BRPI0410331A - método para tratar doença de disco degenerativa - Google Patents

método para tratar doença de disco degenerativa

Info

Publication number
BRPI0410331A
BRPI0410331A BRPI0410331-9A BRPI0410331A BRPI0410331A BR PI0410331 A BRPI0410331 A BR PI0410331A BR PI0410331 A BRPI0410331 A BR PI0410331A BR PI0410331 A BRPI0410331 A BR PI0410331A
Authority
BR
Brazil
Prior art keywords
disc disease
antagonist
degenerative disc
disease
treat degenerative
Prior art date
Application number
BRPI0410331-9A
Other languages
English (en)
Inventor
Hassan Serhan
Thomas M Dimauro
Mohamed Attawia
Melissa Grace
Sudhakar Kadiyala
David Urbahns
Scott Bruder
Gregory Collins
Laura J Brown
Jeff Geesin
Pamela L Plouhar
Catherine Smith
John Siekierka
Original Assignee
Depuy Spine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/456,948 external-priority patent/US7344716B2/en
Priority claimed from US10/610,355 external-priority patent/US7429378B2/en
Priority claimed from US10/631,487 external-priority patent/US20040229878A1/en
Priority claimed from US10/640,412 external-priority patent/US7553827B2/en
Application filed by Depuy Spine Inc filed Critical Depuy Spine Inc
Publication of BRPI0410331A publication Critical patent/BRPI0410331A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Abstract

"MéTODO PARA TRATAR DOENçA DE DISCO DEGENERATIVA". A presente invenção refere-se a métodos de tratamento de doença de disco degenerativa por injeção de um antagonista tal como um antagonista de citocina de especificidade elevada, antagonista de afinidade elevada de MMPs, um inibidor de p38 cinase específico elevado, e um composto de ciclina em um disco intervertebral doente são descritos aqui.
BRPI0410331-9A 2003-05-13 2004-05-13 método para tratar doença de disco degenerativa BRPI0410331A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US47009803P 2003-05-13 2003-05-13
US10/456,948 US7344716B2 (en) 2003-05-13 2003-06-06 Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US10/610,355 US7429378B2 (en) 2003-05-13 2003-06-30 Transdiscal administration of high affinity anti-MMP inhibitors
US10/631,487 US20040229878A1 (en) 2003-05-13 2003-07-31 Transdiscal administration of specific inhibitors of P38 kinase
US10/640,412 US7553827B2 (en) 2003-08-13 2003-08-13 Transdiscal administration of cycline compounds
PCT/US2004/015285 WO2005000283A2 (en) 2003-05-13 2004-05-13 A method of treating degenerative disc disease

Publications (1)

Publication Number Publication Date
BRPI0410331A true BRPI0410331A (pt) 2006-05-30

Family

ID=33556747

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410331-9A BRPI0410331A (pt) 2003-05-13 2004-05-13 método para tratar doença de disco degenerativa

Country Status (8)

Country Link
EP (2) EP1631266B1 (pt)
JP (1) JP2007502327A (pt)
KR (1) KR20060014048A (pt)
AU (1) AU2004251042A1 (pt)
BR (1) BRPI0410331A (pt)
CA (1) CA2525928A1 (pt)
MX (1) MXPA05012275A (pt)
WO (1) WO2005000283A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US7744651B2 (en) 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
JP2006515765A (ja) 2002-11-15 2006-06-08 エスディージーアイ・ホールディングス・インコーポレーテッド 滑膜性関節を治療するためのコラーゲンベース材料および方法
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US7344716B2 (en) 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US20050100538A1 (en) * 2003-07-31 2005-05-12 Attawia Mohamed Intradiscal injection of anti-oxidants
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US20070043118A1 (en) * 2005-08-16 2007-02-22 Discogen, Llc Method of treating a subject suffering from degenerative disc disease using a nitric oxide synthase inhibitor
CA3008270A1 (en) 2005-09-21 2007-03-29 The Regents Of The University Of California Systems, compositions, and methods for local imaging and treatment of pain
US8828977B2 (en) 2006-02-16 2014-09-09 Discogen, Llc Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor
US8118779B2 (en) 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
US8399619B2 (en) 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8986696B2 (en) 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
UA113831C2 (xx) 2008-07-31 2017-03-27 Способи і проміжні сполуки для одержання підсилювачів солодкого смаку
WO2017176196A1 (en) * 2016-04-04 2017-10-12 Chalmers Ventures Ab Methods and compositions for the treatment of intervertebral disc herniation
CA3076662A1 (en) * 2017-09-25 2019-03-28 Ondrej SLABY Methods for treating degenerative disc disease and chronic lower back pain
WO2019152917A1 (en) * 2018-02-02 2019-08-08 Galen Therapeutics Llc Apparatus and method for protecting neurons and reducing inflammation and scarring
WO2020033420A1 (en) 2018-08-07 2020-02-13 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof
CN110613837A (zh) * 2019-10-24 2019-12-27 内蒙古医科大学第二附属医院 TGF-β在制备预防或治疗腰椎间盘突出药物中的应用

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DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
DE3888224T2 (de) 1987-04-24 1994-07-21 Teijin Ltd Bestimmung vom Tumornekrosefaktor; monoklonaler Antikörper und Zusammensetzung.
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
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DE10399036I1 (de) 1989-08-07 2004-04-01 Peptide Technology Ltd Bindeligande für Tumornekrosisfaktor.
GB9022648D0 (en) 1990-10-18 1990-11-28 Charing Cross Sunley Research Polypeptide and its use
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Also Published As

Publication number Publication date
AU2004251042A2 (en) 2005-01-06
AU2004251042A1 (en) 2005-01-06
CA2525928A1 (en) 2005-01-06
JP2007502327A (ja) 2007-02-08
MXPA05012275A (es) 2006-02-10
EP1631266A2 (en) 2006-03-08
EP1631266B1 (en) 2011-03-16
EP2286804A1 (en) 2011-02-23
KR20060014048A (ko) 2006-02-14
WO2005000283A2 (en) 2005-01-06
WO2005000283A3 (en) 2005-08-11

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired