antibodies, cross-reactive antibodies and method for producing the same____________________________________
|
DE69933216T2
(de)
*
|
1998-06-15 |
2007-09-20 |
GTC Biotherapeutics, Inc., Framingham |
Erythropoietin-analog-menschliches serum-albumin fusionsprotein
|
US20050181482A1
(en)
*
|
2004-02-12 |
2005-08-18 |
Meade Harry M. |
Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
|
US20070003545A9
(en)
*
|
1999-06-02 |
2007-01-04 |
Eaton Dan L |
Interleukin-8 homologous polypeptides and therapeutic uses thereof
|
US7291712B2
(en)
*
|
1998-06-25 |
2007-11-06 |
Genentech, Inc. |
Interleukin-8 homologous polypeptides and therapeutic uses thereof
|
US20020099197A1
(en)
*
|
1998-07-21 |
2002-07-25 |
Rory A.J. Curtis |
Novel potassium channel molecules and uses therefor
|
US20030166132A1
(en)
*
|
1998-08-26 |
2003-09-04 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
ES2252999T3
(es)
*
|
1998-08-31 |
2006-05-16 |
Biogen Idec Ma Inc. |
Modulacion de celulas t efectoras y de memoria con un ligando de cd2.
|
AU762616B2
(en)
|
1998-10-16 |
2003-07-03 |
Biogen Ma Inc. |
Polymer conjugates of interferon beta-1a and uses
|
PL200586B1
(pl)
*
|
1998-10-16 |
2009-01-30 |
Biogen Idec Inc |
Polipeptydy zawierające mutanty interferonu-beta-1a, kodujące je cząsteczki kwasów nukleinowych, komórki gospodarza transformowane tymi cząsteczkami, sposób wytwarzania polipeptydów, zawierające je kompozycje farmaceutyczne i zastosowania polipeptydów
|
US6660843B1
(en)
*
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
MEP42108A
(en)
|
1998-10-23 |
2011-02-10 |
Kiren Amgen Inc |
Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
|
US7488590B2
(en)
*
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
WO2000027885A1
(fr)
*
|
1998-11-05 |
2000-05-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Nouveau popypeptide chimerique
|
CA2350771A1
(en)
*
|
1998-11-10 |
2000-05-18 |
Human Genome Sciences, Inc. |
Chemokine .beta.-7
|
US7294482B2
(en)
*
|
1998-11-19 |
2007-11-13 |
Millennium Pharmaceuticals, Inc. |
EGF-like nucleic acids
|
US7238790B2
(en)
*
|
1999-01-12 |
2007-07-03 |
Genentech, Inc. |
PRO1313 polypeptides
|
AU3224700A
(en)
*
|
1999-02-08 |
2000-08-25 |
Chiron Corporation |
Fibroblast growth factor receptor-immunoglobulin fusion
|
AU764382B2
(en)
|
1999-03-19 |
2003-08-14 |
Genentech Inc. |
Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist
|
US7011833B1
(en)
*
|
1999-05-06 |
2006-03-14 |
Genetics Institute, Inc. |
Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent
|
US20050079577A1
(en)
*
|
1999-05-14 |
2005-04-14 |
Ashkenazi Avi J. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
DK1187852T3
(da)
*
|
1999-05-19 |
2007-11-26 |
Merck Patent Gmbh |
Ekspression og eksport af interferon-alpha-proteiner som Fc-fusionsproteiner
|
CA2375700A1
(en)
*
|
1999-06-01 |
2000-12-07 |
Biogen, Inc. |
Polymer conjugates of hedgehog proteins and uses
|
WO2000073498A1
(en)
*
|
1999-06-02 |
2000-12-07 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
US6924359B1
(en)
*
|
1999-07-01 |
2005-08-02 |
Yale University |
Neovascular-targeted immunoconjugates
|
CA2373735A1
(en)
*
|
1999-07-02 |
2001-01-11 |
Genentech, Inc. |
Fviia antagonists
|
JP4387625B2
(ja)
|
1999-07-02 |
2009-12-16 |
ジェネンテック・インコーポレーテッド |
Her2に結合する化合物
|
US7011967B1
(en)
*
|
1999-07-12 |
2006-03-14 |
Merck Patent Gmbh |
Seripancrin
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
SK782002A3
(en)
*
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
WO2001007084A1
(en)
*
|
1999-07-23 |
2001-02-01 |
Regents Of The University Of California |
Anti-growth factor receptor avidin fusion proteins as universal vectors for drug delivery
|
JP2003512303A
(ja)
*
|
1999-08-06 |
2003-04-02 |
ジェネンテック・インコーポレーテッド |
因子viiaのペプチドアンタゴニスト
|
MXPA02001417A
(es)
*
|
1999-08-09 |
2002-08-12 |
Lexigen Pharm Corp |
Complejos multiples de citosina-anticuerpo.
|
PT1210428E
(pt)
|
1999-08-23 |
2015-07-21 |
Genetics Inst Llc |
Pd-1, um recetor para b7-4 e suas utilizações
|
US20030166858A1
(en)
*
|
1999-09-16 |
2003-09-04 |
Samuel Davis |
TIE-2 ligands, methods of making and uses thereof
|
US6323334B1
(en)
*
|
1999-09-24 |
2001-11-27 |
Millennium Pharmaceuticals, Inc. |
Nucleic acid molecules encoding a 103 gene product and uses therefor
|
IL149202A0
(en)
*
|
1999-11-05 |
2002-11-10 |
Biogen Inc |
Hedgehog fusion proteins and uses
|
US20050202538A1
(en)
*
|
1999-11-12 |
2005-09-15 |
Merck Patent Gmbh |
Fc-erythropoietin fusion protein with improved pharmacokinetics
|
JP2003514552A
(ja)
|
1999-11-12 |
2003-04-22 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
改善された性質を有するエリトロポエチンの形態
|
US7122632B2
(en)
*
|
1999-12-23 |
2006-10-17 |
Zymogenetics, Inc. |
Soluble Interleukin-20 receptor
|
US6610286B2
(en)
*
|
1999-12-23 |
2003-08-26 |
Zymogenetics, Inc. |
Method for treating inflammation using soluble receptors to interleukin-20
|
US7307153B2
(en)
*
|
1999-12-23 |
2007-12-11 |
Genentech, Inc. |
Antibodies that bind PRO9912
|
US7164001B2
(en)
*
|
2000-01-20 |
2007-01-16 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
EP1252192B1
(en)
|
2000-02-11 |
2006-08-16 |
MERCK PATENT GmbH |
Enhancing the circulating half-life of antibody-based fusion proteins
|
KR20020086540A
(ko)
*
|
2000-02-21 |
2002-11-18 |
어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. |
Il-18 저해물질의 용도
|
US7572631B2
(en)
*
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
US7541184B2
(en)
*
|
2000-02-24 |
2009-06-02 |
Invitrogen Corporation |
Activation and expansion of cells
|
US20060073547A1
(en)
*
|
2000-03-01 |
2006-04-06 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
US6984519B2
(en)
|
2000-03-01 |
2006-01-10 |
Genetech, Inc. |
Nucleic acids encoding peptides that induce chondrocyte redifferentiation
|
US20060002943A1
(en)
*
|
2000-03-02 |
2006-01-05 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
US20020064820A1
(en)
*
|
2000-03-13 |
2002-05-30 |
Jean-Michel Dayer |
Apo-A-I regulation of T-cell signaling
|
US7514239B2
(en)
*
|
2000-03-28 |
2009-04-07 |
Amgen Inc. |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
|
JP2003530108A
(ja)
*
|
2000-04-10 |
2003-10-14 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
クリプティック様分泌型タンパク質
|
CA2405709A1
(en)
*
|
2000-04-12 |
2001-10-25 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US6946134B1
(en)
|
2000-04-12 |
2005-09-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20050100991A1
(en)
*
|
2001-04-12 |
2005-05-12 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
AU5914201A
(en)
*
|
2000-04-25 |
2001-11-07 |
Idec Pharma Corp |
Intrathecal administration of rituximab for treatment of central nervous system lymphomas
|
US6756480B2
(en)
|
2000-04-27 |
2004-06-29 |
Amgen Inc. |
Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
|
AU2001257445B2
(en)
*
|
2000-04-28 |
2006-11-02 |
Planet Biotechnology, Inc. |
Immunoadhesin for the prevention of rhinovirus infection
|
US20060015969A1
(en)
*
|
2000-04-28 |
2006-01-19 |
Planet Biotechnology, Inc. |
Novel immunoadhesins for treating and prventing toxicity and pathogen-mediated diseases
|
AU2001259432B2
(en)
*
|
2000-05-03 |
2005-04-21 |
Amgen Inc. |
Modified peptides, comprising an FC domain, as therapeutic agents
|
US20020102232A1
(en)
*
|
2000-05-11 |
2002-08-01 |
Chang Tse W. |
Compositions and methods for induction of active autoimmunity
|
BR0110779A
(pt)
*
|
2000-05-12 |
2005-01-11 |
Beth Israel Hospital |
Composições e métodos para adquirir supressão imunológica
|
EP1714661A3
(en)
|
2000-05-19 |
2012-03-14 |
The Center for Blood Research, INC. |
Methods for diagnosing and treating hemostatic disorders by modulating p-selectin activity
|
US20040034193A1
(en)
*
|
2001-06-13 |
2004-02-19 |
Samy Ashkar |
Biosynthetic oncolytic molecules and uses therefor
|
US20050048614A1
(en)
*
|
2000-06-13 |
2005-03-03 |
Children's Medical Center Corporation |
Biosynthetic oncolytic molecules and uses therefor
|
DK1325115T3
(en)
*
|
2000-06-26 |
2016-11-21 |
Zymogenetics Inc |
CYTOKINRECEPTOR ZCYTOR17
|
US20030096339A1
(en)
*
|
2000-06-26 |
2003-05-22 |
Sprecher Cindy A. |
Cytokine receptor zcytor17
|
CA2414331C
(en)
|
2000-06-28 |
2011-11-29 |
Genetics Institute, Llc. |
Pd-l2 molecules: novel pd-1 ligands and uses therefor
|
RU2272644C2
(ru)
*
|
2000-06-29 |
2006-03-27 |
Мерк Патент Гмбх |
Усиление иммунной реакции, медиатором которой является слитый протеин антитело-цитокин, при помощи комбинированного лечения агентами, увеличивающими поглощение иммуноцитокина
|
UA81743C2
(uk)
|
2000-08-07 |
2008-02-11 |
Центокор, Инк. |
МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
|
US7288390B2
(en)
|
2000-08-07 |
2007-10-30 |
Centocor, Inc. |
Anti-dual integrin antibodies, compositions, methods and uses
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
JP5015404B2
(ja)
*
|
2000-08-08 |
2012-08-29 |
ザイモジェネティクス, インコーポレイテッド |
可溶性zcytor11サイトカイン受容体
|
US20030215916A1
(en)
*
|
2000-08-18 |
2003-11-20 |
Feder John N. |
Novel imidazoline receptor homologs
|
CA2417432C
(en)
|
2000-09-01 |
2010-11-02 |
The Center For Blood Research, Inc. |
Modified polypeptides stabilized in a desired conformation and methods for producing same
|
US20020119148A1
(en)
|
2000-09-01 |
2002-08-29 |
Gerritsen Mary E. |
ErbB4 antagonists
|
JP2004525076A
(ja)
*
|
2000-09-14 |
2004-08-19 |
ベス・イスラエル・ディーコニス・メディカル・センター・インコーポレーテッド |
Il−2およびil−15媒介t細胞応答の調節
|
DE60135158D1
(de)
|
2000-09-26 |
2008-09-11 |
Genentech Inc |
Antagonisten des ige-rezeptors
|
AU2001294913A1
(en)
*
|
2000-09-29 |
2002-04-08 |
Bristol-Myers Squibb Company |
Identification and cloning of a full-length human cink-related gene, mist (mast cell immunoreceptor signal transducer)
|
US20030211549A1
(en)
*
|
2000-10-06 |
2003-11-13 |
Murphy Andrew J. |
Functional proteins and therapeutic and diagnostic methods for use thereof
|
EP1364019A2
(en)
*
|
2000-11-07 |
2003-11-26 |
Board of Regents, The University of Texas System |
Methods and compositions relating to muscle specific sarcomeric calcineurin-binding proteins (calsarcins)
|
AU2002216481B2
(en)
*
|
2000-12-04 |
2008-05-01 |
Auckland Uniservices Limited |
Immunomodulatory constructs and their uses
|
EP1642910B1
(en)
*
|
2000-12-05 |
2012-02-08 |
Alexion Pharmaceuticals, Inc. |
Rationally designed antibodies
|
US20040253242A1
(en)
*
|
2000-12-05 |
2004-12-16 |
Bowdish Katherine S. |
Rationally designed antibodies
|
US7396917B2
(en)
*
|
2000-12-05 |
2008-07-08 |
Alexion Pharmaceuticals, Inc. |
Rationally designed antibodies
|
EP1430121A4
(en)
*
|
2001-02-16 |
2004-09-22 |
Bristol Myers Squibb Co |
A NEW GLYCINE RECEPTOR ALPHA UNIT EXPRESSED IN THE GASTRIDGE TRACT, HGRA4, CODING POLYNUCLEOTIDES AND SPLICE VERSION THEREOF
|
DK1366067T3
(da)
*
|
2001-03-07 |
2012-10-22 |
Merck Patent Gmbh |
Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed
|
US8163289B2
(en)
|
2001-03-09 |
2012-04-24 |
Iterative Therapeutics, Inc. |
Methods and compositions involving polymeric immunoglobulin fusion proteins
|
CA2437958C
(en)
|
2001-03-09 |
2018-10-30 |
University Of Chicago |
Polymeric immunoglobulin fusion proteins that target low-affinity fc.gamma.receptors
|
US6992174B2
(en)
*
|
2001-03-30 |
2006-01-31 |
Emd Lexigen Research Center Corp. |
Reducing the immunogenicity of fusion proteins
|
CA2442066C
(en)
|
2001-04-02 |
2005-11-01 |
Wyeth |
Pd-1, a receptor for b7-4, and uses therefor
|
US20060084794A1
(en)
*
|
2001-04-12 |
2006-04-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US7507413B2
(en)
|
2001-04-12 |
2009-03-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20050054051A1
(en)
*
|
2001-04-12 |
2005-03-10 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20050244931A1
(en)
*
|
2001-04-12 |
2005-11-03 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
ITRE20010042A1
(it)
*
|
2001-04-24 |
2002-10-24 |
Corghi Spa |
Dispositivo sollevatore per macchine smontagomme
|
US20050089932A1
(en)
*
|
2001-04-26 |
2005-04-28 |
Avidia Research Institute |
Novel proteins with targeted binding
|
US7265208B2
(en)
*
|
2001-05-01 |
2007-09-04 |
The Regents Of The University Of California |
Fusion molecules and treatment of IgE-mediated allergic diseases
|
BR0209177A
(pt)
*
|
2001-05-03 |
2004-10-05 |
Merck Patent Gmbh |
Anticorpo especìfico a tumor recombinante e uso do mesmo
|
CA2446189C
(en)
|
2001-05-11 |
2011-10-18 |
Amgen, Inc. |
Peptides and related molecules that bind to tall-1
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
JP2004537991A
(ja)
*
|
2001-06-15 |
2004-12-24 |
タノックス インコーポレーテッド |
アレルギー及び喘息治療用Fcε融合タンパク質
|
US20060073141A1
(en)
*
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
WO2004003019A2
(en)
*
|
2002-06-28 |
2004-01-08 |
Domantis Limited |
Immunoglobin single variant antigen-binding domains and dual-specific constructs
|
AU2002320352A1
(en)
*
|
2001-07-24 |
2003-02-17 |
Biogen Idec Ma Inc. |
Methods for treating or preventing sclerotic disorders using cd2-binding agents
|
JP2005507870A
(ja)
*
|
2001-08-13 |
2005-03-24 |
ユニバーシティ・オブ・サザン・カリフォルニア |
低毒性のインターロイキン−2突然変異体
|
US6900292B2
(en)
*
|
2001-08-17 |
2005-05-31 |
Lee-Hwei K. Sun |
Fc fusion proteins of human erythropoietin with increased biological activities
|
NZ543755A
(en)
|
2001-08-29 |
2008-04-30 |
Genentech Inc |
Bv8 nucleic acids and polypeptides with mitogenic activity
|
AU2002323501C1
(en)
*
|
2001-08-30 |
2010-04-29 |
Biorexis Technology, Inc |
Modified transferrin fusion proteins
|
US6797493B2
(en)
|
2001-10-01 |
2004-09-28 |
Lee-Hwei K. Sun |
Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
|
WO2003030821A2
(en)
*
|
2001-10-05 |
2003-04-17 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
US7205275B2
(en)
*
|
2001-10-11 |
2007-04-17 |
Amgen Inc. |
Methods of treatment using specific binding agents of human angiopoietin-2
|
DE60224822T2
(de)
*
|
2001-10-19 |
2009-01-22 |
Zymogenetics, Inc., Seattle |
Dimerisierter wachstumsfaktor sowie materialien und verfahren zu seiner herstellung
|
WO2003040311A2
(en)
*
|
2001-10-25 |
2003-05-15 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services |
Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4
|
US20070118934A1
(en)
*
|
2001-10-26 |
2007-05-24 |
Planet Biotechnology, Inc. |
Chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax
|
PT1454138E
(pt)
*
|
2001-12-04 |
2012-03-28 |
Merck Patent Gmbh |
Imunocitoquinas com seletividade modulada
|
ES2337989T3
(es)
*
|
2001-12-18 |
2010-05-03 |
Endocube Sas |
Nuevas proteinas asociadas a la muerte de la familia thap y rutas par4 relacionadas implicadas en el control de la apoptosis.
