JPH05503009A - リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質 - Google Patents
リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質Info
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- JPH05503009A JPH05503009A JP3501520A JP50152091A JPH05503009A JP H05503009 A JPH05503009 A JP H05503009A JP 3501520 A JP3501520 A JP 3501520A JP 50152091 A JP50152091 A JP 50152091A JP H05503009 A JPH05503009 A JP H05503009A
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- C12N15/62—DNA sequences coding for fusion proteins
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
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Abstract
Description
Claims (49)
- 1.血小板成長因子受容体またはインスリン受容体でないリガンド結合パートナ ータンパク質および安定血漿タンパク質からなるポリペプチド融合物。
- 2.安定血漿タンパク質が免疫グロブリン鎖であり、リガンド結合パートナータ ンパク質と免疫グロブリンがC−またはN−末端アミノまたはカルボキシル基を 通して融合している請求項1のポリペプチド。
- 3.免疫グロブリンの定常ドメインの一部がそのN−末端で、該リガンド結合パ ートナーのC−末端に結合している請求項2のポリペプチド。
- 4.免疫グロブリンの定常ドメインのFc部分がそのN−末端で、該リガンド結 合パートナーのC−末端に結合している請求項2のポリペプチド。
- 5.免疫グロブリン配列がIgG1、IgG2、IgG3、IgG4、IgA、 1gE、IgD、またはIgMから得られる請求項2のポリペプチド。
- 6.リガンド結合パートナーがLHRからなる請求項2のポリペプチド。
- 7.リガンド結合パートナーが細胞表面接着性分子からなる請求項2のポリペプ チド。
- 8.検出可能な標識に結合した請求項2のポリペプチド。
- 9.該免疫グロブリン配列がヒト由来である請求項2のポリペプチド。
- 10.該リガンド結合パートナーがヒト由来である請求項2のポリペプチド。
- 11.定常ドメインがIgG重鎖の定常ドメインである請求項2のポリペプチド 。
- 12.リガンド結合パートナーが、リンパ様組織の高内皮細静脈に結合するLH Rである請求項2のポリペプチド。
- 13.グリコシル化を伴わない請求項2のポリペプチド。
- 14.生理学的に許容される担体中の請求項2のポリペプチド。
- 15.担体が滅菌等張溶液である請求項14のポリペプチド。
- 16.担体が徐放性製剤である請求項14のポリペプチド。
- 17.担体がリポソームである請求項14のポリペプチド。
- 18.融合物中の該リガンド結合パートナータンパク質が細胞膜に係留不能であ る請求項2のポリペプチド。
- 19.該免疫グロブリンが該結合パートナーとは異なる種に由来する請求項2の ポリペプチド。
- 20.リガンド結合パートナーが一本鎖である請求項2のポリペプチド。
- 21.リガンド結合パートナーが1本より多いポリペプチド鎖を含有し、その鎖 の1本が免疫グロブリン定常領域に融合している請求項2のポリペプチド。
- 22.リガンド結合パートナーの融合鎖が、その貫膜および細胞質ドメインを欠 いている請求項21のポリペプチド。
- 23.該リガンド結合パートナーが細胞膜タンパク質である請求項2のポリペプ チド。
- 24.該リガンド結合パートナーが免疫グロブリン・スーパーファミリー構成要 素の定常領域様ドメインである請求項2のポリペプチド。
- 25.リガンド結合パートナーが第1リガンド結合パートナーであり、該融合物 がさらに第2リガンド結合パートナーと免疫グロブリンとの追加融合物を含む請 求項2のポリペプチド融合物。
- 26.第2リガンド結合パートナーが第1リガンド結合パートナーとは異なる請 求項25のポリペプチド融合物。
- 27.第1リガンド結合パートナーがLHRであり、第2リガンド結合パートナ ーがCD4である請求項26のポリペプチド融合物。
- 28.第1リガンド結合パートナー融合物と第2リガンド結合パートナー融合物 がジスルフィド結合によって架橋されている請求項25のポリペプチド融合物。
- 29.第1リガンド結合パートナー融合物と第2リガンド結合パートナー融合物 が非共有結合的に会合している請求項25のポリペプチド融合物。
- 30.該リガンド結合パートナーがLHR炭水化物結合ドメイン、LHR表皮成 長因子ドメインおよびしHR補体結合ドメインを有するLHRであって、該LH R炭水化物結合ドメインが削除されているか、もしくは異種の炭水化物結合ドメ インによって置換されている請求項27のポリペプチド。
- 31.該リガンド結合パートナーがLHR炭水化物結合ドメイン、LHR表皮成 長因子ドメインおよびLHR補体結合ドメインを有するLHRであって、該LH R表皮成長因子結合ドメインが削除されているか、もしくは異種の表皮成長因子 結合ドメインによって置換されている請求項27のポリペプチド。
- 32.該リガンド結合パートナーがLHR炭水化物結合ドメイン、LHR表皮成 長因子ドメインおよびしHR補体結合ドメインを有するLHRであって、該LH R補体結合ドメインが削除されているか、もしくは異種の補体結合ドメインによ って置換されている請求項27のポリペプチド。
- 33.該リガンド結合パートナーがLHR炭水化物結合ドメイン、LHR表皮成 長因子ドメイン、LHR補体結合ドメイン、LHR細胞質ドメインおよびLHR 貫膜ドメインを有するLHRであって、該LHR細胞質および貫膜ドメインが不 活化されている請求項27のポリペプチド。
- 34.安定血漿タンパク質が、血清アルブミン、トランスフェリン、リボタンパ ク質およびアポリボタンパク質からなる群から選択される請求項1のポリペプチ ド。
- 35.血漿タンパク質がアルブミンである請求項34のポリペプチド。
- 36.リガンド結合パートナーがCD抗原である請求項1のポリペプチド。
