MX344076B - Polipeptidos funcionalizados. - Google Patents
Polipeptidos funcionalizados.Info
- Publication number
- MX344076B MX344076B MX2012011299A MX2012011299A MX344076B MX 344076 B MX344076 B MX 344076B MX 2012011299 A MX2012011299 A MX 2012011299A MX 2012011299 A MX2012011299 A MX 2012011299A MX 344076 B MX344076 B MX 344076B
- Authority
- MX
- Mexico
- Prior art keywords
- functionalized
- polypeptides
- functionalized polypeptides
- improved
- tissue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a polipéptidos funcionalizados, especialmente polipéptidos terapéuticos (por ejemplo, scFv), que comprenden una secuencia enlazadora que puede funcionalizarse rápida y específicamente mediante la adición de una o de porciones funcionales (por ejemplo, PEG) o especificidades de unión (por ejemplo, una secuencia de aminoácidos con una especificidad de unión particular) Tales polipéptidos funcionalizados son ventajosos porque tienen propiedades farmacocinéticas mejoradas (por ejemplo, vida media in vivo mejorada, penetración de tejido y tiempo de residencia de tejido) sobre polipéptidos no funcionalizados. También se proporcionan métodos para la generación rápida y reproducible de polipéptidos funcionalizados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7677508P | 2008-06-30 | 2008-06-30 | |
PCT/CH2009/000225 WO2010006454A2 (en) | 2008-06-30 | 2009-06-30 | Functionalized polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX344076B true MX344076B (es) | 2016-12-05 |
Family
ID=41139486
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012011299A MX344076B (es) | 2008-06-30 | 2009-06-30 | Polipeptidos funcionalizados. |
MX2011000006A MX2011000006A (es) | 2008-06-30 | 2009-06-30 | Polipeptidos funcionalizados. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011000006A MX2011000006A (es) | 2008-06-30 | 2009-06-30 | Polipeptidos funcionalizados. |
Country Status (12)
Country | Link |
---|---|
US (3) | US8637022B2 (es) |
EP (2) | EP2304033B1 (es) |
JP (3) | JP5988580B2 (es) |
KR (2) | KR101678925B1 (es) |
CN (2) | CN102089431A (es) |
AU (1) | AU2009270405B2 (es) |
BR (1) | BRPI0915343A2 (es) |
CA (1) | CA2729185A1 (es) |
MX (2) | MX344076B (es) |
RU (2) | RU2582244C2 (es) |
WO (1) | WO2010006454A2 (es) |
ZA (1) | ZA201008596B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110031373A (ko) | 2008-07-10 | 2011-03-25 | 에스바테크, 언 알콘 바이오메디칼 리서치 유닛 엘엘씨 | 마크로분자 전달을 증강하는 방법 및 조성물 |
US20100056766A1 (en) * | 2008-08-27 | 2010-03-04 | Abbott Laboratories | Purification of biological conjugates by size exclusion chromatography |
AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
CN109608543A (zh) | 2011-10-20 | 2019-04-12 | 艾斯巴技术-诺华有限责任公司 | 稳定的多抗原结合抗体 |
EP3122777B1 (en) | 2014-03-26 | 2020-12-23 | Cell Medica Switzerland AG | Binding members to tnf alpha |
TWI806150B (zh) | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
KR20220062494A (ko) * | 2019-08-15 | 2022-05-17 | 얀센 바이오테크 인코포레이티드 | 개선된 단일 사슬 가변 단편을 위한 재료 및 방법 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB9225453D0 (en) * | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
WO1998031700A1 (en) | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
US20050159343A1 (en) * | 1999-03-26 | 2005-07-21 | Board Of Regents, University Of Texas System | Inhibitors of glycosaminoglycans |
DK1165112T3 (da) | 1999-03-26 | 2006-10-09 | Univ Texas | Modulatorer af polysaccharider og anvendelser deraf |
AU7346400A (en) | 1999-09-03 | 2001-04-10 | School Of Pharmacy, University Of London, The | Degradable polymers |
EP1222217B1 (en) | 1999-09-08 | 2005-06-15 | Polytherics Limited | Uniform molecular weight polymers |
US20050287153A1 (en) * | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
CA2390691C (en) | 1999-12-24 | 2016-05-10 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
CA2406593A1 (en) * | 2000-04-20 | 2001-11-01 | Cangene Corporation | Rhamm peptide conjugates |
US7211395B2 (en) * | 2001-03-09 | 2007-05-01 | Dyax Corp. | Serum albumin binding moieties |
CA2444098C (en) * | 2001-04-19 | 2016-06-21 | The Scripps Research Institute | Methods and composition for the production of orthogonal trna-aminoacyltrna synthetase pairs |
GB0131112D0 (en) | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
GB0209022D0 (en) | 2002-04-19 | 2002-05-29 | Imp College Innovations Ltd | Compounds |
DK1506236T3 (da) * | 2002-05-22 | 2013-03-04 | Esbatech A Novartis Co Llc | Immunglobulin-frameworks, der udviser forbedret stabilitet i det intracellulære miljø og fremgangsmåder til identifikation deraf |
AU2003301122B2 (en) | 2002-12-19 | 2009-11-26 | Nektar Therapeutics | Cyanovirin variant-polymer conjugates |
