HRP20170444T1 - Projektirana anti-il-23 antitijela - Google Patents
Projektirana anti-il-23 antitijela Download PDFInfo
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- HRP20170444T1 HRP20170444T1 HRP20170444TT HRP20170444T HRP20170444T1 HR P20170444 T1 HRP20170444 T1 HR P20170444T1 HR P20170444T T HRP20170444T T HR P20170444TT HR P20170444 T HRP20170444 T HR P20170444T HR P20170444 T1 HRP20170444 T1 HR P20170444T1
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- Prior art keywords
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- binding fragment
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- 239000012634 fragment Substances 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000003306 harvesting Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108010065637 Interleukin-23 Proteins 0.000 claims 1
- 102000013264 Interleukin-23 Human genes 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (17)
1. Antitijelo, ili njegov antigen-vežući fragment, naznačen time, što se veže za humani IL- 23p19 na epitopu koji sadrži rezidue 82-95 i rezidue 133-140 SEQ ID NO: 29.
2. Antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 1, naznačen time, što se veže za epitop koji sadrži rezidue E82, G86, S87, D88, T91, G92, E93, P94, S95, H106, P133, S134, Q135, P136, W137, R139 i L140 SEQ ID NO: 29.
3. Antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 1, naznačen time, što antitijelo sadrži:
CDRL1 koji se sastoji od rezidua 43-53 SEQ ID NO: 4;
CDRL2 koji se sastoji od rezidua 69-75 SEQ ID NO: 4;
CDRL3 koji se sastoji od rezidua 108-116 SEQ ID NO: 4;
CDRH1 koji se sastoji od rezidua 45-54 SEQ ID NO: 3;
CDRH2 koji se sastoji od rezidua 69-85 SEQ ID NO: 3; i
CDRH3 koji se sastoji od rezidua 118-123 SEQ ID NO: 3.
4. Antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 3, naznačen time, što: varijabilna regija lakog lanca antitijela, ili njegovog vežućeg fragmenta, sadrži sekvencu rezidua 20-129 SEQ ID NO: 4, ili njenu varijantu; i varijabilna regija teškog lanca antitijela, ili njegovog vežućeg fragmenta, sadrži sekvencu rezidua 20-134 SEQ ID NO: 3, ili njenu varijantu; pri čemu varijanta sadrži do 20 konzervativno modificiranih aminokiselinskih supstitucija.
5. Antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 4, naznačen time, što je vezujući spoj antitijelo, ili njegov vežući fragment, koji uključuje:
varijabilnu regiju lakog lanca koji sadrži rezidue 20-129 SEQ ID NO: 4; i
varijabilnu regiju teškog lanca koji sadrži rezidue 20-134 SEQ ID NO: 3.
6. Antitijelo ili njegov antigen-vežući fragment iz zahtjeva 3, naznačen time, što blokira aktivnost posredovanu IL-23.
7. Izolirana nukleinska kiselina, naznačena time, što kodira varijabilnu regiju lakog lanca i varijabilnu regiju teškog lanca antitijela, ili njegovog antigen-vežućeg fragmenta, iz zahtjeva 4.
8. Ekspresijski vektor, naznačen time, što sadrži nukleinsku kiselinu iz zahtjeva 7 operabilno povezanu sa kontrolnim sekvencama koje prepoznaje stanica-domaćin, kada se stanica-domaćin transfektira vektorom.
9. Stanica-domaćin, naznačena time, što sadrži ekspresijski vektor iz zahtjeva 8.
10. Metoda proizvodnje polipeptida, naznačena time, što uključuje:
kultiviranje stanice-domaćina iz zahtjeva 9 u kultivacijskom mediju pod uvjetima pod kojima se eksprimira sekvenca nukleinske kiseline, čime se proizvode polipeptidi koji sadrže varijabilne regije lakog i teškog lanca; i sakupljanje polipeptida iz stanice-domaćina ili kultivacijskog medija.
11. Antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 2, naznačen time, što sadrži konstantnu regiju humanog γ1 teškog lanca.
12. Antitijelo ili njegov antigen-vežući fragment iz zahtjeva 2, naznačen time, što sadrži konstantnu regiju humanog γ4 teškog lanca.
13. Antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 1, naznačen time, što se fragment antitijela bira iz grupe koja se sastoji od Fab, Fab’, Fab’-SH, Fv, scFv, F(ab’)2 i dijatela.
14. Smjesa, naznačena time, što sadrži antitijelo, ili njegov antigen-vežući fragment, iz zahtjeva 4 u kombinaciji sa farmaceutski prihvatljivim nosačem ili razblaživačem.
15. Smjesa iz zahtjeva 14, naznačena time, što sadrži još i imunosupresivno ili antiupalnog sredstvo.
16. Stanica-domaćin, naznačena time, što sadrži:
(a) ekspresijski vektor koji uključuje sekvencu nukleinske kiseline koja kodira laki lanac antitijela, ili njegovog antigen-vežućeg fragmenta, iz zahtjeva 4; i
(b) ekspresijski vektor koji uključuje sekvencu nukleinske kiseline koja kodira teški lanac antitijela, ili njegovog antigen-vežućeg fragmenta, iz zahtjeva 4.
17. Metoda proizvodnje vežućeg spoja naznačena time, što uključuje:
kultiviranje stanice-domaćina iz zahtjeva 16 u kultivacijskom mediju pod uvjetima u kojima se eksprimiraju sekvence nukleinske kiseline, čime se proizvode polipeptidi koji sadrže lake i teške lance antitijela, ili njegovog antigen-vežućeg fragmenta; i sakupljanje antitijela, ili njegovog antigen-vežućeg fragmenta iz stanice-domaćina ili kultivacijskog medija.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71358505P | 2005-08-31 | 2005-08-31 | |
PCT/US2006/033764 WO2007027714A2 (en) | 2005-08-31 | 2006-08-29 | Engineered anti-il-23 antibodies |
EP06802592.3A EP1931710B1 (en) | 2005-08-31 | 2006-08-29 | Engineered anti-il-23 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20170444T1 true HRP20170444T1 (hr) | 2017-05-19 |
Family
ID=37685722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170444TT HRP20170444T1 (hr) | 2005-08-31 | 2017-03-20 | Projektirana anti-il-23 antitijela |
Country Status (17)
Country | Link |
---|---|
US (3) | US7807160B2 (hr) |
EP (3) | EP2354160A1 (hr) |
JP (2) | JP5350793B2 (hr) |
CN (1) | CN101296944A (hr) |
CA (1) | CA2620802A1 (hr) |
CY (2) | CY1118760T1 (hr) |
DK (1) | DK1931710T3 (hr) |
ES (1) | ES2619845T3 (hr) |
HR (1) | HRP20170444T1 (hr) |
HU (2) | HUE032131T2 (hr) |
LT (2) | LT1931710T (hr) |
ME (1) | ME02705B (hr) |
PL (1) | PL1931710T3 (hr) |
PT (1) | PT1931710T (hr) |
RS (1) | RS55788B1 (hr) |
SG (2) | SG165322A1 (hr) |
WO (1) | WO2007027714A2 (hr) |
Families Citing this family (70)
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EP3501537A1 (en) | 2005-06-30 | 2019-06-26 | Janssen Biotech, Inc. | Anti-il23 antibodies, compositions, methods and uses |
EP2354160A1 (en) | 2005-08-31 | 2011-08-10 | Schering Corporation | Engineered anti-IL-23-antibodies |
US20080199460A1 (en) | 2005-09-01 | 2008-08-21 | Schering Corporation | Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease |
AU2006342792A1 (en) * | 2005-12-02 | 2007-11-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R |
PL1971366T3 (pl) | 2005-12-29 | 2015-01-30 | Janssen Biotech Inc | Ludzkie przeciwciała skierowane przeciw IL-23, kompozycje, sposoby i zastosowanie |
US7790862B2 (en) * | 2006-06-13 | 2010-09-07 | Zymogenetics, Inc. | IL-17 and IL-23 antagonists and methods of using the same |
US7910703B2 (en) * | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
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TWI426918B (zh) | 2007-02-12 | 2014-02-21 | Merck Sharp & Dohme | Il-23拮抗劑於治療感染之用途 |
SG178804A1 (en) * | 2007-02-23 | 2012-03-29 | Schering Corp | Engineered anti-il-23p19 antibodies |
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EP2379710A1 (en) | 2008-12-19 | 2011-10-26 | Schering Corporation | Feed supplement for mammalian cell culture and methods of use |
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- 2006-08-29 SG SG201006284-2A patent/SG165322A1/en unknown
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PL1931710T3 (pl) | 2017-06-30 |
CA2620802A1 (en) | 2007-03-08 |
CY2019041I1 (el) | 2020-05-29 |
US7807160B2 (en) | 2010-10-05 |
CN101296944A (zh) | 2008-10-29 |
JP2009505677A (ja) | 2009-02-12 |
RS55788B1 (sr) | 2017-08-31 |
EP2354160A1 (en) | 2011-08-10 |
US20070048315A1 (en) | 2007-03-01 |
US20110002942A1 (en) | 2011-01-06 |
WO2007027714A3 (en) | 2007-06-21 |
SG10201402712QA (en) | 2014-08-28 |
EP1931710A2 (en) | 2008-06-18 |
HUE032131T2 (en) | 2017-09-28 |
US20090156788A1 (en) | 2009-06-18 |
SG165322A1 (en) | 2010-10-28 |
PT1931710T (pt) | 2017-03-28 |
CY2019041I2 (el) | 2020-05-29 |
WO2007027714A2 (en) | 2007-03-08 |
JP5350793B2 (ja) | 2013-11-27 |
EP3190125A1 (en) | 2017-07-12 |
ME02705B (me) | 2017-10-20 |
DK1931710T3 (en) | 2017-04-03 |
US8362212B2 (en) | 2013-01-29 |
CY1118760T1 (el) | 2017-07-12 |
EP1931710B1 (en) | 2017-01-18 |
LTPA2019520I1 (lt) | 2019-11-11 |
ES2619845T3 (es) | 2017-06-27 |
LT1931710T (lt) | 2017-03-27 |
JP2011130771A (ja) | 2011-07-07 |
HUS1900050I1 (hu) | 2019-11-28 |
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