- 37.リガンド結合パートナーがLHRである請求項1のポリペプチド。
- 38.第1リガンド結合パートナーおよび安定血漿タンパク質からなるポリペプ チド融合物であって、該触合物がさらに第2リガンド結合パートナーと第2安定 血漿タンパク質の追加融合物を含有し、該第1および第2リガンド結合パートナ ーが異なる、ポリペプチド融合物。
- 39.免疫グロブリンでない安定血漿タンパク質およびリガンド結合パートナー からなるポリペプチド融合物。
- 40.一本鎖融合物からなる、リガンド結合パートナーおよび安定血漿タンパク 質からなるポリペプチド融合物。
- 41.第1リガンド結合パートナーおよび安定血漿タンパク質からなるポリペプ チド融合物であって、該融合物がさらに第2リガンド結合パートナーと第2安定 血漿タンパク質の追加融合物を含有し、該安定血漿タンパク質のそれぞれが免疫 グロブリン定常ドメインであるポリペプチド融合物。
- 42.請求項1のポリペプチドをコードする核酸。
- 43.請求項42の核酸を含有する複製可能な発現ベクター。
- 44.請求項43の組換え発現ベクターで形質転換した細胞からなる組成物。
- 45.細胞が哺乳類細胞である請求項44の組成物。
- 46.細胞がチャイニーズ・ハムスターの卵巣細胞株である請求項44の組成物 。
- 47.形質転換細胞を培養し、その細胞培養からポリペプチドを回収することか らなる請求項44の細胞の培養法。
- 48.ポリペプチドを宿主細胞から回収する請求項47の方法。
- 49.ポリペプチドが培養培地中に分泌され、その培養培地から回収される請求 項47の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US444,625 | 1989-11-22 | ||
US07/440,625 US5116964A (en) | 1989-02-23 | 1989-11-22 | Hybrid immunoglobulins |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2002026825A Division JP2002325589A (ja) | 1989-11-22 | 2002-02-04 | リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質 |
Publications (1)
Publication Number | Publication Date |
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JPH05503009A true JPH05503009A (ja) | 1993-05-27 |
Family
ID=23749509
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP3501520A Withdrawn JPH05503009A (ja) | 1989-11-22 | 1990-11-21 | リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質 |
JP2002026825A Withdrawn JP2002325589A (ja) | 1989-11-22 | 2002-02-04 | リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2002026825A Withdrawn JP2002325589A (ja) | 1989-11-22 | 2002-02-04 | リガンド結合タンパク質および安定血漿タンパク質からなる融合タンパク質 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5116964A (ja) |
EP (3) | EP0526452B2 (ja) |
JP (2) | JPH05503009A (ja) |
AT (2) | ATE396735T1 (ja) |
CA (1) | CA2072642C (ja) |
DE (3) | DE69034253D1 (ja) |
DK (2) | DK0526452T4 (ja) |
ES (2) | ES2308826T3 (ja) |
GR (1) | GR3035856T3 (ja) |
HK (2) | HK1013298A1 (ja) |
LU (1) | LU91498I2 (ja) |
NL (1) | NL300372I1 (ja) |
WO (1) | WO1991008298A2 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997042319A1 (fr) * | 1996-05-02 | 1997-11-13 | Mochida Pharmaceutical Co., Ltd. | NOUVEAUX DERIVES DE L'ANTIGENE Fas |
JP2003530070A (ja) * | 1999-05-19 | 2003-10-14 | レキシジェン ファーマシューティカルズ コーポレイション | Fc融合タンパク質としてのインターフェロン−αタンパク質の発現および搬出 |
JP2004536576A (ja) * | 2001-03-09 | 2004-12-09 | ユニバーシティ オブ シカゴ | 低親和性Fcγレセプターを標的化する重合体の免疫グロブリン融合タンパク質 |
JP2005508623A (ja) * | 2001-08-30 | 2005-04-07 | バイオレクシス ファーマシューティカル コーポレイション | 改変されたトランスフェリン融合タンパク質 |
JP2007524365A (ja) * | 2003-03-26 | 2007-08-30 | アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 改良したFc融合タンパク質 |
US8163289B2 (en) | 2001-03-09 | 2012-04-24 | Iterative Therapeutics, Inc. | Methods and compositions involving polymeric immunoglobulin fusion proteins |
WO2021230233A1 (ja) * | 2020-05-14 | 2021-11-18 | 学校法人日本医科大学 | 感染症の治療又は予防剤 |
