DE69937899D1 - Antikörper-serumprotein hybride - Google Patents
Antikörper-serumprotein hybrideInfo
- Publication number
- DE69937899D1 DE69937899D1 DE69937899T DE69937899T DE69937899D1 DE 69937899 D1 DE69937899 D1 DE 69937899D1 DE 69937899 T DE69937899 T DE 69937899T DE 69937899 T DE69937899 T DE 69937899T DE 69937899 D1 DE69937899 D1 DE 69937899D1
- Authority
- DE
- Germany
- Prior art keywords
- serum protein
- antibody serum
- protein hybrid
- hybrid
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9824632 | 1998-11-10 | ||
GBGB9824632.5A GB9824632D0 (en) | 1998-11-10 | 1998-11-10 | Biological compounds |
PCT/GB1999/003747 WO2000027435A1 (en) | 1998-11-10 | 1999-11-10 | Antibody-serum protein hybrids |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69937899D1 true DE69937899D1 (de) | 2008-02-14 |
DE69937899T2 DE69937899T2 (de) | 2008-12-24 |
Family
ID=10842195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69937899T Expired - Fee Related DE69937899T2 (de) | 1998-11-10 | 1999-11-10 | Antikörper-serumprotein hybride |
Country Status (8)
Country | Link |
---|---|
US (2) | US7105160B1 (de) |
EP (2) | EP1808155A3 (de) |
AT (1) | ATE382370T1 (de) |
AU (1) | AU1062700A (de) |
DE (1) | DE69937899T2 (de) |
ES (1) | ES2299268T3 (de) |
GB (1) | GB9824632D0 (de) |
WO (1) | WO2000027435A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19926475A1 (de) * | 1999-06-10 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Träger-Pharmaka-Konjugate |
EP1444264A4 (de) * | 2001-10-17 | 2005-10-26 | Pharmaceuticals Inc Faulk | Verfahren und materialien zum targeting und zur beeinflussung ausgewählter zellen |
WO2004041865A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Stabilized single domain antibodies |
GB0411186D0 (en) * | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
EP2102244A2 (de) | 2006-12-19 | 2009-09-23 | Ablynx N.V. | Gegen metalloproteinase aus der adam-familie gerichtete aminosäuresequenzen und diese enthaltende polypeptide zur behandlung von mit adam in zusammenhang stehenden krankheiten und störungen |
AU2007336242B2 (en) | 2006-12-19 | 2012-08-30 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
EP2260058A2 (de) | 2008-04-07 | 2010-12-15 | Ablynx N.V. | Variable einzeldomänen gegen notch-signalwege |
EP2313436B1 (de) | 2008-07-22 | 2014-11-26 | Ablynx N.V. | Gegen multitarget-scavenger-rezeptoren und polypeptide gerichtete aminosäuresequenzen |
JP5647222B2 (ja) | 2009-04-10 | 2014-12-24 | アブリンクス エン.ヴェー. | Il−6r関連疾患及び障害の治療のためのil−6rに指向性を有する改善されたアミノ酸配列及びこれを含むポリペプチド |
DK2438087T3 (en) | 2009-06-05 | 2017-08-28 | Ablynx Nv | TRIVALENT NANOBODY CONSTRUCTIONS AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) FOR PREVENTION AND / OR TREATMENT OF AIR INFECTIONS |
US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2011073180A1 (en) | 2009-12-14 | 2011-06-23 | Ablynx N.V. | Single variable domain antibodies against ox40l, constructs and therapeutic use |
WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
KR20130066631A (ko) | 2010-05-06 | 2013-06-20 | 노파르티스 아게 | 치료적 저밀도 지단백질-관련 단백질 6 (lrp6) 다가 항체에 대한 조성물 및 사용 방법 |
ES2949159T3 (es) | 2010-05-06 | 2023-09-26 | Novartis Ag | Composiciones y métodos de uso para anticuerpos terapéuticos de proteína 6 relacionada con lipoproteínas de baja densidad (LRP6) |
WO2011144749A1 (en) | 2010-05-20 | 2011-11-24 | Ablynx Nv | Biological materials related to her3 |
EP3578568A3 (de) | 2010-11-08 | 2020-01-08 | Ablynx N.V. | Cxcr2-bindende polypeptide |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
JP2014525736A (ja) | 2011-06-23 | 2014-10-02 | アブリンクス エン.ヴェー. | IgEに対する免疫グロブリン単一可変ドメイン |