US7834258B2 (en) * | 2003-06-30 | 2010-11-16 | Mu-Hyeon Choe | Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same |
GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
GB0400264D0 (en) | 2004-01-07 | 2004-02-11 | Polytherics Ltd | Complexes |
EP1769000B1 (en) * | 2004-07-16 | 2014-12-24 | Amgen Research (Munich) GmbH | Expression-enhanced polypeptides |
NZ553500A (en) * | 2004-09-23 | 2009-11-27 | Genentech Inc Genentech Inc | Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain |
CA2580796C (en) * | 2004-09-24 | 2013-03-26 | Amgen Inc. | Modified fc molecules having peptides inserted in internal loop regions |
US20060147862A1 (en) * | 2005-01-06 | 2006-07-06 | Jeffrey Bell | Reduced smoking wick and candle |
US7723472B2 (en) * | 2005-02-28 | 2010-05-25 | The Regents Of The University Of California | Extracellular matrix binding chimeric proteins and methods of use thereof |
KR101457223B1 (ko) | 2005-06-07 | 2014-11-04 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | TNFα를 억제하는 안정적이고 가용성인 항체 |
JP2009509535A (ja) * | 2005-09-27 | 2009-03-12 | アムニクス, インコーポレイテッド | タンパク様薬剤およびその使用 |
KR101571027B1 (ko) * | 2006-06-12 | 2015-11-23 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | 효과기 기능을 갖는 단일쇄 다가 결합 단백질 |
RU2438708C2 (ru) | 2006-07-10 | 2012-01-10 | Эсбатек, Эн Элкон Биомедикал Рисёрч Юнит Ллк | ScFv-АНТИТЕЛА, КОТОРЫЕ ПРОХОДЯТ ЧЕРЕЗ ЭПИТЕЛИАЛЬНЫЙ И/ИЛИ ЭНДОТЕЛИАЛЬНЫЙ СЛОИ |
RU2010102064A (ru) | 2007-06-25 | 2011-07-27 | Эсбатек, Эн Элкон Биомедикал Рисёрч Юнит Ллк (Ch) | Способ конструирования, основанный на определении последовательностей, способ оптимизации одноцепочечных антител |
MX2009013328A (es) * | 2007-06-25 | 2010-06-02 | Esbatech An Alcon Biomedical R | Metodos para modificar anticuerpos, y anticuerpos modificados con propiedades funcionales mejoradas. |
EP3216803B1 (en) * | 2008-06-25 | 2020-03-11 | Novartis Ag | Stable and soluble antibodies inhibiting vegf |
-
2009
- 2009-06-30 EP EP09775731.4A patent/EP2304033B1/en not_active Not-in-force
- 2009-06-30 EP EP16187295.7A patent/EP3130603A1/en not_active Withdrawn
- 2009-06-30 RU RU2011103168/10A patent/RU2582244C2/ru not_active IP Right Cessation
- 2009-06-30 MX MX2012011299A patent/MX344076B/es unknown
- 2009-06-30 MX MX2011000006A patent/MX2011000006A/es active IP Right Grant
- 2009-06-30 CN CN2009801247812A patent/CN102089431A/zh active Pending
- 2009-06-30 KR KR1020117001520A patent/KR101678925B1/ko active IP Right Grant
- 2009-06-30 KR KR1020167010129A patent/KR101711472B1/ko active IP Right Grant
- 2009-06-30 AU AU2009270405A patent/AU2009270405B2/en not_active Ceased
- 2009-06-30 CN CN201510689528.9A patent/CN105153300A/zh active Pending
- 2009-06-30 BR BRPI0915343A patent/BRPI0915343A2/pt not_active IP Right Cessation
- 2009-06-30 US US13/000,499 patent/US8637022B2/en not_active Expired - Fee Related
- 2009-06-30 CA CA2729185A patent/CA2729185A1/en not_active Abandoned
- 2009-06-30 WO PCT/CH2009/000225 patent/WO2010006454A2/en active Application Filing
- 2009-06-30 RU RU2016108598A patent/RU2016108598A/ru not_active Application Discontinuation
- 2009-06-30 JP JP2011515053A patent/JP5988580B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-30 ZA ZA2010/08596A patent/ZA201008596B/en unknown
-
2013
- 2013-12-19 US US14/134,988 patent/US9371525B2/en not_active Expired - Fee Related
-
2014
- 2014-03-19 JP JP2014055758A patent/JP2014111670A/ja active Pending
-
2016
- 2016-05-20 JP JP2016101272A patent/JP2016147909A/ja active Pending
- 2016-05-24 US US15/163,208 patent/US20160354479A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2010006454A2 (en) | 2010-01-21 |
WO2010006454A3 (en) | 2010-03-25 |
ZA201008596B (en) | 2012-02-29 |
AU2009270405A1 (en) | 2010-01-21 |
CN102089431A (zh) | 2011-06-08 |
US8637022B2 (en) | 2014-01-28 |
US9371525B2 (en) | 2016-06-21 |
JP2016147909A (ja) | 2016-08-18 |
BRPI0915343A2 (pt) | 2015-10-27 |
RU2016108598A (ru) | 2018-11-23 |
JP5988580B2 (ja) | 2016-09-07 |
MX2011000006A (es) | 2011-08-03 |
EP3130603A1 (en) | 2017-02-15 |
RU2011103168A (ru) | 2012-08-10 |
JP2011526145A (ja) | 2011-10-06 |
KR20160046927A (ko) | 2016-04-29 |
EP2304033B1 (en) | 2016-09-07 |
CA2729185A1 (en) | 2010-01-21 |
KR101678925B1 (ko) | 2016-11-24 |
KR101711472B1 (ko) | 2017-03-02 |
US20160354479A1 (en) | 2016-12-08 |
CN105153300A (zh) | 2015-12-16 |
EP2304033A2 (en) | 2011-04-06 |
RU2582244C2 (ru) | 2016-04-20 |
AU2009270405B2 (en) | 2014-06-05 |
JP2014111670A (ja) | 2014-06-19 |
US20110200594A1 (en) | 2011-08-18 |
KR20110039274A (ko) | 2011-04-15 |
US20140178386A1 (en) | 2014-06-26 |
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