|
US7858297B2
(en)
*
|
2001-12-18 |
2010-12-28 |
Centre National De La Recherche Scientifique Cnrs |
Chemokine-binding protein and methods of use
|
AU2002364587A1
(en)
*
|
2001-12-21 |
2003-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
CA2471363C
(en)
*
|
2001-12-21 |
2014-02-11 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
KR101271635B1
(ko)
*
|
2001-12-21 |
2013-06-12 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
알부민 융합 단백질
|
EP1961811B1
(en)
|
2002-01-18 |
2010-08-25 |
ZymoGenetics, Inc. |
Cytokine ligand for the treatment of asthma and airway hyper-responsiveness
|
GEP20074024B
(en)
|
2002-01-18 |
2007-01-10 |
Biogen Idec Inc |
Polyalkylene glycol comprising a radical for conjugation of biologically active compound
|
US7164002B2
(en)
|
2002-02-06 |
2007-01-16 |
Genentech, Inc. |
FVIIa antagonists
|
US20030211470A1
(en)
*
|
2002-03-15 |
2003-11-13 |
Olson William C. |
CD4-IgG2-based salvage therapy of HIV-1 infection
|
MXPA04009874A
(es)
*
|
2002-04-10 |
2005-10-19 |
Applied Research Systems |
Antagonistas novedosos de proteinas mcp.
|
US20040016010A1
(en)
*
|
2002-04-17 |
2004-01-22 |
Marion Kasaian |
IL-21 receptor knockout animal and methods of use thereof
|
WO2003100056A1
(fr)
|
2002-05-29 |
2003-12-04 |
Yamasa Corporation |
Nouvelle enzyme polyphosphate :amp phosphotransferase
|
DE60334453D1
(de)
*
|
2002-05-30 |
2010-11-18 |
Macrogenics Inc |
Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
|
NZ519371A
(en)
*
|
2002-06-04 |
2004-11-26 |
Auckland Uniservices Ltd |
Immunomodulatory constructs and their uses
|
EP1369128A1
(en)
*
|
2002-06-07 |
2003-12-10 |
Procorde GmbH |
Inhibitors of glycoprotein VI and their therapeutic use
|
US20090130021A1
(en)
*
|
2002-06-07 |
2009-05-21 |
Gotz Munch |
Methods, products and uses involving platelets and/or the vasculature
|
US20070071744A1
(en)
*
|
2002-06-07 |
2007-03-29 |
Gotz Munch |
Agents which bind to epitopes of glycoprotein VI
|
US7531178B2
(en)
*
|
2002-06-07 |
2009-05-12 |
Trigen Gmbh |
Immunoadhesin comprising a glycoprotein VI domain
|
US8029803B2
(en)
|
2002-06-20 |
2011-10-04 |
Paladin Labs, Inc. |
Chimeric antigens for eliciting an immune response
|
US8025873B2
(en)
*
|
2002-06-20 |
2011-09-27 |
Paladin Labs, Inc. |
Chimeric antigens for eliciting an immune response
|
US20070104710A1
(en)
*
|
2002-06-28 |
2007-05-10 |
Domants Limited |
Ligand that has binding specificity for IL-4 and/or IL-13
|
AU2003280130B2
(en)
|
2002-06-28 |
2009-06-11 |
Centocor, Inc. |
Mammalian CH1 deleted mimetibodies, compositions, methods and uses
|
CN1241946C
(zh)
*
|
2002-07-01 |
2006-02-15 |
美国福源集团 |
对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
|
JP5068931B2
(ja)
*
|
2002-07-12 |
2012-11-07 |
ザ ジョンズ ホプキンス ユニバーシティー |
独自のクローン形質のリンパ球受容体に結合する試薬および方法
|
WO2004007682A2
(en)
*
|
2002-07-15 |
2004-01-22 |
Wyeth |
Methods and compositions for modulating t helper (th) cell development and function
|
US20040110681A1
(en)
*
|
2002-08-08 |
2004-06-10 |
Xiao-Min Fan |
Method to identify targeting molecules
|
US20040136992A1
(en)
|
2002-08-28 |
2004-07-15 |
Burton Paul B. J. |
Compositions and method for treating cardiovascular disease
|
DE10251463A1
(de)
*
|
2002-11-05 |
2004-05-19 |
BSH Bosch und Siemens Hausgeräte GmbH |
Elektrisch angetriebene Pumpe
|
US20050054054A1
(en)
*
|
2002-11-12 |
2005-03-10 |
Foss Francine M. |
Interleukin-7 molecules with altered biological properties
|
CA2510180C
(en)
*
|
2002-12-17 |
2012-09-11 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
|
JP2006523090A
(ja)
*
|
2002-12-27 |
2006-10-12 |
ドマンティス リミテッド |
リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
|
GB0230203D0
(en)
*
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
US20110223168A1
(en)
*
|
2002-12-27 |
2011-09-15 |
Greg Winter |
Ligand that has binding specificity for il-4 and/or il-13
|
EP1596804A4
(en)
*
|
2003-01-13 |
2008-02-06 |
Macrogenics Inc |
SOLUBLE FCyR FUSION PROTEINS AND METHODS OF USE
|
CA2513213C
(en)
|
2003-01-22 |
2013-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
US20060234340A1
(en)
*
|
2003-02-06 |
2006-10-19 |
Novozymes A/S |
Human heavy chain antibody expression in flamentous fungi
|
US20050096264A1
(en)
*
|
2003-02-25 |
2005-05-05 |
Macdonald Lynn |
Methods for treating obesity and related conditions with glycoprotein hormone beta family hormones
|
EP1615659B1
(en)
|
2003-03-12 |
2014-04-16 |
Genentech, Inc. |
Use of bv8 and/or eg-vegf to promote hematopoiesis
|
US20050142139A1
(en)
*
|
2003-03-21 |
2005-06-30 |
Norbert Schulke |
CD4-IgG2 formulations
|
EA009026B1
(ru)
*
|
2003-03-24 |
2007-10-26 |
Займоджинетикс, Инк. |
Антитела против il-22ra, их партнеры по связыванию и способы их применения при воспалениях
|
SI1606318T1
(sl)
*
|
2003-03-26 |
2009-12-31 |
Apogenix Gmbh |
Izboljšani Fc fuzijski proteini
|
TWI353991B
(en)
*
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
CA2522690A1
(en)
*
|
2003-05-06 |
2004-11-25 |
Syntonix Pharmaceuticals, Inc. |
Inhibition of drug binding to serum albumin
|
DK2298347T3
(en)
|
2003-05-06 |
2016-01-11 |
Biogen Hemophilia Inc |
COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER
|
US7348004B2
(en)
|
2003-05-06 |
2008-03-25 |
Syntonix Pharmaceuticals, Inc. |
Immunoglobulin chimeric monomer-dimer hybrids
|
EP2286804A1
(en)
|
2003-05-13 |
2011-02-23 |
DePuy Spine, Inc. |
A method of treating degenerative disc disease
|
US7344716B2
(en)
*
|
2003-05-13 |
2008-03-18 |
Depuy Spine, Inc. |
Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
|
DK1622939T3
(da)
*
|
2003-05-13 |
2012-04-10 |
Merck Serono Sa |
Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
|
US20040229878A1
(en)
*
|
2003-05-13 |
2004-11-18 |
Depuy Spine, Inc. |
Transdiscal administration of specific inhibitors of P38 kinase
|
US7553827B2
(en)
*
|
2003-08-13 |
2009-06-30 |
Depuy Spine, Inc. |
Transdiscal administration of cycline compounds
|
US8273347B2
(en)
|
2003-05-13 |
2012-09-25 |
Depuy Spine, Inc. |
Autologous treatment of degenerated disc with cells
|
US7429378B2
(en)
*
|
2003-05-13 |
2008-09-30 |
Depuy Spine, Inc. |
Transdiscal administration of high affinity anti-MMP inhibitors
|
US7435808B2
(en)
*
|
2003-06-25 |
2008-10-14 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
|
PL1639011T3
(pl)
*
|
2003-06-30 |
2009-05-29 |
Domantis Ltd |
Pegilowane przeciwciała jednodomenowe (dAb)
|
WO2005007121A2
(en)
|
2003-07-18 |
2005-01-27 |
Massachusetts Institute Of Technology |
Mutant interleukin-2(il-2) polypeptides
|
US8361467B2