RU2014122602A (ru) | 2011-11-04 | 2015-12-10 | Новартис Аг | Конструкции на основе белка, родственного липопротеинам низкой плотности, 6(lrp6), и удлинителя полупериода существования |
US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
WO2018014260A1 (en) | 2016-07-20 | 2018-01-25 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
WO2018068201A1 (en) | 2016-10-11 | 2018-04-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against ctla-4 |
EP3541846A1 (de) | 2016-11-16 | 2019-09-25 | Ablynx NV | T-zell-rekrutierende polypeptide mit fähigkeit zur bindung von cd123 und tcr-alpha/beta |
CA3065630A1 (en) | 2017-06-02 | 2018-12-06 | Ablynx Nv | Aggrecan binding immunoglobulins |
CA3082280A1 (en) | 2017-12-28 | 2019-07-04 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against tigit |
TWI802633B (zh) | 2018-01-15 | 2023-05-21 | 大陸商南京傳奇生物科技有限公司 | 針對pd-1之單域抗體及其變異體 |
EP3774917A4 (de) | 2018-03-30 | 2022-01-19 | Nanjing Legend Biotech Co., Ltd. | Einzeldomänenantikörper gegen lag-3 und verwendungen davon |
AU2022224636A1 (en) | 2021-02-19 | 2023-09-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4749570A (en) * | 1981-12-31 | 1988-06-07 | The Governors Of The University Of Alberta | Targeting conjugates of albumin and therapeutic agents |
US4751286A (en) * | 1985-11-19 | 1988-06-14 | The Johns Hopkins University | Protein label and drug delivery system |
JPH05507924A (ja) * | 1990-07-03 | 1993-11-11 | アクゾ・エヌ・ヴエー | 免疫反応性化合物 |
CA2074945A1 (en) * | 1990-11-30 | 1992-05-31 | Atsushi Isoai | Tumor cell invasion-inhibiting peptides, peptide complexes and cancer metastasis inhibitors |
GB9112536D0 (en) | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
EP0602290B1 (de) * | 1992-12-04 | 1999-08-25 | ConjuChem, Inc. | Antikörper-konjugiertes-Hepatitis B-Oberflächenantigen und dessen Verwendung |
CA2184002A1 (en) * | 1994-02-23 | 1995-08-31 | Jeffrey M. Blaney | Method and compositions for increasing the serum half-life of pharmacologically active agents |
AU2823495A (en) * | 1994-06-09 | 1996-01-04 | Houston Biotechnology Incorporated | Methods and compositions for modulation of wound healing |
US5670132A (en) * | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
WO1997034631A1 (en) * | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
WO1998048845A1 (en) * | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Method of demarcating tissue |
-
1998
- 1998-11-10 GB GBGB9824632.5A patent/GB9824632D0/en not_active Ceased
-
1999
- 1999-11-10 EP EP07075275A patent/EP1808155A3/de not_active Withdrawn
- 1999-11-10 ES ES99954209T patent/ES2299268T3/es not_active Expired - Lifetime
- 1999-11-10 US US09/831,534 patent/US7105160B1/en not_active Expired - Fee Related
- 1999-11-10 EP EP99954209A patent/EP1128847B1/de not_active Expired - Lifetime
- 1999-11-10 WO PCT/GB1999/003747 patent/WO2000027435A1/en active IP Right Grant
- 1999-11-10 DE DE69937899T patent/DE69937899T2/de not_active Expired - Fee Related
- 1999-11-10 AT AT99954209T patent/ATE382370T1/de not_active IP Right Cessation
- 1999-11-10 AU AU10627/00A patent/AU1062700A/en not_active Abandoned
-
2006
- 2006-07-24 US US11/492,187 patent/US20060263375A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1128847B1 (de) | 2008-01-02 |
ATE382370T1 (de) | 2008-01-15 |
US7105160B1 (en) | 2006-09-12 |
WO2000027435A1 (en) | 2000-05-18 |
DE69937899T2 (de) | 2008-12-24 |
AU1062700A (en) | 2000-05-29 |
EP1128847A1 (de) | 2001-09-05 |
ES2299268T3 (es) | 2008-05-16 |
GB9824632D0 (en) | 1999-01-06 |
EP1808155A3 (de) | 2007-10-31 |
US20060263375A1 (en) | 2006-11-23 |
EP1808155A2 (de) | 2007-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: UCB PHARMA, S.A., BRUXELLES, BE |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |