PE20061324A1 - Anticuerpos anti-il-6, composiciones, metodos y usos - Google Patents

Anticuerpos anti-il-6, composiciones, metodos y usos

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Publication number
PE20061324A1
PE20061324A1 PE2006000449A PE2006000449A PE20061324A1 PE 20061324 A1 PE20061324 A1 PE 20061324A1 PE 2006000449 A PE2006000449 A PE 2006000449A PE 2006000449 A PE2006000449 A PE 2006000449A PE 20061324 A1 PE20061324 A1 PE 20061324A1
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PE
Peru
Prior art keywords
nos
seq
group consists
antibodies
compositions
Prior art date
Application number
PE2006000449A
Other languages
English (en)
Inventor
Yan Chen
Debra Gardner
Michael W Lark
David J Shealy
Vedrama Stojanovic-Ssulic
Susan H Tam
Jing Yang
Eric Michael Smith
Alain Phillipe Vasserot
David Matthew Marquis
Sheng-Jiun Wu
Raymond W Sweet
Xiao-Yu R Song
Bailin Liang
David M Knight
Original Assignee
Centocor Inc
Applied Molecular Evolution
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Centocor Inc, Applied Molecular Evolution filed Critical Centocor Inc
Publication of PE20061324A1 publication Critical patent/PE20061324A1/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

SE REFIERE A UN ANTICUERPO IL-6 AISLADO QUE COMPRENDE: A) UNA REGION VARIBLE DE CADENA LIVIANA DONDE AL MENOS UN MIEMBRO DEL GRUPO CONSISTE EN CDRL1 SELECCIONADO DE SEC ID NOS: 1, 3, 5, 7, 9, 11, 13 Y 15; CDRL2 SELECCIONADO DE SEC ID NOS: 17, 19, 21, 23, 25 Y 27; CDRL3 SELECCIONADO DE SEC ID NOS: 29, 31, 33, 35 Y 37; B) UNA REGION VARIABLE DE CADENA PESADA DONDE AL MENOS UN MIEMBRO DEL GRUPO CONSISTE EN CDRH1 SELECCIONADO DE SEC ID NOS: 37, 39, 41, 43, 45 Y 47; CDRH2 SELECCIONADO DE SEC ID NOS: 49, 51, 53, 55, 57, 59, 61, ENTRE OTROS; CDRH3 SELECCIONADO DE SEC ID NOS: 79, 81, 83, 85, 87, 89, 91 Y 114. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, OSTEOLISIS, LUPUS NEFRITIS, CARCINOMA DE CELULAS RENALES, ENTRE OTROS
PE2006000449A 2005-04-29 2006-04-27 Anticuerpos anti-il-6, composiciones, metodos y usos PE20061324A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67649805P 2005-04-29 2005-04-29
US67731905P 2005-05-03 2005-05-03

Publications (1)

Publication Number Publication Date
PE20061324A1 true PE20061324A1 (es) 2007-01-15

Family

ID=37308556

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000449A PE20061324A1 (es) 2005-04-29 2006-04-27 Anticuerpos anti-il-6, composiciones, metodos y usos

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US (11) US7560112B2 (es)
EP (3) EP2842968B1 (es)
JP (4) JP4763043B2 (es)
KR (1) KR101340950B1 (es)
CN (2) CN102924596B (es)
AR (1) AR053370A1 (es)
AU (1) AU2006242347B2 (es)
BR (1) BRPI0609869B1 (es)
CA (1) CA2606348C (es)
CR (1) CR9551A (es)
CY (1) CY1120739T1 (es)
DK (2) DK2842968T3 (es)
EA (1) EA015262B1 (es)
EC (1) ECSP077888A (es)
ES (2) ES2676732T3 (es)
HK (2) HK1116398A1 (es)
HN (1) HN2006016512A (es)
HR (2) HRP20150740T1 (es)
HU (2) HUE025376T2 (es)
IL (3) IL186965A0 (es)
JO (1) JO3058B1 (es)
LT (1) LT2842968T (es)
ME (1) ME02185B (es)
MY (2) MY142835A (es)
NI (1) NI200700278A (es)
NO (1) NO342898B1 (es)
NZ (3) NZ562771A (es)
PA (1) PA8672101A1 (es)
PE (1) PE20061324A1 (es)
PL (2) PL1874351T3 (es)
PT (2) PT2842968T (es)
RS (2) RS54133B1 (es)
SI (2) SI1874351T1 (es)
SV (1) SV2006002513A (es)
TR (1) TR201809676T4 (es)
TW (1) TWI445546B (es)
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