(en)
*
|
2003-07-30 |
2013-01-29 |
Depuy Spine, Inc. |
Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
|
US8007805B2
(en)
*
|
2003-08-08 |
2011-08-30 |
Paladin Labs, Inc. |
Chimeric antigens for breaking host tolerance to foreign antigens
|
EP2520654B8
(en)
|
2003-08-26 |
2017-04-19 |
The Regents of the University of Colorado, a body corporate |
Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
|
US20050069521A1
(en)
*
|
2003-08-28 |
2005-03-31 |
Emd Lexigen Research Center Corp. |
Enhancing the circulating half-life of interleukin-2 proteins
|
UA89481C2
(uk)
*
|
2003-09-30 |
2010-02-10 |
Центокор, Инк. |
Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
|
US20070274988A1
(en)
*
|
2003-10-10 |
2007-11-29 |
Five Prime Therapeautics, Inc. |
Kiaa0779, Splice Variants Thereof, and Methods of Their Use
|
WO2005037999A2
(en)
*
|
2003-10-14 |
2005-04-28 |
Biogen Idec Ma Inc. |
Treatment of cancer using antibodies to lrrc15
|
US8129506B2
(en)
*
|
2003-10-24 |
2012-03-06 |
Genzyme Corporation |
Modulation of the interaction of MUC1 with MUC1 ligands
|
EP1697415A1
(en)
|
2003-11-12 |
2006-09-06 |
Biogen Idec MA Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
BRPI0406605B8
(pt)
*
|
2003-11-13 |
2021-05-25 |
Hanmi Holdings Co Ltd |
conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo
|
US8110665B2
(en)
|
2003-11-13 |
2012-02-07 |
Hanmi Holdings Co., Ltd. |
Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
|
US8895540B2
(en)
|
2003-11-26 |
2014-11-25 |
DePuy Synthes Products, LLC |
Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
|
EP1699822B1
(en)
|
2003-12-30 |
2008-04-23 |
MERCK PATENT GmbH |
Il-7 fusion proteins with antibody portions, their preparation and their use
|
ES2387028T3
(es)
*
|
2003-12-31 |
2012-09-12 |
Merck Patent Gmbh |
Proteína de fusión de Fc-eritropoyetina con farmacocinética mejorada
|
PL1706428T3
(pl)
|
2004-01-22 |
2010-02-26 |
Merck Patent Gmbh |
Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
|
MXPA06008918A
(es)
*
|
2004-02-06 |
2007-03-07 |
Astellas Llc |
Metodos de tratamiento de trastornos de la piel.
|
NZ549040A
(en)
|
2004-02-17 |
2009-07-31 |
Schering Corp |
Use for interleukin-33 (IL33) and the IL-33 receptor complex
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
CA2563379A1
(en)
*
|
2004-03-31 |
2005-10-20 |
Centocor, Inc. |
Human glp-1 mimetibodies, compositions, methods and uses
|
US20080020383A1
(en)
*
|
2004-05-04 |
2008-01-24 |
Genaissance Pharmaceuticals, Inc. |
Haplotype Markers And Methods Of Using The Same To Determine Response To Treatment
|
EP1750747A1
(en)
*
|
2004-05-07 |
2007-02-14 |
Astellas US LLC |
Soluble lfa-3 polypeptide for treating viral disorders
|
US20060063208A1
(en)
*
|
2004-08-02 |
2006-03-23 |
Woolf Clifford J |
DRG11-responsive (DRAGON) gene and uses thereof
|
US7393662B2
(en)
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
PL1804835T3
(pl)
*
|
2004-09-13 |
2010-11-30 |
Genzyme Corp |
Konstrukty multimeryczne
|
EP1797127B1
(en)
|
2004-09-24 |
2017-06-14 |
Amgen Inc. |
Modified fc molecules
|
EP1802334B1
(en)
|
2004-10-21 |
2012-08-29 |
Genentech, Inc. |
Method for treating intraocular neovascular diseases
|
MX2007004770A
(es)
|
2004-10-22 |
2007-11-22 |
Zymogenetics Inc |
Anticuerpos anti-il-22ra y moleculas y metodos para usarlos en inflamacion.
|
US20090311259A1
(en)
*
|
2004-11-17 |
2009-12-17 |
Victoria Smith |
Compositions and Methods for Treatment of Tumor of Hematopoietic Origin
|
CN101072793B
(zh)
*
|
2004-12-09 |
2012-06-20 |
默克专利有限公司 |
具有降低的免疫原性的il-7变体
|
CN100515491C
(zh)
*
|
2005-01-04 |
2009-07-22 |
健能隆医药技术(上海)有限公司 |
白介素-22的医药用途
|
ES2408704T3
(es)
|
2005-01-05 |
2013-06-21 |
Biogen Idec Ma Inc. |
Moléculas de unión a Cripto
|
WO2006081190A2
(en)
|
2005-01-25 |
2006-08-03 |
Five Prime Therapeutics, Inc. |
Compositions and methods for treating cardiac conditions
|
US20090155267A1
(en)
*
|
2005-02-09 |
2009-06-18 |
Apollo Life Sciences Limited |
Molecule and chimeric molecules thereof
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물
|
CA2605024C
(en)
*
|
2005-04-15 |
2018-05-22 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US9963510B2
(en)
*
|
2005-04-15 |
2018-05-08 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US11254748B2
(en)
|
2005-04-15 |
2022-02-22 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
US9284375B2
(en)
*
|
2005-04-15 |
2016-03-15 |
Macrogenics, Inc. |
Covalent diabodies and uses thereof
|
PE20061324A1
(es)
|
2005-04-29 |
2007-01-15 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, metodos y usos
|
CN101198624B
(zh)
|
2005-05-06 |
2012-10-10 |
津莫吉尼蒂克斯公司 |
Il-31单克隆抗体及使用方法
|
EP2388274A1
(en)
*
|
2005-06-17 |
2011-11-23 |
Janssen Alzheimer Immunotherapy |
Methods of purifying anti A Beta antibodies
|
TR201902033T4
(tr)
|
2005-06-30 |
2019-03-21 |
Janssen Biotech Inc |
Anti-IL-23 antikorları, bileşimleri, yöntemleri ve kullanımları.
|
EP2238986A3
(en)
|
2005-07-08 |
2010-11-03 |
Biogen Idec MA Inc. |
Sp35 antibodies and uses thereof
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
EP1926747A1
(en)
*
|
2005-08-12 |
2008-06-04 |
Schering Corporation |
Mcp1 fusions
|
CA2616479A1
(en)
|
2005-09-01 |
2007-03-08 |
Ares Trading S.A. |
Treatment of optic neuritis
|
US20070104689A1
(en)
*
|
2005-09-27 |
2007-05-10 |
Merck Patent Gmbh |
Compositions and methods for treating tumors presenting survivin antigens
|
US20090238822A1
(en)
*
|
2005-10-13 |
2009-09-24 |
Virexx Medical Corp. |
Chimeric Hepatitis C Virus Antigens For Eliciting an Immune Response
|
TW200722436A
(en)
*
|
2005-10-21 |
2007-06-16 |
Hoffmann La Roche |
A peptide-immunoglobulin-conjugate
|
CA2628928A1
(en)
*
|
2005-11-10 |
2007-05-24 |
Receptor Biologix, Inc. |
Hepatocyte growth factor intron fusion proteins
|
ES2433251T5
(es)
|
2005-11-14 |
2020-03-13 |
Teva Pharmaceuticals Int Gmbh |
Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos
|
EP1957536A2
(en)
*
|
2005-12-01 |
2008-08-20 |
Domantis Limited |
Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
|
US20070136826A1
(en)
*
|
2005-12-02 |
2007-06-14 |
Biogen Idec Inc. |
Anti-mouse CD20 antibodies and uses thereof
|
US20070161546A1
(en)
*
|
2005-12-15 |
2007-07-12 |
Colm King |
Methods and compositions for treatment of cancer
|
JP2009521503A
(ja)
*
|
2005-12-22 |
2009-06-04 |
ディー・エイチ・ワイ・アンド・カンパニー・リミテッド |
インターロイキン−22結合タンパク質に対する抗体と、代謝性疾患の処置のためのその使用
|
MX2008008621A
(es)
|
2005-12-29 |
2008-11-27 |
Centocor Inc |
Anticuerpos anti-il-23 humanos, composiciones, metodos y usos.
|
ATE555125T1
(de)
*
|
2005-12-30 |
2012-05-15 |
Merck Patent Gmbh |
Interleukin-12p40-varianten mit verbesserter stabilität
|
EA016429B1
(ru)
|
2005-12-30 |
2012-04-30 |
Мерк Патент Гмбх |
Антитела против cd19 с пониженной иммуногенностью
|
EP1991581A2
(en)
*
|
2006-01-10 |
2008-11-19 |
Zymogenetics, Inc. |
Methods of treating pain and inflammation in neuronal tissue using il-31 antagonists
|
US7625564B2
(en)
|
2006-01-27 |
2009-12-01 |
Novagen Holding Corporation |
Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
|
AR059193A1
(es)
|
2006-01-31 |
2008-03-12 |
Bayer Schering Pharma Ag |
Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
|
GB0604187D0
(en)
*
|
2006-03-02 |
2006-04-12 |
Fusion Antibodies Ltd |
Peptide and uses thereof
|
EP2007538A4
(en)
*
|
2006-03-31 |
2011-04-20 |
Centocor Ortho Biotech Inc |
BINDING PARTNER WITH MODIFIED IMMUNOGLOBULINDOMAS FOR EXTENDED SEMI-VALUE TIME
|
WO2007135172A2
(en)
|
2006-05-24 |
2007-11-29 |
Laboratoires Serono S.A. |
Cladribine regimen for treating multiple sclerosis
|
AU2007257683A1
(en)
*
|
2006-06-12 |
2007-12-21 |
Symphogen A/S |
Pan-cell surface receptor- specific therapeutics
|
WO2007149586A2
(en)
*
|
2006-06-22 |
2007-12-27 |
Vaccinex, Inc. |
Anti-c35 antibodies for treating cancer
|
WO2008036449A2
(en)
*
|
2006-06-29 |
2008-03-27 |
The Regents Of The University Of California |
Chemical antibodies for immunotherapy and imaging
|
US8637469B2
(en)
|
2006-07-11 |
2014-01-28 |
Roy C. Levitt |
Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
|
US20080014285A1
(en)
*
|
2006-07-13 |
2008-01-17 |
Di Mauro Thomas M |
Method of treating neurodegenerative brain disease with a composite comprising superparamagnetic nanoparticles and a therapeutic compound
|
DK2068889T3
(da)
|
2006-08-10 |
2020-02-03 |
Roy C Levitt |
Anakinra til anvendelse i behandling af bronchiolitis obliterans syndrom
|
WO2008020079A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
US7833527B2
(en)
*
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
EP2067041A2
(en)
|
2006-10-03 |
2009-06-10 |
Biogen Idec MA, Inc. |
Biomarkers and assays for the treatment of cancer
|
JP5519287B2
(ja)
|
2006-11-02 |
2014-06-11 |
ダニエル・ジェイ・カポン |
可動部を備えたハイブリッド免疫グロブリン
|
PE20081250A1
(es)
*
|
2006-11-28 |
2008-10-07 |
Centelion |
FUSIONES Fc CON RECEPTOR PARA FGF SOLUBLE MODIFICADAS, CON ACTIVIDAD BIOLOGICA MEJORADA
|
CN103408661B
(zh)
|
2007-01-05 |
2016-04-06 |
苏黎世大学 |
提供疾患特异性结合分子和靶的方法
|
AU2008205244B2
(en)
|
2007-01-09 |
2013-02-07 |
Biogen Ma Inc. |
Sp35 antibodies and uses thereof
|
CA2678493A1
(en)
|
2007-02-23 |
2008-08-28 |
The Trustees Of Columbia University In The City Of New York |
Methods to activate or block the hla-e/qa-1 restricted cd8+ t cell regulatory pathway to treat immunological disease
|
US20100028951A1
(en)
*
|
2007-03-07 |
2010-02-04 |
Stephen Hamilton |
Production of glycoproteins with modified fucosylation
|
CA2690825C
(en)
|
2007-05-11 |
2019-02-12 |
Altor Bioscience Corporation |
Fusion molecules and il-15 variants
|
US7906149B2
(en)
*
|
2007-05-25 |
2011-03-15 |
Boval Company, L.P. |
Method for treating allergic dermatitis
|
ES2456963T3
(es)
*
|
2007-06-04 |
2014-04-24 |
Rappaport Family Institute For Research In The Medical Sciences |
Agentes para el tratamiento de enfermedades inflamatorias y métodos para usar los mismos
|
MX2009012968A
(es)
*
|
2007-06-06 |
2010-04-01 |
Domantis Ltd |
Polipeptidos, dominios variables de anticuerpo y antagonistas.
|
WO2009151717A2
(en)
|
2008-04-02 |
2009-12-17 |
Macrogenics, Inc. |
Bcr-complex-specific antibodies and methods of using same
|
US8067548B2
(en)
*
|
2007-07-26 |
2011-11-29 |
Novagen Holding Corporation |
Fusion proteins having mutated immunoglobulin hinge region
|
GB0717337D0
(en)
*
|
2007-09-06 |
2007-10-17 |
Ucb Pharma Sa |
Method of treatment
|
JP2011500005A
(ja)
|
2007-10-11 |
2011-01-06 |
ユニバーシティー ヘルス ネットワーク |
ヒト造血幹細胞の生着を増加させるためのSIRPα−CD47相互作用の調節およびそのための化合物
|
BRPI0818033A2
(pt)
*
|
2007-10-16 |
2015-03-24 |
Symphogen As |
Composições compreendendo multímeros otimizados de her1 e her3 e métodos para usos dos mesmos
|
EP2612868B1
(en)
*
|
2007-11-01 |
2018-08-15 |
Astellas Pharma Inc. |
Immunosuppressive polypeptides and nucleic acids
|
WO2009061853A2
(en)
*
|
2007-11-05 |
2009-05-14 |
Massachusetts Institute Of Technology |
Mutant interleukin-2 (il-2) polypeptides
|
EP2217261B1
(en)
|
2007-11-09 |
2015-10-07 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist compositions and methods of use
|
EP2222707B1
(en)
|
2007-11-21 |
2016-01-06 |
Oregon Health & Science University |
Anti-factor xi monoclonal antibodies and methods of use thereof
|
WO2009090493A2
(en)
*
|
2007-12-06 |
2009-07-23 |
Korea Advanced Institute Of Science And Technology |
Tlr4 decoy receptor protein
|
EP2796466B1
(en)
|
2007-12-07 |
2017-11-22 |
ZymoGenetics, Inc. |
Humanized antibody molecules specific for IL-31
|
US8986696B2
(en)
*
|
2007-12-21 |
2015-03-24 |
Depuy Mitek, Inc. |
Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
|
US20090162351A1
(en)
*
|
2007-12-21 |
2009-06-25 |
Depuy Spine, Inc. |
Transdiscal administration of inhibitors of p38 MAP kinase
|
NZ587292A
(en)
|
2008-03-04 |
2012-09-28 |
Pfizer Ltd |
Use of anti-CGRP (calcitonin gene-related peptide) antagonists to treat chronic pain
|
WO2009133208A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Novartis Ag |
Improved fibronectin-based binding molecules and uses thereof
|
RU2553517C2
(ru)
|
2008-05-06 |
2015-06-20 |
Дженентек, Инк. |
Варианты crig с созревшей аффинностью
|
ES2675730T3
(es)
*
|
2008-06-04 |
2018-07-12 |
Macrogenics, Inc. |
Anticuerpos con unión alterada a FcRn y métodos de uso de los mismos
|
AU2009269099B2
(en)
|
2008-07-09 |
2016-03-10 |
Biogen Ma Inc. |
Compositions comprising antibodies to LINGO or fragments thereof
|
AR072596A1
(es)
|
2008-07-23 |
2010-09-08 |
Hanmi Pharmaceutical Co Ltd |
Un complejo proteico que comprende una proteina dimerica y un polimero no peptidico
|
US20100159485A1
(en)
*
|
2008-12-19 |
2010-06-24 |
Centre For Dna Fingerprinting And Diagnostics |
Detection of mycobacterium tuberculosis
|
PL2949666T3
(pl)
|
2008-12-19 |
2019-07-31 |
Biogen International Neuroscience Gmbh |
Ludzkie przeciwciała przeciwko alfa-synukleinie
|
CN102341411A
(zh)
|
2008-12-31 |
2012-02-01 |
比奥根艾迪克Ma公司 |
抗-淋巴细胞毒素抗体
|
EP2411412B1
(en)
|
2009-03-24 |
2015-05-27 |
Teva Biopharmaceuticals USA, Inc. |
Humanized antibodies against light and uses thereof
|
KR101766927B1
(ko)
|
2009-04-01 |
2017-08-09 |
제넨테크, 인크. |
인슐린 저항성 장애의 치료
|
US10618964B2
(en)
|
2009-04-10 |
2020-04-14 |
Ablynx N.V. |
Nanobody against IL-6R
|
US8748581B2
(en)
|
2009-04-10 |
2014-06-10 |
Ablynx N.V. |
Anti-IL-6R polypeptides and pharmaceutical compositions thereof
|
CA2759333A1
(en)
|
2009-04-22 |
2010-10-28 |
Merck Patent Gmbh |
Antibody fusion proteins with modified fcrn binding sites
|
KR101183262B1
(ko)
|
2009-04-22 |
2012-09-14 |
(주)알테오젠 |
체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법
|
MX2011011718A
(es)
|
2009-05-08 |
2012-01-27 |
Vaccinex Inc |
Anticuerpos anti-cd100 y metodos para su uso.