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US5336603A (en) * | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
US5750375A (en) * | 1988-01-22 | 1998-05-12 | Zymogenetics, Inc. | Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions |
US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
US6685941B1 (en) | 1988-11-23 | 2004-02-03 | The Regents Of The University Of Michigan | Methods of treating autoimmune disease via CTLA-4Ig |
US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5242687A (en) * | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
DE59010941D1 (de) | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
US7264944B1 (en) | 1989-04-21 | 2007-09-04 | Amgen Inc. | TNF receptors, TNF binding proteins and DNAs coding for them |
IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
US6143866A (en) * | 1989-07-18 | 2000-11-07 | Amgen, Inc. | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same |
US6267964B1 (en) * | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
NZ235148A (en) | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
US5945397A (en) * | 1989-09-05 | 1999-08-31 | Immunex Corporation | Purified p75 (type II) tumor necrosis factor receptor polypeptides |
EP0417563B1 (de) * | 1989-09-12 | 2000-07-05 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
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- 1989-11-22 US US07/440,625 patent/US5116964A/en not_active Expired - Lifetime
-
1990
- 1990-11-21 ES ES99123412T patent/ES2308826T3/es not_active Expired - Lifetime
- 1990-11-21 WO PCT/US1990/006849 patent/WO1991008298A2/en active IP Right Grant
- 1990-11-21 DK DK91901202T patent/DK0526452T4/da active
- 1990-11-21 ES ES91901202T patent/ES2155819T5/es not_active Expired - Lifetime
- 1990-11-21 DE DE69034253T patent/DE69034253D1/de not_active Expired - Lifetime
- 1990-11-21 DE DE69033705T patent/DE69033705T3/de not_active Expired - Lifetime
- 1990-11-21 DE DE122008000063C patent/DE122008000063I2/de active Active
- 1990-11-21 JP JP3501520A patent/JPH05503009A/ja not_active Withdrawn
- 1990-11-21 DK DK99123412T patent/DK1029870T3/da active
- 1990-11-21 EP EP91901202A patent/EP0526452B2/en not_active Expired - Lifetime
- 1990-11-21 CA CA002072642A patent/CA2072642C/en not_active Expired - Lifetime
- 1990-11-21 AT AT99123412T patent/ATE396735T1/de active
- 1990-11-21 EP EP08005947A patent/EP1970386A2/en not_active Withdrawn
- 1990-11-21 AT AT91901202T patent/ATE199261T1/de not_active IP Right Cessation
- 1990-11-21 EP EP99123412A patent/EP1029870B1/en not_active Expired - Lifetime
-
1998
- 1998-12-22 HK HK98114595A patent/HK1013298A1/xx not_active IP Right Cessation
- 1998-12-22 HK HK01101079A patent/HK1030222A1/xx not_active IP Right Cessation
-
2001
- 2001-05-11 GR GR20010400708T patent/GR3035856T3/el unknown
-
2002
- 2002-02-04 JP JP2002026825A patent/JP2002325589A/ja not_active Withdrawn
-
2008
- 2008-11-19 LU LU91498C patent/LU91498I2/xx unknown