|
EP2429574B1
(en)
|
2009-05-15 |
2015-05-06 |
University Health Network |
Compositions and methods for treating hematologic cancers targeting the sirp - cd47 interaction
|
US8685398B2
(en)
|
2009-06-15 |
2014-04-01 |
Biokine Therapeutics Ltd. |
Chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer
|
US20110039300A1
(en)
|
2009-08-10 |
2011-02-17 |
Robert Bayer |
Antibodies with enhanced adcc functions
|
US20110053223A1
(en)
|
2009-08-14 |
2011-03-03 |
Robert Bayer |
Cell culture methods to make antibodies with enhanced adcc function
|
WO2011024113A1
(en)
|
2009-08-28 |
2011-03-03 |
Rinat Neuroscience Corporation |
Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide
|
WO2011044368A1
(en)
|
2009-10-07 |
2011-04-14 |
Macrogenics, Inc. |
Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
|
TW201117824A
(en)
|
2009-10-12 |
2011-06-01 |
Amgen Inc |
Use of IL-17 receptor a antigen binding proteins
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
WO2011056494A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
US20110165122A1
(en)
*
|
2009-11-10 |
2011-07-07 |
The Regents Of The University Of California |
Method for targeted and sustained antiviral therapy
|
WO2011071957A1
(en)
|
2009-12-07 |
2011-06-16 |
Sea Lane Biotechnologies, Llc |
Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
|
US20130052195A1
(en)
|
2009-12-23 |
2013-02-28 |
Emergent Product Development Seattle,LLC |
Compositions Comprising TNF-alpha and IL-6 Antagonists and Methods of Use Thereof
|
US8637637B2
(en)
|
2010-01-12 |
2014-01-28 |
Bill Nai-Chau Sun |
Fc fusion proteins of human growth hormone
|
MY182680A
(en)
|
2010-01-15 |
2021-01-29 |
Amgen K A Inc |
Antibody formulation and therapeutic regimens
|
EP2536435B1
(en)
|
2010-02-18 |
2017-11-15 |
Janssen Biotech, Inc. |
Monkey homolog of human interferon omega
|
US8802091B2
(en)
|
2010-03-04 |
2014-08-12 |
Macrogenics, Inc. |
Antibodies reactive with B7-H3 and uses thereof
|
CA2791658C
(en)
|
2010-03-04 |
2019-10-01 |
Macrogenics, Inc. |
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
|
WO2011109280A1
(en)
|
2010-03-05 |
2011-09-09 |
Lerner Research Institute |
Methods and compositions to treat immune-mediated disorders
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
EP2552947A4
(en)
|
2010-03-26 |
2013-11-13 |
Dartmouth College |
VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING ACTIVE SUBSTANCES AND USE THEREOF
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
US20110243943A1
(en)
*
|
2010-04-02 |
2011-10-06 |
Athena Discovery, Inc. |
Treatment using relaxin-fusion proteins with extended in vivo half-lives
|
JP5908888B2
(ja)
|
2010-04-16 |
2016-04-26 |
ヤンセン バイオテツク,インコーポレーテツド |
改変された植物のシステインプロテアーゼ及びその使用
|
US8524217B2
(en)
|
2010-05-11 |
2013-09-03 |
Merck Sharp & Dohme Corp. |
MCP1-Ig fusion variants
|
AU2011268146A1
(en)
|
2010-06-17 |
2013-01-10 |
Actogenix Nv |
Compositions and methods for treating inflammatory conditions
|
EP3508573A1
(en)
|
2010-07-09 |
2019-07-10 |
Bioverativ Therapeutics Inc. |
Systems for factor viii processing and methods thereof
|
JP5964300B2
(ja)
|
2010-08-02 |
2016-08-03 |
マクロジェニクス,インコーポレーテッド |
共有結合型ダイアボディおよびその使用
|
EP2601214B1
(en)
|
2010-08-06 |
2017-11-01 |
Genzyme Corporation |
Vegf antagonist compositions and uses thereof
|
EP2611832B1
(en)
|
2010-09-02 |
2017-11-29 |
Vaccinex, Inc. |
Anti-cxcl13 antibodies and methods of using the same
|
US11053299B2
(en)
|
2010-09-21 |
2021-07-06 |
Immunity Bio, Inc. |
Superkine
|
KR20140020228A
(ko)
|
2010-09-21 |
2014-02-18 |
알토 바이오사이언스 코포레이션 |
다량체성 아이엘 15 용해성 융합 분자 및 그의 제조 및 사용 방법
|
EP2621950A4
(en)
|
2010-09-27 |
2015-09-02 |
Janssen Biotech Inc |
ANTIBODIES FOR BINDING HUMAN COLLAGEN II
|
SI2627672T1
(sl)
|
2010-10-11 |
2018-10-30 |
Biogen International Neuroscience Gmbh |
Človeška protitelesa anti-tau
|
KR101333958B1
(ko)
*
|
2010-10-20 |
2013-11-27 |
주식회사 한독 |
인간 인터루킨-1 수용체 길항제-하이브리드 Fc 융합단백질
|
AR083546A1
(es)
|
2010-10-25 |
2013-03-06 |
Genentech Inc |
Tratamiento de inflamacion gastrointestinal, soriasis y asma
|
EP2638068B1
(en)
|
2010-11-08 |
2018-12-26 |
Novartis AG |
Cxcr2 binding polypeptides
|
CN103380145B
(zh)
|
2010-12-17 |
2016-10-12 |
生物控股有限公司 |
人类抗-sod1抗体
|
AR086515A1
(es)
|
2011-05-20 |
2013-12-18 |
Alderbio Holdings Llc |
Uso de anticuerpos o fragmentos de anticuerpos anti-cgrp o anti-cgrp-r para tratar o prevenir las formas cronicas y agudas de la diarrea
|
CN107827982B
(zh)
|
2011-05-20 |
2021-07-06 |
H.伦德贝克公司 |
抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途
|
SI3495392T1
(sl)
|
2011-05-20 |
2021-11-30 |
H. Lundbeck A/S |
Sestavki proti CGRP in uporaba le-teh
|
JP6145088B2
(ja)
|
2011-05-21 |
2017-06-07 |
マクロジェニクス,インコーポレーテッド |
脱免疫化血清結合ドメイン及び血清半減期を延長するためのその使用
|
AU2012260601B2
(en)
|
2011-05-25 |
2018-02-01 |
Innate Pharma, S.A. |
Anti-KIR antibodies for the treatment of inflammatory disorders
|
SI2723379T1
(sl)
|
2011-06-23 |
2019-03-29 |
Biogen International Neuroscience Gmbh |
Molekule, ki se vežejo ma anti alfa-sinuklein
|
EP2723370A4
(en)
|
2011-06-24 |
2015-06-03 |
Univ Colorado Regents |
COMPOSITIONS, PROCESS AND USE OF ALPHA-1-ANTITRYPHIN FUSION MOLECULES
|
CA2840944A1
(en)
*
|
2011-07-08 |
2013-01-17 |
Bayer Intellectual Property Gmbh |
Fusion proteins releasing relaxin and uses thereof
|
US9738707B2
(en)
|
2011-07-15 |
2017-08-22 |
Biogen Ma Inc. |
Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
|
US20140234330A1
(en)
|
2011-07-22 |
2014-08-21 |
Amgen Inc. |
Il-17 receptor a is required for il-17c biology
|
EP2747782B1
(en)
*
|
2011-09-23 |
2018-01-17 |
Ablynx NV |
Prolonged inhibition of interleukin-6 mediated signaling
|
US11951157B2
(en)
|
2011-10-11 |
2024-04-09 |
Universitat Zurich |
Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody
|
PL3351261T3
(pl)
*
|
2011-10-11 |
2021-12-06 |
Universität Zürich |
Lek złożony zawierający IL-12 i środek do blokowania cząsteczek hamujących komórki T w terapii nowotworów
|
US8846034B2
(en)
|
2011-10-24 |
2014-09-30 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
KR102348985B1
(ko)
|
2012-01-10 |
2022-01-12 |
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 |
알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
|
US9890213B2
(en)
|
2012-03-02 |
2018-02-13 |
Vaccinex, Inc. |
Methods for the treatment of B cell-mediated inflammatory diseases
|
MX349035B
(es)
|
2012-05-17 |
2017-07-07 |
Extend Biosciences Inc |
Portadores para el suministro mejorado de farmaco.
|
EP2852610B1
(en)
|
2012-05-23 |
2018-07-11 |
Glykos Finland Oy |
Production of fucosylated glycoproteins
|
AU2013277051B2
(en)
|
2012-06-22 |
2018-06-07 |
King's College London |
Novel VISTA-Ig constructs and the use of VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
CA2878404A1
(en)
|
2012-07-10 |
2014-01-16 |
The Trustees Of The University Of Pennsylvania |
Biomaterials for enhanced implant-host integration
|
EP2879710B1
(en)
|
2012-08-03 |
2019-11-13 |
Dana-Farber Cancer Institute, Inc. |
Medical uses of agents that modulate immune cell activation and corresponding screening methods
|
MY181648A
(en)
|
2012-08-24 |
2020-12-30 |
Univ California |
Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
|
AU2013312211B2
(en)
|
2012-09-07 |
2018-03-29 |
King's College London |
VISTA modulators for diagnosis and treatment of cancer
|
US9278124B2
(en)
|
2012-10-16 |
2016-03-08 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
WO2014094122A1
(en)
|
2012-12-17 |
2014-06-26 |
Trillium Therapeutics Inc. |
Treatment of cd47+ disease cells with sirp alpha-fc fusions
|
PT2935326T
(pt)
|
2012-12-21 |
2020-09-14 |
Biogen Ma Inc |
Anticorpos anti-tau humanos
|
US9771413B2
(en)
|
2012-12-31 |
2017-09-26 |
Neurimmune Holding Ag |
Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases
|
US9487587B2
(en)
|
2013-03-05 |
2016-11-08 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
|
AU2013205589A1
(en)
|
2013-03-08 |
2014-09-25 |
Vaccinex, Inc. |
Anti-CXCL13 antibodies and associated epitope sequences
|
US9458246B2
(en)
|
2013-03-13 |
2016-10-04 |
Amgen Inc. |
Proteins specific for BAFF and B7RP1
|
JOP20140087B1
(ar)
|
2013-03-13 |
2021-08-17 |
Amgen Inc |
بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
|
WO2014159940A1
(en)
|
2013-03-14 |
2014-10-02 |
Macrogenics, Inc. |
Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor
|
SG11201507429TA
(en)
|
2013-03-15 |
2015-10-29 |
Genentech Inc |
Il-22 polypeptides and il-22 fc fusion proteins and methods of use
|
AU2014228938B2
(en)
|
2013-03-15 |
2019-05-02 |
Bioverativ Therapeutics Inc. |
Factor IX polypeptide formulations
|
ES2708565T3
(es)
|
2013-03-15 |
2019-04-10 |
Atyr Pharma Inc |
Conjugados de Fc-histidil-ARNt sintetasa
|
EP3816625A1
(en)
|
2013-05-06 |
2021-05-05 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
EP3293275B1
(en)
|
2013-06-06 |
2021-08-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment prevention, and treatment of cancer using pd-l1 isoforms
|
AR096891A1
(es)
|
2013-07-12 |
2016-02-03 |
Hanmi Pharm Ind Co Ltd |
Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
|
US11384149B2
(en)
|
2013-08-09 |
2022-07-12 |
Macrogenics, Inc. |
Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
|
UA116479C2
(uk)
|
2013-08-09 |
2018-03-26 |
Макродженікс, Інк. |
БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ
|
EP2840091A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
|
EP2839842A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
|
WO2015048312A1
(en)
|
2013-09-26 |
2015-04-02 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
EP3077048B1
(en)
|
2013-12-07 |
2019-07-17 |
Case Western Reserve University |
Compositions and methods of treating thrombosis
|
US11708411B2
(en)
|
2013-12-20 |
2023-07-25 |
Wake Forest University Health Sciences |
Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
|
WO2015097536A2
(en)
|
2013-12-24 |
2015-07-02 |
Janssen Pharmaceutical Nv |
Anti-vista antibodies and fragments
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
EP3096776B1
(en)
*
|
2014-01-22 |
2020-12-02 |
Antagonis Biotherapeutics GmbH |
Novel glycosaminoglycan-antagonising fusion proteins and methods of using same
|
US10556945B2
(en)
|
2014-03-21 |
2020-02-11 |
Teva Pharmaceuticals International Gmbh |
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
|
UA123759C2
(uk)
|
2014-03-21 |
2021-06-02 |
Тева Фармасьютікалз Інтернешнл Гмбх |
Застосування моноклонального антитіла, яке інгібує шлях пов'язаного з геном кальциноніну пептиду (cgrp), для лікування або зниження частоти випадків мігренозного головного болю у суб'єкта
|
US20170174772A1
(en)
|
2014-03-31 |
2017-06-22 |
Kirin-Amgen, Inc. |
Methods of treating nail and scalp psoriasis
|
AU2015274504B2
(en)
|
2014-06-11 |
2021-02-04 |
Kathy A. Green |
Use of VISTA agonists and antagonists to suppress or enhance humoral immunity
|
US9925247B2
(en)
|
2014-06-30 |
2018-03-27 |
Altor Bioscience Corporation |
IL-15-based molecules and methods of use thereof
|
CA2954974A1
(en)
|
2014-07-21 |
2016-01-28 |
Glykos Finland Oy |
Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
|
EP3177638B1
(en)
|
2014-08-04 |
2019-11-27 |
Case Western Reserve University |
Targeting peptides and methods of use
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
EP3201227A4
(en)
|
2014-09-29 |
2018-04-18 |
Duke University |
Bispecific molecules comprising an hiv-1 envelope targeting arm
|
AU2015326911B2
(en)
|
2014-09-30 |
2021-07-08 |
Neurimmune Holding Ag |
Human-derived anti-dipeptide repeats (DPRs) antibody
|
AU2015334984A1
(en)
|
2014-10-21 |
2017-04-13 |
Ablynx Nv |
Treatment of IL-6R related diseases
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
WO2016065052A1
(en)
|
2014-10-22 |
2016-04-28 |
Extend Biosciences, Inc. |
Insulin vitamin d conjugates
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
AU2015357463B2
(en)
|
2014-12-05 |
2021-10-07 |
Immunext, Inc. |
Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
|
AU2015360903B2
(en)
|
2014-12-08 |
2021-03-25 |
Dana-Farber Cancer Institute, Inc. |
Methods for upregulating immune responses using combinations of anti-RGMB and anti-PD-1 agents
|
JP2018506275A
(ja)
|
2015-01-28 |
2018-03-08 |
ジェネンテック, インコーポレイテッド |
多発性硬化症の遺伝子発現マーカー及び治療
|
US11820807B2
(en)
|
2015-06-12 |
2023-11-21 |
Ubi Pharma Inc |
Immunoglobulin fusion proteins and uses thereof
|
BR112017027870A2
(pt)
|
2015-06-24 |
2018-08-28 |
Janssen Pharmaceutica Nv |
anticorpos e fragmentos anti-vista
|
RU2740672C2
(ru)
|
2015-08-07 |
2021-01-19 |
ЭйЭлЭкс Онколоджи Инк. |
Конструкции, имеющие sirp-альфа домен или его вариант
|
JP7020687B2
(ja)
|
2015-09-15 |
2022-02-16 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
T細胞受容体(tcr)結合抗体及びその使用
|
US11338065B2
(en)
|
2015-10-08 |
2022-05-24 |
Massachusetts Institute Of Technology |
In situ expansion of engineered devices for regeneration
|
US11207393B2
(en)
|
2015-10-16 |
2021-12-28 |
President And Fellows Of Harvard College |
Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
|
MX2020011500A
(es)
|
2015-12-17 |
2020-12-07 |
Alonbio Ltd |
Moléculas pequeñas para inhibir la actividad de quimiocinas, la actividad de una cinasa y/o el crecimiento de células cancerosas.