- 2008-11-27 NL NL300372C patent/NL300372I1/nl unknown
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6953847B2 (en) | 1996-05-02 | 2005-10-11 | Mochida Pharmaceutical Co., Ltd. | Fas antigen derivative |
US6306395B1 (en) | 1996-05-02 | 2001-10-23 | Mochida Pharmaceutical Co., Ltd. | Fas antigen derivatives |
WO1997042319A1 (fr) * | 1996-05-02 | 1997-11-13 | Mochida Pharmaceutical Co., Ltd. | NOUVEAUX DERIVES DE L'ANTIGENE Fas |
JP2003530070A (ja) * | 1999-05-19 | 2003-10-14 | レキシジェン ファーマシューティカルズ コーポレイション | Fc融合タンパク質としてのインターフェロン−αタンパク質の発現および搬出 |
US7897729B2 (en) | 2001-03-09 | 2011-03-01 | Iterative Therapeutics, Inc. | Polymeric immunoglobulin fusion proteins that target low affinity FcγReceptors |
US7511121B2 (en) | 2001-03-09 | 2009-03-31 | Arnason Barry G W | Polymeric immunoglobulin fusion proteins that target low-affinity Fcγreceptors |
JP2004536576A (ja) * | 2001-03-09 | 2004-12-09 | ユニバーシティ オブ シカゴ | 低親和性Fcγレセプターを標的化する重合体の免疫グロブリン融合タンパク質 |
US8163289B2 (en) | 2001-03-09 | 2012-04-24 | Iterative Therapeutics, Inc. | Methods and compositions involving polymeric immunoglobulin fusion proteins |
US8986698B2 (en) | 2001-03-09 | 2015-03-24 | Iterative Therapeutics, Inc. | Method of using fusion proteins |
US9127063B2 (en) | 2001-03-09 | 2015-09-08 | Iterative Therapeutics, Inc. | Nucleic acids related to fusion proteins |
JP2005508623A (ja) * | 2001-08-30 | 2005-04-07 | バイオレクシス ファーマシューティカル コーポレイション | 改変されたトランスフェリン融合タンパク質 |
JP2010004891A (ja) * | 2001-08-30 | 2010-01-14 | Biorexis Pharmaceutical Corp | 改変されたトランスフェリン融合タンパク質 |
JP2007524365A (ja) * | 2003-03-26 | 2007-08-30 | アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 改良したFc融合タンパク質 |
WO2021230233A1 (ja) * | 2020-05-14 | 2021-11-18 | 学校法人日本医科大学 | 感染症の治療又は予防剤 |
Also Published As
Publication number | Publication date |
---|---|
EP1970386A2 (en) | 2008-09-17 |
NL300372I1 (nl) | 2009-02-02 |
HK1013298A1 (en) | 1999-08-20 |
ES2155819T5 (es) | 2007-09-16 |
ES2308826T3 (es) | 2008-12-01 |
DE69034253D1 (de) | 2008-07-10 |
GR3035856T3 (en) | 2001-08-31 |
EP0526452A1 (en) | 1993-02-10 |
EP1029870B1 (en) | 2008-05-28 |
HK1030222A1 (en) | 2001-04-27 |
DE69033705D1 (de) | 2001-03-29 |
DE69033705T2 (de) | 2001-08-02 |
EP1029870A3 (en) | 2000-12-13 |
DK0526452T3 (da) | 2001-06-18 |
DE69033705T3 (de) | 2007-07-12 |
WO1991008298A2 (en) | 1991-06-13 |
LU91498I2 (fr) | 2009-01-19 |
WO1991008298A3 (en) | 1991-10-17 |
EP1970386A8 (en) | 2009-07-08 |
DE122008000063I1 (de) | 2009-02-19 |
ES2155819T3 (es) | 2001-06-01 |
ATE199261T1 (de) | 2001-03-15 |
EP1029870A2 (en) | 2000-08-23 |
US5116964A (en) | 1992-05-26 |
DE122008000063I2 (de) | 2011-06-16 |
ATE396735T1 (de) | 2008-06-15 |
CA2072642C (en) | 2002-07-23 |
DK0526452T4 (da) | 2007-05-07 |
DK1029870T3 (da) | 2008-09-29 |
EP0526452B1 (en) | 2001-02-21 |
JP2002325589A (ja) | 2002-11-12 |
EP0526452B2 (en) | 2007-01-03 |
CA2072642A1 (en) | 1991-05-23 |
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