|
WO2017103931A1
(en)
|
2015-12-17 |
2017-06-22 |
Biokine Therapeutics Ltd. |
Small molecules against cancer
|
EP3397274A1
(en)
|
2015-12-31 |
2018-11-07 |
The Regents of the University of Colorado, a body corporate |
Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications
|
US10899836B2
(en)
|
2016-02-12 |
2021-01-26 |
Janssen Pharmaceutica Nv |
Method of identifying anti-VISTA antibodies
|
RU2756109C2
(ru)
|
2016-03-10 |
2021-09-28 |
Виела Байо, Инк. |
Связывающие ilt7 молекулы и способы их применения
|
SG11201808979UA
(en)
|
2016-04-15 |
2018-11-29 |
Macrogenics Inc |
Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof
|
CA3020848A1
(en)
|
2016-04-15 |
2017-10-19 |
Janssen Pharmaceuticals, Inc. |
Anti-human vista antibodies and use thereof
|
WO2017205726A1
(en)
|
2016-05-27 |
2017-11-30 |
Altor Bioscience Corporation |
Construction and characterization of multimeric il-15-based molecules with cd3 binding domains
|
JP2018035137A
(ja)
|
2016-07-13 |
2018-03-08 |
マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag |
新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用
|
US10392434B2
(en)
|
2016-09-23 |
2019-08-27 |
Teva Pharmaceuticals International Gmbh |
Treating refractory migraine
|
SG11201903306SA
(en)
|
2016-10-21 |
2019-05-30 |
Altor Bioscience Corp |
Multimeric il-15-based molecules
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
CN110234351A
(zh)
|
2017-01-30 |
2019-09-13 |
詹森生物科技公司 |
用于治疗活动性银屑病关节炎的抗tnf抗体、组合物和方法
|
US11649288B2
(en)
|
2017-02-07 |
2023-05-16 |
Seattle Children's Hospital |
Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
|
CN110418652A
(zh)
|
2017-02-07 |
2019-11-05 |
詹森生物科技公司 |
用于治疗活动性强直性脊柱炎的抗tnf抗体、组合物和方法
|
WO2018160622A1
(en)
|
2017-02-28 |
2018-09-07 |
Endocyte, Inc. |
Compositions and methods for car t cell therapy
|
AU2018229278A1
(en)
|
2017-02-28 |
2019-10-17 |
Sanofi |
Therapeutic RNA
|
CN110785435B
(zh)
|
2017-03-06 |
2024-01-23 |
艾尔特生物科技公司 |
与il-12和il-18的基于il-15的融合物
|
US20190048055A1
(en)
|
2017-03-31 |
2019-02-14 |
Altor Bioscience Corporation |
Alt-803 in combination with anti-cd38 antibody for cancer therapies
|
WO2018195338A1
(en)
|
2017-04-20 |
2018-10-25 |
Atyr Pharma, Inc. |
Compositions and methods for treating lung inflammation
|
AU2018261947A1
(en)
|
2017-05-05 |
2019-11-07 |
Vaccinex, Inc. |
Human anti-semaphorin 4D antibody
|
AU2018323455B2
(en)
|
2017-08-28 |
2022-02-03 |
Altor Bioscience Llc |
IL-15-based fusions to IL-7 and IL-21
|
US11311576B2
(en)
|
2018-01-22 |
2022-04-26 |
Seattle Children's Hospital |
Methods of use for CAR T cells
|
CR20200327A
(es)
|
2018-01-26 |
2020-11-05 |
Genentech Inc |
Proteínas de fusión fc il-22 y métodos de uso
|
CA3088763A1
(en)
|
2018-01-26 |
2019-08-01 |
Genentech, Inc. |
Compositions and methods of use
|
AU2019226085A1
(en)
|
2018-02-21 |
2020-09-17 |
Genentech, Inc. |
Dosing for treatment with IL-22 Fc fusion proteins
|
CN111867612A
(zh)
|
2018-03-26 |
2020-10-30 |
阿尔托生物科学有限责任公司 |
抗PDL1、IL-15和TGF-β受体组合分子
|
CN112041333A
(zh)
|
2018-04-26 |
2020-12-04 |
古德T细胞有限公司 |
新型融合蛋白和用于预防或治疗癌症的包含该融合蛋白的药物组合物
|
US20210196787A1
(en)
*
|
2018-06-28 |
2021-07-01 |
National University Corporation Okayama University |
Agent for enhancing phagocytosis ability of neutrophils
|
US20210347849A1
(en)
*
|
2018-07-24 |
2021-11-11 |
Good T Cells, Inc. |
Composition for Preventing or Treating Immune-Related Diseases
|
CN110964116A
(zh)
|
2018-09-26 |
2020-04-07 |
北京辅仁瑞辉生物医药研究院有限公司 |
GLP1-Fc融合蛋白及其缀合物
|
AU2020206241A1
(en)
|
2019-01-08 |
2021-08-26 |
H. Lundbeck A/S |
Acute treatment and rapid treatment of headache using anti-CGRP antibodies
|
JP2022518208A
(ja)
|
2019-01-15 |
2022-03-14 |
ヤンセン バイオテツク,インコーポレーテツド |
若年性特発性関節炎の治療のための抗tnf抗体、組成物、及び方法
|
WO2020152544A1
(en)
|
2019-01-23 |
2020-07-30 |
Janssen Biotech, Inc. |
Anti-tnf antibody compositions for use in methods for the treatment of psoriatic arthritis
|
CN113795513A
(zh)
|
2019-02-13 |
2021-12-14 |
布里格姆妇女医院 |
抗外周淋巴结地址素抗体及其用途
|
MA55283A
(fr)
|
2019-03-14 |
2022-01-19 |
Janssen Biotech Inc |
Procédés de production de compositions d'anticorps anti-tnf
|
KR20210142002A
(ko)
|
2019-03-14 |
2021-11-23 |
얀센 바이오테크 인코포레이티드 |
항-tnf 항체 조성물을 생성하기 위한 제조 방법
|
CA3133388A1
(en)
|
2019-03-14 |
2020-09-17 |
Janssen Biotech, Inc. |
Methods for producing anti-tnf antibody compositions
|
CA3090315C
(en)
|
2019-05-15 |
2023-09-19 |
Biokine Therapeutics Ltd. |
8-phenoxy-quinolinone derivatives for treating cancer, inhibiting chemokine activity and/or inducing cell death
|
US11780911B2
(en)
|
2019-05-23 |
2023-10-10 |
Janssen Biotech, Inc. |
Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha
|
WO2020243338A1
(en)
|
2019-05-31 |
2020-12-03 |
ALX Oncology Inc. |
Methods of treating cancer with sirp alpha fc fusion in combination with an immune checkpoint inhibitor
|
CN113939531A
(zh)
|
2019-06-03 |
2022-01-14 |
詹森生物科技公司 |
用于治疗银屑病关节炎的抗tnf抗体组合物和方法
|
MX2021014882A
(es)
|
2019-06-03 |
2022-03-25 |
Janssen Biotech Inc |
Anticuerpos anti-tnf, composiciones y métodos para el tratamiento de la espondilitis anquilosante activa.
|
WO2021028752A1
(en)
|
2019-08-15 |
2021-02-18 |
Janssen Biotech, Inc. |
Anti-tfn antibodies for treating type i diabetes
|
WO2021178843A1
(en)
|
2020-03-05 |
2021-09-10 |
DiaMedica USA Inc. |
Ulinastatin polypeptides
|
WO2021207662A1
(en)
|
2020-04-10 |
2021-10-14 |
Genentech, Inc. |
Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome
|
WO2021230233A1
(ja)
*
|
2020-05-14 |
2021-11-18 |
学校法人日本医科大学 |
感染症の治療又は予防剤
|
WO2022261183A2
(en)
|
2021-06-08 |
2022-12-15 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
|
CN117957251A
(zh)
|
2021-07-09 |
2024-04-30 |
詹森生物科技公司 |
用于制备抗tnf抗体组合物的制造方法
|
WO2023281462A1
(en)
|
2021-07-09 |
2023-01-12 |
Janssen Biotech, Inc. |
Manufacturing methods for producing anti-tnf antibody compositions
|
WO2023097119A2
(en)
|
2021-11-29 |
2023-06-01 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions to modulate riok2
|
WO2023168426A1
(en)
|
2022-03-03 |
2023-09-07 |
Enosi Therapeutics Corporation |
Compositions and cells containing mixtures of oligo-trap fusion proteins (ofps) and uses thereof
|
WO2023173084A1
(en)
|
2022-03-11 |
2023-09-14 |
University Of Rochester |
Cyclopeptibodies and uses thereof
|
US11780910B1
(en)
|
2022-05-02 |
2023-10-10 |
Novo Nordisk A/S |
Anti-ANGPTL3 antibodies suitable for high concentration compositions and subcutaneous administration
|